The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Peroxynitrite Activatable NIR-II Fluorescent Molecular Probe for Drug-Induced Hepatotoxicity Monitoring
Abstract
Drug-induced hepatotoxicity represents an important challenge for safety in drug development. The production of peroxynitrite (ONOO – ) is proposed as an early sign in the progression of drug-induced hepatotoxicity. Currently, reported ONOO – probes mainly emit in the visible range or the first NIR window, which have limited in vivo biosensing application due to the autofluorescence and photon scattering. Herein, we developed a peroxynitrite activatable second near-infrared window (NIR-II) molecular probe for drug-induced hepatotoxicity monitoring, based on the fusion of an NIR-II fluorescence turn-on benzothiopyrylium cyanines skeleton and the phenyl borate. In the presence of ONOO –, the probe IRBTP-B can turn on its NIR-II fluorescence by yielding its fluorophore IRBTP-O and display good linear response to ONOO – . Tissue phantom study confirmed reliable activated signals could be acquired at a penetration depth up to 5 mm. Using this probe, we disclose the upregulation of ONOO – in a preclinical drug-induced liver injury model and the remediation with N-acetyl cysteine (NAC) in vivo. We expect that this strategy will serve as a general method for the development of an activatable NIR-II probe based on the hydroxyl functionalized reactive sites by analyte-specific triggering.
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Cites
Second window for in vivo imaging
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A small-molecule dye for NIR-II imaging
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Next-generation in vivo optical imaging with short-wave infrared quantum dots
Bruns, O. T., Bischof, T. S., Harris, D. K., Franke, D., Shi, Y., Riedemann, L., Bartelt, A., Jaworski, F. B., Carr, J. A., Rowlands, C. J., et al. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-017-0056 · Cited by 686
A bright organic NIR-II nanofluorophore for three-dimensional imaging into biological tissues
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Cited by
Advanced Fluorescence Imaging Technology in the Near-Infrared-II Window for Biomedical Applications
Li, C., Chen, G., Zhang, Y., Wu, F., & Wang, Q. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c07022 · Cited by 1,037
Design of superior phototheranostic agents guided by Jablonski diagrams
Feng, G., Zhang, G.-Q., & Ding, D. (2020) · Chemical Society Reviews · doi:10.1039/d0cs00671h · Cited by 783
Recent Progress in NIR-II Contrast Agent for Biological Imaging
Cao, J., Zhu, B., Zheng, K., He, S., Meng, L., Song, J., & Yang, H. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00487 · Cited by 313
Ren, T., Wang, Z., Xiang, Z., Lu, P., Lai, H., Yuan, L., Zhang, X., & Tan, W. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202009986 · Cited by 273
Dou, K., Feng, W., Fan, C., Cao, Y., Xiang, Y., & Liu, Z. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.0c04990 · Cited by 67
Metadata
- Authors
- Li, D., Wang, S., Lei, Z., Sun, C., El-Toni, A. M., Alhoshan, M. S., Fan, Y., & Zhang, F.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-02-27
- Volume
- 91
- Issue
- 7
- Pages
- 4771-4779
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2915948896
- Cited by
- 188
- References
- 8
- FWCI
- 11.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- Li, D., Wang, S., Lei, Z., Sun, C., El-Toni, A. M., Alhoshan, M. S., Fan, Y., & Zhang, F. (2019). Peroxynitrite Activatable NIR-II Fluorescent Molecular Probe for Drug-Induced Hepatotoxicity Monitoring. Analytical Chemistry. https://doi.org/10.1021/acs.analchem.9b00317
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