Cited by 72Per- and polyfluoroalkyl substances researchFluorine in Organic ChemistrySynthesis and properties of polymers

Bioaccumulation of Novel Per- and Polyfluoroalkyl Substances in Mice Dosed with an Aqueous Film-Forming Foam

McDonough, Carrie A., Choyke, Sarah, Ferguson, P. Lee, DeWitt, Jamie C., Higgins, Christopher P.·2020·Environmental Science & Technology

Abstract

Per- and polyfluoroalkyl substances (PFASs) are widespread in the blood of the general human population, and their bioaccumulation is of considerable scientific and regulatory interest. PFAS exposure resulting from aqueous film-forming foam (AFFF) ingestion is poorly understood due to the complexity of AFFF mixtures and the presence of polyfluorinated substances that may undergo metabolic transformation. C57BL/6 mice were dosed with an AFFF primarily containing electrochemically fluorinated PFASs for 10 days, followed by a 6 day depuration. Urine was collected throughout the study and serum was collected post-depuration. Samples were analyzed via high-resolution mass spectrometry. Relative to the dosing solution, C6 and C7 perfluoroalkyl sulfonates (PFSAs) were enriched in dosed mouse serum, suggesting in vivo transformation of sulfonamide precursors. Some substituted C8 PFSAs [keto-perfluorooctane sulfonate (PFOS), hydrogen-PFOS, and unsaturated PFOS] appeared to be more bioaccumulative than linear PFOS, or were formed in vivo from unidentified precursors. A series of seven peaks in dosed mouse serum was tentatively identified as sulfonimide dimers that were either a minor component of the AFFF or were formed via metabolism of other AFFF components. This work highlights the importance of sulfonamide precursors in contributing to bioaccumulation of AFFF-associated PFSAs and identifies several classes of potentially bioaccumulative novel PFASs that warrant further investigation.

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Crossref · 10.1021/acs.est.0c00234

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Authors
McDonough, C. A., Choyke, S., Ferguson, P. L., DeWitt, J. C., & Higgins, C. P.
Affiliations
  • Colorado School of Mines (US)
  • Duke University (US)
  • East Carolina University (US)
Corresponding author
  • McDonough, Carrie A.
  • Higgins, Christopher P.
Venue
Environmental Science & Technology
Published
2020-04-06
Volume
54
Issue
9
Pages
5700-5709
ISSN
  • 0013-936X (ISSN-L)
  • 1520-5851
OpenAlex
W3014956432
Cited by
72
References
51
Citations by year
2026: 5 · 2025: 12 · 2024: 15 · 2023: 9 · 2022: 15 · 2021: 10 · 2020: 6
FWCI
3.70
Type
journal article
Language
en
Open access
closed
Locations
  • Environmental Science & Technology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Fluorine in Organic Chemistry
  • Physical Sciences › Materials Science › Polymers and Plastics › Synthesis and properties of polymers
Keywords
per- and polyfluoroalkyl substances, aqueous film-forming foam, bioaccumulation, perfluoroalkyl sulfonates, PFOS, depuration, mouse serum
MeSH terms
Bioaccumulation, Alkanesulfonates, Animals, Fluorocarbons, Humans, Mice, Inbred C57BL, Water, Water Pollutants, Chemical, Alkanesulfonic Acids, Mice

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