Exposure to Per-Fluoroalkyl and Polyfluoroalkyl Substances Leads to Immunotoxicity: Epidemiological and Toxicological Evidence

A Never-Ending Story of Per- and Polyfluoroalkyl Substances (PFASs)?

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Serum Vaccine Antibody Concentrations in Children Exposed to Perfluorinated Compounds

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Pre-natal Exposure to Perfluoroalkyl Substances May Be Associated with Altered Vaccine Antibody Levels and Immune-Related Health Outcomes in Early Childhood

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Suppression of Humoral Immunity in Mice following Exposure to Perfluorooctane Sulfonate

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Estimated exposures to perfluorinated compounds in infancy predict attenuated vaccine antibody concentrations at age 5-years

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Ulcerative Colitis and Perfluorooctanoic Acid (PFOA) in a Highly Exposed Population of Community Residents and Workers in the Mid-Ohio Valley

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Perfluorooctanoic Acid–Induced Immunomodulation in Adult C57BL/6J or C57BL/6N Female Mice

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Serum Polyfluoroalkyl Concentrations, Asthma Outcomes, and Immunological Markers in a Case–Control Study of Taiwanese Children

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Occupational exposure to wood dust and risk of lung cancer in two population-based case–control studies in Montreal, Canada

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Perfluoroalkyl and polyfluoroalkyl substances and indicators of immune function in children aged 12–19 y: National Health and Nutrition Examination Survey

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A critical review of perfluorooctanoate and perfluorooctanesulfonate exposure and immunological health conditions in humans

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Potent suppression of the adaptive immune response in mice upon dietary exposure to the potent peroxisome proliferator, perfluorooctanoic acid

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Gestational Exposure to Perfluorooctane Sulfonate Suppresses Immune Function in B6C3F1 Mice

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Influenza Vaccine Response in Adults Exposed to Perfluorooctanoate and Perfluorooctanesulfonate

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Effects of peroxisome proliferators on the thymus and spleen of mice

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Immunotoxicity—The Risk is Real

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Chronic effects of perfluorooctanesulfonate exposure on immunotoxicity in adult male C57BL/6 mice

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Prenatal exposure to perfluorinated chemicals and relationship with allergies and infectious diseases in infants

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A cohort incidence study of workers exposed to perfluorooctanoic acid (PFOA)

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Prenatal exposure to environmental chemical contaminants and asthma and eczema in school-age children

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The effect of prenatal perfluorinated chemicals exposures on pediatric atopy.

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Sub-chronic effect of perfluorooctanesulfonate (PFOS) on the balance of type 1 and type 2 cytokine in adult C57BL6 mice

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Immunotoxic changes associated with a 7-day oral exposure to perfluorooctanesulfonate (PFOS) in adult male C57BL/6 mice

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Antibody Response to Booster Vaccination with Tetanus and Diphtheria in Adults Exposed to Perfluorinated Alkylates

Kielsen, K., Shamim, Z., Ryder, L. P., Nielsen, F., Grandjean, P., Budtz-Jørgensen, E., & Heilmann, C. (2016) · Journal of Immunotoxicology · doi:10.3109/1547691x.2015.1067259 · Cited by 116 · see citing works

Further evidence for the involvement of inhibition of cell proliferation and development in thymic and splenic atrophy induced by the peroxisome proliferator perfluoroctanoic acid in mice33Abbreviations: PFOA, perfluorooctanoic acid; PP, peroxisome proliferator; FBS, fetal bovine serum; FITC, fluorescein isothiocyanate; and DEHP, di(2-ethylhexyl)phthalate.

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Perfluoroalkyl Chemicals and Asthma among Children 12–19 Years of Age: NHANES (1999–2008)

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Exposure to the Immunosuppresant, Perfluorooctanoic Acid, Enhances the Murine IgE and Airway Hyperreactivity Response to Ovalbumin

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Evaluation of the immune system in rats and mice administered linear ammonium perfluorooctanoate.

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Structural equation modeling of immunotoxicity associated with exposure to perfluorinated alkylates

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Toxicological Profile for Perfluoroalkyls: Draft for Public Comment

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Chronic exposure to perfluorinated compounds: Impact on airway hyperresponsiveness and inflammation

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Prenatal exposure to perfluoroalkyl acids and allergic diseases in early childhood

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Current Status of Developmental Immunotoxicity

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Prenatal exposure to phthalates, bisphenol A and perfluoroalkyl substances and cord blood levels of IgE, TSLP and IL-33

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Association between perfluoroalkyl substance exposure and asthma and allergic disease in children as modified by MMR vaccination

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Suppression of humoral immunity by perfluorooctanoic acid is independent of elevated serum corticosterone concentration in mice.

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Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and childhood atopic dermatitis: a prospective birth cohort study

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Self-Reported Health Effects among Community Residents Exposed to Perfluorooctanoate

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Suppression of Immune Function and Susceptibility to Infections in Humans: Association of Immune Function with Clinical Disease

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Immunomodulatory Effects of Dietary Potassium Perfluorooctane Sulfonate (PFOS) Exposure in Adult Sprague-Dawley Rats

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28-Day dietary exposure of mice to a low total dose (7 mg/kg) of perfluorooctanesulfonate (PFOS) alters neither the cellular compositions of the thymus and spleen nor humoral immune responses: Does the route of administration play a pivotal role in PFOS-induced immunotoxicity?

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Associating Changes in the Immune System with Clinical Diseases for Interpretation in Risk Assessment

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Investigative Immunotoxicology

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The Sheep Erythrocyte T-Dependent Antibody Response (TDAR)

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Evaluating Antigen-Specific IgE Using the Rat Basophil Leukemia Cell (RBL) Assay

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Associating Changes in the Immune System with Clinical Diseases for Interpretation in Risk Assessment

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Per- and Polyfluoroalkyl Substance Toxicity and Human Health Review: Current State of Knowledge and Strategies for Informing Future Research

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Assessing the Ecological Risks of Per- and Polyfluoroalkyl Substances: Current State-of-the Science and a Proposed Path Forward

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Guideline levels for PFOA and PFOS in drinking water: the role of scientific uncertainty, risk assessment decisions, and social factors

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Perfluoroalkyl substances (PFAS) and their effects on the placenta, pregnancy, and child development: a potential mechanistic role for placental peroxisome proliferator-activated receptors (PPARs)

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Thermal Stability and Decomposition of Perfluoroalkyl Substances on Spent Granular Activated Carbon

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Internal exposure to perfluoroalkyl substances (PFASs) and biological markers in 101 healthy 1-year-old children: associations between levels of perfluorooctanoic acid (PFOA) and vaccine response

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Remediation of per- and polyfluoroalkyls (PFAS) via electrochemical methods

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Sorption and Desorption Mechanisms of Cationic and Zwitterionic Per- and Polyfluoroalkyl Substances in Natural Soils: Thermodynamics and Hysteresis

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Determinants of per- and polyfluoroalkyl substances (PFAS) in midlife women: Evidence of racial/ethnic and geographic differences in PFAS exposure

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Review: Evolution of evidence on PFOA and health following the assessments of the C8 Science Panel.

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Per- and polyfluoroalkyl substances (PFAS) exposure and thyroid cancer risk

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Application of the Key Characteristics of Carcinogens to Per and Polyfluoroalkyl Substances

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Exposure, health effects, sensing, and remediation of the emerging PFAS contaminants – Scientific challenges and potential research directions

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Effect of granular activated carbon and other porous materials on thermal decomposition of per- and polyfluoroalkyl substances: Mechanisms and implications for water purification

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Severity of COVID-19 at elevated exposure to perfluorinated alkylates

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Per- and Polyfluoroalkyl Substances in Food Packaging: Migration, Toxicity, and Management Strategies

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Exposure to Perfluoroalkyl Substances in a Cohort of Women Firefighters and Office Workers in San Francisco

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Toward a Mechanistic Understanding of Poly- and Perfluoroalkylated Substances and Cancer

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Impact of per- and polyfluorinated alkyl substances (PFAS) on the marine environment: Raising awareness, challenges, legislation, and mitigation approaches under the One Health concept

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Per- and polyfluoroalkyl substances (PFAS) and cancer: Detection methodologies, epidemiological insights, potential carcinogenic mechanisms, and future perspectives

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Serum Perfluoroalkyl Substances, Vaccine Responses, and Morbidity in a Cohort of Guinea-Bissau Children

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Assessment of PFAS fate, transport, and treatment inhibition associated with a simulated AFFF release within a WASTEWATER treatment plant

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Systematic review and meta-analysis of epidemiologic data on vaccine response in relation to exposure to five principal perfluoroalkyl substances

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Exposure to perfluoroalkyl substances during fetal life and hospitalization for infectious disease in childhood: A study among 1,503 children from the Odense Child Cohort

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Does Low Maternal Exposure to Per- and Polyfluoroalkyl Substances Elevate the Risk of Spontaneous Preterm Birth? A Nested Case-Control Study in China.

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Adverse PFAS effects on mouse oocyte in vitro maturation are associated with carbon‐chain length and inclusion of a sulfonate group

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Bioaccumulation of Novel Per- and Polyfluoroalkyl Substances in Mice Dosed with an Aqueous Film-Forming Foam

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Concentration and distribution of metals, total fluorine, per- and poly-fluoroalkyl substances (PFAS) in vertical soil profiles in industrialized areas

Gan, C., Peng, M.-Y., Liu, H.-B., & Yang, J. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.134855 · Cited by 70 · see citing works

Montmorillonite clay-based sorbents decrease the bioavailability of per- and polyfluoroalkyl substances (PFAS) from soil and their translocation to plants

Hearon, S. E., Orr, A. A., Moyer, H., Wang, M., Tamamis, P., & Phillips, T. D. (2022) · Environmental Research · doi:10.1016/j.envres.2021.112433 · Cited by 65 · see citing works

Decoding per- and polyfluoroalkyl substances (PFAS) in hepatocellular carcinoma: a multi-omics and computational toxicology approach

Hong, Y., Wang, D., Liu, Z., Chen, Y., Wang, Y., & Li, J. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06517-z · Cited by 64 · see citing works

Spatiotemporal variations, sources and health risk assessment of perfluoroalkyl substances in a temperate bay adjacent to metropolis, North China

Han, T., Gao, L., Chen, J., He, X., & Wang, B. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.115011 · Cited by 63 · see citing works

Per- and Polyfluoroalkyl Substances, Epigenetic Age and DNA Methylation: A Cross-Sectional Study of Firefighters

Goodrich, J. M., Calkins, M. M., Caban-Martinez, A. J., Stueckle, T. A., Grant, C. C., Calafat, A. M., Nematollahi, A., Jung, A. M., Graber, J. M., Jenkins, T. G., et al. (2021) · Epigenomics · doi:10.2217/epi-2021-0225 · Cited by 62 · see citing works

Associations between exposures to perfluoroalkyl substances and diabetes, hyperglycemia, or insulin resistance: a scoping review

Margolis, R., & Sant, K. E. (2021) · Journal of Xenobiotics · doi:10.3390/jox11030008 · Cited by 59 · see citing works

Immunotoxicity of Per- and Polyfluoroalkyl Substances: Insights into Short-Chain PFAS Exposure

Woodlief, T., Vance, S. A., Hu, Q., & DeWitt, J. C. (2021) · Toxics · doi:10.3390/toxics9050100 · Cited by 58 · see citing works

Effects of exposure to per- and polyfluoroalkyl substances on vaccine antibodies: A systematic review and meta-analysis based on epidemiological studies

Zhang, X., Xue, L., Deji, Z., Wang, X., Liu, P., Lu, J., Zhou, R., & Huang, Z. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.119442 · Cited by 58 · see citing works

Effects of perfluorooctanoic acid on stem Leydig cell functions in the rat

Lu, H., Zhang, H., Gao, J., Li, Z., Bao, S., Chen, X., Wang, Y., Ge, R., & Ye, L. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2019.03.120 · Cited by 58 · see citing works

Self-Healable Antifreeze Hydrogel Based on Dense Quadruple Hydrogen Bonding

Choi, J., Kim, S., Yoo, J. H., Choi, S., & Char, K. (2021) · Macromolecules · doi:10.1021/acs.macromol.1c00295 · Cited by 57 · see citing works

Endocrine-disrupting chemicals and autoimmune diseases

Huang, R., Li, X., Wang, Y., Wu, H., Li, K.-D., Jin, X., Du, Y.-J., Wang, H., Qian, F., & Li, B. (2023) · Environmental Research · doi:10.1016/j.envres.2023.116222 · Cited by 57 · see citing works

Release of soil colloids during flow interruption increases the pore-water PFAS concentration in saturated soil

Borthakur, A., Cranmer, B. K., Dooley, G. P., Blotevogel, J., Mahendra, S., & Mohanty, S. K. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.117297 · Cited by 53 · see citing works

Association of Early Pregnancy Perfluoroalkyl and Polyfluoroalkyl Substance Exposure With Birth Outcomes

Zhang, Y., Mustieles, V., Sun, Q., Coull, B. A., McElrath, T. F., Rifas‐Shiman, S. L., Martin, L. J., Sun, Y., Wang, Y., Oken, E., et al. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.14934 · Cited by 55 · see citing works

Plasma perfluoroalkyls are associated with decreased levels of proteomic inflammatory markers in a cross-sectional study of an elderly population

Salihović, S., Lind, L., Larsson, A. O., & Lind, P. (2020) · Environment International · doi:10.1016/j.envint.2020.106099 · Cited by 54 · see citing works

Immunomodulation and exposure to per- and polyfluoroalkyl substances: an overview of the current evidence from animal and human studies

Antoniou, E. E., Colnot, T., Zeegers, M. P., & Dekant, W. (2022) · Archives of Toxicology · doi:10.1007/s00204-022-03303-4 · Cited by 51 · see citing works

Are cosmetics a significant source of PFAS in Europe? product inventories, chemical characterization and emission estimates

Pütz, K. W., Namazkar, S., Plassmann, M. M., & Benskin, J. P. (2022) · Environmental Science Processes & Impacts · doi:10.1039/d2em00123c · Cited by 57 · see citing works

Internal Relative Potency Factors Based on Immunotoxicity for the Risk Assessment of Mixtures of Per- and Polyfluoroalkyl Substances (PFAS) in Human Biomonitoring

Bil, W., Ehrlich, V., Chen, G., Vandebriel, R., Zeilmaker, M., Luijten, M., Uhl, M., Marx-Stoelting, P., Halldorsson, T. I., & Bokkers, B. (2023) · Environment International · doi:10.1016/j.envint.2022.107727 · Cited by 51 · see citing works

Predicting the effects of per- and polyfluoroalkyl substance mixtures on peroxisome proliferator-activated receptor alpha activity in vitro

Nielsen, G. H., Heiger‐Bernays, W., Schlezinger, J. J., & Webster, T. F. (2021) · Toxicology · doi:10.1016/j.tox.2021.153024 · Cited by 48 · see citing works

Exposure to Perfluoroalkyl Substances and Mortality for COVID-19: A Spatial Ecological Analysis in the Veneto Region (Italy)

Catelan, D., Biggeri, A., Russo, F., Gregori, D., Pitter, G., Da Re, F., Fletcher, T., & Canova, C. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18052734 · Cited by 47 · see citing works

A vision for safer food contact materials: Public health concerns as drivers for improved testing

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Hexafluoropropylene oxide dimer acid (HFPO-DA) induced developmental cardiotoxicity and hepatotoxicity in hatchling chickens: Roles of peroxisome proliferator activated receptor alpha

Xu, X., Ni, H., Guo, Y., Lin, Y., Ji, J., Jin, C., Yuan, F., Feng, M., Ji, N., Zheng, Y., et al. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.118112 · Cited by 46 · see citing works

Identification of point source dischargers of per‐ and polyfluoroalkyl substances in the United States

Andrews, D. Q., Hayes, J., Stoiber, T. L., Brewer, B., Campbell, C., & Naidenko, O. V. (2021) · AWWA Water Science · doi:10.1002/aws2.1252 · Cited by 47 · see citing works

Survey of legacy and emerging per- and polyfluorinated alkyl substances in Mediterranean seafood from a North African ecosystem

Barhoumi, B., Sander, S. G., Driss, M. R., & Tolosa, I. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.118398 · Cited by 47 · see citing works

Behavioral effects of early-life exposure to perfluorooctanoic acid might synthetically link to multiple aspects of dopaminergic neuron development and dopamine functions in zebrafish larvae

Yu, T., Zhou, G., Cai, Z., Liang, W., Du, Y., & Wang, W. (2021) · Aquatic Toxicology · doi:10.1016/j.aquatox.2021.105926 · Cited by 45 · see citing works

An environmentally relevant mixture of per- and polyfluoroalkyl substances (PFAS) impacts proliferation, steroid hormone synthesis, and gene transcription in primary human granulosa cells

Clark, K. L., Shukla, M., George, J. W., Gustin, S. L. F., Rowley, M. J., & Davis, J. S. (2024) · Toxicological Sciences · doi:10.1093/toxsci/kfae049 · Cited by 44 · see citing works

Association between prenatal exposure to perfluoroalkyl substances and asthma in 5-year-old children in the Odense Child Cohort

Beck, I. H., Timmermann, C. A. G., Nielsen, F., Schoeters, G. E. R., Jøhnk, C., Kyhl, H. B., Høst, A., & Jensen, T. K. (2019) · Environmental Health · doi:10.1186/s12940-019-0541-z · Cited by 42 · see citing works

Concentrations of tetanus and diphtheria antibodies in vaccinated Greenlandic children aged 7–12 years exposed to marine pollutants, a cross sectional study

Timmermann, C. A. G., Pedersen, H. S., Weihe, P., Bjerregaard, P., Nielsen, F., Heilmann, C. J., & Grandjean, P. (2021) · Environmental Research · doi:10.1016/j.envres.2021.111712 · Cited by 44 · see citing works

Per- and polyfluoroalkyl substances in the atmospheric total suspended particles in Karachi, Pakistan: Profiles, potential sources, and daily intake estimates

Lin, H., Taniyasu, S., Yamashita, N., Khan, M. K., Masood, S. S., Saied, S., & Khwaja, H. A. (2021) · Chemosphere · doi:10.1016/j.chemosphere.2021.132432 · Cited by 44 · see citing works

Hunting the missing fluorine in aqueous film-forming foams containing per- and polyfluoroalkyl substances

Liu, M., Glover, C. M., Munoz, G., Duy, S. V., Sauvé, S., & Liu, J. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2023.133006 · Cited by 43 · see citing works

Co-exposure to PCB126 and PFOS increases biomarkers associated with cardiovascular disease risk and liver injury in mice

Deng, P., Wang, C., Wahlang, B., Sexton, T. R., Morris, A. J., & Hennig, B. (2020) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2020.115301 · Cited by 42 · see citing works

Emergency of per- and polyfluoroalkyl substances in drinking water: Status, regulation, and mitigation strategies in developing countries

Adewuyi, A., & Li, Q. (2024) · Eco-Environment & Health · doi:10.1016/j.eehl.2024.05.008 · Cited by 43 · see citing works

Association between urinary per- and poly-fluoroalkyl substances and COVID-19 susceptibility

Ji, J., Song, L., Wang, J., Yang, Z., Yan, H., Li, T., Li, Y., Jian, L., Jiang, F., Li, J., et al. (2021) · Environment International · doi:10.1016/j.envint.2021.106524 · Cited by 39 · see citing works

Involvement of per-and polyfluoroalkyl compounds in tumor development

Pesonen, M., & Vähäkangas, K. (2024) · Archives of Toxicology · doi:10.1007/s00204-024-03685-7 · Cited by 40 · see citing works

Yale School of Public Health Symposium: An overview of the challenges and opportunities associated with per- and polyfluoroalkyl substances (PFAS).

Hagstrom, A. L., Anastas, P., Boissevain, A. L., Borrel, A., Deziel, N., Fenton, S., Fields, C. A., Fortner, J., Franceschi-Hofmann, N., Frigon, R., et al. (2021) · Science of the Total Environment · doi:10.1016/j.scitotenv.2021.146192 · Cited by 31 · see citing works

Per- and Polyfluoroalkyl Substances and Risk of Myocardial Infarction and Stroke: A Nested Case–Control Study in Sweden

Schillemans, T., Donat‐Vargas, C., Lindh, C. H., de Faire, U., Wolk, A., Leander, K., & Åkesson, A. (2022) · Environmental Health Perspectives · doi:10.1289/ehp9791 · Cited by 40 · see citing works

Evaluating maternal exposure to an environmental per and polyfluoroalkyl substances (PFAS) mixture during pregnancy: Adverse maternal and fetoplacental effects in a New Zealand White (NZW) rabbit model

Crute, C., Hall, S., Landon, C. D., Garner, A., Everitt, J. I., Zhang, S., Blake, B. E., Olofsson, D., Chen, H., Murphy, S. K., et al. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.156499 · Cited by 40 · see citing works

Childhood PFAS Exposure and Immunotoxicity: A Systematic Review and Meta-Analysis of Human Studies

Antoniou, E. E., & Dekant, W. (2024) · Systematic Reviews · doi:10.1186/s13643-024-02596-z · Cited by 38 · see citing works

Evaluation of Neural Regulation and Microglial Responses to Brain Injury in Larval Zebrafish Exposed to Perfluorooctane Sulfonate

Paquette, S. E., Martin, N. R., Rodd, A. L., Manz, K. E., Allen, E., Camarillo, M., Pennell, A., Weller, H. I., Pennell, K. D., & Plavicki, J. S. (2023) · Environmental Health Perspectives · doi:10.1289/ehp12861 · Cited by 35 · see citing works

Immune response to COVID-19 vaccination in a population with a history of elevated exposure to per- and polyfluoroalkyl substances (PFAS) through drinking water

Bailey, J. M., Wang, L., McDonald, J. M., Gray, J. S., Petrie, J. G., Martin, E. T., Savitz, D. A., Karrer, T. A., Fisher, K. A., Geiger, M. J., et al. (2023) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/s41370-023-00564-8 · Cited by 34 · see citing works

Per- and polyfluoroalkyl substances alter innate immune function: evidence and data gaps

Phelps, D. W., Connors, A. M., Ferrero, G., DeWitt, J. C., & Yoder, J. A. (2024) · Journal of Immunotoxicology · doi:10.1080/1547691x.2024.2343362 · Cited by 34 · see citing works

Immunotoxicity of an Electrochemically Fluorinated Aqueous Film-Forming Foam

McDonough, C. A., Ward, C., Hu, Q., Vance, S. A., Higgins, C. P., & DeWitt, J. C. (2020) · Toxicological Sciences · doi:10.1093/toxsci/kfaa138 · Cited by 33 · see citing works

Perfluorooctanesulfonic Acid–Induced Toxicity on Zebrafish Embryos in the Presence or Absence of the Chorion

Mylroie, J. E., Wilbanks, M. S., Kimble, A. N., To, K. T., Cox, C. S., McLeod, S., Gust, K. A., Moore, D. W., Perkins, E. J., & García‐Reyero, N. (2020) · Environmental Toxicology and Chemistry · doi:10.1002/etc.4899 · Cited by 36 · see citing works

Exposure to perfluorooctanoic acid (PFOA) decreases neutrophil migration response to injury in zebrafish embryos

Pecquet, A. M., Maier, A., Kasper, S., Sumanas, S., & Yadav, J. S. (2020) · BMC Research Notes · doi:10.1186/s13104-020-05255-3 · Cited by 33 · see citing works

Serum vaccine antibody concentrations in adults exposed to per- and polyfluoroalkyl substances: A birth cohort in the Faroe Islands

Shih, Y.-H., Blomberg, A. J., Bind, M., Holm, D., Nielsen, F., Heilmann, C., Weihe, P., & Grandjean, P. (2021) · Journal of Immunotoxicology · doi:10.1080/1547691x.2021.1922957 · Cited by 33 · see citing works

Hexafluoropropylene oxide dimer acid (GenX) exposure induces apoptosis in HepG2 cells

Yoo, H. J., Pyo, M. C., Park, Y., Kim, B., & Lee, K. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e08272 · Cited by 32 · see citing works

Perfluorooctane sulfonate‐induced apoptosis in kidney cells by triggering the NOX4 / ROS / JNK axis and antagonism of cannabidiol

Du, Y., Xu, T., Luo, D., Wang, Y., Yin, H., Liu, C., & Li, S. (2023) · Environmental Toxicology · doi:10.1002/tox.23794 · Cited by 32 · see citing works

Investigating Molecular Mechanisms of Immunotoxicity and the Utility of ToxCast for Immunotoxicity Screening of Chemicals Added to Food

Naidenko, O. V., Andrews, D. Q., Temkin, A. M., Stoiber, T. L., Uche, U. I., Evans, S., & Perrone‐Gray, S. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18073332 · Cited by 32 · see citing works

Legacy and emerging per- and polyfluoroalkyl substances suppress the neutrophil respiratory burst

Phelps, D. W., Palekar, A. I., Conley, H. E., Ferrero, G., Driggers, J. H., Linder, K. E., Kullman, S. W., Reif, D. M., Sheats, M. K., DeWitt, J. C., et al. (2023) · Journal of Immunotoxicology · doi:10.1080/1547691x.2023.2176953 · Cited by 33 · see citing works

Perfluorooctane sulfonate promotes doxycycline-induced liver tumor progression in male Kras transgenic zebrafish

Zhu, Y., Yang, D., Duan, X., Zhang, Y., Chen, D., Gong, Z., & Liu, C. (2021) · Environmental Research · doi:10.1016/j.envres.2021.110962 · Cited by 31 · see citing works

Domestic Dogs and Horses as Sentinels of Per- and Polyfluoroalkyl Substance Exposure and Associated Health Biomarkers in Gray’s Creek North Carolina

Rock, K. D., Polera, M. E., Guillette, T. C., Starnes, H. M., Dean, K., Watters, M., Stevens-Stewart, D., & Belcher, S. M. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.3c01146 · Cited by 31 · see citing works

Perfluorooctanoic acid (PFOA) and hexafluoropropylene oxide-dimer acid (GenX): Hepatic stress and bile acid metabolism with different pathways

Yoo, H. J., Pyo, M. C., Rhee, K. H., Lim, J.-M., Yang, S.-A., Yoo, M. K., & Lee, K. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115001 · Cited by 28 · see citing works

Derivation of a chronic reference dose for perfluorohexane sulfonate (PFHxS) for reproductive toxicity in mice

Ali, J. M., Roberts, S. M., Gordon, D. S., & Stuchal, L. D. (2019) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2019.104452 · Cited by 26 · see citing works

Effect of Perfluorooctanesulfonic acid (PFOS) on immune cell development and function in mice

Torres, L., Redko, A., Limper, C., Imbiakha, B., Chang, S., & August, A. (2021) · Immunology Letters · doi:10.1016/j.imlet.2021.03.006 · Cited by 27 · see citing works

Translatability and transferability of in silico models: Context of use switching to predict the effects of environmental chemicals on the immune system

Pappalardo, F., Russo, G. L., Corsini, E., Paini, A., & Worth, A. P. (2022) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.03.024 · Cited by 27 · see citing works

The immune modulatory role of marjoram extract on imidacloprid induced toxic effects in thymus and spleen of adult rats

Khayal, E. E.-S., Alabiad, M. A., Elkholy, M. R., Shalaby, A. M., Nosery, Y., & El-Sheikh, A. A. (2022) · Toxicology · doi:10.1016/j.tox.2022.153174 · Cited by 27 · see citing works

Thermal processing reduces PFAS concentrations in blue food – A systematic review and meta-analysis

Vendl, C., Pottier, P., Taylor, M. D., Bräunig, J., Gibson, M., Hesselson, D., Neely, G. G., Lagisz, M., & Nakagawa, S. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.119081 · Cited by 27 · see citing works

Exploring the sources, occurrence, transformation, toxicity, monitoring, and remediation strategies of per- and polyfluoroalkyl substances: a review

Elgarahy, A. M., Eloffy, M. G., Saber, A. N., Abouzid, M., Rashad, E., Ghorab, M. A., El‐Sherif, D. M., & Elwakeel, K. Z. (2024) · Environmental Monitoring and Assessment · doi:10.1007/s10661-024-13334-2 · Cited by 27 · see citing works

Association between maternal per- and polyfluoroalkyl substance exposure and newborn telomere length: Effect modification by birth seasons

Pan, D., Shao, Y., Song, Y., Huang, D., Liu, S., Zeng, X., Liang, J. L., Tan, H. J. J., & Qiu, X. (2022) · Environment International · doi:10.1016/j.envint.2022.107125 · Cited by 26 · see citing works

Associations of per- and polyfluoroalkyl substances (PFAS) and their mixture with risk of rheumatoid arthritis in the U.S. adult population

Qiao, J.-C., Li, Z.-H., Ma, Y., Ma, H.-Y., Zhang, M., Zhang, X.-J., & Hu, C. (2024) · Environmental Health · doi:10.1186/s12940-024-01073-3 · Cited by 25 · see citing works

Associations of PFAS and OH-PCBs with risk of multiple sclerosis onset and disability worsening

Vaivade, A., Erngren, I., Carlsson, H., Freyhult, E., Khoonsari, P. E., Noui, Y., Al-Grety, A., Åkerfeldt, T., Spjuth, O., Gallo, V., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-57172-3 · Cited by 27 · see citing works

Per- and Polyfluoroalkyl Substances (PFAS) Enhance Cholesterol Accumulation and Dysregulate Inflammatory Responses in Macrophages

Connolly, J. C., Ishihara, Y., Sawaya, E., Whitfield, V., Garrity, N., Sohata, R., Tsymbal, M., Lundberg, A., Merrill, M. A. L., DeWitt, J. C., et al. (2025) · Cardiovascular Toxicology · doi:10.1007/s12012-025-10048-w · Cited by 25 · see citing works

Bioavailability of inhaled or ingested PFOA adsorbed to house dust

Gustafsson, Å., Wang, B., Gerde, P., Bergman, Å., & Yeung, L. W. Y. (2022) · Environmental Science and Pollution Research · doi:10.1007/s11356-022-20829-3 · Cited by 25 · see citing works

Per- and polyfluoroalkyl substances (PFAS) exposure through munitions in the Russia–Ukraine conflict

Koban, L. A., & Pfluger, A. R. (2022) · Integrated Environmental Assessment and Management · doi:10.1002/ieam.4672 · Cited by 25 · see citing works

Effects of endocrine disrupting chemicals on the expression of RACK1 and LPS-induced THP-1 cell activation

Masi, M., Maddalon, A., Iulini, M., Linciano, P., Galbiati, V., Marinovich, M., Racchi, M., Corsini, E., & Buoso, E. (2022) · Toxicology · doi:10.1016/j.tox.2022.153321 · Cited by 25 · see citing works

The association between endocrine disrupting chemicals and MAFLD: Evidence from NHANES survey

Lei, R., Xue, B., Tian, X., Liu, C., Li, Y., Zheng, J., & Luo, B. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.114836 · Cited by 25 · see citing works

Quantifying the impact of PFOA exposure on B-cell development and antibody production

Taylor, K. D., Woodlief, T., Ahmed, A., Hu, Q., Duncker, P. C., & DeWitt, J. C. (2023) · Toxicological Sciences · doi:10.1093/toxsci/kfad043 · Cited by 24 · see citing works

Improving the Hydrophobicity of Powder Activated Carbon to Enhance the Adsorption Kinetics of Per- and Polyfluoroalkyl Substances

Reid, E., Ma, Q., Gan, L., He, J., Igou, T. K. S., Huang, C., & Chen, Y. (2025) · ACS ES&T Water · doi:10.1021/acsestwater.4c01222 · Cited by 25 · see citing works

Per- and poly-fluoroalkyl substances (PFAS) and human health: a review of exposure routes and potential toxicities across the lifespan

Ly, C. Y. S., Alrazihi, L. A., Wong, S. T., & Wong, S. F. (2025) · Environmental Toxicology and Chemistry · doi:10.1093/etojnl/vgaf172 · Cited by 27 · see citing works

Outcome of a public consultation on the draft risk assessment of perfluoroalkyl substances in food

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Perfluorooctanoic acid and perfluorooctanesulfonic acid induce immunotoxicity through the NF-κB pathway in black-spotted frog (Rana nigromaculata)

Liu, Z., Lin, H., Zheng, Y., Feng, Y., Shi, C., Zhu, R., Shen, X., Han, Y., Zhang, H., & Zhong, Y. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.137622 · Cited by 24 · see citing works

Red Blood Cell Folate Modifies the Association between Serum Per- and Polyfluoroalkyl Substances and Antibody Concentrations in U.S. Adolescents

Zhang, Y., Mustieles, V., Wang, Y., Sun, Q., Coull, B. A., Sun, Y., Slitt, A. L., & Messerlian, C. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.2c07152 · Cited by 25 · see citing works

Insight into the effect of natural aging of polystyrene microplastics on the sorption of legacy and emerging per- and polyfluorinated alkyl substances in seawater

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Unlocking the sorption mechanism of perfluoroalkyl acids (PFAAs) on geosynthetics: Case of the geotextile components of geosynthetic clay liners

Mikhael, E., Bouazza, A., Gates, W. P., & Haque, A. (2024) · Geotextiles and Geomembranes · doi:10.1016/j.geotexmem.2023.09.002 · Cited by 23 · see citing works

A critical review of perfluorooctanoate and perfluorooctanesulfonate exposure and immunological health conditions in humans

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Weight of evidence evaluation for chemical-induced immunotoxicity for PFOA and PFOS: findings from an independent panel of experts

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A systematic evidence map of chronic inflammation and immunosuppression related to per- and polyfluoroalkyl substance (PFAS) exposure

Zhang, L., Louie, A., Rigutto, G., Guo, H., Zhao, Y., Ahn, S., Dahlberg, S., Sholinbeck, M., & Smith, M. T. (2022) · Environmental Research · doi:10.1016/j.envres.2022.115188 · Cited by 108 · see citing works

Advances on immunotoxicities induced by per- and polyfluoroalkylated substances

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Immunotoxicity of Perfluorinated Compounds: Recent Developments

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