Flexible Designing Strategy to Construct Activatable NIR-II Fluorescent Probes with Emission Maxima beyond 1200 nm
Abstract
Activatable second near-infrared (NIR-II) fluorescent probes that can be lighted up by specific targets have attracted great attention because of their high specificity and resolution, which hold great promise in deep-tissue imaging. However, such probes were relatively rarely reported so far, and the emission maximum is still limited (mainly located at 900–1000 nm). To solve the problem, herein, we proposed a flexible strategy to modulate the emission wavelength of NIR-II fluorescent probes, and four proof-of-concept probes ( WH-1, WH-2, WH-3, and WH-4 ) based on D−π-A molecular skeleton were obtained. These probes can be activated by H 2 S and the emission maximum located from 925 to 1205 nm, which was attributed to the cooperation of elongating the π-conjugated system and enhancing the electron-donating ability of the donor region. In these probes, WH-3 exhibited the combination of long excitation/emission (925/1140 nm) and moderate quantum yield as well as high sensitivity toward H 2 S, enabling us to track and image H 2 S in vivo with high contrast. We expected that such a molecular design strategy will become an important approach to developing activatable NIR-II fluorescent probes with long emission.
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The BODIPY framework has been utilized to develop H2S activable D-π-A probes with emission reaching more than 1200 nm.
“The BODIPY framework has also been utilized to develop H2S activable D-π-A probes with emission reaching more than 1200 nm.66”
Cites
Fluorescent indicators based on BODIPY
Boens, N., Leen, V., & Dehaen, W. (2011) · Chemical Society Reviews · doi:10.1039/c1cs15132k · Cited by 2,271 · see citing works
A small-molecule dye for NIR-II imaging
Antaris, A. L., Chen, H., Cheng, K., Sun, Y., Hong, G., Qu, C., Diao, S., Deng, Z., Hu, X., Zhang, B., et al. (2016) · Nature Materials · doi:10.1038/nmat4476 · Cited by 1,778 · see citing works
Carbon Nanomaterials for Biological Imaging and Nanomedicinal Therapy
Hong, G., Diao, S., Antaris, A. L., & Dai, H. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00008 · Cited by 1,394 · see citing works
Förster resonance energy transfer (FRET)-based small-molecule sensors and imaging agents
Wu, L., Huang, C., Emery, B. P., Sedgwick, A. C., Bull, S. D., He, X., Tian, H., Yoon, J., Sessler, J. L., & James, T. D. (2020) · Chemical Society Reviews · doi:10.1039/c9cs00318e · Cited by 1,038 · see citing works
Multifunctional in vivo vascular imaging using near-infrared II fluorescence
Hong, G., Lee, J. C., Robinson, J. T., Raaz, U., Xie, L., Huang, N. F., Cooke, J. P., & Dai, H. (2012) · Nature Medicine · doi:10.1038/nm.2995 · Cited by 995 · see citing works
Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter
Wallace, J. L., & Wang, R. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4433 · Cited by 882 · see citing works
Szabó, C., Coletta, C., Chao, C., Módis, K., Szczęsny, B., Papapetropoulos, A., & Hellmich, M. R. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1306241110 · Cited by 768 · see citing works
Gasotransmitters in cancer: from pathophysiology to experimental therapy
Szabó, C. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2015.1 · Cited by 723 · see citing works
Li, B., Lu, L., Zhao, M., Lei, Z., & Zhang, F. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201801226 · Cited by 658 · see citing works
Fluorogenic probes for disease-relevant enzymes
Zhang, J., Chai, X., He, X., Kim, H.-J., Yoon, J., & Tian, H. (2018) · Chemical Society Reviews · doi:10.1039/c7cs00907k · Cited by 606 · see citing works
Optical nano-agents in the second near-infrared window for biomedical applications
Cai, Y., Wei, Z., Song, C., Tang, C., Han, W., & Dong, X. (2019) · Chemical Society Reviews · doi:10.1039/c8cs00494c · Cited by 603 · see citing works
Zhong, Y., Ma, Z., Zhu, S., Yue, J., Zhang, M., Antaris, A. L., Yuan, J., Cui, R., Wan, H., Zhou, Y., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00917-6 · Cited by 557 · see citing works
Huang, J., & Pu, K. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202001783 · Cited by 548 · see citing works
Recent advances in near-infrared II fluorophores for multifunctional biomedical imaging
Ding, F., Zhan, Y., Lu, X., & Sun, Y. (2018) · Chemical Science · doi:10.1039/c8sc01153b · Cited by 540 · see citing works
Bene, J. E. D., Person, W. B., & Szczepaniak, K. (1995) · The Journal of Physical Chemistry · doi:10.1021/j100027a005 · Cited by 430 · see citing works
Flavylium Polymethine Fluorophores for Near‐ and Shortwave Infrared Imaging
Cosco, E. D., Caram, J. R., Bruns, O. T., Franke, D., Day, R. A., Farr, E. P., Bawendi, M. G., & Sletten, E. M. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201706974 · Cited by 415 · see citing works
Robinson, J. T., Hong, G., Liang, Y., Zhang, B., Yaghi, O., & Dai, H. (2012) · Journal of the American Chemical Society · doi:10.1021/ja303737a · Cited by 411 · see citing works
Cao, X., Ding, L., Xie, Z., Yang, Y., Whiteman, M., Moore, P. K., & Bian, J. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7058 · Cited by 409 · see citing works
Lei, Z., Sun, C., Pei, P., Wang, S., Li, D., Zhang, X., & Zhang, F. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201904182 · Cited by 362 · see citing works
Recognition Moieties of Small Molecular Fluorescent Probes for Bioimaging of Enzymes
Wu, X., Shi, W. S., Li, X., & Ma, H. (2019) · Accounts of Chemical Research · doi:10.1021/acs.accounts.9b00214 · Cited by 287 · see citing works
Liu, S., Ou, H., Li, Y., Zhang, H., Liu, J., Lu, X., Kwok, R. T. K., Lam, J. W. Y., Ding, D., & Tang, B. Z. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c07193 · Cited by 277 · see citing works
Ren, T., Wang, Z., Xiang, Z., Lu, P., Lai, H., Yuan, L., Zhang, X., & Tan, W. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202009986 · Cited by 273 · see citing works
Molecular Fluorophores for Deep-Tissue Bioimaging
Wang, S., Li, B., & Zhang, F. (2020) · ACS Central Science · doi:10.1021/acscentsci.0c00544 · Cited by 268 · see citing works
Artzi, N., Oliva, N., Puron, C., Shitreet, S., Artzi, S., Ramos, A. B., Groothuis, A., Sahagian, G. G., & Edelman, E. R. (2011) · Nature Materials · doi:10.1038/nmat3095 · Cited by 234 · see citing works
The Therapeutic Potential of Cystathionine β-Synthetase/Hydrogen Sulfide Inhibition in Cancer
Hellmich, M. R., Coletta, C., Chao, C., & Szabó, C. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.5933 · Cited by 234 · see citing works
Meng, X., Zhang, J., Sun, Z., Zhou, L., Deng, G., Li, S., Li, W., Gong, P., & Cai, L. (2018) · Theranostics · doi:10.7150/thno.26607 · Cited by 231 · see citing works
Fang, Y., Shang, J., Liu, D., Shi, W., Li, X., & Ma, H. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c08187 · Cited by 223 · see citing works
Chen, C., Tian, R., Zeng, Y., Chu, C., & Liu, G. (2020) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.9b00734 · Cited by 214 · see citing works
Ouyang, J., Sun, L., Zeng, Z., Zeng, C., Zeng, F., & Wu, S. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201913149 · Cited by 212 · see citing works
Lei, Z., Sun, C., Pei, P., Wang, S., Li, D., Zhang, X., & Zhang, F. (2019) · Angewandte Chemie · doi:10.1002/ange.201904182 · Cited by 209 · see citing works
Rational Design of Near-Infrared-II Organic Molecular Dyes for Bioimaging and Biosensing
Li, B., Zhao, M., & Zhang, F. (2020) · ACS Materials Letters · doi:10.1021/acsmaterialslett.0c00157 · Cited by 205 · see citing works
Aharoni, A., Mokari, T., Popov, I., & Banin, U. (2005) · Journal of the American Chemical Society · doi:10.1021/ja056326v · Cited by 202 · see citing works
Li, D., Wang, S., Lei, Z., Sun, C., El‐Toni, A. M., Alhoshan, M. S., Fan, Y., & Zhang, F. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b00317 · Cited by 191 · see citing works
Recent advances in the development of NIR-II organic emitters for biomedicine
Li, J., Liu, Y., Xu, Y., Li, L., Sun, Y., & Huang, W. (2020) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2020.213318 · Cited by 174 · see citing works
Hayes, R. T., Wasielewski, M. R., & Gosztola, D. J. (2000) · Journal of the American Chemical Society · doi:10.1021/ja000219d · Cited by 168 · see citing works
Wang, R., Chen, J., Gao, J., Chen, J., Xu, G., Zhu, T., Gu, X., Guo, Z., Zhu, W., & Zhao, C. (2019) · Chemical Science · doi:10.1039/c9sc02093d · Cited by 167 · see citing works
Recent Advances on Activatable NIR‐II Fluorescence Probes for Biomedical Imaging
Tang, Y., Pei, F., Lü, X., Fan, Q., & Huang, W. (2019) · Advanced Optical Materials · doi:10.1002/adom.201900917 · Cited by 167 · see citing works
Lighting Up NIR-II Fluorescence in Vivo: An Activable Probe for Noninvasive Hydroxyl Radical Imaging
Feng, W., Zhang, Y., Li, Z., Zhai, S., Lv, W., & Liu, Z. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b04002 · Cited by 134 · see citing works
Self-citationDou, K., Huang, W., Xiang, Y., Li, S., & Liu, Z. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.0c00634 · Cited by 126 · see citing works
Self-citationModes of Physiologic H 2 S Signaling in the Brain and Peripheral Tissues
Paul, B. D., & Snyder, S. H. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.5917 · Cited by 76 · see citing works
Imaging of ovarian cancers using enzyme activatable probes with second near-infrared window emission
Chen, J., Pan, H., Wang, Z., Gao, J., Tan, J., Ouyang, Z., Guo, W., & Gu, X. (2020) · Chemical Communications · doi:10.1039/c9cc09158k · Cited by 71 · see citing works
Excited state absorption and decay kinetics of near IR polymethine dyes
Junior, L. A. P., Webster, S., Hu, H., Przhonska, O. V., Hagan, D. J., Stryland, E. W. V., Bondar, M. V., Davydenko, I. G., Slominskiĭ, Y. L., & Kachkovski, A. D. (2008) · Chemical Physics · doi:10.1016/j.chemphys.2008.05.007 · Cited by 69 · see citing works
Faraj, A. A., Shaik, A. S., Sayed, B. A., Halwani, R., & Jammaz, I. A. (2015) · Nanomedicine · doi:10.2217/nnm.15.182 · Cited by 62 · see citing works
Ye, F., Huang, W., Li, C., Li, G., Yang, W., Liu, S. H., Yin, J., Sun, Y., & Yang, G. (2020) · Advanced Therapeutics · doi:10.1002/adtp.202000170 · Cited by 39 · see citing works
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Near-infrared (NIR) fluorescence-emitting small organic molecules for cancer imaging and therapy
Li, H., Kim, Y., Jung, H., Hyun, J. Y., & Shin, I. (2022) · Chemical Society Reviews · doi:10.1039/d2cs00722c · Cited by 356 · see citing works
The Chemistry of Organic Contrast Agents in the NIR‐II Window
Mu, J., Xiao, M. W., Shi, Y., Geng, X., Li, H., Yin, Y., & Chen, X. S. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202114722 · Cited by 318 · see citing works
Xanthene-Based NIR-II Dyes for <i>In Vivo</i> Dynamic Imaging of Blood Circulation
Liu, D., He, Z., Zhao, Y., Yang, Y., Shi, W., Li, X., & Ma, H. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.1c07711 · Cited by 217 · see citing works
Engineering of BODIPY-based theranostics for cancer therapy
Mao, Z., Kim, J. H., Lee, J., Xiong, H., Zhang, F., & Kim, J. S. (2022) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2022.214908 · Cited by 159 · see citing works
Liu, X., Yu, B., Shen, Y., & Cong, H. (2022) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2022.214609 · Cited by 151 · see citing works
Qin, Z., Ren, T., Zhou, H., Zhang, X., He, L., Li, Z., Zhang, X., & Yuan, L. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202201541 · Cited by 140 · see citing works
Activatable NIR-II organic fluorescent probes for bioimaging
Zhang, X., Li, S., Ma, H., Wang, H., Zhang, X., & Zhang, X. (2022) · Theranostics · doi:10.7150/thno.71359 · Cited by 138 · see citing works
Li, B., Zhao, M., Lin, J., Huang, P., & Chen, X. S. (2022) · Chemical Society Reviews · doi:10.1039/d2cs00131d · Cited by 127 · see citing works
Polymethine Molecular Platform for Ratiometric Fluorescent Probes in the Second near-Infrared Window
Lan, Q., Yu, P., Yan, K., Li, X., Zhang, F., & Lei, Z. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c10041 · Cited by 125 · see citing works
Ma, D., Bian, H., Gu, M., Wang, L., Chen, X., & Peng, X. (2024) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2024.215677 · Cited by 124 · see citing works
Recent advances in small-molecule fluorescent probes for diagnosis of cancer cells/tissues
Wang, K., Liu, C., Zhu, H., Zhang, Y., Su, M., Wang, X., Liu, M., Rong, X., & Zhu, B. (2022) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2022.214946 · Cited by 117 · see citing works
Recent Progress of Cyanine Fluorophores for NIR‐II Sensing and Imaging
Zhou, H., & Ren, T. (2022) · Chemistry - An Asian Journal · doi:10.1002/asia.202200147 · Cited by 76 · see citing works
Chen, P., Qu, F., Chen, S., Li, J., Shen, Q., Sun, P., & Fan, Q. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202208463 · Cited by 74 · see citing works
Liu, S., Xu, W., Li, X., Pang, D., & Xiong, H. (2022) · ACS Nano · doi:10.1021/acsnano.2c08619 · Cited by 56 · see citing works
Construction and optimization of organic fluorophores in NIR-II fluorescence imaging
Li, X., Yang, Y., Zhang, R., & Huang, W. (2025) · Chemical Society Reviews · doi:10.1039/d5cs00063g · Cited by 52 · see citing works
NIR‐II cyanine@albumin fluorophore for deep tissue imaging and imaging‐guided surgery
Zhang, Y., Jia, Y., & Zhu, S. (2023) · SmartMat · doi:10.1002/smm2.1245 · Cited by 48 · see citing works
Zhang, X., Shen, S., Liu, D., Li, X., Shi, W. S., & Ma, H. (2023) · Chemical Science · doi:10.1039/d3sc00355h · Cited by 46 · see citing works
NIR-II Fluorescence Imaging for In Vivo Quantitative Analysis
Chen, H.-J., Wang, L., Zhu, H., Wang, Z., & Liu, S. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c04913 · Cited by 44 · see citing works
Design strategies and applications of smart optical probes in the second near-infrared window
Chang, B., Chen, J., Bao, J., Dong, K., Chen, S., & Cheng, Z. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114637 · Cited by 43 · see citing works
Wang, M., Bai, S., & Zhang, Y. (2025) · Chemical Society Reviews · doi:10.1039/d5cs00502g · Cited by 41 · see citing works
Piwoński, H., Nozue, S., & Habuchi, S. (2022) · ACS Nanoscience Au · doi:10.1021/acsnanoscienceau.1c00038 · Cited by 39 · see citing works
The Chemistry of Organic Contrast Agents in the NIR‐II Window
Mu, J., Xiao, M. W., Shi, Y., Geng, X., Li, H., Yin, Y., & Chen, X. S. (2021) · Angewandte Chemie · doi:10.1002/ange.202114722 · Cited by 38 · see citing works
Ye, M., Xiang, Y., Gong, J., Wang, X., Mao, Z., & Liu, Z. (2023) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.130612 · Cited by 37 · see citing works
Self-citationSmart Fluorescent Probe Strategy for Precision Targeting Hypoxic Tumor
Wang, Y., & Chen, L. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c00433 · Cited by 36 · see citing works
Kong, L., Lu, W., Cao, X., Wei, Y., Sun, J., & Wang, Y. (2022) · Journal of Materials Chemistry B · doi:10.1039/d2tb01210c · Cited by 33 · see citing works
McNamara, L. E., Boyn, J.-N., Melnychuk, C., Anferov, S. W., Mazziotti, D. A., Schaller, R. D., & Anderson, J. S. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c04976 · Cited by 31 · see citing works
Bioresponsive fluorescent probes active in the second near‐infrared window
Chen, Y., Chen, J., & Chang, B. (2023) · iRadiology · doi:10.1002/ird3.10 · Cited by 31 · see citing works
Yang, H., Li, D., Wu, J., & Pu, K. (2025) · Journal of the American Chemical Society · doi:10.1021/jacs.5c06682 · Cited by 30 · see citing works
Activatable Second Near-Infrared Fluorescent Probes: A New Accurate Diagnosis Strategy for Diseases
Li, D., Pan, J., Xu, S., Fu, S., Chu, C., & Liu, G. (2021) · Biosensors · doi:10.3390/bios11110436 · Cited by 30 · see citing works
Liu, D., He, Z., Gao, W., Shang, J., Yang, Y., Zhang, X., Li, X., Ma, H., & Shi, W. (2025) · Nature Communications · doi:10.1038/s41467-025-60241-2 · Cited by 32 · see citing works
Activatable Molecular Probes With Clinical Promise for NIR‐II Fluorescent Imaging
Chen, Z., Zhou, Y., Li, L., Ma, W., Li, Y., & Yang, Z. (2025) · Small · doi:10.1002/smll.202411787 · Cited by 26 · see citing works
Zhang, L., Zhang, Y., Chi, W., Yan, C., Zhao, Z., Liu, X., Zhu, W., & Guo, Z. (2022) · ACS Materials Letters · doi:10.1021/acsmaterialslett.2c00451 · Cited by 26 · see citing works
Zeng, C., Long, Y., Tan, Y., Zeng, F., & Wu, S. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.2c03404 · Cited by 26 · see citing works
Recent advances in activatable NIR-II organic fluorophores for biomedical applications
Xu, Y., Zhang, P., Gao, A., Xu, R., Wang, Z., Shen, Q., Zhao, Z., Meng, L., & Dang, D. (2022) · Materials Chemistry Frontiers · doi:10.1039/d2qm01120d · Cited by 26 · see citing works
The fabrication strategies of near-infrared absorbing transition metal complexes
Shen, J., & He, W. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2023.215096 · Cited by 25 · see citing works
Near-infrared-II deep tissue fluorescence microscopy and application
Liu, P., Zhao, R. J., Li, H., Zhu, T., Li, Y., Wang, H., & Zhang, X. (2022) · Nano Research · doi:10.1007/s12274-022-4836-y · Cited by 24 · see citing works
Molecular fluorescent sensors for in vivo imaging
Adair, L. D., & New, E. J. (2023) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2023.102973 · Cited by 22 · see citing works
Shen, L., Li, J., Wen, C., Wang, H., Liu, N., Su, X., Chen, J., & Li, X. (2024) · Science Advances · doi:10.1126/sciadv.ado2037 · Cited by 21 · see citing works
Extended shortwave infrared absorbing antiaromatic fluorenium-indolizine chromophores
Meador, W. E., Saucier, M. A., Tucker, M. R., Kruse, N. A., Mobley, A. J., Brower, C. R., Parkin, S., Clark, K. M., Hammer, N. I., Tschumper, G. S., et al. (2024) · Chemical Science · doi:10.1039/d4sc00733f · Cited by 20 · see citing works
Li, Z., Gao, J., Guo, Z., Zhao, H., Liu, L., Wang, M., Zhang, P., Chen, G., Li, X., & Wei, C. (2021) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2021.131141 · Cited by 19 · see citing works
Zhang, L., Yan, C., Zhang, Y., Ma, D., Huang, J., Zhao, Z., Tao, Y., Liu, C., Li, J., Zhu, W., et al. (2023) · Chemical Communications · doi:10.1039/d3cc01742g · Cited by 19 · see citing works
Dang, Y., Lai, Y., Chen, F., Sun, Q., Ding, C., Zhang, W., & Xu, Z. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.1c04076 · Cited by 18 · see citing works
Zhang, X., Yang, F., Zhao, X., Wu, Q., He, L., Li, Z., Zhou, Z., Ren, T., Zhang, X., & Yuan, L. (2024) · Angewandte Chemie International Edition · doi:10.1002/anie.202410666 · Cited by 18 · see citing works
Segovia-Pérez, R., Ibarra‐Rodríguez, M., Muñoz‐Flores, B. M., & Jimenez‐Perez, V. M. (2025) · Dyes and Pigments · doi:10.1016/j.dyepig.2025.112740 · Cited by 16 · see citing works
Qin, Z., Ren, T., Zhou, H., Zhang, X., He, L., Li, Z., Zhang, X., & Yuan, L. (2022) · Angewandte Chemie · doi:10.1002/ange.202201541 · Cited by 15 · see citing works
Murugan, P., Yang, F., Yu, C., & Liu, S. (2026) · Analytical Chemistry · doi:10.1021/acs.analchem.5c06334 · Cited by 14 · see citing works
Wu, M., Gong, D., Zhou, Y., Zha, Z., & Xia, X. (2023) · Journal of Materials Chemistry B · doi:10.1039/d3tb01590d · Cited by 14 · see citing works
Recent advances in near-infrared-II (NIR-II) small molecule fluorophores for cancer theranostics
Zhu, Q., Nie, J., Li, Y., Li, N., Kong, X., Zhou, H., & Wu, J. (2025) · Journal of Materials Chemistry B · doi:10.1039/d5tb01249j · Cited by 14 · see citing works
Advanced second near-infrared fluorophores for bioapplications
Bai, Q., Yang, Q., Liu, Y., Li, A., Yin, X.-B., & Wu, S. (2025) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2025.217146 · Cited by 14 · see citing works
Near-Infrared Absorbing BODIPY-Xanthene Hybrids for Multiplexed Photoacoustic Imaging
Xu, M., Sun, Q., Wang, X., Gao, H., & Liu, Z. (2024) · Organic Letters · doi:10.1021/acs.orglett.4c00842 · Cited by 12 · see citing works
Self-citationNear-Infrared-II Fluorescence Imaging of Tumors with Organic Small-Molecule Fluorophores
Guo, M., Hu, X., & Du, W. (2025) · Sensors · doi:10.3390/s25227080 · Cited by 11 · see citing works
Zhou, Y., Yang, X., Zhang, J., Xu, S., & Yan, M. (2024) · Talanta · doi:10.1016/j.talanta.2024.125976 · Cited by 10 · see citing works
Zhu, Y., Liu, C., Rong, X., Zhu, Y., Wen, H., Zheng, M., Sheng, W., Huang, S., & Zhu, B. (2025) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2025.138143 · Cited by 10 · see citing works
Chen, G., Xiong, M., Jiang, C., Zhao, Y., Chen, L., Ju, Y., Jiang, J., Xu, Z., Pan, J., Li, X., et al. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2024.107494 · Cited by 6 · see citing works
Chen, C., Yang, J. Q., Jiang, S., Chen, Y., He, Y., Liu, S., Chen, K., Zhou, L., Cheng, W., & Liu, H. (2026) · Chemical & Biomedical Imaging · doi:10.1021/cbmi.5c00278 · Cited by 4 · see citing works
Saucier, M. A., Smith, C. L., Kruse, N. A., Hammer, N., & Delcamp, J. (2023) · Molecules · doi:10.3390/molecules28031287 · Cited by 3 · see citing works
Zhao, S., Xue, Y., Hu, L., Sun, F., Nie, J., & Chang, Y. (2023) · ChemistrySelect · doi:10.1002/slct.202300554 · Cited by 4 · see citing works
Molecular Engineering of Stabilized Silicon-Rosindolizine Shortwave Infrared Fluorophores
Meador, W. E., Lewis, T. A., Shaik, A. K., Wijesinghe, K. H., Yang, B., Dass, A., Hammer, N. I., & Delcamp, J. H. (2024) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.3c01917 · Cited by 4 · see citing works
Feng, J., Zhu, W., Wei, W., Zhou, W., Lo, W., Li, X., Tan, Z., Fang, X., Wong, W., Wong, K., et al. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.5c02811 · Cited by 3 · see citing works
Computational chemistry facilitates the development of second near-infrared xanthene-based dyes
Yuan, Q., Wang, M., Ma, M., Sun, P., Zeng, C., & Chi, W. (2024) · Journal of Molecular Modeling · doi:10.1007/s00894-024-06179-6 · Cited by 2 · see citing works
Sun, S., Yuan, H., Hu, H., Feng, J., Shi, N., & Wang, Y. (2025) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2025.118409 · Cited by 1 · see citing works
Intra-Cavity Raman Laser Operating at 1193 nm Based on Graded-Index Fiber
Hu, C., & Sun, P. (2022) · Photonics · doi:10.3390/photonics10010033
Zhang, X., Yang, F., Zhao, X., Wu, Q., He, L., Li, Z., Zhou, Z., Ren, T., Zhang, X., & Yuan, L. (2024) · Angewandte Chemie · doi:10.1002/ange.202410666
Egbewole, B. I., Oisakede, E. O., Egbon, E., Bello, O. J., Analikwu, C. C., & Olawade, D. B. (2026) · Intelligent Oncology · doi:10.1016/j.intonc.2026.100053
Near-Infrared and Shortwave Infrared Building Blocks for Activity-Based Sensors in Animals
Wang, T., Li, X. L., Guo, L., & Jia, S. (2026) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.6c00039
Zhuang, B.-H., Chen, Y., Tan, K., & Chan, Y. (2026) · ACS Applied Nano Materials · doi:10.1021/acsanm.6c02004
A Versatile Aza-BODIPY-Based Activatable Probe for High-Contrast NIR-II Biosensing
Yao, C., 黄力文, He, Q., Guo, J., Luo, S., Yin, Z., Zhang, X., Gao, F., Fan, Y., & Liu, Y. (2026) · Analytical Chemistry · doi:10.1021/acs.analchem.6c04759
- Authors
- Dou, K., Feng, W., Fan, C., Cao, Y., Xiang, Y., & Liu, Z.
- Affiliations
- Wuhan University (CN)
- Hubei University (CN)
- Corresponding author
- Liu, Zhihong
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2021-02-12
- Volume
- 93
- Issue
- 8
- Pages
- 4006-4014
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W3128399770
- Cited by
- 67
- References
- 44
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 12 · 2023: 9 · 2022: 23 · 2021: 6
- FWCI
- 4.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Analytical Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Lanzhou University (201907)
- National Natural Science Foundation of China (21625503)
- Topics
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Keywords
- activatable fluorescent probes, hydrogen sulfide detection, deep tissue imaging, in vivo imaging, extended π-conjugation, electron-donating ability, quantum yield
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