The DOI matches its Crossref record; 175 of the 177 references it cites were found in a registry or an index.
Placental transport in response to altered maternal nutrition
Open accessAbstract
The mechanisms linking maternal nutrition to fetal growth and programming of adult disease remain to be fully established. We review data on changes in placental transport in response to altered maternal nutrition, including compromized utero-placental blood flow. In human intrauterine growth restriction and in most animal models involving maternal undernutrition or restricted placental blood flow, the activity of placental transporters, in particular for amino acids, is decreased in late pregnancy. The effect of maternal overnutrition on placental transport remains largely unexplored. However, some, but not all, studies in women with diabetes giving birth to large babies indicate an upregulation of placental transporters for amino acids, glucose and fatty acids. These data support the concept that the placenta responds to maternal nutritional cues by altering placental function to match fetal growth to the ability of the maternal supply line to allocate resources to the fetus. On the other hand, some findings in humans and mice suggest that placental transporters are regulated in response to fetal demand signals. These observations are consistent with the idea that fetal signals regulate placental function to compensate for changes in nutrient availability. We propose that the placenta integrates maternal and fetal nutritional cues with information from intrinsic nutrient sensors. Together, these signals regulate placental growth and nutrient transport to balance fetal demand with the ability of the mother to support pregnancy. Thus, the placenta plays a critical role in modulating maternal–fetal resource allocation, thereby affecting fetal growth and the long-term health of the offspring.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Thus, the placenta acts as an environmental sensor, integrating signals of the current availability of oxygen and nutrients, maternal stores of nutrient reserves and of the fetal nutrient demands for growth driven by the genes and actual mass of the fetus (74,204).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [204]
In the citing paper
“In addition, maternal nutrition is a major determinant of placental development and alters the morphological, transport and endocrine characteristics of the placenta with consequences for the fetal nutrient supply in a wide range of species including laboratory and farm species as well as human and non-human primates (47, 144, 204, 522, 550).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [204]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351
The Physiology of Reproduction
Legendre, M., & Jalabert, B. (1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-109-2-176_1 · Cited by 7,876
Hyperglycemia and adverse pregnancy outcomes
(2008) · New England Journal of Medicine · doi:10.1056/nejmoa0707943 · Cited by 5,563
mTOR: from growth signal integration to cancer, diabetes and ageing
Zoncu, R., Efeyan, A., & Sabatini, D. M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3025 · Cited by 3,941
Effect of In Utero and Early-Life Conditions on Adult Health and Disease
Gluckman, P. D., Hanson, M. A., Cooper, C., & Thornburg, K. L. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0708473 · Cited by 3,898
Onuegbu, A. J., Olisekodiaka, J. M., Udo, J., Umeononihu, O. S., Amah, U. K., Okwara, J. E., & Atuegbu, C. (2015) · Medical Principles and Practice · doi:10.1159/000381778 · Cited by 2,057
Maternal obesity and pregnancy outcome: a study of 287 213 pregnancies in London
Sebire, N. J., Jolly, M., Harris, J. P., Wadsworth, J., Joffe, M., Beard, R. W., Regan, L., & Robinson, S. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801670 · Cited by 1,740
Marshall’s Physiology of Reproduction
Lamming, G. E. (1994) · Springer eBooks · doi:10.1007/978-94-011-1286-4 · Cited by 1,377
Knobil and Neill's Physiology of Reproduction
(2015) · Elsevier eBooks · doi:10.1016/c2011-1-07288-0 · Cited by 1,277
Placental-specific IGF-II is a major modulator of placental and fetal growth
Constância, M., Hemberger, M., Hughes, J., Dean, W., Ferguson-Smith, A., Fundele, R., Stewart, F., Kelsey, G., Fowden, A., Sibley, C., et al. (2002) · Nature · doi:10.1038/nature00819 · Cited by 1,054
(1989) · Pediatric Research · doi:10.1203/00006450-198902000-00010 · Cited by 885
Pregnancy complications and outcomes among overweight and obese nulliparous women
Baeten, J. M., Bukusi, E. A., & Lambe, M. P. (2001) · American Journal of Public Health · doi:10.2105/ajph.91.3.436 · Cited by 762
Oxford reviews of reproductive biology
(1981) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(81)93042-5 · Cited by 751
The influence of obesity and diabetes on the prevalence of macrosomia
Ehrenberg, H. M., Mercer, B. M., & Catalano, P. M. (2004) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2004.05.052 · Cited by 670
Maternal Obesity Is Associated with Dysregulation of Metabolic, Vascular, and Inflammatory Pathways
Ramsay, J. E., Ferrell, W. R., Crawford, L., Wallace, A. M., Greer, I. A., & Sattar, N. A. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020311 · Cited by 659
Armitage, J. A., Khan, I. Y., Taylor, P. D., Nathanielsz, P. W., & Poston, L. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.072009 · Cited by 540
Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family
Mackenzie, B., & Erickson, J. D. (2004) · Pfl�gers Archiv European Journal of Physiology · doi:10.1007/s00424-003-1117-9 · Cited by 515
Regulation of Nutrient Transport across the Placenta
Lager, S., & Powell, T. L. (2012) · Journal of Pregnancy · doi:10.1155/2012/179827 · Cited by 484
Self-citationWHITTLE, P. M. (1998) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/fn.79.2.f160 · Cited by 474
Yung, H.-W., Calabrese, S., Hynx, D., Hemmings, B. A., Cetin, I., Charnock-Jones, D. S., & Burton, G. J. (2008) · The American Journal of Pathology · doi:10.2353/ajpath.2008.071193 · Cited by 388
Nutritional programming of the metabolic syndrome
Symonds, M. E., Sebert, S. P., Hyatt, M. A., & Budge, H. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.195 · Cited by 382
Calorie restriction and cancer prevention: metabolic and molecular mechanisms
Longo, V. D., & Fontana, L. (2010) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.11.004 · Cited by 378 · cited 1×
“Calorie restriction in non-pregnant humans and animals typically increases serum concentrations of adiponectin.(131) Maternal serum concentrations of IGF-I are decreased in human IUGR(132) and some studies indicate that maternal serum leptin concentrations are reduced in this pregnancy complication.”
BackgroundConstância, M., Angiolini, E., Sandovici, I., Smith, P., Smith, R., Kelsey, G., Dean, W., Ferguson-Smith, A., Sibley, C. P., Reik, W., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504468103 · Cited by 323 · cited 1×
“This increased nutrient transport maintains fetal growth in the normal range until late pregnancy when compensatory mechanisms fail and IUGR develops.(5,21) Based on a comparison of the placental phenotype in complete igf-2 knockout mice and in mice with knockout of the placental-specific igf-2 only, it has been sugge…”
BackgroundJansson, T., Wennergren, M., & Illsley, N. P. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.6.8263141 · Cited by 320
Self-citationJones, H. N., Woollett, L. A., Barbour, N., Prasad, P. D., Powell, T. L., & Jansson, T. (2008) · The FASEB Journal · doi:10.1096/fj.08-116889 · Cited by 310
Self-citationMaternal Undernutrition Influences Placental-Fetal Development1
Belkacemi, L., Nelson, D. M., Desai, M., & Ross, M. G. (2010) · Biology of Reproduction · doi:10.1095/biolreprod.110.084517 · Cited by 299
Glazier, J. D., Cetin, I., Perugino, G., Ronzoni, S., Grey, A. M., Mahendran, D., Marconi, A. M., Pardi, G., & Sibley, C. P. (1997) · Pediatric Research · doi:10.1203/00006450-199710000-00016 · Cited by 287
Roos, S., Jansson, N., Palmberg, I., Säljö, K., Powell, T. L., & Jansson, T. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.129676 · Cited by 283
Self-citationMiller, J. L., Turan, Ş., & Baschat, A. (2008) · Seminars in Perinatology · doi:10.1053/j.semperi.2008.04.010 · Cited by 271
Frias, A. E., Morgan, T. K., Evans, A. E., Rasanen, J., Oh, K. Y., Thornburg, K. L., & Grove, K. L. (2011) · Endocrinology · doi:10.1210/en.2010-1332 · Cited by 268
Jansson, N., Pettersson, J., Haafiz, A., Ericsson, A., Palmberg, I., Tranberg, M., Ganapathy, V., Powell, T. L., & Jansson, T. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.550004 · Cited by 265
Self-citationJansson, N., Pettersson, J., Haafiz, A., Ericsson, A., Palmberg, I., Tranberg, M., Ganapathy, V., Powell, T. L., & Jansson, T. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.116509 · Cited by 261
Self-citationCetin, I., Corbetta, C., Sereni, L. P., Marconi, A. M., Bozzetti, P., Pardi, G., & Battaglia, F. C. (1990) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(90)90860-a · Cited by 259
Jansson, T., & Powell, T. L. (2006) · Placenta · doi:10.1016/j.placenta.2005.11.010 · Cited by 257
Self-citationDiwan, A. D. (2020) · CRC Press eBooks · doi:10.1201/9781003155966-5 · Cited by 255
Placental Phenotypes of Intrauterine Growth
Sibley, C. P., Turner, M. A., Cetin, I., Ayuk, P. T.-Y., Boyd, C. A. R., D'Souza, S. W., Glazier, J. D., Greenwood, S. L., Jansson, T., & Powell, T. L. (2005) · Pediatric Research · doi:10.1203/01.pdr.0000181381.82856.23 · Cited by 250
Self-citationMaiiendran, D., Donnai, P., Glazier, J. D., D'Souza, S. W., Boyd, R. D., & Sibley, C. P. (1993) · Pediatric Research · doi:10.1203/00006450-199311000-00019 · Cited by 247
Intrauterine Growth Restriction: Implications for Placental Metabolism and Transport. A Review
Cetin, I., & Alvino, G. (2009) · Placenta · doi:10.1016/j.placenta.2008.12.006 · Cited by 246
Jansson, N., Greenwood, S. L., Johansson, B. R., Powell, T. L., & Jansson, T. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021332 · Cited by 243
Self-citationJansson, T., Ekstrand, Y., Björn, C., Wennergren, M., & Powell, T. L. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2214 · Cited by 238
Self-citationImprinted genes in the placenta – A review
Coan, P. M., Burton, G. J., & Ferguson‐Smith, A. C. (2005) · Placenta · doi:10.1016/j.placenta.2004.12.009 · Cited by 238
Placental Transport of Leucine and Lysine Is Reduced in Intrauterine Growth Restriction1
Jansson, T., Scholtbach, V., & Powell, T. L. (1998) · Pediatric Research · doi:10.1203/00006450-199810000-00011 · Cited by 235
Self-citationRegulation of Placental Nutrient Transport – A Review
Jones, H. N., Powell, T. L., & Jansson, T. (2007) · Placenta · doi:10.1016/j.placenta.2007.05.002 · Cited by 226
Self-citationJansson, T., Ylvén, K., Wennergren, M., & Powell, T. L. (2002) · Placenta · doi:10.1053/plac.2002.0826 · Cited by 218
Self-citationLi, M., Sloboda, D. M., & Vickers, M. H. (2011) · Experimental Diabetes Research · doi:10.1155/2011/592408 · Cited by 217
Paolini, C. L., Marconi, A. M., Ronzoni, S., Noio, M. D., Fennessey, P. V., Pardi, G., & Battaglia, F. C. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.11.8036 · Cited by 210
Blood glucose and oxygen tension levels in small-for-gestational-age fetuses
Economides, D. L., & Nicolaides, K. H. (1989) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(89)90453-5 · Cited by 208
Magnusson, A., Waterman, I. J., Wennergren, M., Jansson, T., & Powell, T. L. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032234 · Cited by 206
Self-citationNorberg, S., Powell, T. L., & Jansson, T. (1998) · Pediatric Research · doi:10.1203/00006450-199808000-00016 · Cited by 203
Self-citationOxford Reviews of Reproductive Biology
Cross, B. (1987) · Europe PMC (PubMed Central) · Cited by 199
Coan, P. M., Vaughan, O. R., Sekita, Y., Finn, S. L., Burton, G. J., Constancia, M., & Fowden, A. L. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2009.181214 · Cited by 199
Prepregnancy Obesity Prevalence in the United States, 2004–2005
Chu, S. Y., Kim, S. Y., & Bish, C. L. (2008) · Maternal and Child Health Journal · doi:10.1007/s10995-008-0388-3 · Cited by 196
Coan, P. M., Angiolini, E., Sandovici, I., Burton, G. J., Constância, M., & Fowden, A. L. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.156133 · Cited by 194 · cited 1×
“These observations are in contrast to intra-litter variations in placental nutrient transport and fetal growth in mice, where placental amino acid transport capacity and SNAT2 expression have been reported to be increased in the smallest placentas.(76) There are numerous approaches to induce IUGR in the sheep.”
ResultCord Blood Leptin and Insulin-Like Growth Factor Levels are Independent Predictors of Fetal Growth
Christou, H. A., Connors, J. M., Ziotopoulou, M., Hatzidakis, V., Papathanassoglou, E. D. E., Ringer, S. A., & Mantzoros, C. S. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.2.7217 · Cited by 185
Dubé, E., Gravel, A., Martin, C., Desparois, G., Moussa, I., Ethier-Chiasson, M., Forest, J.-C., Giguère, Y., Masse, A., & Lafond, J. (2012) · Biology of Reproduction · doi:10.1095/biolreprod.111.098095 · Cited by 180
Gambling, L., Danzeisen, R., Susan, G. A. I. R., Lea, R. G., CHARANIA, Z., Solanky, N., JOORY, K. D., Srai, S. K., & McArdle, H. J. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3560883 · Cited by 179
Cetin, I., Marconi, A. M., Bozzetti, P., Sereni, L. P., Corbetta, C., Pardi, G., & Battaglia, F. C. (1988) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(88)90792-2 · Cited by 177
Rosario, F. J., Jansson, N., Kanai, Y., Prasad, P. D., Powell, T. L., & Jansson, T. (2011) · Endocrinology · doi:10.1210/en.2010-1153 · Cited by 176
Self-citationThe emerging role of mTORC1 signaling in placental nutrient-sensing
Jansson, T., Aye, I. L. M. H., & Goberdhan, D. C. I. (2012) · Placenta · doi:10.1016/j.placenta.2012.05.010 · Cited by 175
Self-citationPlacental glucose transport in heat-induced fetal growth retardation
Thureen, P. J., Trembler, K. A., Meschia, G., Makowski, E. L., & Wilkening, R. B. (1992) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1992.263.3.r578 · Cited by 173
Placental leptin in normal, diabetic and fetal growth-retarded pregnancies
Lea, R. G., Howe, D. C., Hannah, L. T., Bonneau, O., Hunter, L., & Hoggard, N. (2000) · Molecular Human Reproduction · doi:10.1093/molehr/6.8.763 · Cited by 171
Animal Models in Diabetes and Pregnancy
Jawerbaum, A., & White, V. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0038 · Cited by 170
Jones, H. N., Jansson, T., & Powell, T. L. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00195.2009 · Cited by 168
Self-citationPlacental glucose transport and GLUT 1 expression in insulin-dependent diabetes
Jansson, T., Wennergren, M., & Powell, T. L. (1999) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(99)70169-9 · Cited by 166
Self-citationCompensatory placental growth after restricted maternal nutrition in early pregnancy
Lunney, L. H. (1998) · Placenta · doi:10.1016/s0143-4004(98)90105-9 · Cited by 164
Plasma amino acids in appropriate- and small-for-gestational-age fetuses
Economides, D. L., Nicolaides, K. H., Gahl, W. A., Bernardini, I. M., & Evans, M. I. (1989) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(89)90670-4 · Cited by 161
Maternal hormones linking maternal body mass index and dietary intake to birth weight
Jansson, N., Nilsfelt, A., Gellerstedt, M., Wennergren, M., Rossander-Hulthén, L., Powell, T. L., & Jansson, T. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.6.1743 · Cited by 159
Self-citationCetin, I., Giovannini, N., Alvino, G., Agostoni, C. V., Riva, E., Giovannini, M., & Pardi, G. (2002) · Pediatric Research · doi:10.1203/00006450-200211000-00023 · Cited by 153
Laviola, L., Perrini, S., Belsanti, G., Natalicchio, A., Montrone, C., Leonardini, A., Vimercati, A., Scioscia, M., Selvaggi, L. E., GIORGINO, R., et al. (2004) · Endocrinology · doi:10.1210/en.2004-1332 · Cited by 151
Farley, D. M., Choi, J., Dudley, D. J., Li, C., Jenkins, S. L., Myatt, L., & Nathanielsz, P. W. (2010) · Placenta · doi:10.1016/j.placenta.2010.06.006 · Cited by 150
Regulation of placental amino acid transporter activity by mammalian target of rapamycin
Roos, S., Kanai, Y., Prasad, P. D., Powell, T. L., & Jansson, T. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00330.2008 · Cited by 150
Self-citationLangley‐Evans, S. C., Gardner, D. S., & Jackson, A. A. (1996) · Reproduction · doi:10.1530/jrf.0.1060307 · Cited by 150
Malandro, M. S., Beveridge, M. J., Kilberg, M. S., & Novak, D. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.1.c295 · Cited by 150
Diabetes Alters the Expression and Activity of the Human Placental GLUT1 Glucose Transporter1
Gaither, K., Quraishi, A. N., & Illsley, N. P. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.2.5438 · Cited by 149
Placental transport and fetal utilization of leucine in a model of fetal growth retardation
J. C. Ross, Fennessey, P. V., Wilkening, R. B., Battaglia, F. C., & Meschia, G. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.270.3.e491 · Cited by 146
Anatomy and Genesis of the Placenta
Burton, G. J., Kaufmann, P., & Huppertz, B. (2006) · Elsevier eBooks · doi:10.1016/b978-012515400-0/50010-5 · Cited by 146
Hypoglycemia and the Origin of Hypoxia-Induced Reduction in Human Fetal Growth
Zamudio, S., Torricos, T., Fik, E., Oyala, M., Echalar, L., Pullockaran, J., Tutino, E., Martin, B., Belliappa, S., Balanza, E., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008551 · Cited by 141
Fetal Medicine: Basic Science and Clinical Practice
Rodeck, C. H., & Whittle, M. J. (2008) · Cited by 139
Fatty Acid Binding Protein 4 Regulates Intracellular Lipid Accumulation in Human Trophoblasts
Scifres, C., Chen, B., Nelson, D. M., & Sadovsky, Y. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2084 · Cited by 139
Zhu, M. J., Ma, Y., Long, N. M., Du, M., & Ford, S. P. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00309.2010 · Cited by 137
Jones, H. N., Jansson, T., & Powell, T. L. (2010) · Diabetes · doi:10.2337/db09-0824 · Cited by 136
Self-citationPlacental Amino Acid Uptake in Normal and Complicated Pregnancies
Dicke, J. M., & Henderson, G. I. (1988) · The American Journal of the Medical Sciences · doi:10.1097/00000441-198803000-00012 · Cited by 135
Kavitha, J., Rosario, F. J., Nijland, M. J., McDonald, T. J., Wu, G., Kanai, Y., Powell, T. L., Nathanielsz, P. W., & Jansson, T. (2013) · The FASEB Journal · doi:10.1096/fj.13-242271 · Cited by 135
Self-citationMarconi, A. M., Paolini, C. L., Stramare, L., Cetin, I., Fennessey, P. V., Pardi, G., & Battaglia, F. C. (1999) · Pediatric Research · doi:10.1203/00006450-199907000-00019 · Cited by 121
Gambling, L., Danzeisen, R., Susan, G. A. I. R., et al. (2001) · Biochemical Journal · doi:10.1042/bj3560883 · Cited by 119
Placental-Specific Igf2 Deficiency Alters Developmental Adaptations to Undernutrition in Mice
Sferruzzi-Perri, A. N., Vaughan, O. R., Coan, P. M., Suciu, M. C., Darbyshire, R., Constancia, M., Burton, G. J., & Fowden, A. L. (2011) · Endocrinology · doi:10.1210/en.2011-0240 · Cited by 115
Placental glucose transport in gestational diabetes mellitus
Jansson, T., Ekstrand, Y., Wennergren, M., & Powell, T. L. (2001) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2001.108075 · Cited by 113
Self-citationKarl, P. I. (1995) · Journal of Cellular Physiology · doi:10.1002/jcp.1041650111 · Cited by 112
Higgins, L. E., Greenwood, S. L., Wareing, M., Sibley, C. P., & Mills, T. A. (2010) · Placenta · doi:10.1016/j.placenta.2010.09.019 · Cited by 112
Heasman, L., Clarke, L., Firth, K., Stephenson, T. J., & Symonds, M. E. (1998) · Pediatric Research · doi:10.1203/00006450-199810000-00013 · Cited by 111
Amino acid transport by the cultured human placental trophoblast: effect of insulin on AIB transport
Karl, P. I., Alpy, K. L., & Fisher, S. E. (1992) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1992.262.4.c834 · Cited by 110
Kuruvilla, A. G., D'Souza, S. W., Glazier, J. D., Mahendran, D., Maresh, M., & Sibley, C. P. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117386 · Cited by 107
Wijendran, V., Bendel, R., Couch, S., Philipson, E., Cheruku, S., & Lammi-Keefe, C. (2000) · Lipids · doi:10.1007/s11745-000-0602-2 · Cited by 107
Placental transport in pregnancy pathologies
Desoyé, G., Gauster, M., & Wadsack, C. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.000851 · Cited by 107
Lésage, J., Hahn, D., Léonhardt, M., Blondeau, B., Bréant, B., & Dupouy, J. (2002) · Journal of Endocrinology · doi:10.1677/joe.0.1740037 · Cited by 106
Rosario, F. J., Schumacher, M. A., Jiang, J. X., Kanai, Y., Powell, T. L., & Jansson, T. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2011.226399 · Cited by 104
Self-citationCrowe, C., Dandekar, P., Fox, M., Dhingra, K., Bennet, L., & Hanson, M. A. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp020986 · Cited by 104
Maternal nutrition in relation to fetal and placental growth
Godfrey, K. M., & Barker, D. J. P. (1995) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/0028-2243(95)02148-l · Cited by 104
Coan, P. M., Fowden, A. L., Constância, M., Ferguson‐Smith, A. C., Burton, G. J., & Sibley, C. P. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.157313 · Cited by 100
Holmes, R. P., Montemagno, R., Jones, J. L., Preece, M. A., Rodeck, C. H., & SOOTHILL, P. W. (1997) · Early Human Development · doi:10.1016/s0378-3782(97)01867-7 · Cited by 98
Current understanding of placental fatty acid transport
Gil-Sánchez, A., Koletzko, B. V., & Larqué, E. (2012) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3283523b6e · Cited by 97
Overexpression of GLUT3 placental glucose transporter in diabetic rats.
Boileau, P., Mrejen, C., Girard, J. R., & Mouzon, S. H. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118036 · Cited by 97
Dysregulation of Placental Endothelial Lipase in Obese Women With Gestational Diabetes Mellitus
Gauster, M., Hiden, U., van Poppel, M. N. M., Frank, S., Wadsack, C., Mouzon, S. H., & Desoyé, G. (2011) · Diabetes · doi:10.2337/db10-1434 · Cited by 96
Sibley, C. P., Brownbill, P., Dilworth, M. R., & Glazier, J. D. (2010) · Placenta · doi:10.1016/j.placenta.2009.12.020 · Cited by 95
Desoyé, G., Hahn, T., Hartmann, M., Blaschitz, A., Dohr, G., Kohnen, G., & Kaufmann, P. (1994) · Histochemistry and Cell Biology · doi:10.1007/bf00315915 · Cited by 93
An Animal Model of Placental Insufficiency-Induced Intrauterine Growth Restriction
Barry, J. S., Rozance, P. J., & Anthony, R. V. (2008) · Seminars in Perinatology · doi:10.1053/j.semperi.2007.11.004 · Cited by 90
Johansson, M., Karlsson, L., Wennergren, M., Jansson, T., & Powell, T. L. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021926 · Cited by 88
Self-citationWallace, J. M., Bourke, D. A., Aitken, R. P., Milne, J. S., & Hay, W. W. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.023333 · Cited by 86
Godfrey, K. M., Matthews, N., Glazier, J. D., Jackson, A. A., Wilman, C., & Sibley, C. P. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.9.5132 · Cited by 85
Altered placental development in undernourished rats: role of maternal glucocorticoids
Belkacemi, L., Jelks, A. T., Chen, C., Ross, M. G., & Desai, M. (2011) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-9-105 · Cited by 83
Lindegaard, M. L. S., Damm, P., Mathiesen, E. R., & Nielsen, L. B. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m600236-jlr200 · Cited by 83
Wooding, F. B. P., & Flint, A. P. F. (1994) · Springer eBooks · doi:10.1007/978-94-011-1286-4_4 · Cited by 83
Roos, S., Powell, T. L., & Jansson, T. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00232.2004 · Cited by 80
Self-citationPlacental transport of threonine and its utilization in the normal and growth-restricted fetus
Anderson, A., Fennessey, P. V., Meschia, G., Wilkening, R. B., & Battaglia, F. C. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.272.5.e892 · Cited by 80
Effects of gestational diabetes on human placental glucose uptake, transfer, and utilisation
Osmond, D. T. D., Nolan, C. J., King, R. G., Brennecke, S. P., & Gude, N. M. (2000) · Diabetologia · doi:10.1007/s001250051346 · Cited by 77
Jansson, T., & Persson, E. (1990) · Pediatric Research · doi:10.1203/00006450-199009000-00007 · Cited by 77
Self-citationGodfrey, K. M. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.9.3320 · Cited by 72
von Versen‐Höynck, F., Rajakumar, A., Parrott, M. S., & Powers, R. W. (2009) · Placenta · doi:10.1016/j.placenta.2009.01.004 · Cited by 71
de Vrijer, B., Regnault, T. R. H., Wilkening, R. B., Meschia, G., & Battaglia, F. C. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00259.2004 · Cited by 70
Johansson, M., Glazier, J. D., Sibley, C. P., Jansson, T., & Powell, T. L. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020214 · Cited by 68
Self-citationDietary composition programmes placental phenotype in mice
Coan, P. M., Vaughan, O. R., McCarthy, J., Mactier, C., Burton, G. J., Constância, M., & Fowden, A. L. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.208629 · Cited by 67
Sferruzzi-Perri, A. N., Owens, J. A., Standen, P., Taylor, R. L., Heinemann, G. K., Robinson, J. S., & Roberts, C. T. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00320.2006 · Cited by 66
Rosso, P. (1977) · Journal of Nutrition · doi:10.1093/jn/107.11.2002 · Cited by 65
Herrera, E., Palacı́n, M., Martín‐Hidalgo, A., & Lasunción, M. A. (1985) · Diabetes · doi:10.2337/diab.34.2.s42 · Cited by 64
Angiolini, E., Coan, P. M., Sandovici, I., Iwajomo, O. H., Peck, G., Burton, G. J., Sibley, C. P., Reik, W., Fowden, A. L., & Constância, M. (2011) · The FASEB Journal · doi:10.1096/fj.10-175273 · Cited by 64
Control of transfer across the mature placenta.
Sibley, C. P., & Boyd, R. D. (1988) · PubMed · Cited by 61
Evolution of Factors Affecting Placental Oxygen Transfer
Carter, A. M. (2008) · Placenta · doi:10.1016/j.placenta.2008.11.006 · Cited by 60
Strid, H., Bucht, E., Jansson, T., Wennergren, M., & Powell, T. L. (2003) · Placenta · doi:10.1053/plac.2002.0941 · Cited by 60
Self-citationShibata, E., Hubel, C. A., Powers, R. W., von Versen‐Höynck, F., Gammill, H. S., Rajakumar, A., & Roberts, J. M. (2008) · Placenta · doi:10.1016/j.placenta.2008.07.001 · Cited by 60
Osmond, D. T. D., King, R. G., Brennecke, S. P., & Gude, N. M. (2001) · Diabetologia · doi:10.1007/s001250100609 · Cited by 58
Diabetes in Pregnancy: Decreased Placental Blood Flow and Disturbed Fetal Development in the Rat
Eriksson, U. J., & Jansson, L. E. (1984) · Pediatric Research · doi:10.1203/00006450-198408000-00012 · Cited by 56
Ayuk, P. T.-Y., Theophanous, D., D'Souza, S. W., Sibley, C. P., & Glazier, J. D. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.2.8204 · Cited by 56
Spatial Polarization of Insulin-Like Growth Factor Receptors on the Human Syncytiotrophoblast
Fang, J., Furesz, T. C., Laurent, R. S., Smith, C. H., & Fant, M. E. (1997) · Pediatric Research · doi:10.1203/00006450-199702000-00017 · Cited by 55
Rosso, P. (1977) · Journal of Nutrition · doi:10.1093/jn/107.11.2006 · Cited by 54
Bibee, K., Illsley, N. P., & Moley, K. H. (2010) · Reproductive Sciences · doi:10.1177/1933719110380276 · Cited by 53
Umbilical Cord and Maternal Blood Leptin Concentrations in Intrauterine Growth Retardation
Yıldız, L., Avcı, B., & İngeç, M. (2002) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2002.195 · Cited by 53
Maternal-fetal fat transport versus new fat synthesis in the pregnant diabetic rat
Shafrir, E., & Khassis, S. (1982) · Diabetologia · doi:10.1007/bf00254839 · Cited by 53
Goyal, R., Lister, R., Leitzke, A., Goyal, D., Gheorghe, C. P., & Longo, L. D. (2010) · Placenta · doi:10.1016/j.placenta.2010.11.004 · Cited by 47
Arroyo, J. A., Brown, L. D., & Galan, H. L. (2009) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2009.07.031 · Cited by 47
Audette, M. C., Challis, J. R. G., Jones, R. L., Sibley, C. P., & Matthews, S. G. (2011) · Endocrinology · doi:10.1210/en.2011-0104 · Cited by 47
Nitzan, M., Orloff, S., & Schulman, J. D. (1979) · Pediatric Research · doi:10.1203/00006450-197902000-00003 · Cited by 46
Barrera, N. P., Morales, B., & Villalón, M. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00343.2003 · Cited by 46
Smerieri, A., Petraroli, M., Ziveri, M. A., Volta, C., Bernasconi, S., & Street, M. E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0029562 · Cited by 46
Schlabritz‐Loutsevitch, N., Ballesteros, B., Dudley, C., Jenkins, S. L., Hubbard, G. B., Burton, G. J., & Nathanielsz, P. W. (2007) · Placenta · doi:10.1016/j.placenta.2006.11.012 · Cited by 45
Devaskar, S. U., Devaskar, U. P., Schroeder, R. E., deMello, D. E., Fiedorek, F. T., & Mueckler, M. M. (1994) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(94)90154-6 · Cited by 43
Strid, H., Care, A. D., Jansson, T., & Powell, T. L. (2002) · Journal of Endocrinology · doi:10.1677/joe.0.1750517 · Cited by 43
Self-citationOgura, K., Sakata, M., Yamaguchi, M., Kurachi, H., & Murata, Y. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1600443 · Cited by 42
Rebholz, S. L., Burke, K. T., Yang, Q., Tso, P., & Woollett, L. A. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00619.2010 · Cited by 42
Zhu, M. J., Du, M., Hess, B. W., Nathanielsz, P. W., & Ford, S. P. (2007) · Placenta · doi:10.1016/j.placenta.2007.05.004 · Cited by 41
Increased Placental Apoptosis in Maternal Food Restricted Gestations: Role of the Fas Pathway
Belkacemi, L., Chen, C. H., Ross, M. G., & Desai, M. (2009) · Placenta · doi:10.1016/j.placenta.2009.06.003 · Cited by 41
Lauszus, F. F. (2001) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(01)01189-9 · Cited by 41
Kusinski, L. C., Jones, C. J. P., Baker, P. N., Sibley, C. P., & Glazier, J. D. (2009) · Placenta · doi:10.1016/j.placenta.2009.11.006 · Cited by 39
Homocysteine is transported by the microvillous plasma membrane of human placenta
Tsitsiou, E., Sibley, C. P., D'Souza, S. W., Cătănescu, O., Jacobsen, D. W., & Glazier, J. D. (2010) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-010-9141-3 · Cited by 38
Mechanisms of Transfer Across the Human Placenta
Hayward, C. E., Jones, R. L., & Sibley, C. P. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-35214-7.00012-3 · Cited by 37
Atkinson, D. E., BOYD, R., & Sibley, C. P. (2006) · Elsevier eBooks · doi:10.1016/b978-012515400-0/50057-9 · Cited by 36
Placental Lactate Transporter Activity and Expression in Intrauterine Growth Restriction
Settle, P., Sibley, C. P., Doughty, I., Johnston, T. A., Glazier, J. D., Powell, T. L., Jansson, T., & D'Souza, S. W. (2006) · Journal of the Society for Gynecologic Investigation · doi:10.1016/j.jsgi.2006.04.006 · Cited by 35
Self-citationEbenbichler, C. F., Kaser, S., Laimer, M. W., Wolf, H. J., Patsch, J. R., & Illsley, N. P. (2002) · Placenta · doi:10.1053/plac.2002.0836 · Cited by 32
Maternal Malnutrition and Placental Transfer of α-Aminoisobutyric Acid in the Rat
Rosso, P. (1975) · Science · doi:10.1126/science.803709 · Cited by 32
Saintonge, J., & Rosso, P. (1981) · Pediatric Research · doi:10.1203/00006450-198102000-00014 · Cited by 30
Glazier, J. D., Sibley, C. P., & Carter, A. M. (1996) · Pediatric Research · doi:10.1203/00006450-199608000-00022 · Cited by 28
Insulin receptors in human placenta in relation to fetal weight and gestational age.
Potau, N., Riudor, E., & Ballabriga, A. (1981) · PubMed · Cited by 28
Effects of protein-calorie malnutrition on transplacental kinetics of aminoisobutyric acid in rats
Varma, D. R., & Ramakrishnan, R. (1991) · Placenta · doi:10.1016/0143-4004(91)90009-5 · Cited by 27
Ahokas, R. A., Lahaye, E. B., Anderson, G. D., & Lipshitz, J. (1981) · Journal of Nutrition · doi:10.1093/jn/111.12.2052 · Cited by 27
Persson, A., Johansson, M., Jansson, T., & Powell, T. L. (2002) · Placenta · doi:10.1053/plac.2002.0807 · Cited by 25
Self-citationThe Endoplasmic Reticulum Stress of Placental Impoverishment
Redman, C. W. G. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.080412 · Cited by 24
The effect of maternal undernutrition on the growth and development of the guinea pig placenta.
Dwyer, C. M., Madgwick, A. J. A., Crook, A. R., & Stickland, N. C. (1992) · PubMed · Cited by 21
Palacı́n, M., Lasunción, M. A., Martín‐Hidalgo, A., & Herrera, E. (2009) · Biology of the Neonate · doi:10.1159/000242172 · Cited by 20
Goldstein, R. M., Levy, E. H., & Shafrir, E. (2009) · Biology of the Neonate · doi:10.1159/000242138 · Cited by 19
Placental expression of glucose transporter proteins 1 and 3 in growth-restricted fetal rats
Reid, G. J., Lane, R. H., Flozak, A. S., & Simmons, R. A. (1999) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(99)70675-7 · Cited by 18
Dicke, J. M., & Verges, D. K. (1994) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767059409017364 · Cited by 17
Copeland, A., & Porterfield, S. P. (1987) · Hormone and Metabolic Research · doi:10.1055/s-2007-1011738 · Cited by 15
Placental transfer and uptake of 2-deoxyglucose in control and diabetic rats
Thomas, C. R., & Lowy, C. (1992) · Metabolism · doi:10.1016/0026-0495(92)90009-y · Cited by 14
Mechanisms of solute transfer across the human placenta: effects of intrauterine growth restriction
Sibley, C. P., D'Souza, S. W., Glazier, J. D., & Greenwood, S. L. (1998) · Fetal and Maternal Medicine Review · doi:10.1017/s0965539598000424 · Cited by 14
Placental Function in Maternofetal Exchange
Sibley, C. P., & Dilworth, M. R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-7020-6956-7.00008-7 · Cited by 10
Honda, M., Lowy, C., & Cr, T. (1990) · PubMed · Cited by 10
Research works printed but not linked: 4
- Gaccioli, 2012, Placental System A and System L amino acid transporter activity and expression in lean and overweight/obese Hispanic women, Reprod Sci, 19, 377A
- Kavitha, 2012, Down regulation of placental amino acid and glucose transporters in response to maternal nutrient restriction in the baboon, Reprod Sci, 19, 378A
- Jansson, 2010, Altered AMPK and mTOR signaling and up-regulation of placental System A amino acid transporter activity and SNAT2 protein expression in obese women giving birth to large babies, Reprod Sci, 17, 260A
- Gaccioli, 2011, Activation of placental mammalian target of rapamycin signaling in obese women, Placenta, 32, A134
Cited by
Sorted by citations
Placental Origins of Chronic Disease
Burton, G. J., Fowden, A. L., & Thornburg, K. L. (2016) · Physiological Reviews · doi:10.1152/physrev.00029.2015 · Cited by 717
Placenta-on-a-chip: a novel platform to study the biology of the human placenta
Lee, J. S., Romero, R. J., Han, Y. M., Kim, H. C., Kim, C. J., Hong, J., & Huh, D. (2015) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2015.1038518 · Cited by 272
Placental Responses to Changes in the Maternal Environment Determine Fetal Growth
Dimasuay, K. G., Boeuf, P., Powell, T. L., & Jansson, T. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00012 · Cited by 258
Self-citationRole of placental nutrient sensing in developmental programming
JANSSON, T., & POWELL, T. L. (2013) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0b013e3182993a2e · Cited by 172
Self-citationAye, I. L. M. H., Rosario, F. J., Powell, T. L., & Jansson, T. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1515484112 · Cited by 165
Self-citation
Metadata
- Authors
- Gaccioli, F., Lager, S., Powell, T. L., & Jansson, T.
- Affiliations
- The University of Texas at San Antonio Health Science Center (US)
- Corresponding author
- Jansson, T.
- Venue
- Journal of Developmental Origins of Health and Disease
- Publisher
- Cambridge University Press (CUP)
- Published
- 2012-07-31
- Volume
- 4
- Issue
- 2
- Pages
- 101-115
- ISSN
- 2040-1744 (ISSN-L)
- 2040-1752
- PMC
- PMC4237017
- OpenAlex
- W2164709834
- Cited by
- 129
- References
- 177
- Citations by year
- 2026: 13 · 2025: 7 · 2024: 7 · 2023: 12 · 2022: 10 · 2021: 13 · 2020: 11 · 2019: 7 · 2018: 10 · 2017: 15 · 2016: 8 · 2015: 7 · 2014: 4 · 2013: 4 · 2012: 1
- FWCI
- 4.49
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Developmental Origins of Health and Disease (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r01hd068370-11)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK089989)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R21HD071306, R01-HD068370, R01HD065007)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Keywords
- placental nutrient transport, maternal nutrition, fetal growth restriction, maternal undernutrition, maternal overnutrition, placental blood flow, amino acid transporters, glucose transport, fatty acid uptake, fetal programming, fetal growth, diabetes in pregnancy, placental development
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
