Cited by 315Advanced Chemical Sensor TechnologiesGas Sensing Nanomaterials and SensorsElectrochemical sensors and biosensors

Prospects and Challenges of Volatile Organic Compound Sensors in Human Healthcare

Jalal, Ahmed H., Alam, Fahmida, Roychoudhury, Sohini, Umasankar, Yogeswaran, Pala, Nezih, Bhansali, Shekhar·2018·ACS Sensors

Abstract

The chemical signatures of volatile organic compounds (VOCs) in humans can be utilized for point-of-care (POC) diagnosis. Apart from toxic exposure studies, VOCs generated in humans can provide insights into one's healthy and diseased metabolic states, acting as a biomarker for identifying numerous diseases noninvasively. VOC sensors and the technology of e-nose have received significant attention for continuous and selective monitoring of various physiological and pathophysiological conditions of an individual. Noninvasive detection of VOCs is achieved from biomatrices of breath, sweat and saliva. Among these, detection from sweat and saliva can be continuous in real-time. The sensing approaches include optical, chemiresistive and electrochemical techniques. This article provides an overview of such techniques. These, however, have limitations of reliability, precision, selectivity, and stability in continuous monitoring. Such limitations are due to lack of sensor stability and complexity of samples in a multivariate environment, which can lead to false readings. To overcome selectivity barriers, sensor arrays enabling multimodal sensing, have been used with pattern recognition techniques. Stability and precision issues have been addressed through advancements in nanotechnology. The use of various forms of nanomaterial not only enhance sensing performance, but also plays a major role in detection on a miniaturized scale. The rapid growth in medical Internet of Things (IoT) and artificial intelligence paves a pathway for improvements in human theranostics.

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Crossref · 10.1021/acssensors.8b00400

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Authors
Jalal, A. H., Alam, F., Roychoudhury, S., Umasankar, Y., Pala, N., & Bhansali, S.
Affiliations
Florida International University (US)
Corresponding author
Bhansali, Shekhar
Venue
ACS Sensors
Published
2018-06-08
Volume
3
Issue
7
Pages
1246-1263
ISSN
2379-3694 (ISSN-L)
OpenAlex
W2806075947
Cited by
315
References
154
Citations by year
2026: 43 · 2025: 47 · 2024: 52 · 2023: 40 · 2022: 41 · 2021: 40 · 2020: 34 · 2019: 16 · 2018: 2
FWCI
1.87
Type
journal article
Language
en
Open access
closed
Locations
  • ACS Sensors (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University Graduate School, Florida International University
  • National Science Foundation (EEC-1160483)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Advanced Chemical Sensor Technologies
  • Physical Sciences › Engineering › Electrical and Electronic Engineering › Gas Sensing Nanomaterials and Sensors
  • Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
Keywords
volatile organic compounds, VOC sensors, electronic nose, point-of-care diagnosis, non-invasive biomarkers, breath analysis, sweat analysis, saliva testing, electrochemical sensor, chemiresistive sensors, optical sensors, sensor arrays, pattern recognition, nanomaterials, Internet of Medical Things, artificial intelligence, theranostics, continuous physiological monitoring
MeSH terms
Animals, Breath Tests, Chemistry Techniques, Analytical, Equipment Design, Humans, Saliva, Sweat, Biosensing Techniques, Biomarkers, Extracellular Fluid, Volatile Organic Compounds, Electronic Nose

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