CoChat
Sign Up
Cited by 67

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Altered Expression Levels of MicroRNA-132 and Nurr1 in Peripheral Blood of Parkinson’s Disease: Potential Disease Biomarkers

Yang, Zhaofei, Li, Tianbai, Li, Song, Wei, Min, Qi, Hongqian, Shen, Bairong, Chang, Raymond Chuen-Chung, Le, Weidong, Piao, Fengyuan·2019·ACS Chemical Neuroscience
DOI 10.1021/acschemneuro.8b00460
Open this paper in CoChat — free account

Abstract

MicroRNAs (miRNAs) are small and evolutionary conserved noncoding RNAs that are involved in post-transcriptional gene regulation. Differential expression levels of miRNAs can be used as potential biomarkers of disease. Previous animal studies have indicated that the expression level of miR-132 is negatively correlated with its downstream molecule nuclear receptor related 1 protein (Nurr1), which is one of the key factors for the maintenance of dopaminergic function and is particularly vulnerable in Parkinson's disease (PD). However, this correlation has not been confirmed in human patients with PD. Moreover, the possible involvement of miR-132 during the pathogenesis and progression of PD is not fully investigated. Therefore, in the present study, we determined the peripheral circulation levels of miR-132 and Nurr1 in patients with PD, neurological disease controls (NDC) and healthy controls (HC) by reverse transcription real-time quantitative PCR (RT-qPCR). Our data clearly demonstrated that the plasma miR-132 level in PD was significantly higher than those in HC (178%, p < 0.05) and NDC (188%, p < 0.001). When adjusted for gender and age, higher level of miR-132 expression was associated with the significantly increased risk for PD in males and was closely related with the disease stages and disease severity. Furthermore, peripheral Nurr1 was significantly decreased in PD compared with HC (56%, p < 0.001) and NDC (58%, p < 0.001). Much more interestingly, further analysis r…

Overview

Integrity signals

Registry

Crossref · 10.1021/acschemneuro.8b00460

Cites

4 of 4 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Research works printed but not linked: 36

  1. 10.3389/fnins.2016.00298 · DOI
  2. 10.3390/ijms17060904 · DOI
  3. 10.1016/S0140-6736(14)61393-3 · DOI · Paper page
  4. 10.1007/s12264-017-0178-2 · DOI
  5. 10.1016/S0896-6273(03)00568-3 · DOI · Paper page
  6. 10.1016/S0092-8674(04)00045-5 · DOI
  7. 10.1007/s12264-017-0160-z · DOI
  8. 10.1126/science.1140481 · DOI · Paper page
  9. 10.1038/cddis.2017.214 · DOI
  10. 10.1074/jbc.M109.086827 · DOI · Paper page
  11. 10.1016/j.ajhg.2007.09.021 · DOI
  12. 10.1073/pnas.1305623110 · DOI · Paper page
  13. 10.1016/j.neuroscience.2014.03.015 · DOI
  14. 10.18632/aging.100624 · DOI
  15. 10.1096/fj.201601308 · DOI · Paper page
  16. 10.18632/aging.100486 · DOI · Paper page
  17. 10.1016/j.bbadis.2016.06.001 · DOI
  18. 10.1016/j.neulet.2013.08.001 · DOI
  19. 10.1111/cns.12536 · DOI
  20. 10.1038/nature01645 · DOI
  21. 10.1038/nrneurol.2013.209 · DOI
  22. 10.1016/j.cell.2009.01.038 · DOI · Paper page
  23. 10.1242/jcs.086421 · DOI
  24. 10.1016/j.jns.2008.06.007 · DOI
  25. 10.1111/j.1468-1331.2011.03644.x · DOI
  26. 10.1080/00207454.2016.1209754 · DOI
  27. 10.1017/S003118201400167X · DOI
  28. 10.1136/jnnp.2006.104695 · DOI
  29. 10.1016/j.parkreldis.2014.10.018 · DOI
  30. 10.1016/j.parkreldis.2015.11.014 · DOI · Paper page
  31. 10.1016/j.molcel.2010.06.010 · DOI
  32. 10.1002/cne.20828 · DOI
  33. 10.3389/fnagi.2018.00392 · DOI
  34. 10.3892/mmr.2015.4105 · DOI
  35. 10.3233/JAD-142847 · DOI · Paper page
  36. 10.1002/mds.27362 · DOI · Paper page

Cited by

Sorted by citations

See all 67

Metadata

Authors
Yang, Z., Li, T., Li, S., Wei, M., Qi, H., Shen, B., Chang, R. C.-C., Le, W., & Piao, F.
Affiliations
  • Department of Occupational and Environmental Health, Dalian Medical University, Dalian 116044, China
  • Center for Clinical Research on Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, Dalian 116021, China
  • Institute for Systems Genetics, West China Hospital, Sichuan University, Chengdu 610041, China
  • Laboratory of Neurodegenerative Diseases, LKS Faculty of Medicine, School of Biomedical Sciences, The University of Hong Kong, Hong Kong, China
ORCID
Venue
ACS Chemical Neuroscience
Publisher
American Chemical Society (ACS)
Published
2019-02-28
Volume
10
Issue
5
Pages
2243-2249
ISSN
1948-7193
DOI
10.1021/acschemneuro.8b00460
Cited by
67
References
4
Language
en
Licence
Funders
  • Ministry of Science and Technology of the People's Republic of China (2016YFC1306603)
  • National Natural Science Foundation of China (81370470, 81430021)
  • Liaoning Province (LQ2017018)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review