The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Targeted Single-Wall Carbon Nanotube-Mediated Pt(IV) Prodrug Delivery Using Folate as a Homing Device
Open accessAbstract
Most low-molecular-weight platinum anticancer drugs have short blood circulation times that are reflected in their reduced tumor uptake and intracellular DNA binding. A platinum(IV) complex of the formula c, c, t-[Pt(NH 3) 2Cl 2(O 2CCH 2CH 2CO 2H)(O 2CCH 2CH 2CONH-PEG-FA)] ( 1), containing a folate derivative (FA) at an axial position, was prepared and characterized. Folic acid offers a means of targeting human cells that highly overexpress the folate receptor (FR). Compound 1 was attached to the surface of an amine-functionalized single-walled carbon nanotube (SWNT-PL-PEG-NH 2) through multiple amide linkages to use the SWNTs as a "longboat delivery system" for the platinum warhead, carrying it to the tumor cell and releasing cisplatin upon intracellular reduction of Pt(IV) to Pt(II). The ability of SWNT tethered 1 to destroy selectively FR(+) vs FR(-) cells demonstrated its ability to target tumor cells that overexpress the FR on their surface. That the SWNTs deliver the folate-bearing Pt(IV) cargos into FR(+) cancer cells by endocytosis was demonstrated by the localization of fluorophore-labeled SWNTs using fluorescence microscopy. Once inside the cell, cisplatin, formed upon reductive release from the longboat oars, enters the nucleus and reacts with its target nuclear DNA, as determined by platinum atomic absorption spectroscopy of cell extracts. Formation of the major cisplatin 1,2-intrastrand d(GpG) cross-links on the nuclear DNA was demonstrated by use of a monoclonal antibody specific for this adduct. The SWNT-tethered compound 1 is the first construct in which both the targeting and delivery moieties have been incorporated into the same molecule; it is also the first demonstration that intracellular reduction of a Pt(IV) prodrug leads to the cis-{Pt((NH 3) 2} 1,2-intrastrand d(GpG) cross-link in nuclear DNA.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cellular processing of platinum anticancer drugs
Wang, D., & Lippard, S. J. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1691 · Cited by 3,801
Self-citation
Cited by
Nanoparticles as drug delivery systems
Wilczewska, A. Z., Niemirowicz, K., Markiewicz, K. H., & Car, H. (2012) · Pharmacological Reports · doi:10.1016/s1734-1140(12)70901-5 · Cited by 1,445
A route to brightly fluorescent carbon nanotubes for near-infrared imaging in mice
Welsher, K., Liu, Z., Sherlock, S. P., Robinson, J. T., Chen, Z., Daranciang, D., & Dai, H. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.294 · Cited by 1,287
Self-citationCarbon nanotubes: properties, synthesis, purification, and medical applications
Eatemadi, A., Daraee, H., Karimkhanloo, H., Kouhi, M., Zarghami, N., Akbarzadeh, A., Abasi, M., Hanifehpour, Y., & Joo, S. W. (2014) · Nanoscale Research Letters · doi:10.1186/1556-276x-9-393 · Cited by 1,239
Nanotechnology-based combinational drug delivery: an emerging approach for cancer therapy
Parhi, P., Mohanty, C., & Sahoo, S. K. (2012) · Drug Discovery Today · doi:10.1016/j.drudis.2012.05.010 · Cited by 573
Mechanisms of drug release in nanotherapeutic delivery systems
Wong, P. T., & Choi, S. K. (2015) · Chemical Reviews · doi:10.1021/cr5004634 · Cited by 507
Yuan, Y., Kwok, R. T. K., Tang, B. Z., & Liu, B. (2014) · Journal of the American Chemical Society · doi:10.1021/ja411811w · Cited by 474
Functionalized carbon nanotubes for potential medicinal applications
Zhang, Y., Bai, Y., & Yan, B. (2010) · Drug Discovery Today · doi:10.1016/j.drudis.2010.04.005 · Cited by 396
Nanocarriers for delivery of platinum anticancer drugs
Oberoi, H. S., Nukolova, N. V., Kabanov, A. V., & Bronich, T. K. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.09.014 · Cited by 396
Nanoparticle-Mediated Combination Therapy: Two-in-One Approach for Cancer
Gurunathan, S., Kang, M.-H., Qasim, M., & Kim, J.-H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103264 · Cited by 367
Advancement in carbon nanotubes: basics, biomedical applications and toxicity
Beg, S., Rizwan, M., Sheikh, A. M., Hasnain, M. S., Anwer, K., & Kohli, K. (2011) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.2010.01167.x · Cited by 306
Nanoparticle formulations of cisplatin for cancer therapy
Duan, X., He, C., Kron, S. J., & Lin, W. (2016) · WIREs Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1390 · Cited by 216
Jayaraman, T., Murthy, A. P., Elakkiya, V., Chandrasekaran, S., Nithyadharseni, P., Khan, Z., Senthil, R. A., Shanker, R., Raghavender, M., Kuppusami, P., et al. (2018) · Journal of Industrial and Engineering Chemistry · doi:10.1016/j.jiec.2018.02.029 · Cited by 183
Liu, H.-Y., Wu, P.-J., Kuo, S.-Y., Chen, C.-P., Chang, E.-H., Wu, C.-Y., & Chan, Y.-H. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b06710 · Cited by 181
Nagai, H., & Toyokuni, S. (2012) · Cancer Science · doi:10.1111/j.1349-7006.2012.02326.x · Cited by 98
Functionalized carbon nanotubes for anticancer drug delivery
Lay, C. L., Liu, J., & Liu, Y. (2011) · Expert Review of Medical Devices · doi:10.1586/erd.11.34 · Cited by 71
PEGylated Single-Walled Carbon Nanotubes as Nanocarriers for Cyclosporin A Delivery
Hadidi, N., Kobarfard, F., Nafissi-Varcheh, N., & Aboofazeli, R. (2013) · AAPS PharmSciTech · doi:10.1208/s12249-013-9944-2 · Cited by 39
Vitol, E. A., Rozhkova, E. A., Rose, V., Stripe, B. D., Young, N. R., Cohen, E. E. W., Leoni, L., & Novosad, V. (2014) · Advanced Materials Interfaces · doi:10.1002/admi.201400182 · Cited by 24
Metadata
- Authors
- Dhar, S., Liu, Z., Thomale, J., Dai, H., & Lippard, S. J.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-07-29
- Volume
- 130
- Issue
- 34
- Pages
- 11467-11476
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2072166383
- Cited by
- 700
- References
- 1
- FWCI
- 19.14
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
