Endocytosis and Autophagy: Exploitation or Cooperation?
Open accessAbstract
Autophagy is a lysosome-mediated degradative system that is a highly conserved pathway present in all eukaryotes. In all cells, double-membrane autophagosomes form and engulf cytoplasmic components, delivering them to the lysosome for degradation. Autophagy is essential for cell health and can be activated to function as a recycling pathway in the absence of nutrients or as a quality-control pathway to eliminate damaged organelles or even to eliminate invading pathogens. Autophagy was first identified as a pathway in mammalian cells using morphological techniques, but the Atg (autophagy-related) genes required for autophagy were identified in yeast genetic screens. Despite tremendous advances in elucidating the function of individual Atg proteins, our knowledge of how autophagosomes form and subsequently interact with the endosomal pathway has lagged behind. Recent progress toward understanding where and how both the endocytotic and autophagic pathways overlap is reviewed here.
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The mutations in the gene analyzed here are likely more disruptive of Clec16a function than alleles associated with human disease risk.
“Importantly, the mutations in the gene analyzed here are likely more disruptive of Clec16a function than alleles associated with human disease risk12163342.”
From Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival (2016) · cites this paper as [12]
The passages on autophagy machinery and the References section (pages not provided) do not address Clec16a mutations or human disease-risk alleles. Searches for “Clec16a” and “Clec16a mutations human disease risk” found no passage comparing their effects on Clec16a function. (LLM, conf=0.75)
Experimental — accuracy not yet measuredSNPs in CLEC16A associated with autoimmunity may correlate with either increased or decreased CLEC16A protein expression in humans.
“single nucleotide polymorphisms (SNPs) in CLEC16A that are associated with autoimmunity may correlate with either increased or decreased CLEC16A protein expression in humans”
From Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival (2016) · cites this paper as [12]
Our copy discusses autophagy and membrane trafficking, including the tethering factors section, but does not address CLEC16A variants or their association with autoimmunity. Searches for CLEC16A and for autoimmunity-associated SNPs affecting CLEC16A protein expression found no relevant passage; page numbers were unavailable. (LLM, conf=0.76)
Experimental — accuracy not yet measured
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Homeostatic Roles of the Proteostasis Network in Dendrites
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Selective autophagy controls innate immune response through a TAK1/TAB2/SH3PX1 axis
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PLEKHM1: A Multiprotein Adaptor for the Endolysosomal System
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Recycling endosomal CD133 functions as an inhibitor of autophagy at the pericentrosomal region
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- Authors
- Tooze, S. A., Abada, A., & Elazar, Z.
- Affiliations
- Cancer Research UK (GB)
- Weizmann Institute of Science (IL)
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2014-05-01
- Volume
- 6
- Issue
- 5
- Pages
- a018358-a018358
- ISSN
- 1943-0264 (ISSN-L)
- PMC
- PMC3996471
- OpenAlex
- W2110645858
- Cited by
- 202
- References
- 109
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 14 · 2023: 13 · 2022: 24 · 2021: 15 · 2020: 25 · 2019: 28 · 2018: 14 · 2017: 23 · 2016: 14 · 2015: 8 · 2014: 5 · 2013: 1
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cold Spring Harbor Perspectives in Biology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Cancer Research UK (15153)
- Minerva Foundation
- Israel Science Foundation
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Keywords
- autophagy, endocytosis, autophagosome formation, autophagy-related proteins, endocytic pathway, nutrient cycling, pathogen removal, autophagy-related genes
- MeSH terms
- Animals, Autophagy, Endocytosis, Humans, Lysosomes, Phagosomes, Endosomes, SNARE Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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