CoChat
Sign Up
Cited by 459

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Blood Exosomes Endowed with Magnetic and Targeting Properties for Cancer Therapy

Qi, Hongzhao, Liu, Chaoyong, Long, Lixia, Ren, Yu, Zhang, Shanshan, Chang, Xiaodan, Qian, Xiaomin, Jia, Huanhuan, Zhao, Jin, Sun, Jinjin, Hou, Xin, Yuan, Xubo, Kang, Chunsheng·2016·ACS Nano
DOI 10.1021/acsnano.5b06939
Open this paper in CoChat — free account

Abstract

Exosomes are a class of naturally occurring nanoparticles that are secreted endogenously by mammalian cells. Clinical applications for exosomes remain a challenge because of their unsuitable donors, low scalability, and insufficient targeting ability. In this study, we developed a dual-functional exosome-based superparamagnetic nanoparticle cluster as a targeted drug delivery vehicle for cancer therapy. The resulting exosome-based drug delivery vehicle exhibits superparamagnetic behavior at room temperature, with a stronger response to an external magnetic field than individual superparamagnetic nanoparticles. These properties enable exosomes to be separated from the blood and to target diseased cells. In vivo studies using murine hepatoma 22 subcutaneous cancer cells showed that drug-loaded exosome-based vehicle delivery enhanced cancer targeting under an external magnetic field and suppressed tumor growth. Our developments overcome major barriers to the utility of exosomes for cancer application.

Overview

Integrity signals

Registry

Crossref · 10.1021/acsnano.5b06939

Cites

2 of 2 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 2 references

Research works printed but not linked: 34

  1. 10.1126/science.279.5349.377 · DOI
  2. 10.1016/j.jconrel.2011.07.031 · DOI
  3. 10.1002/smll.200801602 · DOI
  4. 10.1016/j.addr.2008.09.001 · DOI
  5. 10.1016/S0378-5173(01)00720-7 · DOI · Paper page
  6. 10.1016/j.addr.2012.06.014 · DOI
  7. 10.1021/nn901824n · DOI
  8. 10.1016/j.addr.2012.07.002 · DOI
  9. 10.1016/j.biomaterials.2013.11.083 · DOI
  10. 10.1038/mt.2011.164 · DOI · Paper page
  11. 10.1073/pnas.0914843107 · DOI
  12. 10.1038/nbt.1807 · DOI · Paper page
  13. 10.1038/85438 · DOI
  14. 10.1038/sj.cdd.4402237 · DOI
  15. 10.1158/0008-5472.CAN-11-0241 · DOI
  16. 10.1016/j.bcmd.2005.04.008 · DOI
  17. Johnstone R. M., 1989, Blood, 74, 1844, 10.1182/blood.V74.5.1844.1844 · DOI · Paper page
  18. 10.1093/intimm/dxh267 · DOI
  19. 10.1016/S0022-1759(00)00321-5 · DOI
  20. 10.1016/j.nano.2014.11.009 · DOI
  21. 10.1002/anie.200700197 · DOI
  22. 10.1016/j.jim.2008.03.001 · DOI
  23. 10.1002/pmic.200900351 · DOI
  24. 10.1016/j.ceb.2009.03.007 · DOI
  25. 10.1073/pnas.80.8.2258 · DOI
  26. 10.1148/radiology.171.2.2704823 · DOI
  27. 10.1148/radiology.185.3.1438767 · DOI
  28. 10.1161/01.HYP.23.4.464 · DOI
  29. 10.1016/S1748-0132(07)70084-1 · DOI
  30. Algire G. H., 1945, J. Natl. Cancer Inst., 6, 73, 10.1093/jnci/6.1.73 · DOI
  31. Vaupel P., 1989, Cancer Res., 49, 6449
  32. 10.1002/adma.201403387 · DOI
  33. 10.1634/stemcells.2007-0295 · DOI
  34. 10.1016/j.biomaterials.2008.09.010 · DOI

Cited by

Sorted by citations

Metadata

Authors
Qi, H., Liu, C., Long, L., Ren, Y., Zhang, S., Chang, X., Qian, X., Jia, H., Zhao, J., Sun, J., Hou, X., Yuan, X., & Kang, C.
Venue
ACS Nano
Publisher
American Chemical Society (ACS)
Published
2016-03-07
Volume
10
Issue
3
Pages
3323-3333
ISSN
  • 1936-0851
  • 1936-086X
DOI
10.1021/acsnano.5b06939
Cited by
459
References
2
Language
en
Funders
  • Ministry of Science and Technology of the People's Republic of China (2012AA02A508, 2014AA021102)
  • National Natural Science Foundation of China (51303125, 51473119)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review