Cited by 105Cognitive Abilities and TestingNeural and Behavioral Psychology StudiesGenetic Associations and Epidemiology

Genetic Contribution to Variation in Cognitive Function: An fMRI Study in Twins

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Koten, Jan Willem, Wood, Guilherme, Hagoort, Peter, Goebel, Rainer, Propping, Peter, Willmes, Klaus, Boomsma, Dorret I.·2009·Science

Abstract

Little is known about the genetic contribution to individual differences in neural networks subserving cognition function. In this functional magnetic resonance imaging (fMRI) twin study, we found a significant genetic influence on brain activation in neural networks supporting digit working memory tasks. Participants activating frontal-parietal networks responded faster than individuals relying more on language-related brain networks. There were genetic influences on brain activation in language-relevant brain circuits that were atypical for numerical working memory tasks as such. This suggests that differences in cognition might be related to brain activation patterns that differ qualitatively among individuals.

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Crossref · 10.1126/science.1167371

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24 of 24 references verified0 citation errors · 0 not checkable

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Authors
Koten, J. W., Wood, G., Hagoort, P., Goebel, R., Propping, P., Willmes, K., & Boomsma, D. I.
Affiliations
  • Radboud University Nijmegen (NL)
  • Section Neuropsychology, RWTH Aachen University, Germany.
  • Netherlands Institute for Neuroscience (NL)
  • University of Bonn (DE)
Corresponding author
Koten, Jan Willem
Venue
Science
Published
2009-03-27
Volume
323
Issue
5922
Pages
1737-1740
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2146683693
Cited by
105
References
24
Citations by year
2025: 2 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 5 · 2020: 2 · 2019: 4 · 2018: 4 · 2017: 6 · 2016: 8 · 2015: 10 · 2014: 6 · 2013: 9 · 2012: 13
FWCI
17.32
Type
journal article
Language
en
Licence
other-oa
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • Research Publications (Maastricht University) (publishedVersion, other-oa)
  • MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
  • Max Planck Digital Library (submittedVersion, other-oa)
  • RWTH Publications (RWTH Aachen) (submittedVersion)
  • KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
  • VU Research Portal (submittedVersion)
  • Research Publications (Maastricht University) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
genetic factors, heritability, individual differences in cognition, working memory, brain activation, frontoparietal network, language network, artificial neural networks, twins
MeSH terms
Adult, Brain, Brain Mapping, Cognition, Genes, Humans, Magnetic Resonance Imaging, Male, Memory, Short-Term, Nerve Net, Twins, Monozygotic, Siblings, Cerebrum, Mathematical Concepts

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