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The Subgenual Anterior Cingulate Cortex in Mood Disorders
Open accessAbstract
The anterior cingulate cortex (ACC) ventral to the genu of the corpus callosum has been implicated in the modulation of emotional behavior on the basis of neuroimaging studies in humans and lesion analyses in experimental animals. In a combined positron emission tomography/magnetic resonance imaging study of mood disorders, we demonstrated that the mean gray matter volume of this “subgenual” ACC (sgACC) cortex is abnormally reduced in subjects with major depressive disorder (MDD) and bipolar disorder, irrespective of mood state. Neuropathological assessments of sgACC tissue acquired postmortem from subjects with MDD or bipolar disorder confirmed the decrement in gray matter volume, and revealed that this abnormality was associated with a reduction in glia, with no equivalent loss of neurons. In positron emission tomography studies, the metabolic activity was elevated in this region in the depressed relative to the remitted phases of the same MDD subjects, and effective antidepressant treatment was associated with a reduction in sgACC activity. Other laboratories replicated and extended these findings, and the clinical importance of this treatment effect was underscored by a study showing that deep brain stimulation of the sgACC ameliorates depressive symptoms in treatment-resistant MDD. This article discusses the functional significance of these findings within the context of the preclinical literature that implicates the putative homologue of this region in the regulation of emotional behavior and stress response. In experimental animals, this region participates in an extended “visceromotor network” of structures that modulates autonomic/neuroendocrine responses and neurotransmitter transmission during the neural processing of reward, fear, and stress. These data thus hold important implications for the development of neural models of depression that can account for the abnormal motivational, neuroendocrine, autonomic, and emotional manifestations evident in human mood disorders.
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In the citing paper
“The differential effects of these drugs on dendritic atrophy in stressed rats thus resemble their effects on sgACC volume in humans with BD (Moore et al. 2008; Drevets et al. 1997; Drevets and Savitz 2008).”
From Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression (2008) · cites this paper as Drevets and Savitz 2008
Experimental — accuracy not yet measuredIn the citing paper
“a meta-analysis on volumetric fMRI studies has revealed a volume reduction of ACC compared with healthy control subjects (Drevets et al., 2008;Zhao et al., 2014).”
From Social functioning in major depressive disorder (2016) · cites this paper as Drevets et al., 2008
In the citing paper
“In healthy men, intranasal oxytocin administration can increase empathic concern (Hurlemann et al., 2010), enhance empathic accuracy (Bartz et al., 2010) and improve ToM (Domes et al., 2006).”
From Social functioning in major depressive disorder (2016) · cites this paper as Domes et al., 2006
In the citing paper
“Biomarkers that distinguish between depressed and non-depressed individuals have been identified at the neural level (Drevets et al, 2008; Northoff et al, 2011)”
From Resting-state cortico-thalamic-striatal connectivity predicts response to dorsomedial prefrontal rTMS in major depressive disorder (2014) · cites this paper as Drevets et al, 2008
In the citing paper
“Depression has been associated with functional and structural abnormalities in subgenual cingulate, thalamus, striatum, and limbic regions (Alcaro et al, 2010; Drevets et al, 2008; Heller et al, 2009, 2013; Mayberg, 2009; Phillips et al, 2003).”
From Resting-state cortico-thalamic-striatal connectivity predicts response to dorsomedial prefrontal rTMS in major depressive disorder (2014) · cites this paper as Drevets et al, 2008
In the citing paper
“Clinical studies indicate that metabolism in sACC is elevated in the depressed phase relative to the remitted phase of the same patients with major depressive disorder (Drevets et al., 2008).”
From Phasic and sustained fear in humans elicits distinct patterns of brain activity (2011) · cites this paper as Drevets et al., 2008
In the citing paper
“In addition, this structure and neighbouring medial frontal regions and linked basal ganglia have been also been strikingly linked with mood regulation, including depression and anxiety (Drevets et al., 2008; Gutman et al., 2009; Johansen-Berg et al., 2008; Mayberg et al., 2005).”
From The human parental brain: In vivo neuroimaging (2011) · cites this paper as Drevets et al., 2008
In the citing paper
“which is especially involved in fear responses and shows abnormal activity in mood disorders (Drevets et al, 2008).”
From Oxytocin Facilitates Pavlovian Fear Learning in Males (2016) · cites this paper as Drevets et al, 2008
In the citing paper
“The key regions that have gained consensus for an involvement in MDD include the limbic cortex (amygdala, hippocampus), the cingulate cortex, dorsal striatum and the frontal lobe (dorsolateral prefrontal cortex [DLPFC] and medial prefrontal cortex [MPFC]).”
From Widespread reductions in gray matter volume in depression (2013) · cites this paper as Drevets et al., 2008
In the citing paper
“A substantial body of imaging data demonstrates spatially distributed functional abnormalities occurring throughout the brain in MDD (Drevets et al., 2008).”
From Widespread reductions in gray matter volume in depression (2013) · cites this paper as Drevets et al., 2008
In the citing paper
“The functional role of the cingulate cortex—and specifically the ACC—in depression is well described (Drevets et al., 2008).”
From Widespread reductions in gray matter volume in depression (2013) · cites this paper as Drevets et al., 2008
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Citations
Cites
Co-Planar Stereotaxic Atlas of the Human Brain
Talairach, J., & Tournoux, P. (1988) · Medical Entomology and Zoology · Cited by 11,798
DESCARTES' ERROR: Emotion, Reason, and the Human Brain
Marg, E. (1995) · Optometry and Vision Science · doi:10.1002/j.1538-9235.1995.tb03988.x · Cited by 8,178
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120
Co-planar stereotaxic atlas of the human brain
Laitinen, L. (1989) · Clinical Neurology and Neurosurgery · doi:10.1016/0303-8467(89)90128-5 · Cited by 7,565
Cognitive and emotional influences in anterior cingulate cortex
Bush, G., Luu, P., & Posner, M. I. (2000) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01483-2 · Cited by 6,259
Insensitivity to future consequences following damage to human prefrontal cortex
Bechara, A., Damasio, A. R., Damasio, H., & Anderson, S. W. (1994) · Cognition · doi:10.1016/0010-0277(94)90018-3 · Cited by 6,128
Deep Brain Stimulation for Treatment-Resistant Depression
Mayberg, H. S., Lozano, A. M., Voon, V., McNeely, H. E., Seminowicz, D., Hamani, C., Schwalb, J. M., & Kennedy, S. H. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.014 · Cited by 4,059
J Neuropsychiatry Clin Neurosci
Yudofsky, S. C., & Hales, R. E. (1992) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.4.4.359 · Cited by 3,818
Subgenual prefrontal cortex abnormalities in mood disorders
Drevets, W. C., Price, J. L., Simpson, J. R., Todd, R. D., Reich, T., Vannier, M., & Raichle, M. E. (1997) · Nature · doi:10.1038/386824a0 · Cited by 2,693
Self-citationOngur, D. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.206 · Cited by 2,627
Mayberg, H. S., Liotti, M., Brannan, S. K., McGinnis, S., Mahurin, R. K., Jerabek, P. A., Silva, J. A., Tekell, J. L., Martin, C. C., Lancaster, J. L., et al. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.5.675 · Cited by 2,416
Pezawas, L., Meyer-Lindenberg, A., Drabant, E. M., Verchinski, B. A., Munoz, K. E., Kolachana, B. S., Egan, M. F., Mattay, V. S., Hariri, A. R., & Weinberger, D. R. (2005) · Nature Neuroscience · doi:10.1038/nn1463 · Cited by 1,980
Phelps, E. A., Delgado, M. R., Nearing, K. I., & LeDoux, J. E. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.042 · Cited by 1,753
Neurobiology of emotion perception II: implications for major psychiatric disorders
Phillips, M. L., Drevets, W. C., Rauch, S. L., & Lane, R. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00171-9 · Cited by 1,736
Self-citationGlial reduction in the subgenual prefrontal cortex in mood disorders
Öngür, D., Drevets, W. C., & Price, J. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13290 · Cited by 1,525
Self-citationRajkowska, G., Miguel-Hidalgo, J. J., Wei, J., Dilley, G., Pittman, S. D., Meltzer, H. Y., Overholser, J. C., Roth, B. L., & Stockmeier, C. A. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00041-4 · Cited by 1,477
A functional anatomical study of unipolar depression
Drevets, W., Videen, T., Price, J., Preskorn, S., Carmichael, S., & Raichle, M. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-09-03628.1992 · Cited by 1,266
Self-citationHuman cingulate cortex and autonomic control: converging neuroimaging and clinical evidence
Critchley, H. D., Mathias, C. J., Josephs, O., O’Doherty, J., Zanini, S., Dewar, B., Cipolotti, L., Shallice, T., & Dolan, R. J. (2003) · Brain · doi:10.1093/brain/awg216 · Cited by 1,201
The cellular neurobiology of depression
Manji, H. K., Drevets, W. C., & Charney, D. S. (2001) · Nature Medicine · doi:10.1038/87865 · Cited by 1,182
Self-citationDiorio, D., Viau, V, & Meaney, M. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-09-03839.1993 · Cited by 1,151
Mayberg, H. S., Brannan, S. K., Tekell, J. L., Silva, J. A., Mahurin, R. K., McGinnis, S., & Jerabek, P. A. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01036-2 · Cited by 1,115
Cingulate function in depression: a potential predictor of treatment response
Mayberg, H. S., Brannan, S. K., Mahurin, R. K., Jerabek, P. A., Brickman, J. S., Tekell, J. L., Silva, J. A., McGinnis, S., Glass, T. G., Martin, C. C., et al. (1997) · NeuroReport · doi:10.1097/00001756-199703030-00048 · Cited by 1,029
Architectonic subdivision of the human orbital and medial prefrontal cortex
Öngür, D., Ferry, A. T., & Price, J. L. (2003) · Journal of Comparative Neurology · doi:10.1002/cne.10609 · Cited by 944
Dopamine neurons and their role in reward mechanisms
Schultz, W. (1997) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(97)80007-4 · Cited by 809
Cotter, D., Mackay, D., Landau, S., Kerwin, R., & Everall, I. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.6.545 · Cited by 766
Brain activity during transient sadness and happiness in healthy women
(1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.3.341 · Cited by 737
Cellular changes in the postmortem hippocampus in major depression
Stockmeier, C. A., Mahajan, G. J., Konick, L. C., Overholser, J. C., Jurjus, G. J., Meltzer, H. Y., Uylings, H. B. M., Friedman, L., & Rajkowska, G. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.08.022 · Cited by 732
Morgan, M. A., & LeDoux, J. E. (1995) · Behavioral Neuroscience · doi:10.1037/0735-7044.109.4.681 · Cited by 717
Kennedy, S. H., Evans, K. R., Krüger, S., Mayberg, H. S., Meyer, J. H., McCann, S., Arifuzzman, A. I., Houle, S., & Vaccarino, F. J. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.6.899 · Cited by 710
Uranova, N. A., Vostrikov, V. M., Orlovskaya, D. D., & Rachmanova, V. I. (2004) · Schizophrenia Research · doi:10.1016/s0920-9964(03)00181-6 · Cited by 659
Lithium-induced increase in human brain grey matter
Moore, G. J., Bebchuk, J. M., Wilds, I. B., Chen, G., & Menji, H. K. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02793-8 · Cited by 649
Cotter, D. (2002) · Cerebral Cortex · doi:10.1093/cercor/12.4.386 · Cited by 634
Wellman, C. L. (2001) · Journal of Neurobiology · doi:10.1002/neu.1079 · Cited by 594
Energetic basis of brain activity: implications for neuroimaging
Shulman, R. G., Rothman, D. L., Behar, K. L., & Hyder, F. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.06.005 · Cited by 590
Depression, the autonomic nervous system, and coronary heart disease
Carney, R. M., Freedland, K. E., & Veith, R. C. (2005) · Psychosomatic Medicine · doi:10.1097/01.psy.0000162254.61556.d5 · Cited by 582
Drevets, W. (2002) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(02)00102-5 · Cited by 581
Self-citationReduced volume of orbitofrontal cortex in major depression
Bremner, J. D., Vythilingam, M., Vermetten, E., Nazeer, A., Adil, J., Khan, S., Staib, L. H., & Charney, D. S. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01336-1 · Cited by 537
Low glial numbers in the amygdala in major depressive disorder
Bowley, M. P., Drevets, W. C., Öngür, D., & Price, J. L. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01404-x · Cited by 518
Self-citationBipolar and major depressive disorder: Neuroimaging the developmental-degenerative divide
Savitz, J., & Drevets, W. C. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.01.004 · Cited by 494
Self-citationThe neural substrates of affective processing in depressed patients treated with venlafaxine
Davidson, R. J., Irwin, W., Anderle, M. J., & Kalin, N. H. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.1.64 · Cited by 487
Drevets, W. C., Price, J. L., Bardgett, M. E., Reich, T., Todd, R. D., & Raichle, M. E. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00687-6 · Cited by 457
Self-citationQuantitation in Positron Emission Computed Tomography
Huang, S., Hoffman, E. J., Phelps, M. E., & Kuhl, D. E. (1979) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-197912000-00018 · Cited by 443
Czéh, B., Simon, M., Schmelting, B., Hiemke, C., & Fuchs, E. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300982 · Cited by 434
Cortical grey matter reductions associated with treatment-resistant chronic unipolar depression
Shah, P. J., Ebmeier, K. P., Glabus, M. F., & Goodwin, G. M. (1998) · The British Journal of Psychiatry · doi:10.1192/bjp.172.6.527 · Cited by 395
Repeated stress alters dendritic spine morphology in the rat medial prefrontal cortex
Radley, J. J., Rocher, A. B., Rodriguez, A., Ehlenberger, D. B., Dammann, M., McEwen, B. S., Morrison, J. H., Wearne, S. L., & Hof, P. R. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21588 · Cited by 393
McDonald, C., Bullmore, E. T., Sham, P. C., Chitnis, X., Wickham, H., Bramon, E., & Murray, R. M. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.10.974 · Cited by 379
Volumetric Analysis of the Prefrontal Cortex, Amygdala, and Hippocampus in Major Depression
Hastings, R. S., Parsey, R. V., Oquendo, M. A., Arango, V., & Mann, J. J. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300371 · Cited by 378
Stevens (2014) · doi:10.1016/j.neuroimage.2005.06.048 · Cited by 377
Sullivan, R. M., & Gratton, A. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-07-02834.1999 · Cited by 377
Volumetric reduction in left subgenual prefrontal cortex in early onset depression
Botteron, K. N., Raichle, M. E., Drevets, W. C., Heath, A. C., & Todd, R. D. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01280-x · Cited by 371
Self-citationGlial reduction in amygdala in major depressive disorder is due to oligodendrocytes
Hamidi, M., Drevets, W. C., & Price, J. L. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.11.006 · Cited by 369
Self-citationChen, C.-H., Ridler, K., Suckling, J., Williams, S., Fu, C. H. Y., Merlo-Pich, E., & Bullmore, E. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.09.018 · Cited by 354
Drevets, W. C., Öngür, D., & Price, J. L. (1998) · Molecular Psychiatry · doi:10.1038/sj.mp.4000370 · Cited by 352
Self-citationStress and hippocampal plasticity: implications for the pathophysiology of affective disorders
McEwen, B. S., & Magarinos, A. M. (2001) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.266 · Cited by 349
Quantitation in Positron Emission Computed Tomography: 5. Physical–Anatomical Effects
Mazziotta, J. C., Phelps, M. E., Plummer, D. L., & Kuhl, D. E. (1981) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-198110000-00029 · Cited by 337
Functional but not structural subgenual prefrontal cortex abnormalities in melancholia
Pizzagalli, D. A., Oakes, T. R., Fox, A. S., Chung, M. K., Larson, C. L., Abercrombie, H. C., Schaefer, S. M., Benca, R. M., & Davidson, R. J. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001501 · Cited by 334
Liotti, M., Mayberg, H. S., McGinnis, S., Brannan, S. L., & Jerabek, P. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.11.1830 · Cited by 331
Wu, J. C., Buchsbaum, M. S., Gillin, J. C., Tang, C. Y., Cadwell, S., Wiegand, M. H., Najafi, A., Klein, E., Hazen, K., & Bunney, W. E. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.8.1149 · Cited by 330
Decreased Regional Brain Metabolism After ECT
Nobler, M. S., Oquendo, M. A., Kegeles, L. S., Malone, K. M., Campbell, C., Sackeim, H. A., & Mann, J. J. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.2.305 · Cited by 330
Subgenual Cingulate Cortex Volume in First-Episode Psychosis
Hirayasu, Y., Shenton, M. E., Salisbury, D. F., Kwon, J. S., Wible, C. G., Fischer, I. A., Yurgelun-Todd, D., Zarate, C., Kikinis, R., Jolesz, F. A., et al. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.7.1091 · Cited by 301
Rich, B. A., Vinton, D. T., Roberson‐Nay, R., Hommer, R. E., Berghorst, L. H., Tone, E. B., Fromm, S. J., Pine, D. S., & Leibenluft, E. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603246103 · Cited by 293
Effects of mood and subtype on cerebral glucose metabolism in treatment-resistant bipolar disorder
Ketter, T. A., Kimbrell, T. A., George, M. S., Dunn, R. T., Speer, A. M., Benson, B. E., Willis, M. W., Danielson, A., Frye, M. A., Herscovitch, P., et al. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00975-6 · Cited by 291
Greater Cortical Gray Matter Density in Lithium-Treated Patients with Bipolar Disorder
Bearden, C. E., Thompson, P. M., Dalwani, M., Hayashi, K. M., Lee, A. D., Nicoletti, M., Trakhtenbroit, M., Glahn, D. C., Brambilla, P., Sassi, R. B., et al. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.10.027 · Cited by 289
Increased anterior cingulate and caudate activity in bipolar mania
Blumberg, H. P., Stern, E. R., Martínez, D., Ricketts, S., de Asis, J. M., White, T. G., Epstein, J., McBride, P., Eidelberg, D., Kocsis, J. H., et al. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00962-8 · Cited by 279
Neumeister, A., Nugent, A. C., Waldeck, T., Geraci, M., Schwarz, M., Bonne, O., Bain, E. E., Luckenbaugh, D. A., Herscovitch, P., Charney, D. S., et al. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.8.765 · Cited by 273
Self-citationFunctional but not structural subgenual prefrontal cortex abnormalities in melancholia
Pizzagalli, D. A., Oakes, T. R., Fox, A. S., Chung, M. K., Larson, C. L., Abercrombie, H. C., Schaefer, S. M., Benca, R. M., & Davidson, R. J. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001469 · Cited by 265
Frysztak, R. J., & Neafsey, E. J. (1994) · Brain Research · doi:10.1016/0006-8993(94)90024-8 · Cited by 245
Moore, G. J., Cortese, B. M., Glitz, D. A., Zajac-Benitez, C., Quiroz, J. A., Uhde, T. W., Drevets, W. C., & Manji, H. K. (2009) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.07m03745 · Cited by 234
Self-citationHasler, G., Fromm, S., Carlson, P. J., Luckenbaugh, D. A., Waldeck, T., Geraci, M., Roiser, J. P., Neumeister, A., Meyers, N., Charney, D. S., et al. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.5.521 · Cited by 209
Self-citationCortical abnormalities in bipolar disorder investigated with MRI and voxel-based morphometry
Nugent, A. C., Milham, M. P., Bain, E. E., Mah, L., Cannon, D. M., Marrett, S., Zarate, C. A., Pine, D. S., Price, J. L., & Drevets, W. C. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.09.029 · Cited by 206
Self-citationHaznedar, M. M., Roversi, F., Pallanti, S., Rossi, N. B., Schnur, D. B., LiCalzi, E. M., Tang, C. Y., Hof, P. R., Hollander, E., & Buchsbaum, M. S. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.002 · Cited by 203
Selective attention to emotional stimuli in a verbal go/no-go task: an fMRI study
Elliott, R., Rubinsztein, J. S., Sahakian, B. J., & Dolan, R. J. (2000) · NeuroReport · doi:10.1097/00001756-200006050-00028 · Cited by 199
Baumann, B., Danos, P., Krell, D., Diekmann, S., Leschinger, A., Stauch, R., Wurthmann, C., Bernstein, H.-G., & Bogerts, B. (1999) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.11.1.71 · Cited by 198
Voxel-Based Study of Structural Changes in First-Episode Patients with Bipolar Disorder
Adler, C. M., DelBello, M. P., Jarvis, K., Levine, A. D., Adams, J., & Strakowski, S. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.042 · Cited by 196
Regional cerebral metabolism associated with anxiety symptoms in affective disorder patients
Osuch, E. A., Ketter, T. A., Kimbrell, T. A., George, M. S., Benson, B. E., Herscovitch, M. W. W., & Post, R. M. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00920-3 · Cited by 196
Subgenual anterior cingulate activation to valenced emotional stimuli in major depression
Gotlib, I. H., Sivers, H., Gabrieli, J. D. E., Whitfield-Gabrieli, S., Goldin, P., Minor, K. L., & Canli, T. (2005) · NeuroReport · doi:10.1097/01.wnr.0000183901.70030.82 · Cited by 194
Behavioural and neurocognitive responses to sad facial affect are attenuated in patients with mania
LENNOX, B. R., JACOB, R., CALDER, A. J., LUPSON, V., & BULLMORE, E. T. (2004) · Psychological Medicine · doi:10.1017/s0033291704002557 · Cited by 192
Dunn, R. T., Kimbrell, T. A., Ketter, T. A., Frye, M. A., Willis, M. W., Luckenbaugh, D. A., & Post, R. M. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01244-6 · Cited by 184
Eastwood, S. L., & Harrison, P. J. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000741 · Cited by 170
Anatomical MRI Study of Subgenual Prefrontal Cortex in Bipolar and Unipolar Subjects
Brambilla, P. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00352-4 · Cited by 169
Regulation of Neurogenesis and Gliogenesis by Stress and Antidepressant Treatment
Banasr, M., & Duman, R. (2007) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152707783220929 · Cited by 169
Bauer, M., London, E. D., Rasgon, N., Berman, S. M., Frye, M. A., Altshuler, L. L., Mandelkern, M. A., Bramen, J. E., Voytek, B., Woods, R. P., et al. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001647 · Cited by 159
Coryell, W., Nopoulos, P., Drevets, W., Wilson, T., & Andreasen, N. C. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.9.1706 · Cited by 159
Self-citationSerial Vagus Nerve Stimulation Functional MRI in Treatment-Resistant Depression
Nahas, Z. H., Tenebäck, C. C., Chae, J., Mu, Q., Molnar, C., Kozel, F. A., Walker, J., Anderson, B. S., Koola, J., Köse, S., et al. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301288 · Cited by 159
Lochhead, R. A., Parsey, R. V., Oquendo, M. A., & Mann, J. J. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.02.026 · Cited by 157
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Caetano, S. C., Kaur, S., Brambilla, P., Nicoletti, M., Hatch, J. P., Sassi, R. B., Mallinger, A. G., Keshavan, M. S., Kupfer, D. J., Frank, E., et al. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.011 · Cited by 150
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Kaur, S., Sassi, R. B., Axelson, D., Nicoletti, M., Brambilla, P., Monkul, E. S., Hatch, J. P., Keshavan, M. S., Ryan, N. D., Birmaher, B. B., et al. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.9.1637 · Cited by 145
Tang, Y., Wang, F., Xie, G., Liu, J., Li, L., Su, L., Liu, Y., Xian, H., He, Z., & Blumberg, H. P. (2007) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2007.03.005 · Cited by 140
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Boes, A. D., McCormick, L. M., Coryell, W. H., & Nopoulos, P. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.07.018 · Cited by 139
Krüger, S., Seminowicz, D., Goldapple, K., Kennedy, S. H., & Mayberg, H. S. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00691-7 · Cited by 127
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Mah, L., Zarate, C. A., Singh, J. B., Duan, Y.-F., Luckenbaugh, D. A., Manji, H. K., & Drevets, W. C. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.06.009 · Cited by 124
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Bruno, S. D. (2004) · Brain · doi:10.1093/brain/awh274 · Cited by 118
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Chiu, S., Widjaja, F., Bates, M. E., Voelbel, G. T., Pandina, G., Marble, J., Blank, J., Day, J., Brule, N., & Hendren, R. L. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.04.019 · Cited by 75
Sharma, V., Menon, R. S., Carr, T. J., Densmore, M., Mazmanian, D. S., & Williamson, P. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(02)00109-x · Cited by 74
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(2005) · Wiley eBooks · doi:10.1002/9783527619672 · Cited by 71
Anterior cingulate subregion volumes and executive function in bipolar disorder
Zimmerman, M. E., DelBello, M. P., Getz, G. E., Shear, P. K., & Strakowski, S. M. (2006) · Bipolar Disorders · doi:10.1111/j.1399-5618.2006.00298.x · Cited by 69
Haldane, M., Jogia, J., Cobb, A., Kozuch, E., Kumari, V., & Frangou, S. (2007) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2007.05.009 · Cited by 68
Kumano, H., Ida, I., Oshima, A., Takahashi, K., Yuuki, N., Amanuma, M., Oriuchi, N., Endo, K., Matsuda, H., & Mikuni, M. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.03.006 · Cited by 61
Sanches, M., Sassi, R. B., Axelson, D., Nicoletti, M., Brambilla, P., Hatch, J. P., Keshavan, M. S., Ryan, N. D., Birmaher, B. B., & Soares, J. C. (2005) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2004.11.004 · Cited by 61
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Kegeles, L., Malone, K. M., Slifstein, M., Ellis, S., Xanthopoulos, E., Keilp, J., Campbell, C., Oquendo, M., Heertum, R. V. V., & Mann, J. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.1.76 · Cited by 55
Clark, C. P., Brown, G. G., Frank, L. R., Thomas, L. S., Sutherland, A. N., & Gillin, J. C. (2006) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2005.12.008 · Cited by 52
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Smith, G. S., Kramer, E., Hermann, C. R., Goldberg, S., Ma, Y., DHAWAN, V. M., Barnes, A., Chaly, T., Belakhleff, A., Laghrissi‐Thode, F., et al. (2002) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200211000-00010 · Cited by 44
Inagaki, M., Yoshikawa, E., Kobayakawa, M., Matsuoka, Y., Sugawara, Y., Nakano, T., Akizuki, N., Fujimori, M., Akechi, T., Kinoshitá, T., et al. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.08.019 · Cited by 34
Winokur, G., & Coryell, W. H. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90062-5 · Cited by 34
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Self-citationRosoklija, G., Toomayan, G., Ellis, S. P., Keilp, J., Mann, J. J., Latov, N., Hays, A. P., & Dwork, A. J. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.4.349 · Cited by 1
Research works printed but not linked: 8
- 10.1016/S0924-977X(02)00102-5 · DOI · Paper page
- Drevets, The New Encyclopedia of Neuroscience
- Drevets, 1995, Functional anatomical differences between major depressive subtypes, J Cereb Blood Flow Metab, 15, S93
- Moore, J Clin Psychiatry
- Drevets, 2004, The Neurobiological Foundation Of Mental Illness, 461
- Rauch, 2008, Stress-Induced and Fear Circuitry Disorders: Refining the Research Agenda for DSM-V, 235
- 10.1016/j.jpsychires.2006.03.006 · DOI
- Drevets, 2003, Neuromorphometric MRI assessments of the hippocampal subiculum in mood disorders, Biol Psychiatry, 53, 189S
Cited by
Sorted by citations
Drevets, W. C., Price, J. L., & Furey, M. L. (2008) · Brain Structure and Function · doi:10.1007/s00429-008-0189-x · Cited by 2,241
“The differential effects of these drugs on dendritic atrophy in stressed rats thus resemble their effects on sgACC volume in humans with BD (Moore et al. 2008; Drevets et al. 1997; Drevets and Savitz 2008).”
BackgroundSelf-citationNeurocircuitry of Mood Disorders
Price, J. L., & Drevets, W. C. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.104 · Cited by 1,606
Self-citationfor the ENIGMA-Major Depressive Disorder Working Group, Schmaal, L., Hibar, D. P., Sämann, P. G., Hall, G. B., Baune, B. T., Jahanshad, N., Cheung, J. W., van Erp, T. G. M., Bos, D., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.60 · Cited by 1,330
Vago, D. R., & Silbersweig, D. A. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00296 · Cited by 1,310
Fox, M. D., Buckner, R. L., White, M. P., Greicius, M. D., & Pascual-Leone, A. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.04.028 · Cited by 1,270
Metadata
- Authors
- Drevets, W. C., Savitz, J., & Trimble, M.
- Affiliations
- National Institutes of Health (US)
- National Institute of Mental Health (US)
- National Hospital for Neurology and Neurosurgery (GB)
- Venue
- CNS Spectrums
- Publisher
- Cambridge University Press (CUP)
- Published
- 2008-08
- Volume
- 13
- Issue
- 8
- Pages
- 663-681
- ISSN
- 1092-8529 (ISSN-L)
- 2165-6509
- PMC
- PMC2729429
- OpenAlex
- W1582811168
- Cited by
- 1,109
- References
- 108
- Citations by year
- 2026: 55 · 2025: 58 · 2024: 64 · 2023: 48 · 2022: 68 · 2021: 112 · 2020: 62 · 2019: 63 · 2018: 57 · 2017: 55 · 2016: 72 · 2015: 63 · 2014: 68 · 2013: 70 · 2012: 68
- FWCI
- 4.49
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- CNS Spectrums (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (Z01MH002790)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- subgenual anterior cingulate cortex, mood disorders, major depressive disorder, bipolar disorder, gray matter volume, antidepressant response, deep brain stimulation, stress response, emotional behavior, neuroendocrine regulation, autonomic responses
- MeSH terms
- Corpus Callosum, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Mood Disorders
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