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microRNA‐132: a key noncoding RNA operating in the cellular phase of Alzheimer's disease

Salta, Evgenia, De Strooper, Bart·2017·The FASEB Journal
DOI 10.1096/fj.201601308
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Abstract

With the consideration of the broad involvement of microRNAs (miRNAs) in the regulation of molecular networks in the brain, it is not surprising that miRNA dysregulation causes neurodegeneration in animal models. miRNA profiling in the human brain has revealed miR‐132 as one of the most severely down‐regulated miRNAs at the intermediate and late Braak stages of Alzheimer's disease (AD), as well as in other neurodegenerative disorders. Suppression of miR‐132 aggravates multiple layers of pathology at the molecular and functional level. We describe the potential therapeutic implications of these findings and suggest miRNA targeting or replacement as a realistic multi‐hit, therapeutic strategy for AD. Salta, E., De Strooper, B. microRNA‐132: a key noncoding RNA operating in the cellular phase of Alzheimer's disease. FASEB J. 31, 424–433 (2017). www.fasebj.org

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Metadata

Authors
Salta, E., & De Strooper, B.
Affiliations
Vlaams Instituut voor Biotechnologie (VIB) Center for Brain and Disease VIB‐Leuven Leuven Belgium
Venue
The FASEB Journal
Publisher
Wiley
Published
2017-01-13
Volume
31
Issue
2
Pages
424-433
ISSN
  • 0892-6638
  • 1530-6860
DOI
10.1096/fj.201601308
Cited by
99
References
13
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Funders
  • Fonds Wetenschappelijk Onderzoek
  • Alzheimer's Association
  • European Research Council (ERC-2010-AG_268675)
  • KU Leuven
  • Vlaamse regering

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