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Cited by 336

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

Evolution of neuropsychological dysfunction during the course of schizophrenia and bipolar disorder

Lewandowski, K. E., Cohen, B. M., Öngur, D.·2011·Psychological Medicine
DOI 10.1017/s0033291710001042
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Abstract

Background: Neurocognitive dysfunction in schizophrenia (SZ), bipolar (BD) and related disorders represents a core feature of these illnesses, possibly a marker of underlying pathophysiology. Substantial overlap in domains of neuropsychological deficits has been reported among these disorders after illness onset. However, it is unclear whether deficits follow the same longitudinal pre- and post-morbid course across diagnoses. We examine evidence for neurocognitive dysfunction as a core feature of all idiopathic psychotic illnesses, and trace its evolution from pre-morbid and prodromal states through the emergence of overt psychosis and into chronic illness in patients with SZ, BD and related disorders. Method: Articles reporting on neuropsychological functioning in patients with SZ, BD and related disorders before and after illness onset were reviewed. Given the vast literature on these topics and the present focus on cross-diagnostic comparisons, priority was given to primary data papers that assessed cross-diagnostic samples and recent meta-analyses. Results: Patients with SZ exhibit dysfunction preceding the onset of illness, which becomes more pronounced in the prodrome and early years following diagnosis, then settles into a stable pattern. Patients with BD generally exhibit typical cognitive development pre-morbidly, but demonstrate deficits by first episode that are amplified with worsening symptoms and exacerbations. Conclusions: Neuropsychological deficits represent a core feature of SZ and BD; however, their onset and progression differ between diagnostic groups. A lifetime perspective on the evolution of neurocognitive deficits in SZ and BD reveals distinct patterns, and may provide a useful guide to the examination of the pathophysiological processes underpinning these functions across disorders.

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Metadata

Authors
Lewandowski, K. E., Cohen, B. M., & Öngur, D.
Venue
Psychological Medicine
Publisher
Cambridge University Press (CUP)
Published
2010-05-19
Volume
41
Issue
2
Pages
225-241
ISSN
  • 0033-2917 (ISSN-L)
  • 1469-8978
DOI
10.1017/s0033291710001042
OpenAlex
W2076782400
Cited by
336
References
13
FWCI
13.96
Type
journal article
Language
en
Open access
closed

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