The DOI matches its Crossref record; 108 of the 108 references it cites were found in a registry or an index.
The Subgenual Anterior Cingulate Cortex in Mood Disorders
Open accessAbstract
The anterior cingulate cortex (ACC) ventral to the genu of the corpus callosum has been implicated in the modulation of emotional behavior on the basis of neuroimaging studies in humans and lesion analyses in experimental animals. In a combined positron emission tomography/magnetic resonance imaging study of mood disorders, we demonstrated that the mean gray matter volume of this “subgenual” ACC (sgACC) cortex is abnormally reduced in subjects with major depressive disorder (MDD) and bipolar disorder, irrespective of mood state. Neuropathological assessments of sgACC tissue acquired postmortem from subjects with MDD or bipolar disorder confirmed the decrement in gray matter volume, and revealed that this abnormality was associated with a reduction in glia, with no equivalent loss of neurons. In positron emission tomography studies, the metabolic activity was elevated in this region in the depressed relative to the remitted phases of the same MDD subjects, and effective antidepressant treatment was associated with a reduction in sgACC activity. Other laboratories replicated and extended these findings, and the clinical importance of this treatment effect was underscored by a study showing that deep brain stimulation of the sgACC ameliorates depressive symptoms in treatment-resistant MDD. This article discusses the functional significance of these findings within the context of the preclinical literature that implicates the putative homologue of this region in the regulation of emotional behavior and stress response. In experimental animals, this region participates in an extended “visceromotor network” of structures that modulates autonomic/neuroendocrine responses and neurotransmitter transmission during the neural processing of reward, fear, and stress. These data thus hold important implications for the development of neural models of depression that can account for the abnormal motivational, neuroendocrine, autonomic, and emotional manifestations evident in human mood disorders.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The differential effects of these drugs on dendritic atrophy in stressed rats thus resemble their effects on sgACC volume in humans with BD (Moore et al. 2008; Drevets et al. 1997; Drevets and Savitz 2008).”
From Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression (2008) · cites this paper as Drevets and Savitz 2008
Experimental — accuracy not yet measuredIn the citing paper
“a meta-analysis on volumetric fMRI studies has revealed a volume reduction of ACC compared with healthy control subjects (Drevets et al., 2008;Zhao et al., 2014).”
From Social functioning in major depressive disorder (2016) · cites this paper as Drevets et al., 2008
In the citing paper
“In healthy men, intranasal oxytocin administration can increase empathic concern (Hurlemann et al., 2010), enhance empathic accuracy (Bartz et al., 2010) and improve ToM (Domes et al., 2006).”
From Social functioning in major depressive disorder (2016) · cites this paper as Domes et al., 2006
In the citing paper
“Biomarkers that distinguish between depressed and non-depressed individuals have been identified at the neural level (Drevets et al, 2008; Northoff et al, 2011)”
From Resting-state cortico-thalamic-striatal connectivity predicts response to dorsomedial prefrontal rTMS in major depressive disorder (2014) · cites this paper as Drevets et al, 2008
In the citing paper
“Depression has been associated with functional and structural abnormalities in subgenual cingulate, thalamus, striatum, and limbic regions (Alcaro et al, 2010; Drevets et al, 2008; Heller et al, 2009, 2013; Mayberg, 2009; Phillips et al, 2003).”
From Resting-state cortico-thalamic-striatal connectivity predicts response to dorsomedial prefrontal rTMS in major depressive disorder (2014) · cites this paper as Drevets et al, 2008
In the citing paper
“Clinical studies indicate that metabolism in sACC is elevated in the depressed phase relative to the remitted phase of the same patients with major depressive disorder (Drevets et al., 2008).”
From Phasic and sustained fear in humans elicits distinct patterns of brain activity (2011) · cites this paper as Drevets et al., 2008
In the citing paper
“In addition, this structure and neighbouring medial frontal regions and linked basal ganglia have been also been strikingly linked with mood regulation, including depression and anxiety (Drevets et al., 2008; Gutman et al., 2009; Johansen-Berg et al., 2008; Mayberg et al., 2005).”
From The human parental brain: In vivo neuroimaging (2011) · cites this paper as Drevets et al., 2008
In the citing paper
“which is especially involved in fear responses and shows abnormal activity in mood disorders (Drevets et al, 2008).”
From Oxytocin Facilitates Pavlovian Fear Learning in Males (2016) · cites this paper as Drevets et al, 2008
In the citing paper
“The key regions that have gained consensus for an involvement in MDD include the limbic cortex (amygdala, hippocampus), the cingulate cortex, dorsal striatum and the frontal lobe (dorsolateral prefrontal cortex [DLPFC] and medial prefrontal cortex [MPFC]).”
From Widespread reductions in gray matter volume in depression (2013) · cites this paper as Drevets et al., 2008
In the citing paper
“A substantial body of imaging data demonstrates spatially distributed functional abnormalities occurring throughout the brain in MDD (Drevets et al., 2008).”
From Widespread reductions in gray matter volume in depression (2013) · cites this paper as Drevets et al., 2008
In the citing paper
“The functional role of the cingulate cortex—and specifically the ACC—in depression is well described (Drevets et al., 2008).”
From Widespread reductions in gray matter volume in depression (2013) · cites this paper as Drevets et al., 2008
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Co-Planar Stereotaxic Atlas of the Human Brain
Talairach, J., & Tournoux, P. (1988) · Medical Entomology and Zoology · Cited by 11,798
DESCARTES' ERROR: Emotion, Reason, and the Human Brain
Marg, E. (1995) · Optometry and Vision Science · doi:10.1002/j.1538-9235.1995.tb03988.x · Cited by 8,178
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120
Co-planar stereotaxic atlas of the human brain
Laitinen, L. (1989) · Clinical Neurology and Neurosurgery · doi:10.1016/0303-8467(89)90128-5 · Cited by 7,565
Cognitive and emotional influences in anterior cingulate cortex
Bush, G., Luu, P., & Posner, M. I. (2000) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01483-2 · Cited by 6,259
Insensitivity to future consequences following damage to human prefrontal cortex
Bechara, A., Damasio, A. R., Damasio, H., & Anderson, S. W. (1994) · Cognition · doi:10.1016/0010-0277(94)90018-3 · Cited by 6,128
Deep Brain Stimulation for Treatment-Resistant Depression
Mayberg, H. S., Lozano, A. M., Voon, V., McNeely, H. E., Seminowicz, D., Hamani, C., Schwalb, J. M., & Kennedy, S. H. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.014 · Cited by 4,059
J Neuropsychiatry Clin Neurosci
Yudofsky, S. C., & Hales, R. E. (1992) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.4.4.359 · Cited by 3,818
Subgenual prefrontal cortex abnormalities in mood disorders
Drevets, W. C., Price, J. L., Simpson, J. R., Todd, R. D., Reich, T., Vannier, M., & Raichle, M. E. (1997) · Nature · doi:10.1038/386824a0 · Cited by 2,693
Self-citationOngur, D. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.206 · Cited by 2,627
Research works printed but not linked: 8
- 10.1016/S0924-977X(02)00102-5 · DOI · Paper page
- Drevets, The New Encyclopedia of Neuroscience
- Drevets, 1995, Functional anatomical differences between major depressive subtypes, J Cereb Blood Flow Metab, 15, S93
- Moore, J Clin Psychiatry
- Drevets, 2004, The Neurobiological Foundation Of Mental Illness, 461
- Rauch, 2008, Stress-Induced and Fear Circuitry Disorders: Refining the Research Agenda for DSM-V, 235
- 10.1016/j.jpsychires.2006.03.006 · DOI
- Drevets, 2003, Neuromorphometric MRI assessments of the hippocampal subiculum in mood disorders, Biol Psychiatry, 53, 189S
Cited by
Sorted by citations
Drevets, W. C., Price, J. L., & Furey, M. L. (2008) · Brain Structure and Function · doi:10.1007/s00429-008-0189-x · Cited by 2,241
“The differential effects of these drugs on dendritic atrophy in stressed rats thus resemble their effects on sgACC volume in humans with BD (Moore et al. 2008; Drevets et al. 1997; Drevets and Savitz 2008).”
BackgroundSelf-citationNeurocircuitry of Mood Disorders
Price, J. L., & Drevets, W. C. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.104 · Cited by 1,606
Self-citationfor the ENIGMA-Major Depressive Disorder Working Group, Schmaal, L., Hibar, D. P., Sämann, P. G., Hall, G. B., Baune, B. T., Jahanshad, N., Cheung, J. W., van Erp, T. G. M., Bos, D., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.60 · Cited by 1,330
Vago, D. R., & Silbersweig, D. A. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00296 · Cited by 1,310
Fox, M. D., Buckner, R. L., White, M. P., Greicius, M. D., & Pascual-Leone, A. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.04.028 · Cited by 1,270
The role of sleep in emotional brain function
Goldstein, A. N., & Walker, M. P. (2014) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032813-153716 · Cited by 1,052
“…the mechanisms underlying affective brain processes (Critchley 2005, Delgado et al 2006, Hartley & Phelps 2010, Ochsner et al 2009), translationally bridging animal models of emotion regulation and relevant clinical disorders (Davidson 2002, Delgado et al 2006, Drevets et al 2008, Etkin 2010).”
BackgroundCRP, IL-6 and depression: a systematic review and meta-analysis of longitudinal studies.
Valkanova, V., Ebmeier, K. P., & Allan, C. L. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.06.004 · Cited by 972
Resting-state functional connectivity in major depressive disorder: A review
Mulders, P. C., van Eijndhoven, P. F., Schene, A. H., Beckmann, C. F., & Tendolkar, I. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.07.014 · Cited by 884
The cingulate cortex and limbic systems for emotion, action, and memory
Rolls, E. T. (2019) · Brain Structure and Function · doi:10.1007/s00429-019-01945-2 · Cited by 859
Emotion and the prefrontal cortex: an integrative review
Dixon, M. L., Thiruchselvam, R., Todd, R., & Christoff, K. (2017) · Psychological Bulletin · doi:10.1037/bul0000096 · Cited by 745
Social functioning in major depressive disorder
Kupferberg, A., Bicks, L., & Hasler, G. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.07.002 · Cited by 663
The organization of the stress system and its dysregulation in depressive illness
Gold, P. W. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.163 · Cited by 654
Zhu, X., Wang, X., Xiao, J., Liao, J., Zhong, M., Wang, W., & Yao, S. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.10.035 · Cited by 638
The influence of negative emotions on pain: Behavioral effects and neural mechanisms
Wiech, K., & Tracey, I. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.05.059 · Cited by 614
Anatomy of bipolar disorder and schizophrenia: A meta-analysis
Ellison-Wright, I., & Bullmore, E. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2009.12.022 · Cited by 565
Processing of facial emotion expression in major depression: a review
Bourke, C., Douglas, K., & Porter, R. (2010) · Australian & New Zealand Journal of Psychiatry · doi:10.3109/00048674.2010.496359 · Cited by 557
The neurobiology of depression and antidepressant action
Willner, P., Scheel-Krüger, J., & Belzung, C. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.12.007 · Cited by 519
Rive, M. M., van Rooijen, G., Veltman, D. J., .Phillips, M. L., Schene, A. H., & Ruhé, H. G. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.07.018 · Cited by 481
Bipolar and major depressive disorder: Neuroimaging the developmental-degenerative divide
Savitz, J., & Drevets, W. C. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.01.004 · Cited by 494
Self-citationLener, M. S., Niciu, M. J., Ballard, E. D., Park, M., Park, L. T., Nugent, A. C., & Zarate, C. A. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.05.005 · Cited by 468
Sanches, R. F., de Lima Osório, F., dos Santos, R. G., Macedo, L. R. H., Maia-de-Oliveira, J. P., Wichert-Ana, L., de Araujo, D. B., Riba, J., Crippa, J. A. S., & Hallak, J. E. C. (2016) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000436 · Cited by 466
Avery, J. A., Drevets, W. C., Moseman, S. E., Bodurka, J., Barcalow, J. C., & Simmons, W. K. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.11.027 · Cited by 442
Self-citationHeller, A. S., Johnstone, T., Shackman, A. J., Light, S. N., Peterson, M. J., Kolden, G. G., Kalin, N. H., & Davidson, R. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910651106 · Cited by 444
Barrett, J., & Fleming, A. S. (2011) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2010.02306.x · Cited by 433
Herringa, R. J., Birn, R. M., Ruttle, P. L., Burghy, C. A., Stodola, D. E., Davidson, R. J., & Essex, M. J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1310766110 · Cited by 426
Groenewold, N. A., Opmeer, E. M., de Jonge, P., Aleman, A., & Costafreda, S. G. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.11.015 · Cited by 417
Simmons, W. K., Avery, J. A., Barcalow, J. C., Bodurka, J., Drevets, W. C., & Bellgowan, P. (2013) · Human Brain Mapping · doi:10.1002/hbm.22113 · Cited by 401
Self-citationEpigenetics of the depressed brain: role of histone acetylation and methylation
Sun, H., Kennedy, P. J., & Nestler, E. J. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.73 · Cited by 413
Fox, M. D., Halko, M. A., Eldaief, M. C., & Pascual-Leone, A. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.03.035 · Cited by 395
Widespread reductions in gray matter volume in depression
Grieve, S. M., Korgaonkar, M. S., Koslow, S. H., Gordon, E., & Williams, L. M. (2013) · NeuroImage: Clinical · doi:10.1016/j.nicl.2013.08.016 · Cited by 388
Emotions and brain function are altered up to one month after a single high dose of psilocybin.
Barrett, F. S., Doss, M. K., Sepeda, N. D., Pekar, J. J., & Griffiths, R. R. (2020) · Scientific Reports · doi:10.1038/s41598-020-59282-y · Cited by 375
Ansell, E. B., Rando, K., Tuit, K., Guarnaccia, J., & Sinha, R. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.11.022 · Cited by 354
Mindfulness and emotion regulation—an fMRI study
Lutz, J., Herwig, U., Opialla, S., Hittmeyer, A., Jäncke, L., Rufer, M., Grosse Holtforth, M., & Brühl, A. B. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nst043 · Cited by 342
Exercise effects on depression: Possible neural mechanisms
Gujral, S., Aizenstein, H., Reynolds, C. F., Butters, M. A., & Erickson, K. I. (2017) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2017.04.012 · Cited by 334
Affective Cognition and its Disruption in Mood Disorders
Elliott, R., Zahn, R., Deakin, J. F. W., & Anderson, I. M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.77 · Cited by 330
Salomons, T. V., Dunlop, K., Kennedy, S. H., Flint, A., Geraci, J., Giacobbe, P., & Downar, J. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.222 · Cited by 299
Rilling, J. K., DeMarco, A. C., Hackett, P. D., Thompson, R., Ditzen, B., Patel, R., & Pagnoni, G. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.013 · Cited by 303
Phasic and sustained fear in humans elicits distinct patterns of brain activity
Alvarez, R. P., Chen, G., Bodurka, J., Kaplan, R., & Grillon, C. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2010.11.057 · Cited by 299
Scheidegger, M., Walter, M., Lehmann, M., Metzger, C., Grimm, S., Boeker, H., Boesiger, P., Henning, A., & Seifritz, E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044799 · Cited by 282
Mindful attention reduces neural and self-reported cue-induced craving in smokers
Westbrook, C., Creswell, J. D., Tabibnia, G., Julson, E., Kober, H., & Tindle, H. A. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsr076 · Cited by 278
Effect of antidepressant treatment on peripheral inflammation markers – A meta-analysis
Więdłocha, M., Marcinowicz, P., Krupa, R., Janoska-Jaździk, M., Janus, M., Dębowska, W., Mosiołek, A., Waszkiewicz, N., & Szulc, A. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.04.026 · Cited by 233
The human parental brain: In vivo neuroimaging
Swain, J. E. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.10.017 · Cited by 234
Northoff, G., Wiebking, C., Feinberg, T., & Panksepp, J. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.12.007 · Cited by 222
Sezer, I., Pizzagalli, D. A., & Sacchet, M. D. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104583 · Cited by 214
“As aberrant sgACC-DMN hyperconnectivity has been observed in depression (Connolly et al., 2013; Drevets et al., 2008), it has been speculated that decreased connectivity in these regions mediated by mindfulness training may relate to an antidepressant effect (Yang et al., 2016).”
BackgroundUrry, H. L., van Reekum, C. M., Johnstone, T., & Davidson, R. J. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.05.069 · Cited by 196
Electroconvulsive therapy-induced brain plasticity determines therapeutic outcome in mood disorders
Dukart, J., Regen, F., Kherif, F., Colla, M., Bajbouj, M., Heuser, I., Frackowiak, R. S., & Draganski, B. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1321399111 · Cited by 195
Gray matter volume in major depressive disorder: A meta-analysis of voxel-based morphometry studies
Lai, C.-H. (2013) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2012.06.006 · Cited by 191
Dupont, A.-C., Largeau, B., Santiago Ribeiro, M., Guilloteau, D., Tronel, C., & Arlicot, N. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040785 · Cited by 182
Association of BDNF Val66Met Polymorphism and Brain BDNF Levels with Major Depression and Suicide
Youssef, M. M., Underwood, M. D., Huang, Y.-Y., Hsiung, S.-C., Liu, Y., Simpson, N. R., Bakalian, M. J., Rosoklija, G. B., Dwork, A. J., Arango, V., et al. (2018) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy008 · Cited by 183
Plastic modulation of PTSD resting‐state networks and subjective wellbeing by EEG neurofeedback
Kluetsch, R. C., Ros, T., Théberge, J., Frewen, P. A., Calhoun, V. D., Schmahl, C., Jetly, R., & Lanius, R. A. (2014) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12229 · Cited by 183
Sex differences in mood disorders: Perspectives from humans and rodent models
Seney, M. L., & Sibille, E. (2014) · Biology of Sex Differences · doi:10.1186/s13293-014-0017-3 · Cited by 181
Lipsman, N., Lam, E., Volpini, M., Sutandar, K., Twose, R., Giacobbe, P., Sodums, D. J., Smith, G. S., Woodside, D. B., & Lozano, A. M. (2017) · The Lancet Psychiatry · doi:10.1016/s2215-0366(17)30076-7 · Cited by 174
Davey, C. G., Harrison, B. J., Yücel, M., & Allen, N. B. (2012) · Psychological Medicine · doi:10.1017/s0033291712000323 · Cited by 176
Meier, T. B., Drevets, W. C., Wurfel, B. E., Ford, B. N., Morris, H. M., Victor, T. A., Bodurka, J., Teague, T. K., Dantzer, R., & Savitz, J. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.11.003 · Cited by 175
Self-citationSavitz, J., Frank, M. B., Victor, T., Bebak, M., Marino, J. H., Bellgowan, P. S. F., McKinney, B. A., Bodurka, J., Kent Teague, T., & Drevets, W. C. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.10.007 · Cited by 146
Self-citationSavitz, J. B., Price, J. L., & Drevets, W. C. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.02.008 · Cited by 145
Self-citationA review of fMRI studies during visual emotive processing in major depressive disorder
Jaworska, N., Yang, X.-R., Knott, V., & MacQueen, G. (2015) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2014.885659 · Cited by 133
Cromheeke, S., & Mueller, S. C. (2014) · Brain Structure and Function · doi:10.1007/s00429-013-0549-z · Cited by 132
Changing Brain Networks Through Non-invasive Neuromodulation
To, W. T., De Ridder, D., Hart Jr., J., & Vanneste, S. (2018) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2018.00128 · Cited by 135
“…regions such as the subgenual ACC have been targeted with invasive neuromodulation, such as deep brain stimulation (e.g., Mayberg et al., 2005; Drevets et al., 2008; Mayberg, 2009; Fox et al., Frontiers in Human Neuroscience | www.frontiersin.org 8 April 2018 | Volume 12 | Article 128 2012a)…”
BackgroundMethodPortella, M. J., de Diego-Adeliño, J., Gómez-Ansón, B., Morgan-Ferrando, R., Vives, Y., Puigdemont, D., Pérez-Egea, R., Ruscalleda, J., Álvarez, E., & Pérez, V. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.08.010 · Cited by 127
When grief heats up: Pro-inflammatory cytokines predict regional brain activation
O'Connor, M.-F., Irwin, M. R., & Wellisch, D. K. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.05.049 · Cited by 123
Synaptic Modifications in the Medial Prefrontal Cortex in Susceptibility and Resilience to Stress
Wang, M., Perova, Z., Arenkiel, B. R., & Li, B. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.5294-13.2014 · Cited by 116
Peciña, M., Mickey, B. J., Love, T., Wang, H., Langenecker, S. A., Hodgkinson, C., Shen, P.-H., Villafuerte, S., Hsu, D., Weisenbach, S. L., et al. (2013) · Cortex · doi:10.1016/j.cortex.2012.01.010 · Cited by 123
Orozco-Solis, R., Montellier, E., Aguilar-Arnal, L., Sato, S., Vawter, M. P., Bunney, B. G., Bunney, W. E., & Sassone-Corsi, P. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.02.1176 · Cited by 119
Autonomic and Brain Morphological Predictors of Stress Resilience
Carnevali, L., Koenig, J., Sgoifo, A., & Ottaviani, C. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00228 · Cited by 117
Endogenous opioids mediate left dorsolateral prefrontal cortex rTMS-induced analgesia
Taylor, J. J., Borckardt, J. J., & George, M. S. (2012) · Pain · doi:10.1016/j.pain.2012.02.030 · Cited by 112
Alexander, L., Wood, C. M., Gaskin, P. L. R., Sawiak, S. J., Fryer, T. D., Hong, Y. T., McIver, L., Clarke, H. F., & Roberts, A. C. (2020) · Nature Communications · doi:10.1038/s41467-020-19167-0 · Cited by 100
Harel, M., Perini, I., Kämpe, R., Alyagon, U., Shalev, H., Besser, I., Sommer, W. H., Heilig, M., & Zangen, A. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.11.020 · Cited by 115
Ketamine normalizes subgenual cingulate cortex hyper-activity in depression
Morris, L. S., Costi, S., Tan, A., Stern, E. R., Charney, D. S., & Murrough, J. W. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-019-0591-5 · Cited by 104
Thomaes, K., Dorrepaal, E., Draijer, N., de Ruiter, M. B., Elzinga, B. M., Sjoerds, Z., van Balkom, A. J., Smit, J. H., & Veltman, D. J. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsr084 · Cited by 103
Posner, J., Maia, T. V., Fair, D., Peterson, B. S., Sonuga-Barke, E. J., & Nagel, B. J. (2011) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2011.02.005 · Cited by 104
Philippi, C. L., Motzkin, J. C., Pujara, M. S., & Koenigs, M. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.10.005 · Cited by 93
Heightened aversion to risk and loss in depressed patients with a suicide attempt history
Baek, K., Kwon, J., Chae, J.-H., Chung, Y. A., Kralik, J. D., Min, J.-A., Huh, H., Choi, K. M., Jang, K.-I., Lee, N.-B., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-10541-5 · Cited by 98
Novembre, G., Zanon, M., & Silani, G. (2015) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu038 · Cited by 92
Oxytocin Facilitates Pavlovian Fear Learning in Males
Eckstein, M., Scheele, D., Patin, A., Preckel, K., Becker, B., Walter, A., Domschke, K., Grinevich, V., Maier, W., & Hurlemann, R. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.245 · Cited by 87
Intrinsic Brain Network Biomarkers of Antidepressant Response: a Review
Dunlop, K., Talishinsky, A., & Liston, C. (2019) · Current Psychiatry Reports · doi:10.1007/s11920-019-1072-6 · Cited by 80
Zhao, J., Verwer, R. W. H., van Wamelen, D. J., Qi, X.-R., Gao, S.-F., Lucassen, P. J., & Swaab, D. F. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.06.017 · Cited by 83
Brain activation predicts treatment improvement in patients with major depressive disorder
Samson, A. C., Meisenzahl, E., Scheuerecker, J., Rose, E., Schoepf, V., Wiesmann, M., & Frodl, T. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.03.009 · Cited by 78
Global long non-coding RNA expression in the rostral anterior cingulate cortex of depressed suicides
Zhou, Y., Lutz, P.-E., Wang, Y. C., Ragoussis, J., & Turecki, G. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0267-7 · Cited by 77
Sebastian, C. L., McCrory, E. J., Dadds, M. R., Cecil, C. A. M., Lockwood, P. L., Hyde, Z. H., De Brito, S. A., & Viding, E. (2014) · Psychological Medicine · doi:10.1017/s0033291713000482 · Cited by 75
Neural Correlates of Antidepressant Treatment Response in Adolescents with Major Depressive Disorder
Cullen, K. R., Klimes-Dougan, B., Vu, D. P., Westlund Schreiner, M., Mueller, B. A., Eberly, L. E., Camchong, J., Westervelt, A., & Lim, K. O. (2016) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2015.0232 · Cited by 75
A two-factor model of relapse/recurrence vulnerability in unipolar depression
Farb, N. A. S., Irving, J. A., Anderson, A. K., & Segal, Z. V. (2015) · Journal of Abnormal Psychology · doi:10.1037/abn0000031 · Cited by 75
Wu, X., Lin, P., Yang, J., Song, H., Yang, R., & Yang, J. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.04.046 · Cited by 73
Neuroanatomical profiles of alexithymia dimensions and subtypes
Goerlich‐Dobre, K. S., Votinov, M., Habel, U., Pripfl, J., & Lamm, C. (2015) · Human Brain Mapping · doi:10.1002/hbm.22879 · Cited by 71
Liu, C.-H., Ma, X., Song, L.-P., Fan, J., Wang, W.-D., Lv, X.-Y., Zhang, Y., Li, F., Wang, L., & Wang, C.-Y. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.11.047 · Cited by 71
Gärtner, M., Aust, S., Bajbouj, M., Fan, Y., Wingenfeld, K., Otte, C., Heuser-Collier, I., Böker, H., Hättenschwiler, J., Seifritz, E., et al. (2019) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2019.02.008 · Cited by 66
Zhang, A., Yang, C., Li, G., Wang, Y., Liu, P., Liu, Z., Sun, N., & Zhang, K. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.05.053 · Cited by 62
Baeken, C., Vanderhasselt, M. A., Remue, J., Rossi, V., Schiettecatte, J., Anckaert, E., & De Raedt, R. (2014) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2014.02.019 · Cited by 63
Disrupted Amygdala Reactivity in Depressed 4- to 6-Year-Old Children
Gaffrey, M. S., Barch, D. M., Singer, J., Shenoy, R., & Luby, J. L. (2013) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2013.04.009 · Cited by 62
Associations between maternal negative affect and adolescent's neural response to peer evaluation
Tan, P. Z., Lee, K. H., Dahl, R. E., Nelson, E. E., Stroud, L. J., Siegle, G. J., Morgan, J. K., & Silk, J. S. (2014) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2014.01.006 · Cited by 59
Oxytocin and anxiety disorders
Gottschalk, M. G., & Domschke, K. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_25 · Cited by 61
Perini, I., Gustafsson, P. A., Hamilton, J. P., Kämpe, R., Mayo, L. M., Heilig, M., & Zetterqvist, M. (2019) · EClinicalMedicine · doi:10.1016/j.eclinm.2019.06.016 · Cited by 53
Inkster, B., Rao, A. W., Ridler, K., Nichols, T. E., Saemann, P. G., Auer, D. P., Holsboer, F., Tozzi, F., Muglia, P., Merlo-Pich, E., et al. (2011) · Journal of Neuroimaging · doi:10.1111/j.1552-6569.2010.00515.x · Cited by 56
A dimensional approach to modeling symptoms of neuropsychiatric disorders in the marmoset monkey
Oikonomidis, L., Santangelo, A. M., Shiba, Y., Clarke, F. H., Robbins, T. W., & Roberts, A. C. (2017) · Developmental Neurobiology · doi:10.1002/dneu.22446 · Cited by 54
Assaf, M., Rabany, L., Zertuche, L., Bragdon, L., Tolin, D., Goethe, J., & Diefenbach, G. (2018) · Brain and Behavior · doi:10.1002/brb3.1015 · Cited by 48
Guo, C. C., Hyett, M. P., Nguyen, V. T., Parker, G. B., & Breakspear, M. J. (2016) · Psychological Medicine · doi:10.1017/s0033291716000179 · Cited by 45
A ghrelin receptor and oxytocin receptor heterocomplex impairs oxytocin mediated signalling
Wallace Fitzsimons, S. E., Chruścicka, B., Druelle, C., Stamou, P., Nally, K., Dinan, T. G., Cryan, J. F., & Schellekens, H. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.12.022 · Cited by 49
Jiang, C., Lin, W.-J., Labonté, B., Tamminga, C. A., Turecki, G., Nestler, E. J., Russo, S. J., & Salton, S. R. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-018-0277-4 · Cited by 43
Alexopoulos, G. S., Manning, K., Kanellopoulos, D., McGovern, A., Seirup, J. K., Banerjee, S., & Gunning, F. (2015) · Psychological Medicine · doi:10.1017/s0033291715001075 · Cited by 43
van Velzen, L. S., Schmaal, L., Milaneschi, Y., van Tol, M.-J., van der Wee, N. J. A., Veltman, D. J., & Penninx, B. W. J. H. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.10.019 · Cited by 38
Metadata
- Authors
- Drevets, W. C., Savitz, J., & Trimble, M.
- Affiliations
- National Institutes of Health (US)
- National Institute of Mental Health (US)
- National Hospital for Neurology and Neurosurgery (GB)
- Venue
- CNS Spectrums
- Publisher
- Cambridge University Press (CUP)
- Published
- 2008-08
- Volume
- 13
- Issue
- 8
- Pages
- 663-681
- ISSN
- 1092-8529 (ISSN-L)
- 2165-6509
- PMC
- PMC2729429
- OpenAlex
- W1582811168
- Cited by
- 1,109
- References
- 108
- Citations by year
- 2026: 55 · 2025: 58 · 2024: 64 · 2023: 48 · 2022: 68 · 2021: 112 · 2020: 62 · 2019: 63 · 2018: 57 · 2017: 55 · 2016: 72 · 2015: 63 · 2014: 68 · 2013: 70 · 2012: 68
- FWCI
- 4.49
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- CNS Spectrums (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (Z01MH002790)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- subgenual anterior cingulate cortex, mood disorders, major depressive disorder, bipolar disorder, gray matter volume, antidepressant response, deep brain stimulation, stress response, emotional behavior, neuroendocrine regulation, autonomic responses
- MeSH terms
- Corpus Callosum, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Mood Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
