Clinical and psychometric correlates of dopamine D2 binding in depression
Abstract
BACKGROUND: Single photon emission tomography (SPET) with the dopamine D2/3 ligand 123I-IBZM gives a semi-quantitative estimate of dopamine binding. In depressed patients, we predicted evidence of reduced function, i.e. increased binding, particularly in more retarded patients. METHODS: Fifteen depressed patients with major depressive illness and 15 healthy, age- and sex- matched volunteerS were examined with a clinical and neuropsychological test battery and high resolution IBZM-SPET. Estimates for specific binding were computed by averaging striatum to whole slice or frontal uptake ratios over 8-10 scans acquired from 70 min after tracer injection. RESULTS: Using whole slice as reference, left striatal uptake ratios did not significantly differ for patients from controls. Right ratios were significantly higher in patients than controls (P = 0.03). There were significant correlations between IBZM binding in left and right striatum and measures of reaction time and verbal fluency. CONCLUSIONS: Increased IBZM binding in striatum probably reflects reduced dopamine function, whether due to reduced release of dopamine, or secondary up-regulation of receptors. The observed abnormalities may be trait or state related, an issue that needs to be addressed with longitudinal study designs. The possible role of medication as a confounding variable requires further exploration.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Decreased D2 binding among depressed patients was significantly correlated with reduced speech rate.
“Further, decreased D2 binding among depressed patients was significantly correlated with reduced speech rate (FAS-Verbal Fluency test) and reduced speed of movement on a reaction time task (Shah et al., 1997).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Shah et al., 1997
Decreased D2 binding among depressed patients was significantly correlated with reduced speed of movement on a reaction time task.
“Further, decreased D2 binding among depressed patients was significantly correlated with reduced speech rate (FAS-Verbal Fluency test) and reduced speed of movement on a reaction time task (Shah et al., 1997).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Shah et al., 1997
Cited by
Sorted by citations
Reconsidering anhedonia in depression: Lessons from translational neuroscience
Treadway, M. T., & Zald, D. H. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.06.006 · Cited by 1,579 · see citing works
The role of dopamine in the pathophysiology of depression
Dunlop, B. W., & Nemeroff, C. B. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.3.327 · Cited by 1,244 · see citing works
Depression, Stress, and Anhedonia: Toward a Synthesis and Integrated Model
Pizzagalli, D. A. (2014) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050212-185606 · Cited by 1,155 · see citing works
depue, R. A., & morrone-strupinsky, J. V. (2005) · Behavioral and Brain Sciences · doi:10.1017/s0140525x05000063 · Cited by 958 · see citing works
Cryan, J. F., & Mombereau, C. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001457 · Cited by 616 · see citing works
Dopamine dysregulation syndrome: implications for a dopamine hypothesis of bipolar disorder
Berk, M., Dodd, S., Kauer‐Sant’Anna, M., Malhi, G. S., Bourin, M., Kapczinski, F., & Norman, T. (2007) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2007.01058.x · Cited by 396 · see citing works
Lower dopamine transporter binding potential in striatum during depression
Meyer, J. H., Krüger, S., Wilson, A. A., Christensen, B. K., Goulding, V. S., Schaffer, A., Minifie, C., Houle, S., Hussey, D., & Kennedy, S. H. (2001) · Neuroreport · doi:10.1097/00001756-200112210-00052 · Cited by 269 · see citing works
Miller, A. H. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2008.08.006 · Cited by 261 · see citing works
Matsuo, K., Glahn, D. C., Peluso, M. A. M., Hatch, J. P., Monkul, E. S., Najt, P., Sanches, M., Zamarripa, F., Li, J., Lancaster, J. L., et al. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001894 · Cited by 251 · see citing works
The role of the brain reward system in depression
Naranjo, C. A., Tremblay, L. K., & Busto, U. E. (2001) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(01)00156-7 · Cited by 245 · see citing works
Depression: a decision-theoretic analysis
Huys, Q. J. M., Daw, N. D., & Dayan, P. (2015) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071714-033928 · Cited by 221 · see citing works
Tremblay, L. K., Naranjo, C. A., Cardenas, L., Herrmann, N., & Busto, U. E. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.5.409 · Cited by 229 · see citing works
Developmental origins of brain disorders: roles for dopamine
Money, K. M., & Stanwood, G. D. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00260 · Cited by 221 · see citing works
Dooley, L. N., Kuhlman, K. R., Robles, T. F., Eisenberger, N. I., Craske, M. G., & Bower, J. E. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.006 · Cited by 176 · see citing works
Dopaminergic mechanism of antidepressant action in depressed patients
Willner, P., Hale, A. S., & Argyropoulos, S. (2005) · Journal of Affective Disorders · doi:10.1016/j.jad.2004.12.010 · Cited by 169 · see citing works
Meyer, J. H., McNeely, H. E., Sagrati, S., Boovariwala, A., Martin, K., Verhoeff, N. P. L. G., Wilson, A. A., & Houle, S. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.9.1594 · Cited by 160 · see citing works
Amphetamine-induced displacement of [18F] fallypride in striatum and extrastriatal regions in humans
Riccardi, P., Li, R., Ansari, M. S., Zald, D., Park, S., Dawant, B., Anderson, S., Doop, M., Woodward, N., Schoenberg, E., et al. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300916 · Cited by 134 · see citing works
Dopamine D2 receptor availability and amphetamine-induced dopamine release in unipolar depression
Parsey, R. V., Oquendo, M. A., Zea-Ponce, Y., Rodenhiser, J., Kegeles, L. S., Pratap, M., Cooper, T. B., Van Heertum, R., Mann, J. J., & Laruelle, M. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01089-7 · Cited by 133 · see citing works
Majer, M., Welberg, L. A. M., Capuron, L., Pagnoni, G., Raison, C. L., & Miller, A. H. (2008) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.12.009 · Cited by 124 · see citing works
Psychomotor slowing as a predictor of fluoxetine nonresponse in depressed outpatients
Taylor, B. P., Bruder, G. E., Stewart, J. W., McGrath, P. J., Halperin, J., Ehrlichman, H., & Quitkin, F. M. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.1.73 · Cited by 109 · see citing works
Zhang, Y., Wang, Y., Wang, L., Bai, M., Zhang, X., & Zhu, X. (2015) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv025 · Cited by 104 · see citing works
Roiser, J. P., McLean, A., Ogilvie, A. D., Blackwell, A. D., Bamber, D. J., Goodyer, I., Jones, P. B., & Sahakian, B. J. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300659 · Cited by 96 · see citing works
Self-citationKuroda, Y., Motohashi, N., Ito, H., Ito, S., Takano, A., Nishikawa, T., & Suhara, T. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.03.029 · Cited by 77 · see citing works
“There have been a few studies that compared BP obtained with [I]iodobenzamide (IBZM) in depressed patients with that in age-matched healthy controls (D'haenen and Bossuyt, 1994; Ebert et al., 1994, 1996; Shah et al., 1997; Klimke et al., 1999; Parsey et al., 2001).”
ResultPsychomotor Changes in Major Depressive Disorder during Sertraline Treatment
Schrijvers, D., Maas, Y. J., Pier, M. P. B. I., Madani, Y., Hulstijn, W., & Sabbe, B. G. C. (2009) · Neuropsychobiology · doi:10.1159/000205516 · Cited by 36 · see citing works
Neuroimaging and Neuropathological Studies of Mood Disorders
Drevets, W. C., & Price, J. L. (2005) · Biology of Depression · doi:10.1002/9783527619672.ch17 · Cited by 26 · see citing works
- Authors
- SHAH, P. J., OGILVIE, A. D., GOODWIN, G. M., & EBMEIER, K. P.
- Affiliations
- Royal Edinburgh Hospital (GB)
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 1997-11
- Volume
- 27
- Issue
- 6
- Pages
- 1247-1256
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W2131366636
- Cited by
- 170
- References
- 0
- Citations by year
- 2026: 3 · 2025: 4 · 2023: 3 · 2022: 8 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 7 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 9 · 2013: 4 · 2012: 9
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- depression, dopamine D2 receptor binding, [123I]IBZM, striatum, single photon emission tomography, neuropsychological correlates, reaction time, verbal fluency, major depressive disorder, trait versus state
- MeSH terms
- Adult, Basal Ganglia, Benzamides, Corpus Striatum, Depressive Disorder, Female, Humans, Functional Laterality, Male, Middle Aged, Neuropsychological Tests, Psychomotor Performance, Pyrrolidines, Reaction Time, Sex Factors, Verbal Behavior, Up-Regulation, Tomography, Emission-Computed, Single-Photon, Receptors, Dopamine D2, Dopamine Antagonists
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
