Rhomboidal Pt (II) metallacycle-based NIR-II theranostic nanoprobe for tumor diagnosis and image-guided therapy
Open accessAbstract
Significance The biomedical applications of fluorescent anticancer agents in the first near-IR region (NIR-I) have been hampered by problems of photostability, autofluorescence, and limited penetration depth in biological tissues. To shift the fluorescence theranostic region from the NIR-I to the longer-wavelength region for accurate cancer diagnosis and treatment, Pt(II) metallacycle-based fluorescent nanoprobe 1 with fluorescence emission in the NIR-II region is designed. In vitro and in vivo studies demonstrate that 1 has good photostability and the ability to efficiently inhibit the growth of tumor with minimal side effects. It also improves the fluorescent imaging quality and signal-to-noise ratio for cancer theranostics. This study provides an opportunity for further design of NIR-II theranostic anticancer agents for future biomedical applications.
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Compared with cisplatin, this NIR-II theranostic agent showed good efficiency of tumor growth inhibition and better biocompatibility.
“Compared with cisplatin, this NIR-II theranostic agent showed good efficiency of tumor growth inhibition and better biocompatibility (Figure 13g).”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [200]
Stang and Sun developed a new method by assembling Pt (II) metallacycles based SCCs with a NIR-II dye (SY1100) in the presence of DSPE-PEG5000 as a carrier.
“Recently, Stang and Sun developed a new method by assembling Pt (II) metallacycles based SCCs with a NIR-II dye (SY1100) in the presence of DSPE-PEG5000 as a carrier [200].”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [200]
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- Authors
- Sun, Y., Ding, F., Zhou, Z., Li, C., Pu, M., Xu, Y., Zhan, Y., Lu, X., Li, H., Yang, G., Sun, Y., & Stang, P. J.
- Affiliations
- University of Utah (US)
- Central China Normal University (CN)
- RWTH Aachen University (DE)
- Hubei Polytechnic University (CN)
- Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 430079 Wuhan, China;
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2019-01-22
- Volume
- 116
- Issue
- 6
- Pages
- 1968-1973
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC6369813
- OpenAlex
- W2911761965
- Cited by
- 165
- References
- 38
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 16 · 2023: 16 · 2022: 20 · 2021: 33 · 2020: 39 · 2019: 30
- FWCI
- 10.75
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (R01CA215157)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Health Sciences › Medicine › Oncology › Metal complexes synthesis and properties
- Keywords
- NIR-II fluorescence, theranostic nanoprobes, cancer diagnosis, image-guided therapy, photostability, anticancer agents, tumor growth inhibition, fluorescence imaging
- MeSH terms
- Theranostic Nanomedicine, Animals, Magnetic Resonance Imaging, Mice, Inbred C57BL, Neoplasms, Neoplasms, Experimental, Photons, Mice, Signal-To-Noise Ratio
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