Cited by 76Probiotics and Fermented FoodsGut microbiota and healthMicrobial Metabolites in Food Biotechnology

Probiotic Bacteria for Healthier Aging: Immunomodulation and Metabolism of Phytoestrogens

Open access
Landete, José María, Gaya, Pilar, Rodríguez, Eva, Langa, Susana, Peirotén, Ángela, Medina, Margarita, Arqués, Juan L.·2017·BioMed Research International

Abstract

Age-related degeneration gives rise to a number of pathologies, many of them associated with imbalances of the microbiota and the gut-associated immune system. Thus, the intestine is considered a key target organ to improve the quality of life in senescence. Gut microbiota can have a powerful impact in the deterioration linked to aging by its nutritional and immunomodulatory activity. Reduced numbers of beneficial species and low microbial biodiversity in the elderly have been linked with pathogenesis of many diseases. A healthy lifestyle with an elderly customized diet including probiotics can contribute to reducing the chronic proinflammatory status and other age-related pathologies. Beneficial effects of probiotic lactic acid bacteria and bifidobacteria to alleviate some of these disorders based on their immunomodulatory properties as well as their capacity to produce bioactive metabolites from dietary phytoestrogens are summarized. On one hand, the preservation of gut barrier integrity and an increased ability to fight infections are the main reported immune benefits of probiotics. On the other hand, the intake of a diet rich in phytoestrogens along with the presence of selected probiotic bacteria may lead to the production of equol, enterolignans, and urolithins, which are considered protective against chronic diseases related to aging.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1155/2017/5939818

Cites

141 of 141 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

1 retracted

Flagged first, then by citations

Research works printed but not linked: 3

  1. [102]Setchell K. D. R. Equol - Origins, actions, and clinical relevance of this specific soy isoflavone metabolite J Nutr—Journal of Nutrition 2004 134 1235S 1236S
  2. [112]Uchiyama S. Ueno T. Suzuki T. Identification of a newly isolated equol-producing lactic acid bacterium from the human feces J Intest Microbiol—Journal of Intestinal Microbiology 2007 21 217 220
  3. [120]Gutte K. B. Sahoo A. K. Ranveer R. C. Bioactive components of flaxseed and its health benefits Int J PharmSci Rev Res—International Journal of Pharmaceutical Sciences Review and Research 2015 31 42 51

Cited by

Sorted by citations

Authors
Landete, J. M., Gaya, P., Rodríguez, E., Langa, S., Peirotén, Á., Medina, M., & Arqués, J. L.
Affiliations
  • Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (ES)
  • Departamento Tecnología de Alimentos, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Carretera de La Coruña Km 7, 28040 Madrid, Spain
Corresponding author
Arqués, Juan L.
Venue
BioMed Research International
Publisher
Wiley
Published
2017
Volume
2017
Pages
1-10
ISSN
  • 1110-7243 (ISSN-L)
  • 2314-6133
  • 2314-6141
OpenAlex
W2757316484
Cited by
76
References
139
Citations by year
2026: 1 · 2025: 6 · 2024: 6 · 2023: 12 · 2022: 12 · 2021: 10 · 2020: 11 · 2019: 12 · 2018: 6
FWCI
0.86
Type
journal article
Language
en
Open access
Locations
  • BioMed Research International (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
Funders
Ministerio de Economía y Competitividad (RM12-00004-00-00, RTA2013-00029-00-00)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords
probiotics, healthy aging, gut microbiota, immunomodulation, phytoestrogens, lactic acid bacteria, Bifidobacterium, equol, enterolignans, urolithins, intestinal barrier integrity, chronic inflammation, age-related diseases, elderly nutrition
MeSH terms
Gastrointestinal Microbiome, Aged, Aging, Bifidobacterium, Humans, Immune System, Intestines, Quality of Life, Probiotics, Phytoestrogens, Immunomodulation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review