The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Intracellularly Acid-Switchable Multifunctional Micelles for Combinational Photo/Chemotherapy of the Drug-Resistant Tumor
Abstract
The intrinsic or acquired drug resistance is the main challenge for cancer chemotherapy today. So far, many nanosized drug delivery systems (NDDS) have been exploited to combat cancer drug resistance. However, the therapy efficacy of current NDDS is severely impaired by the limited tumor penetration of the nanoparticles due to the existence of physiological and pathological barriers in the solid tumor. In this study, we report on the design and fabrication of intracellularly acid-switchable multifunctional micelles for combinational photo- and chemotherapy of the drug-resistant tumor. The micelles were composed of a pH-responsive diblock copolymer, a photosensitizer, and a polymeric prodrug of doxorubicin. The micelle displayed silenced fluorescence and photoactivity during the blood circulation and switched to an active state in weakly acid conditions (i.e., pH ≤ 6.2) in the endocytic vesicles to dramatically induce a 7.5-fold increase of the fluorescence signal for fluorescence imaging. Upon near-infrared (NIR) laser irradiation, the micelle induced notable reactive oxygen species generation to trigger cytosol release of the chemotherapeutics and perform photodynamic therapy (PDT). Moreover, the micelle efficiently converted the NIR light to local heat for enhancing tumor penetration of the anticancer drug, tumor specific photothermal therapy, and photoacoustic (PA) imaging. Furthermore, the micelles could generate amplified magnetic resonance (MR) signal in an acidic microenvironment to perform MR imaging. Collectively, this study presents a robust nanoplatform for multimodal imaging and combinational therapy of the drug-resistant tumor, which might provide an insight for developing polymer-based NDDS for cancer therapy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Stimuli-responsive nanocarriers for drug delivery
Mura, S., Nicolas, J., & Couvreur, P. (2013) · Nature Materials · doi:10.1038/nmat3776 · Cited by 6,289
Multidrug resistance in cancer: role of ATP–dependent transporters
Gottesman, M. M., Fojo, T., & Bates, S. E. (2002) · Nature Reviews Cancer · doi:10.1038/nrc706 · Cited by 5,536
Delivering nanomedicine to solid tumors
Jain, R. K., & Stylianopoulos, T. (2010) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2010.139 · Cited by 3,180
Knocking down barriers: advances in siRNA delivery
Whitehead, K. A., Langer, R., & Anderson, D. G. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2742 · Cited by 3,115
In vivo near-infrared fluorescence imaging
Frangioni, J. V. (2003) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2003.08.007 · Cited by 2,653
Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size
Cabral, H., Matsumoto, Y., Mizuno, K., Chen, Q., Murakami, M., Kimura, M., Terada, Y., Kano, M. R., Miyazono, K., Uesaka, M., et al. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.166 · Cited by 2,429
In vivo imaging of tumors with protease-activated near-infrared fluorescent probes
Weissleder, R., Tung, C.-H., Mahmood, U., & Bogdanov, A. (1999) · Nature Biotechnology · doi:10.1038/7933 · Cited by 1,591
Nanomaterials for Theranostics: Recent Advances and Future Challenges
Lim, E.-K., Kim, T., Paik, S., Haam, S., Huh, Y.-M., & Lee, K. (2015) · Chemical Reviews · doi:10.1021/cr300213b · Cited by 1,233
Semiconducting polymer nanoparticles as photoacoustic molecular imaging probes in living mice
Pu, K., Shuhendler, A. J., Jokerst, J. V., Mei, J., Gambhir, S. S., Bao, Z., & Rao, J. (2014) · Nature Nanotechnology · doi:10.1038/nnano.2013.302 · Cited by 1,185
Du, J.-Z., Du, X.-J., Mao, C.-Q., & Wang, J. (2011) · Journal of the American Chemical Society · doi:10.1021/ja207150n · Cited by 1,172
Photosensitizers in clinical PDT
Allison, R. R., Downie, G. H., Cuenca, R., Hu, X.-H., Childs, C. J., & Sibata, C. H. (2004) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/s1572-1000(04)00007-9 · Cited by 1,059
In Vivo Magnetic Resonance Detection of Cancer by Using Multifunctional Magnetic Nanocrystals
Huh, Y.-M., Jun, Y.-W., Song, H.-T., Kim, S., Choi, J.-S., Lee, J.-H., Yoon, S., Kim, K.-S., Shin, J.-S., Suh, J.-S., et al. (2005) · Journal of the American Chemical Society · doi:10.1021/ja052337c · Cited by 859
Chen, H., Tian, J., He, W., & Guo, Z. (2015) · Journal of the American Chemical Society · doi:10.1021/ja511420n · Cited by 813
Strategies for advancing cancer nanomedicine
Chauhan, V. P., & Jain, R. K. (2013) · Nature Materials · doi:10.1038/nmat3792 · Cited by 812
Wang, Y., Zhou, K., Huang, G., Hensley, C., Huang, X., Ma, X., Zhao, T., Sumer, B. D., DeBerardinis, R. J., & Gao, J. (2014) · Nature Materials · doi:10.1038/nmat3819 · Cited by 773
A microenvironmental model of carcinogenesis
Gatenby, R. A., & Gillies, R. J. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2255 · Cited by 721
Recent advances in magnetic nanoparticle-based multi-modal imaging
Shin, T.-H., Choi, Y., Kim, S., & Cheon, J. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00345d · Cited by 602
Ling, D., Park, W., Park, S.-J., Lu, Y., Kim, K. S., Hackett, M. J., Kim, B. H., Yim, H., Jeon, Y. S., Na, K., et al. (2014) · Journal of the American Chemical Society · doi:10.1021/ja4108287 · Cited by 517
A smart and versatile theranostic nanomedicine platform based on nanoporphyrin
Li, Y., Lin, T.-Y., Luo, Y., Liu, Q., Xiao, W., Guo, W., Lac, D., Zhang, H., Feng, C., Wachsmann-Hogiu, S., et al. (2014) · Nature Communications · doi:10.1038/ncomms5712 · Cited by 414
Self-citationTumor Redox Heterogeneity‐Responsive Prodrug Nanocapsules for Cancer Chemotherapy
Wang, J., Sun, X., Mao, W., Sun, W., Tang, J., Sui, M., Shen, Y., & Gu, Z. (2013) · Advanced Materials · doi:10.1002/adma.201300929 · Cited by 395
Dai, J., Lin, S., Cheng, D., Zou, S., & Shuai, X. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201103806 · Cited by 382
Hypoxia-specific ultrasensitive detection of tumours and cancer cells in vivo
Zheng, X., Wang, X., Mao, H., Wu, W., Liu, B., & Jiang, X. (2015) · Nature Communications · doi:10.1038/ncomms6834 · Cited by 362
Shokeen, M., & Anderson, C. J. (2009) · Accounts of Chemical Research · doi:10.1021/ar800255q · Cited by 315
Smart Albumin‐Biomineralized Nanocomposites for Multimodal Imaging and Photothermal Tumor Ablation
Wang, Y., Yang, T., Ke, H., Zhu, A., Wang, Y., Wang, J., Shen, J., Liu, G., Chen, C., Zhao, Y., et al. (2015) · Advanced Materials · doi:10.1002/adma.201500229 · Cited by 313
Polymers for siRNA Delivery: Inspired by Viruses to be Targeted, Dynamic, and Precise
Wagner, E. (2012) · Accounts of Chemical Research · doi:10.1021/ar2002232 · Cited by 308
Zhang, X.-A., Lovejoy, K. S., Jasanoff, A., & Lippard, S. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702393104 · Cited by 294
Ultra-pH-Sensitive Nanoprobe Library with Broad pH Tunability and Fluorescence Emissions
Ma, X., Wang, Y., Zhao, T., Li, Y., Su, L.-C., Wang, Z., Huang, G., Sumer, B. D., & Gao, J. (2014) · Journal of the American Chemical Society · doi:10.1021/ja5053158 · Cited by 292
Self-citationYu, H., Cui, Z., Yu, P., Guo, C., Feng, B., Jiang, T., Wang, S., Yin, Q., Zhong, D., Yang, X., et al. (2015) · Advanced Functional Materials · doi:10.1002/adfm.201404484 · Cited by 253
Self-citationYu, H., Zou, Y., Wang, Y., Huang, X., Huang, G., Sumer, B. D., Boothman, D. A., & Gao, J. (2011) · ACS Nano · doi:10.1021/nn203503h · Cited by 238
Self-citationPluronics and MDR reversal: an update
Alakhova, D. Y., & Kabanov, A. V. (2014) · Molecular Pharmaceutics · doi:10.1021/mp500298q · Cited by 224
Li, J., Yu, X., Wang, Y., Yuan, Y., Xiao, H., Cheng, D., & Shuai, X. (2014) · Advanced Materials · doi:10.1002/adma.201403877 · Cited by 215
Sun, X., Huang, X., Yan, X., Wang, Y., Guo, J., Jacobson, O., Liu, D., Szajek, L. P., Zhu, W., Niu, G., et al. (2014) · ACS Nano · doi:10.1021/nn502950t · Cited by 187
Hybrid nanoparticles for combination therapy of cancer
He, C., Lu, J., & Lin, W. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.09.029 · Cited by 174
A PEGylation-Free Biomimetic Porphyrin Nanoplatform for Personalized Cancer Theranostics
Cui, L., Lin, Q., Jin, C. S., Jiang, W., Huang, H., Ding, L., Muhanna, N., Irish, J. C., Wang, F., Chen, J., et al. (2015) · ACS Nano · doi:10.1021/acsnano.5b01077 · Cited by 172
Wang, X., Li, J., Wang, Y., Cho, K. J., Kim, G., Gjyrezi, A., Koenig, L., Giannakakou, P., Shin, H. J. C., Tighiouart, M., et al. (2009) · ACS Nano · doi:10.1021/nn900649v · Cited by 165
An MRI‐Sensitive, Non‐Photobleachable Porphysome Photothermal Agent
MacDonald, T. D., Liu, T. W., & Zheng, G. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201400133 · Cited by 163
Managing drug resistance in cancer: lessons from HIV therapy
Bock, C., & Lengauer, T. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3297 · Cited by 160
Liu, Y., Zhang, D., Qiao, Z., Qi, G., Liang, X., Chen, X., & Wang, H. (2015) · Advanced Materials · doi:10.1002/adma.201501502 · Cited by 157
Peng, Z., & Kopec̆ek, J. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b00922 · Cited by 151
Paulus, M. J., Gleason, S. S., Easterly, M. E., & Foltz, C. J. (2001) · PubMed · Cited by 146
Mi, P., Dewi, N., Yanagië, H., Kokuryo, D., Suzuki, M., Sakurai, Y., Li, Y., Aoki, I., Ono, K., Takahashi, H., et al. (2015) · ACS Nano · doi:10.1021/acsnano.5b00532 · Cited by 141
Self-citationReversal of doxorubicin resistance in breast cancer by mitochondria-targeted pH-responsive micelles
Yu, P., Yu, H., Guo, C., Cui, Z., Chen, X., Yin, Q., Zhang, P., Yang, X., Cui, H., & Li, Y. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.12.001 · Cited by 137
Self-citationNg, K. K., Lovell, J. F., Vedadi, A., Hajian, T., & Zheng, G. (2013) · ACS Nano · doi:10.1021/nn400418y · Cited by 127
Guo, C., Yin, S., Yu, H., Liu, S., Dong, Q., Goto, T., Zhang, Z., Li, Y., & Sato, T. (2013) · Nanoscale · doi:10.1039/c3nr01025b · Cited by 103
Self-citationTumor-Homing, Size-Tunable Clustered Nanoparticles for Anticancer Therapeutics
Kim, J., Lee, Y. M., Kang, Y., & Kim, W. J. (2014) · ACS Nano · doi:10.1021/nn503349g · Cited by 101
Intracellular pH-activated PEG-b-PDPA wormlike micelles for hydrophobic drug delivery
Yu, H., Xu, Z., Wang, D., Chen, X., Zhang, Z., Yin, Q., & Li, Y. (2013) · Polymer Chemistry · doi:10.1039/c3py00849e · Cited by 61
Self-citation
Cited by
Polymer–drug conjugate therapeutics: advances, insights and prospects
Ekladious, I., Colson, Y. L., & Grinstaff, M. W. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-018-0005-0 · Cited by 855
Self‐Assembled Peptide‐Based Nanomaterials for Biomedical Imaging and Therapy
Qi, G., Gao, Y., Wang, L., & Wang, H. (2018) · Advanced Materials · doi:10.1002/adma.201703444 · Cited by 527
Supramolecular cancer nanotheranostics
Zhou, J., Rao, L., Yu, G., Cook, T. R., Chen, X., & Huang, F. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00011f · Cited by 411
Song, R., Li, T., Ye, J., Sun, F., Hou, B., Saeed, M., Gao, J., Wang, Y., Zhu, Q., Xu, Z., et al. (2021) · Advanced Materials · doi:10.1002/adma.202101155 · Cited by 308
Self-citationOrganelle-Targeted Photosensitizers for Precision Photodynamic Therapy
Wang, R., Li, X., & Yoon, J. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c02019 · Cited by 293
Metadata
- Authors
- Wang, T., Wang, D., Yu, H., Wang, M., Liu, J., Feng, B., Zhou, F., Yin, Q., Zhang, Z., Huang, Y., & Li, Y.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-02-15
- Volume
- 10
- Issue
- 3
- Pages
- 3496-3508
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2258701952
- Cited by
- 295
- References
- 46
- FWCI
- 22.80
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
