Bioaccumulation of Novel Per- and Polyfluoroalkyl Substances in Mice Dosed with an Aqueous Film-Forming Foam
Abstract
Per- and polyfluoroalkyl substances (PFASs) are widespread in the blood of the general human population, and their bioaccumulation is of considerable scientific and regulatory interest. PFAS exposure resulting from aqueous film-forming foam (AFFF) ingestion is poorly understood due to the complexity of AFFF mixtures and the presence of polyfluorinated substances that may undergo metabolic transformation. C57BL/6 mice were dosed with an AFFF primarily containing electrochemically fluorinated PFASs for 10 days, followed by a 6 day depuration. Urine was collected throughout the study and serum was collected post-depuration. Samples were analyzed via high-resolution mass spectrometry. Relative to the dosing solution, C6 and C7 perfluoroalkyl sulfonates (PFSAs) were enriched in dosed mouse serum, suggesting in vivo transformation of sulfonamide precursors. Some substituted C8 PFSAs [keto-perfluorooctane sulfonate (PFOS), hydrogen-PFOS, and unsaturated PFOS] appeared to be more bioaccumulative than linear PFOS, or were formed in vivo from unidentified precursors. A series of seven peaks in dosed mouse serum was tentatively identified as sulfonimide dimers that were either a minor component of the AFFF or were formed via metabolism of other AFFF components. This work highlights the importance of sulfonamide precursors in contributing to bioaccumulation of AFFF-associated PFSAs and identifies several classes of potentially bioaccumulative novel PFASs that warrant further investigation.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Most PFAS identified in this study were also reported by Houtz et al. (2013), Barzen-Hanson et al. (2017), and McDonough et al. (2020) for the same or similar AFFF commercial products.
“Most PFAS identified in this study were also reported by Houtz et al. (2013) [49], Barzen-Hanson et al. (2017) [2], and McDonough et al. (2020) [29] for the same or similar AFFF commercial products.”
From In-Vitro and In-Silico Assessment of Per- and Polyfluoroalkyl Substances (PFAS) in Aqueous Film-Forming Foam (AFFF) Binding to Human Serum Albumin (2021) · cites this paper as [29]
BCFpseudo serves as a quantitative benchmarking technique to cross-compare bioaccumulation potentials of novel PFAS using qualitative screening data.
“BCFpseudo serves as a quantitative benchmarking technique to cross-compare bioaccumulation potentials of novel PFAS using qualitative screening data [29].”
From In-Vitro and In-Silico Assessment of Per- and Polyfluoroalkyl Substances (PFAS) in Aqueous Film-Forming Foam (AFFF) Binding to Human Serum Albumin (2021) · cites this paper as [29]
Cites
Identifying Small Molecules via High Resolution Mass Spectrometry: Communicating Confidence
Schymanski, E. L., Jeon, J., Gulde, R., Fenner, K., Ruff, M., Singer, H. P., & Hollender, J. (2014) · Environmental Science & Technology · doi:10.1021/es5002105 · Cited by 4,519 · see citing works
Sunderland, E. M., Hu, X. C., Dassuncao, C., Tokranov, A. K., Wagner, C. C., & Allen, J. G. (2019) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/s41370-018-0094-1 · Cited by 2,786 · see citing works
Conder, J. M., Hoke, R. A., Wolf, W. D., Russell, M. H., & Buck, R. C. (2008) · Environmental Science & Technology · doi:10.1021/es070895g · Cited by 1,206 · see citing works
Barzen-Hanson, K. A., Roberts, S. C., Choyke, S., Oetjen, K., McAlees, A., Riddell, N., McCrindle, R., Ferguson, P. L., Higgins, C. P., & Field, J. A. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.6b05843 · Cited by 873 · see citing works
Self-citationIdentification of Novel Fluorochemicals in Aqueous Film-Forming Foams Used by the US Military
Place, B. J., & Field, J. A. (2012) · Environmental Science & Technology · doi:10.1021/es301465n · Cited by 543 · see citing works
Bioaccumulation of Perfluorinated Alkyl Acids: Observations and Models
Ng, C. A., & Hungerbühler, K. (2014) · Environmental Science & Technology · doi:10.1021/es404008g · Cited by 393 · see citing works
Xiao, X., Ulrich, B. A., Chen, B., & Higgins, C. P. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.7b00970 · Cited by 391 · see citing works
Self-citationD’Agostino, L. A., & Mabury, S. A. (2014) · Environmental Science & Technology · doi:10.1021/es403729e · Cited by 387 · see citing works
Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances
(2015) · Molecular and Integrative Toxicology · doi:10.1007/978-3-319-15518-0 · Cited by 360 · see citing works
Self-citationBiotransformation pathways of fluorotelomer-based polyfluoroalkyl substances: A review
Butt, C. M., Muir, D. C. G., & Mabury, S. A. (2013) · Environmental Toxicology and Chemistry · doi:10.1002/etc.2407 · Cited by 336 · see citing works
Kaboré, H. A., Vo Duy, S., Munoz, G., Méité, L., Desrosiers, M., Liu, J., Sory, T. K., & Sauvé, S. (2018) · Science of The Total Environment · doi:10.1016/j.scitotenv.2017.10.210 · Cited by 329 · see citing works
Martin, J. W., Asher, B. J., Beesoon, S., Benskin, J. P., & Ross, M. S. (2010) · Journal of Environmental Monitoring · doi:10.1039/c0em00295j · Cited by 311 · see citing works
Harding-Marjanovic, K. C., Houtz, E. F., Yi, S., Field, J. A., Sedlak, D. L., & Alvarez-Cohen, L. (2015) · Environmental Science & Technology · doi:10.1021/acs.est.5b01219 · Cited by 295 · see citing works
Tissue distribution, metabolism, and elimination of perfluorooctanoic acid in male and female rats
Heuvel, J. P. V., Kuslikis, B. I., Rafelghem, M. J. V., & Peterson, R. E. (1991) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.2570060202 · Cited by 289 · see citing works
Per- and polyfluoroalkyl substances (PFAS) in American Red Cross adult blood donors, 2000–2015
Olsen, G. W., Mair, D. C., Lange, C. C., Harrington, L. M., Church, T. R., Goldberg, C. L., Herron, R., Hanna, H., Nobiletti, J. B., Rios, J. A., et al. (2017) · Environmental Research · doi:10.1016/j.envres.2017.05.013 · Cited by 276 · see citing works
Metabolic products and pathways of fluorotelomer alcohols in isolated rat hepatocytes
Martin, J. W., Mabury, S. A., & O’Brien, P. J. (2005) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2005.06.007 · Cited by 256 · see citing works
DeWitt, J. C., Blossom, S. J., & Schaider, L. A. (2019) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/s41370-018-0097-y · Cited by 241 · see citing works
Self-citationTomy, G. T., Tittlemier, S. A., Palace, V. P., Budakowski, W. R., Braekevelt, E., Brinkworth, L., & Friesen, K. J. (2003) · Environmental Science & Technology · doi:10.1021/es034550j · Cited by 231 · see citing works
Guelfo, J. L., & Adamson, D. T. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2018.01.066 · Cited by 216 · see citing works
Xu, L. S., Krenitsky, D. M., Seacat, A. M., Butenhoff, J. L., & Anders, M. W. (2004) · Chemical Research in Toxicology · doi:10.1021/tx034222x · Cited by 206 · see citing works
Pizzurro, D. M., Seeley, M., Kerper, L. E., & Beck, B. D. (2019) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2019.05.008 · Cited by 206 · see citing works
Kudo, N., Suzuki, É., Katakura, M., Ohmori, K., Noshiro, R., & Kawashima, Y. (2001) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(01)00155-7 · Cited by 205 · see citing works
Rotander, A., Kärrman, A., Toms, L.-M. L., Kay, M., Mueller, J. F., & Gómez Ramos, M. J. (2015) · Environmental Science & Technology · doi:10.1021/es503653n · Cited by 172 · see citing works
Poly- and perfluoroalkyl substances in seawater and plankton from the northwestern Atlantic Margin
Zhang, X., Lohmann, R., & Sunderland, E. M. (2019) · Environmental Science & Technology · doi:10.1021/acs.est.9b03230 · Cited by 163 · see citing works
Cheng, W., & Ng, C. A. (2018) · Environmental Science & Technology · doi:10.1021/acs.est.8b01268 · Cited by 141 · see citing works
Perfluorinated acid isomer profiling in water and quantitative assessment of manufacturing source.
Benskin, J. P., Yeung, L. W. Y., Yamashita, N., Taniyasu, S., Lam, P., & Martin, J. W. (2010) · Environmental Science and Technology · doi:10.1021/es102582x · Cited by 138 · see citing works
Benskin, J. P., Holt, A., & Martin, J. W. (2009) · Environmental Science & Technology · doi:10.1021/es901915f · Cited by 136 · see citing works
Measuring total PFASs in water: The tradeoff between selectivity and inclusivity
McDonough, C. A., Guelfo, J. L., & Higgins, C. P. (2019) · Current Opinion in Environmental Science & Health · doi:10.1016/j.coesh.2018.08.005 · Cited by 132 · see citing works
Self-citationDisposition of perfluorinated acid isomers in sprague-dawley rats; Part 2: Subchronic dose
Silva, A. O. D., Benskin, J. P., Martin, L. J., Arsenault, G. J., McCrindle, R. I., Riddell, N., Martin, J. W., & Mabury, S. A. (2008) · Environmental Toxicology and Chemistry · doi:10.1897/08-254.1 · Cited by 125 · see citing works
Li, Z., Dong, G., Jin, Y., & He, Q. (2008) · Archives of Toxicology · doi:10.1007/s00204-008-0361-3 · Cited by 119 · see citing works
Liu, Y., Qian, M., Ma, X., Zhu, L., & Martin, J. W. (2018) · Environmental Science & Technology · doi:10.1021/acs.est.8b00779 · Cited by 115 · see citing works
Bogdanska, J., Borg, D., Sundström, M., Bergström, U., Halldin, K., Abedi-Valugerdi, M., Bergman, Å., Nelson, B., DePierre, J., & Nobel, S. (2011) · Toxicology · doi:10.1016/j.tox.2011.03.014 · Cited by 109 · see citing works
Are humans exposed to increasing amounts of unidentified organofluorine?
Yeung, L. W. Y., & Mabury, S. A. (2016) · Environmental Chemistry · doi:10.1071/en15041 · Cited by 107 · see citing works
Chen, M., Qiang, L., Pan, X., Fang, S., Han, Y., & Zhu, L. Y. (2015) · Environmental Science & Technology · doi:10.1021/acs.est.5b00488 · Cited by 97 · see citing works
Simonnet-Laprade, C., Budzinski, H., Maciejewski, K., Ménach, K. L., Santos, R., Alliot, F., Goutte, A., & Labadie, P. (2019) · Environmental Science Processes & Impacts · doi:10.1039/c9em00322c · Cited by 95 · see citing works
Huang, M. C., Dzierlenga, A. L., Robinson, V. G., Waidyanatha, S., DeVito, M. J., Eifrid, M. A., Granville, C. A., Gibbs, S. T., & Blystone, C. R. (2019) · Toxicology Reports · doi:10.1016/j.toxrep.2019.06.016 · Cited by 94 · see citing works
Isomer-Specific Biotransformation of Perfluorooctane Sulfonamide in Sprague–Dawley Rats
Ross, M. S., Wong, C. S., & Martin, J. W. (2012) · Environmental Science & Technology · doi:10.1021/es204028v · Cited by 73 · see citing works
Bioconcentration of Aqueous Film-Forming Foam (AFFF) in Juvenile Rainbow Trout (Oncorhyncus mykiss)
Yeung, L. W. Y., & Mabury, S. A. (2013) · Environmental Science & Technology · doi:10.1021/es403170f · Cited by 70 · see citing works
Yi, S., Zhu, L. Y., & Mabury, S. A. (2019) · Environmental Science & Technology · doi:10.1021/acs.est.9b05258 · Cited by 61 · see citing works
Xu, L. S., Krenitsky, D. M., Seacat, A. M., Butenhoff, J. L., Tephly, T. R., & Anders, M. W. (2006) · Drug Metabolism and Disposition · doi:10.1124/dmd.106.009399 · Cited by 59 · see citing works
Xie, W., Wu, Q., Kania‐Korwel, I., Tharappel, J. C., Telu, S., Coleman, M. C., Glauert, H. P., Kannan, K., Mariappan, S. V. S., Spitz, D. R., et al. (2009) · Archives of Toxicology · doi:10.1007/s00204-009-0450-y · Cited by 51 · see citing works
Comprehensive Emerging Chemical Discovery: Novel Polyfluorinated Compounds in Lake Michigan Trout
Fakouri Baygi, S., Crimmins, B. S., Hopke, P. K., & Holsen, T. M. (2016) · Environmental Science & Technology · doi:10.1021/acs.est.6b01349 · Cited by 49 · see citing works
Crimmins, B. S., Xia, X., Hopke, P. K., & Holsen, T. M. (2013) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-013-7519-4 · Cited by 48 · see citing works
Anderson, R. H., Thompson, T., Stroo, H. F., & Leeson, A. (2020) · Environmental Toxicology and Chemistry · doi:10.1002/etc.4694 · Cited by 43 · see citing works
Novel and legacy per- and polyfluoroalkyl substances in bald eagle eggs from the Great Lakes region
Wu, Y., Simon, K. L., Best, D. A., Bowerman, W. W., & Venier, M. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2019.113811 · Cited by 42 · see citing works
Gaillard, J., Veyrand, B., Thomas, M., Dauchy, X., Boiteux, V., Marchand, P., Le Bizec, B., Banas, D., & Feidt, C. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.6b05598 · Cited by 38 · see citing works
Joudan, S., Liu, R., D’eon, J. C., & Mabury, S. A. (2019) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2019.02.032 · Cited by 26 · see citing works
Children's exposure to perfluoroalkyl acids – a modelling approach
Balk, F., Pütz, K. W., Ribbenstedt, A., Gomis, M. I., Filipovic, M., & Cousins, I. T. (2019) · Environmental Science Processes & Impacts · doi:10.1039/c9em00323a · Cited by 22 · see citing works
Jiang, Z., Liu, Y., Shao, Y., Zhao, P., Yuan, J., & Wang, H. (2019) · Polymer International · doi:10.1002/pi.5764 · Cited by 13 · see citing works
Benfodda, Z., Guillen, F., & Blancou, H. (2008) · Heteroatom Chemistry · doi:10.1002/hc.20452 · Cited by 4 · see citing works
Distribution of per- and polyfluoroalkyl substances in human urine and serum
Kato, K., Kalathil, A. A., Calafat, A. M., & Ye, X. (2018) · Drug Metabolism and Pharmacokinetics · doi:10.1016/j.dmpk.2017.11.210 · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Unsaturated PFOS and Other PFASs in Human Serum and Drinking Water from an AFFF-Impacted Community
McDonough, C. A., Choyke, S. J., Barton, K. E., Mass, S., Starling, A. P., Adgate, J. L., & Higgins, C. P. (2021) · Environmental Science & Technology · doi:10.1021/acs.est.1c00522 · Cited by 157 · see citing works
Self-citationFang, Y., Ellis, A., Choi, Y. J., Boyer, T. H., Higgins, C. P., Schaefer, C. E., & Strathmann, T. J. (2021) · Environmental Science & Technology · doi:10.1021/acs.est.1c00769 · Cited by 124 · see citing works
Self-citationFluoroMatch 2.0—making automated and comprehensive non-targeted PFAS annotation a reality
Koelmel, J. P., Stelben, P., McDonough, C. A., Dukes, D. A., Aristizabal‐Henao, J. J., Nason, S. L., Li, Y., Sternberg, S., Lin, E. Z., Beckmann, M., et al. (2021) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-021-03392-7 · Cited by 122 · see citing works
Self-citationHu, J., Lyu, Y., Chen, H., Cai, L., Li, J., Cao, X., & Sun, W. (2023) · Water Research · doi:10.1016/j.watres.2023.119735 · Cited by 121 · see citing works
Widening the Lens on PFASs: Direct Human Exposure to Perfluoroalkyl Acid Precursors (pre-PFAAs)
McDonough, C. A., Li, W., Bischel, H. N., Silva, A. O. D., & DeWitt, J. C. (2022) · Environmental Science & Technology · doi:10.1021/acs.est.2c00254 · Cited by 86 · see citing works
Self-citationEllis, A., Liu, C. J., Fang, Y., Boyer, T. H., Schaefer, C. E., Higgins, C. P., & Strathmann, T. J. (2022) · Water Research · doi:10.1016/j.watres.2022.119019 · Cited by 83 · see citing works
Self-citationJeong, Y., Da Silva, K. M., Iturrospe, E., Fuiji, Y., Boogaerts, T., van Nuijs, A. L. N., Koelmel, J., & Covaci, A. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.129378 · Cited by 76 · see citing works
An Integrated Approach for Determination of Total Per- and Polyfluoroalkyl Substances (PFAS)
Shojaei, M., Kumar, N., & Guelfo, J. L. (2022) · Environmental Science & Technology · doi:10.1021/acs.est.2c05143 · Cited by 67 · see citing works
Londhe, K., Lee, C., Zhang, Y., Grdanovska, S., Kroc, T., Cooper, C., & Venkatesan, A. K. (2021) · ACS ES&T Engineering · doi:10.1021/acsestengg.0c00222 · Cited by 59 · see citing works
Luo, Y., Aly, N. A., McCord, J. P., Strynar, M. J., Chiu, W. A., Dodds, J. N., Baker, E. S., & Rusyn, I. (2020) · Environmental Science & Technology · doi:10.1021/acs.est.0c04798 · Cited by 66 · see citing works
The Need for Testing Isomer Profiles of Perfluoroalkyl Substances to Evaluate Treatment Processes
Londhe, K., Lee, C., McDonough, C. A., & Venkatesan, A. K. (2022) · Environmental Science & Technology · doi:10.1021/acs.est.2c05518 · Cited by 64 · see citing works
Self-citationAli, A., Higgins, C. P., Alarif, W. M., Al-Lihaibi, S. S., Ghandourah, M. A., & Kallenborn, R. (2020) · Environmental Science and Pollution Research · doi:10.1007/s11356-020-09897-5 · Cited by 58 · see citing works
Self-citationLi, W., Hu, Y., & Bischel, H. N. (2021) · Toxics · doi:10.3390/toxics9030063 · Cited by 53 · see citing works
“For instance, PFOS analogs include chloro (Cl), ketone (K), unsaturated (U), hydrogen (H), linear (L), and branched (br)-substituted PFOS [29].”
BackgroundMethodInfluentialNewton, S. R., Bowden, J. A., Charest, N., Jackson, S. R., Koelmel, J., Liberatore, H., Lin, A. M., Lowe, C. N., Nieto, S., Pollitt, K. J. G., et al. (2025) · Environmental Science and Technology Letters · doi:10.1021/acs.estlett.4c00930 · Cited by 50 · see citing works
Wang, Y., Liu, M., Duy, S. V., Munoz, G., Sauvé, S., & Liu, J. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.173682 · Cited by 54 · see citing works
Li, S., Ma, J., Cheng, J., Wu, G., Wang, S., Huang, C., Li, J., & Chen, L. (2024) · Langmuir · doi:10.1021/acs.langmuir.3c02939 · Cited by 52 · see citing works
Yi, S., Yang, D., Zhu, L. Y., & Mabury, S. A. (2021) · Environmental Science & Technology · doi:10.1021/acs.est.1c00616 · Cited by 45 · see citing works
Functionalized bio‐adsorbents for removal of perfluoroalkyl substances: A perspective
Li, D., Londhe, K., Chi, K., Lee, C., Venkatesan, A. K., & Hsiao, B. S. (2021) · AWWA Water Science · doi:10.1002/aws2.1258 · Cited by 46 · see citing works
Li, S., Ma, J., Guan, J., Li, J., Wang, X., Sun, X., & Chen, L. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.130125 · Cited by 44 · see citing works
Liu, L., Lü, M., Cheng, X. M., Yu, G., & Huang, J. G. (2022) · Environment International · doi:10.1016/j.envint.2022.107398 · Cited by 42 · see citing works
Feng, C., Lin, Y., Le, S., Ji, J., Chen, Y., Wang, G., Xiao, P., Zhao, Y., & Lu, D. (2024) · Environmental Science & Technology · doi:10.1021/acs.est.3c07533 · Cited by 40 · see citing works
Barton, K. E., Zell-Baran, L. M., DeWitt, J. C., Brindley, S. M., McDonough, C. A., Higgins, C. P., Adgate, J. L., & Starling, A. P. (2022) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2021.113905 · Cited by 40 · see citing works
Self-citationNew PFASs Identified in AFFF impacted groundwater by passive sampling and nontarget analysis
Ghorbani Gorji, S., Gómez Ramos, M. J., Dewapriya, P., Schulze, B., Mackie, R., Nguyen, T. M. H., Higgins, C. P., Bowles, K., Mueller, J. F., Thomas, K. V., et al. (2024) · Environmental Science & Technology · doi:10.1021/acs.est.3c06591 · Cited by 42 · see citing works
Self-citationBioaccumulation of Perfluoroalkyl Sulfonamides (FASA)
Pickard, H. M., Haque, F., & Sunderland, E. M. (2024) · Environmental Science & Technology Letters · doi:10.1021/acs.estlett.4c00143 · Cited by 40 · see citing works
Kidd, J., Fabricatore, E., & Jackson, D. G. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.155523 · Cited by 36 · see citing works
Joerss, H., & Menger, F. (2023) · Current Opinion in Green and Sustainable Chemistry · doi:10.1016/j.cogsc.2023.100775 · Cited by 37 · see citing works
Immunotoxicity of an Electrochemically Fluorinated Aqueous Film-Forming Foam
McDonough, C. A., Ward, C., Hu, Q., Vance, S. A., Higgins, C. P., & DeWitt, J. C. (2020) · Toxicological Sciences · doi:10.1093/toxsci/kfaa138 · Cited by 33 · see citing works
Self-citationFlynn, R. W., Hoskins, T. D., Iacchetta, M., de Perre, C., Lee, L., Hoverman, J. T., & Sepúlveda, M. S. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.142730 · Cited by 35 · see citing works
Lv, W., Shen, Y., Xu, S., Wu, B., Zhang, Z., & Liu, S. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.165502 · Cited by 33 · see citing works
Tal, T. L., & Vogs, C. (2021) · Environmental Health Perspectives · doi:10.1289/ehp9625 · Cited by 31 · see citing works
Arginine Metabolism Reprogramming in Perfluorooctanoic Acid (PFOA)-Induced Liver Injury
Gao, J., Li, T., Guo, W., Yan, M., Liu, J., Yao, X., Lv, M., Ding, Y., Qin, H., Wang, M., et al. (2025) · Environmental Science & Technology · doi:10.1021/acs.est.4c07971 · Cited by 30 · see citing works
Novel Per- and Polyfluoroalkyl Substances Discovered in Cattle Exposed to AFFF-Impacted Groundwater
Dewapriya, P., Nilsson, S., Gorji, S. G., O'Brien, J. W., Bräunig, J., Gómez, M. J., Donaldson, E., Samanipour, S., Martin, J. W., Mueller, J. F., et al. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.3c03852 · Cited by 32 · see citing works
Valdiviezo, A., Aly, N. A., Luo, Y., Cordova, A. C., Casillas, G. A., Foster, M., Baker, E. S., & Rusyn, I. (2021) · Journal of Environmental Sciences · doi:10.1016/j.jes.2021.08.004 · Cited by 27 · see citing works
Álvarez-Ruiz, R., Lee, L., & Choi, Y. J. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.176540 · Cited by 27 · see citing works
Carrizo, J. C., Munoz, G., Duy, S. V., Liu, M., Houde, M., Amé, M. V., Liu, J., & Sauvé, S. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.163103 · Cited by 25 · see citing works
Source apportionment of serum PFASs in two highly exposed communities
Wallis, D. J., Barton, K. E., Knappe, D. R. U., Kotlarz, N., McDonough, C. A., Higgins, C. P., Hoppin, J. A., & Adgate, J. L. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.158842 · Cited by 26 · see citing works
Self-citationHan, B.-C., Liu, J.-S., Bizimana, A., Zhang, B.-X., Kateryna, S., Zhao, Z., Yu, L., Shen, Z.-Z., & Meng, X. (2023) · Environmental Pollution · doi:10.1016/j.envpol.2023.122663 · Cited by 25 · see citing works
Fan, X., Bao, Y., Mumtaz, M., Huang, J. G., & Yu, G. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.142943 · Cited by 21 · see citing works
Perera, D., Scott, W., Smolinski, R., Mukhopadhyay, L., & McDonough, C. A. (2023) · Trends in Environmental Analytical Chemistry · doi:10.1016/j.teac.2023.e00224 · Cited by 21 · see citing works
Self-citationWang, J., Chen, K., Jin, B., Woo, W., Lum, M., Canchola, A., Zhu, Y., Men, Y., Liu, J., & Lin, Y. (2024) · Environmental Science & Technology · doi:10.1021/acs.est.4c06805 · Cited by 21 · see citing works
Zhou, L., He, S., Shi, Y., Cai, Y., & Zhang, C. (2022) · Environment International · doi:10.1016/j.envint.2022.107289 · Cited by 21 · see citing works
Liu, S., Dukes, D. A., Koelmel, J. P., Stelben, P., Finch, J. P., Okeme, J. O., Lowe, C. N., Williams, A. J., Godri, D., Rennie, E. E., et al. (2024) · Environmental Science & Technology · doi:10.1021/acs.est.4c07750 · Cited by 21 · see citing works
Self-citationLiu, Y., Guo, Y., Lv, M., Wang, Y., Xiang, T., Sun, J., Zhang, Q., Liu, R., Chen, L., Shi, C., et al. (2025) · Environmental Science & Technology · doi:10.1021/acs.est.4c13281 · Cited by 21 · see citing works
Bangma, J., Guillette, T. C., Strynar, M. J., Lindstrom, A. B., McCord, J. P., Hill, D., Lau, C. S., Chernoff, N., & Lang, J. R. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.136159 · Cited by 20 · see citing works
Interactive software for visualization of nontargeted mass spectrometry data—FluoroMatch visualizer
Koelmel, J. P., Stelben, P., Godri, D., Qi, J., McDonough, C. A., Dukes, D. A., Aristizabal‐Henao, J. J., Bowden, J. A., Sternberg, S., Rennie, E. E., et al. (2022) · Exposome · doi:10.1093/exposome/osac006 · Cited by 18 · see citing works
Self-citationHill, N. I., Bečanová, J., Vojta, Š., Barber, L. B., LeBlanc, D. R., Vajda, A. M., Pickard, H. M., & Lohmann, R. (2024) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5926 · Cited by 19 · see citing works
Cao, H., Peng, J., Zhou, Z., Sun, Y., Wang, Y., & Liang, Y. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.151018 · Cited by 20 · see citing works
Yu, Q., Cai, L., Liu, H., Hu, Z., Wu, H., Chen, X., Ren, C., & Zhang, J. (2025) · Journal of Water Process Engineering · doi:10.1016/j.jwpe.2025.108065 · Cited by 17 · see citing works
East, A., Dawson, D. E., Brady, S., Vallero, D. A., & Tornero-Velez, R. (2023) · Toxics · doi:10.3390/toxics11020163 · Cited by 14 · see citing works
Li, M., Hu, J., Cao, X., Chen, H., Lyu, Y., & Sun, W. (2024) · Environmental Science & Technology · doi:10.1021/acs.est.4c07879 · Cited by 15 · see citing works
A Pilot Study of Bis-perfluoroalkyl Sulfonimides in Dust from E-waste and Urban Regions
Zhang, L., Liu, X., Huang, W., Yang, Y. X., & Chen, D. (2024) · Environmental Science & Technology Letters · doi:10.1021/acs.estlett.4c00836 · Cited by 14 · see citing works
Li, W., & Bischel, H. N. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.155850 · Cited by 14 · see citing works
Shojaei, M., Guelfo, J. L., Barlaz, M. A., Cogollo, G., Rivera, N., Hsu‐Kim, H., & Ferguson, P. L. (2025) · Environmental Science & Technology · doi:10.1021/acs.est.5c10116 · Cited by 14 · see citing works
Self-citationDukes, D. A., & McDonough, C. A. (2024) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5939 · Cited by 11 · see citing works
Self-citationAnik, A. H., Aurnab, I. T., Sultan, M. B., Basir, M. S., Murshed, M. F., Jarin, J. M., Sorker, R., Alam, M., & Tareq, S. M. (2025) · Water Air & Soil Pollution · doi:10.1007/s11270-025-08253-y · Cited by 10 · see citing works
Blotevogel, J., Lu, W., & Rappé, A. K. (2024) · Environmental Science & Technology Letters · doi:10.1021/acs.estlett.4c00793 · Cited by 8 · see citing works
Baldwin, W. S., Bloom, M. S., Chung, K. W., Dasgupta, S., DeLorenzo, M. E., Hunt, K. J., Key, P. B., Pearce, J. L., Rock, K. D., Tanabe, P., et al. (2025) · Toxics · doi:10.3390/toxics13090732 · Cited by 9 · see citing works
Deng, Y., Wang, F., Liu, L., Chen, D., Guo, Y., & Li, Z. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.130652 · Cited by 7 · see citing works
Wang, K., Xiao, X., Liu, Z., Wang, J., Zhu, X., Wu, E., Higgins, C. P., & Chen, B. (2024) · Environmental Science & Technology · doi:10.1021/acs.est.4c01610 · Cited by 7 · see citing works
Self-citationDudášová, S., Berger, U., Seiwert, B., Reemtsma, T., Lechtenfeld, O. J., & Fu, Q. (2025) · Environmental Science & Technology · doi:10.1021/acs.est.4c11600 · Cited by 6 · see citing works
Exploring the fluorinome of PFAS-impacted groundwater using 21 tesla FT-ICR mass spectrometry
Lu, W., Babcock‐Adams, L., Sharifan, H., Kornuc, J. J., Hao, S., Higgins, C. P., Young, R. B., Mckenna, A. M., & Blotevogel, J. (2025) · Water Research · doi:10.1016/j.watres.2025.124698 · Cited by 7 · see citing works
Self-citationReal, I., Bryant, Z. K., & Guelfo, J. L. (2025) · Environmental Science & Technology · doi:10.1021/acs.est.5c08377 · Cited by 6 · see citing works
Cramer, J. A., Bunton, C. M., Davis, M. C., Sudol, P. E., Hinnant, K. M., Snow, A. W., & Ananth, R. (2025) · Journal of Surfactants and Detergents · doi:10.1002/jsde.12849 · Cited by 4 · see citing works
Enders, J. R., Weed, R. A., Donovan, E., Phelps, D. W., Campbell, G., May, K., & Baker, E. S. (2025) · Environmental Science & Technology · doi:10.1021/acs.est.5c03600 · Cited by 3 · see citing works
Roth, J., Abusallout, I., Hill, T., Holton, C. W., Thapa, U., & Hanigan, D. J. (2020) · Environmental Science & Technology Letters · doi:10.1021/acs.estlett.0c00678 · Cited by 1 · see citing works
Tackling PFAS Complexity with HRMS and Bioanalytical Techniques
McDonough, C. A., & Scott, W. (2023) · LCGC North America · doi:10.56530/lcgc.na.nr4267c9 · Cited by 1 · see citing works
Self-citationSchulze, B., & Kaserzon, S. (2024) · The handbook of environmental chemistry · doi:10.1007/698_2024_1090
Known and Novel Per/Polyfluoroalkyl Substances (PFASs) in Serum of Tucson (AZ) Firefighters
Chen, Y., Perera, N. L. D., Beitel, S. C., Gulotta, J. J., Calkins, M. M., Burgess, J. L., & McDonough, C. A. (2026) · Environmental Science & Technology · doi:10.1021/acs.est.6c05168
Self-citationTeymoorian, T., Saliu, T. D., Munoz, G., Grenon, M.-C., & Sauvé, S. (2026) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2026.119120
Miller, D. H., Lachapelle, A., Satbhai, K. M., Chien, P., Borys, K. M., & Timme‐Laragy, A. R. (2026) · Environmental Pollution · doi:10.1016/j.envpol.2026.129135
Kalinin, S., Saji, A., Alemani, R., McDonald, Z., Ahmad, I., Sargis, R., Rubinstein, I., & Feinstein, D. L. (2026) · Toxicology Communications · doi:10.1080/24734306.2026.2728767
Ultrashort to Ultralong: An Extensive LC-MS/MS Method for Human Serum PFAS Biomonitoring
Dukes, D. A., Zhang, Z., Panuwet, P., Li, S., Costello, E. J., Aung, M. T., Chatzi, L., Barr, D. B., & Salamova, A. (2026) · Environment & Health · doi:10.1021/envhealth.5c00807
- Authors
- McDonough, C. A., Choyke, S., Ferguson, P. L., DeWitt, J. C., & Higgins, C. P.
- Affiliations
- Colorado School of Mines (US)
- Duke University (US)
- East Carolina University (US)
- Corresponding author
- McDonough, Carrie A.
- Higgins, Christopher P.
- Venue
- Environmental Science & Technology
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-04-06
- Volume
- 54
- Issue
- 9
- Pages
- 5700-5709
- ISSN
- 0013-936X (ISSN-L)
- 1520-5851
- OpenAlex
- W3014956432
- Cited by
- 72
- References
- 51
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 15 · 2023: 9 · 2022: 15 · 2021: 10 · 2020: 6
- FWCI
- 3.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Environmental Science & Technology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Fluorine in Organic Chemistry
- Physical Sciences › Materials Science › Polymers and Plastics › Synthesis and properties of polymers
- Keywords
- per- and polyfluoroalkyl substances, aqueous film-forming foam, bioaccumulation, perfluoroalkyl sulfonates, PFOS, depuration, mouse serum
- MeSH terms
- Bioaccumulation, Alkanesulfonates, Animals, Fluorocarbons, Humans, Mice, Inbred C57BL, Water, Water Pollutants, Chemical, Alkanesulfonic Acids, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review