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MAP Kinases

Chen, Zhu, Gibson, Tara Beers, Robinson, Fred, Silvestro, Loraine, Pearson, Gray, Xu, Bing-e, Wright, Angelique, Vanderbilt, Colleen, Cobb, Melanie H.·2001·Chemical Reviews

DOI 10.1021/cr000241p

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Abstract

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMAP KinasesZhu Chen, Tara Beers Gibson, Fred Robinson, Loraine Silvestro, Gray Pearson, Bing-e Xu, Angelique Wright, Colleen Vanderbilt, and Melanie H. CobbView Author Information Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 Cite this: Chem. Rev. 2001, 101, 8, 2449–2476Publication Date (Web):July 19, 2001Publication History Received26 March 2001Published online19 July 2001Published inissue 1 August 2001https://pubs.acs.org/doi/10.1021/cr000241phttps://doi.org/10.1021/cr000241presearch-articleACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views5004Altmetric-Citations724LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Cell and molecular biology,Peptides and proteins,Post-translational modification,Receptors,Rodent models Get e-Alerts

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MAPKAP Kinase 2 Phosphorylates Serum Response Factor in Vitro and in Vivo
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A Novel Mechanism of JNK1 Activation
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Identification of Amino Acid Residues and Protein Kinases Involved in the Regulation of NFATc Subcellular Localization
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CalDAG-GEFIII Activation of Ras, R-Ras, and Rap1
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Extracellular regulated kinase (ERK) interaction with actin and the calponin homology (CH) domain of actin-binding proteins
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Interdependent Domains Controlling the Enzymatic Activity of Mitogen-Activated Protein Kinase Kinase 1
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The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf
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Protein modification: Docking sites for kinases
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Phosphorylation by CK2 and MAPK enhances calnexin association with ribosomes
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Craf-1 protein kinase is essential for mouse development
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Activation of the p38 Mitogen-Activated Protein Kinase Pathway by Gonadotropin-Releasing Hormone
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A Mycoplasma fermentans-derived Synthetic Lipopeptide Induces AP-1 and NF-κB Activity and Cytokine Secretion in Macrophages via the Activation of Mitogen-activated Protein Kinase Pathways
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Molecular Cloning and Characterization of a Mitogen-activated Protein Kinase-associated Intracellular Chloride Channel
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Interleukin 18 stimulates HIV type 1 in monocytic cells
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Evidence that inactive p42 mitogen-activated protein kinase and inactive Rsk exist as a heterodimer in vivo.
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Building a cellular switch: more lessons from a good egg
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Stability of the ATF2 Transcription Factor Is Regulated by Phosphorylation and Dephosphorylation
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Differential Activation of Extracellular Signal-Regulated Kinase (ERK) 1, ERK2, p38, and c-Jun NH2-Terminal Kinase Mitogen-Activated Protein Kinases by Bacterial Peptidoglycan
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Interaction of the Grb10 Adapter Protein with the Raf1 and MEK1 Kinases
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MAPKAPK5, a Novel Mitogen-Activated Protein Kinase (MAPK)-Activated Protein Kinase, Is a Substrate of the Extracellular-Regulated Kinase (ERK) and p38 Kinase
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Extracellular Signal-Regulated Kinase (ERK) Interacts with Signal Transducer and Activator of Transcription (STAT) 5a
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Involvement of Mitogen-Activated Protein Kinase Pathways in Interleukin-8 Production by Human Monocytes and Polymorphonuclear Cells Stimulated with Lipopolysaccharide orMycoplasma fermentansMembrane Lipoproteins
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Cytoplasmic localization of the mitogen-activated protein kinase activator MEK.
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Phosphorylation of the Transactivation Domain of Pax6 by Extracellular Signal-regulated Kinase and p38 Mitogen-activated Protein Kinase
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MEKK1 interacts with ?-actinin and localizes to stress fibers and focal adhesions
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The p150-Spir protein provides a link between c-Jun N-terminal kinase function and actin reorganization
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Activation of the HIV-1 Long Terminal Repeat by Cytokines and Environmental Stress Requires an Active CSBP/p38 MAP Kinase
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Murine p38-δ Mitogen-activated Protein Kinase, a Developmentally Regulated Protein Kinase That Is Activated by Stress and Proinflammatory Cytokines
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ERKs and p38 Kinases Mediate Ultraviolet B-induced Phosphorylation of Histone H3 at Serine 10
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Mitogen-Activated Protein (MAP) Kinase Phosphorylation of MAP Kinase Kinase: Determination of Phosphorylation Sites by Mass Spectrometry and Site-Directed Mutagenesis1
Mansour, S. J., Resing, K. A., Candi, J. M., Hermann, A. S., Gloor, J. W., Herskind, K. R., Wartmann, M., Davis, R. J., & Ahn, N. G. (1994) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a124524 · Cited by 98
Tyrosine-phosphorylated Vav1 as a Point of Integration for T-cell Receptor- and CD28-mediated Activation of JNK, p38, and Interleukin-2 Transcription
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MEK Kinase 3 Directly Activates MKK6 and MKK7, Specific Activators of the p38 and c-Jun NH2-terminal Kinases
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Activation of Mitogen-activated Protein Kinase Cascades by p21-activated Protein Kinases in Cell-free Extracts of Xenopus Oocytes
Polverino, A. J., Frost, J. A., Yang, P., Hutchison, M. R., Neiman, A. M., Cobb, M. H., & Marcus, S. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.44.26067 · Cited by 95
Self-citation
Isolation of the Protein Kinase TAO2 and Identification of Its Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Kinase Binding Domain
Chen, Z., Hutchison, M. R., & Cobb, M. H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.40.28803 · Cited by 95
Self-citation
All- trans -Retinoic Acid Inhibits Jun N-Terminal Kinase by Increasing Dual-Specificity Phosphatase Activity
Lee, H., Sueoka, N., Hong, W.-K., Mangelsdorf, D. J., Claret, F. X., & Kurie, J. M. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.3.1973 · Cited by 95
Stress Pathway Activation Induces Phosphorylation of Retinoid X Receptor
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Self-citation
Binding of NCK to SOS and Activation of ras -Dependent Gene Expression
Hu, Q., Milfay, D., & Williams, L. T. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.3.1169 · Cited by 94
Activation of the p38 Mitogen-activated Protein Kinase Pathway by Estrogen or by 4-Hydroxytamoxifen Is Coupled to Estrogen Receptor-induced Apoptosis
Zhang, C. C., & Shapiro, D. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.1.479 · Cited by 93
ERK3 Is a Constitutively Nuclear Protein Kinase
Cheng, M. M., Boulton, T. G., & Cobb, M. H. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.15.8951 · Cited by 93
Self-citation
The activation of distinct mitogen-activated protein kinase cascades is required for the stimulation of 2-deoxyglucose uptake by interleukin-1 and insulin-like growth factor-1 in KB cells
Gould, G. W., Cuenda, A., THOMSON, F. J., & Cohen, P. T. W. (1995) · Biochemical Journal · doi:10.1042/bj3110735 · Cited by 92
Signaling from G Protein-coupled Receptors to ERK5/Big MAPK 1 Involves Gαq and Gα12/13 Families of Heterotrimeric G Proteins
Fukuhara, S., Marinissen, M. J., Chiariello, M., & Gutkind, J. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002410200 · Cited by 92
Nerve Growth Factor-mediated Activation of the Mitogen-activated Protein (MAP) Kinase Cascade Involves a Signaling Complex Containing B-Raf and HSP90
Jaiswal, R. K., Weissinger, E. M., Kölch, W., & Landreth, G. E. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.39.23626 · Cited by 90
Physical Association with Ras Enhances Activation of Membrane-bound Raf (RafCAAX)
Mineo, C., Anderson, R. G. W., & White, M. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.16.10345 · Cited by 90
Analysis of the phosphorylation of human heat shock transcription factor-1 by MAP kinase family members
Kim, J., Nueda, A., Meng, Y., Dynan, W. S., & Mivechi, N. F. (1997) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(19971001)67:1<43::aid-jcb5>3.0.co;2-w · Cited by 90
Enzymatic characteristics of the c-Raf-1 proteinkinase.
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Mitogen-activated protein kinase/extracellular signal-regulated kinase 2 regulates cytoskeletal organization and chemotaxis via catalytic and microtubule-specific interactions.
Reszka, A. A., Bulinski, J. C., Krebs, E. G., & Fischer, E. H. (1997) · Molecular Biology of the Cell · doi:10.1091/mbc.8.7.1219 · Cited by 85
Activation of the Raf/MAP kinase cascade by the Ras‐related protein TC21 is required for the TC21‐mediated transformation of NIH 3T3 cells
Rosário, M., Paterson, H. F., & Marshall, C. J. (1999) · The EMBO Journal · doi:10.1093/emboj/18.5.1270 · Cited by 83
Human JIK, a Novel Member of the STE20 Kinase Family That Inhibits JNK and Is Negatively Regulated by Epidermal Growth Factor
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Constitutive activity and differential localization of p38? and p38? MAPKs in adult mouse brain
Lee, S. H., Park, J. H., Che, Y., Han, P., & Lee, J.-K. (2000) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(20000601)60:5<623::aid-jnr7>3.0.co;2-4 · Cited by 82
Structure-Function Studies of p38 Mitogen-activated Protein Kinase
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Cytokine Induction of Inducible Nitric Oxide Synthase in an Oligodendrocyte Cell Line
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The Strength of Interaction at the Raf Cysteine-Rich Domain Is a Critical Determinant of Response of Raf to Ras Family Small GTPases
Okada, T., Hu, C., Jin, T. J., Kariya, K., Yamawaki‐Kataoka, Y., & Kataoka, T. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.9.6057 · Cited by 81
Localization of Endogenous Grb10 to the Mitochondria and Its Interaction with the Mitochondrial-associated Raf-1 Pool
Nantel, A., Huber, M., & Thomas, D. Y. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.50.35719 · Cited by 80
Activation of JNK3α1 Requires both MKK4 and MKK7: Kinetic Characterization of in Vitro Phosphorylated JNK3α1
Lisnock, J., Griffin, P., Calaycay, J., Frantz, B., Parsons, J., O'Keefe, S. J., & LoGrasso, P. (2000) · Biochemistry · doi:10.1021/bi992410+ · Cited by 79
Molecular cloning and characterization of a novel member of the MAP kinase superfamily
Miyata, Y., Akashi, M., & Nishida, E. (1999) · Genes to Cells · doi:10.1046/j.1365-2443.1999.00261.x · Cited by 76
The MEK1 Proline-rich Insert Is Required for Efficient Activation of the Mitogen-activated Protein Kinases ERK1 and ERK2 in Mammalian Cells
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Self-citation
A splicing variant of a death domain protein that is regulated by a mitogen-activated kinase is a substrate for c-Jun N-terminal kinase in the human central nervous system
Zhang, Y., Zhou, L., & Miller, C. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2586 · Cited by 73
Uncoupling Raf1 from MEK1/2 Impairs Only a Subset of Cellular Responses to Raf Activation
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Self-citation
Extracellular signal-regulated kinases 2 autophosphorylates on a subset of peptides phosphorylated in intact cells in response to insulin and nerve growth factor: analysis by peptide mapping.
Robbins, D. J., & Cobb, M. H. (1992) · Molecular Biology of the Cell · doi:10.1091/mbc.3.3.299 · Cited by 71
Self-citation
Nuclear Localization of Mitogen-activated Protein Kinase Kinase 1 (MKK1) Is Promoted by Serum Stimulation and G2-M Progression
Tolwinski, N. S., Shapiro, P. S., Goueli, S. A., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.10.6168 · Cited by 70
Identification of Stathmin as a Novel Substrate for p38 Delta
Parker, C. G., Hunt, J. B., Diener, K., McGinley, M., Soriano, B., Keesler, G. A., Bray, J., Yao, Z., Wang, X. S., Kohno, T., et al. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9250 · Cited by 70
Significance of Nuclear Relocalization of ERK1/2 in Reactivation of c-fos Transcription and DNA Synthesis in Senescent Fibroblasts
Kim‐Kaneyama, J., Nose, K., & Shibanuma, M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m908723199 · Cited by 70

Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases
Cargnello, M., & Roux, P. P. (2011) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00031-10 · Cited by 3,274
MAP kinase signalling pathways in cancer
Dhillon, A. S., Hagan, S., Rath, O., & Kolch, W. (2007) · Oncogene · doi:10.1038/sj.onc.1210421 · Cited by 2,995
Ros and ros-mediated cellular signaling
Zhang, J., Wang, X., Vikash, V., Ye, Q., Wu, D., Liu, Y., & Dong, W. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/4350965 · Cited by 1,980
Differential regulation and properties of MAPKs
Raman, M., Chen, W., & Cobb, M. H. (2007) · Oncogene · doi:10.1038/sj.onc.1210392 · Cited by 1,430
Self-citation
A systems biology approach for pathway level analysis
Draghici, S., Khatri, P., Tarca, A. L., Amin, K., Done, A., Voichita, C., Georgescu, C., & Romero, R. (2007) · Genome Research · doi:10.1101/gr.6202607 · Cited by 1,249

See all 788

Authors: Chen, Z., Gibson, T. B., Robinson, F., Silvestro, L., Pearson, G., Xu, B.-E., Wright, A., Vanderbilt, C., & Cobb, M. H.
Venue: Chemical Reviews
Publisher: American Chemical Society (ACS)
Published: 2001-07-19
Volume: 101
Issue: 8
Pages: 2449-2476
ISSN: 0009-2665 (ISSN-L)
1520-6890
DOI: 10.1021/cr000241p
OpenAlex: W4211258630
Cited by: 788
References: 441
FWCI: 1.46
Type: journal article
Language: en
Open access: closed

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