The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Enhanced Gene Delivery and siRNA Silencing by Gold Nanoparticles Coated with Charge-Reversal Polyelectrolyte
Open accessAbstract
Charge-reversal functional gold nanoparticles first prepared by layer-by-layer technique were employed to deliver small interfering RNA (siRNA) and plasmid DNA into cancer cells. Polyacrylamide gel electrophoresis measurements of siRNA confirmed the occurrence of the charge-reversal property of functional gold nanoparticles. The expression efficiency of enhanced green fluorescent protein (EGFP) was improved by adjuvant transfection with charge-reversal functional gold nanoparticles, which also had much lower toxicity to cell proliferation. Lamin A/C, an important nuclear envelope protein, was effectively silenced by lamin A/C-siRNA delivered by charge-reversal functional gold nanoparticles, whose knockdown efficiency was better than that of commercial Lipofectamine 2000. Confocal laser scanning microscopic images indicated that there was more cy5-siRNA distributed throughout the cytoplasm for cyanine 5-siRNA/polyethyleneimine/cis-aconitic anhydride-functionalized poly(allylamine)/ polyethyleneimine/11-mercaptoundecanoic acid-gold nanoparticle (cy5-siRNA/PEI/PAH-Cit/PEI/MUA-AuNP) complexes. These results demonstrate the feasibility of using charge-reversal functional gold nanoparticles as a means of improving the nucleic acid delivery efficiency.
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Cites
Gold nanoparticles in delivery applications☆
GHOSH, P., HAN, G., DE, M., KIM, C., & ROTELLO, V (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.03.016 · Cited by 2,694
Rational siRNA design for RNA interference
Reynolds, A., Leake, D., Boese, Q., Scaringe, S., Marshall, W. S., & Khvorova, A. (2004) · Nature Biotechnology · doi:10.1038/nbt936 · Cited by 2,094
Oligonucleotide-Modified Gold Nanoparticles for Intracellular Gene Regulation
Rosi, N. L., Giljohann, D. A., Thaxton, C. S., Lytton-Jean, A. K. R., Han, M. S., & Mirkin, C. A. (2006) · Science · doi:10.1126/science.1125559 · Cited by 1,988
siRNA-mediated gene silencing in vitro and in vivo
Xia, H., Mao, Q., Paulson, H. L., & Davidson, B. L. (2002) · Nature Biotechnology · doi:10.1038/nbt739 · Cited by 873
Glutathione-Mediated Delivery and Release Using Monolayer Protected Nanoparticle Carriers
Hong, R., Han, G., Fernández, J. M., Kim, B.-J., Forbes, N. S., & Rotello, V. M. (2006) · Journal of the American Chemical Society · doi:10.1021/ja056726i · Cited by 817
siRNA-directed inhibition of HIV-1 infection
Novina, C. D., Murray, M. F., Dykxhoorn, D. M., Beresford, P. J., Riess, J., Lee, S.-K., Collman, R. G., Lieberman, J., Shankar, P., & Sharp, P. A. (2002) · Nature Medicine · doi:10.1038/nm725 · Cited by 773
LMNA, encoding lamin A/C, is mutated in partial lipodystrophy
Shackleton, S., Lloyd, D. J., Jackson, S. N. J., Evans, R., Niermeijer, M. F., Singh, B. M., Schmidt, H., Brabant, G., Kumar, S., Durrington, P. N., et al. (2000) · Nature Genetics · doi:10.1038/72807 · Cited by 704
Gene Regulation with Polyvalent siRNA−Nanoparticle Conjugates
Giljohann, D. A., Seferos, D. S., Prigodich, A. E., Patel, P. C., & Mirkin, C. A. (2009) · Journal of the American Chemical Society · doi:10.1021/ja808719p · Cited by 637
Thomas, M., & Klibanov, A. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1233634100 · Cited by 549
Paclitaxel-Functionalized Gold Nanoparticles
Gibson, J. D., Khanal, B. P., & Zubarev, E. R. (2007) · Journal of the American Chemical Society · doi:10.1021/ja075181k · Cited by 484
Ghosh, P. S., Kim, C.-K., Han, G., Forbes, N. S., & Rotello, V. M. (2008) · ACS Nano · doi:10.1021/nn800507t · Cited by 459
Layer-by-Layer Assembled Gold Nanoparticles for siRNA Delivery
Elbakry, A., Zaky, A., Liebl, R., Rachel, R., Goepferich, A., & Breunig, M. (2009) · Nano Letters · doi:10.1021/nl9003865 · Cited by 425
Chen, C.-C., Lin, Y.-P., Wang, C.-W., Tzeng, H.-C., Wu, C.-H., Chen, Y.-C., Chen, C.-P., Chen, L.-C., & Wu, Y.-C. (2006) · Journal of the American Chemical Society · doi:10.1021/ja0570180 · Cited by 424
Miyata, K., Oba, M., Nakanishi, M., Fukushima, S., Yamasaki, Y., Koyama, H., Nishiyama, N., & Kataoka, K. (2008) · Journal of the American Chemical Society · doi:10.1021/ja804561g · Cited by 371
Targeted Charge‐Reversal Nanoparticles for Nuclear Drug Delivery
Xu, P., Van Kirk, E. A., Zhan, Y., Murdoch, W. J., Radosz, M., & Shen, Y. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200605254 · Cited by 370
Entrapment of Hydrophobic Drugs in Nanoparticle Monolayers with Efficient Release into Cancer Cells
Kim, C. K., Ghosh, P., Pagliuca, C., Zhu, Z.-J., Menichetti, S., & Rotello, V. M. (2009) · Journal of the American Chemical Society · doi:10.1021/ja808137c · Cited by 340
Prabaharan, M., Grailer, J. J., Pilla, S., Steeber, D. A., & Gong, S. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.07.048 · Cited by 337
Light‐Regulated Release of DNA and Its Delivery to Nuclei by Means of Photolabile Gold Nanoparticles
Han, G., You, C., Kim, B., Turingan, R. S., Forbes, N. S., Martin, C. T., & Rotello, V. M. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200600214 · Cited by 296
Gold, Poly(β-amino ester) Nanoparticles for Small Interfering RNA Delivery
Lee, J.-S., Green, J. J., Love, K. T., Sunshine, J., Langer, R., & Anderson, D. G. (2009) · Nano Letters · doi:10.1021/nl9009793 · Cited by 276
Laser-Activated Gene Silencing via Gold Nanoshell−siRNA Conjugates
Braun, G. B., Pallaoro, A., Wu, G., Missirlis, D., Zasadzinski, J. A., Tirrell, M., & Reich, N. O. (2009) · ACS Nano · doi:10.1021/nn900469q · Cited by 270
Lee, Y., Miyata, K., Oba, M., Ishii, T., Fukushima, S., Han, M., Koyama, H., Nishiyama, N., & Kataoka, K. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200800963 · Cited by 229
Aryal, S., Grailer, J. J., Pilla, S., Steeber, D. A., & Gong, S. (2009) · Journal of Materials Chemistry · doi:10.1039/b914071a · Cited by 226
Schneider, G. F., & Decher, G. (2008) · Langmuir · doi:10.1021/la7021837 · Cited by 212
Niidome, T., Nakashima, K., Takahashi, H., & Niidome, Y. (2004) · Chemical Communications · doi:10.1039/b406189f · Cited by 202
Huang, H.-C., Barua, S., Kay, D. B., & Rege, K. (2009) · ACS Nano · doi:10.1021/nn900947a · Cited by 180
Endosomolysis by Masking of a Membrane-Active Agent (EMMA) for Cytoplasmic Release of Macromolecules
Rozema, D. B., Ekena, K., Lewis, D. L., Loomis, A. G., & Wolff, J. A. (2003) · Bioconjugate Chemistry · doi:10.1021/bc0255945 · Cited by 161
Multifunctional Cytotoxic Stealth Nanoparticles. A Model Approach with Potential for Cancer Therapy
Schneider, G. F., Šubr, V., Ulbrich, K., & Decher, G. (2009) · Nano Letters · doi:10.1021/nl802990w · Cited by 131
Biodegradable nanoparticles modified by branched polyethylenimine for plasmid DNA delivery
Son, S., & Kim, W. J. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.09.024 · Cited by 103
Liu, X., Zhang, J., & Lynn, D. M. (2008) · Soft Matter · doi:10.1039/b804953j · Cited by 78
Lipid–Gold‐Nanoparticle Hybrid‐Based Gene Delivery
Rhim, W., Kim, J., & Nam, J. (2008) · Small · doi:10.1002/smll.200800628 · Cited by 62
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Therapeutic siRNA: state of the art
Hu, B., Zhong, L., Weng, Y., Peng, L., Huang, Y., Zhao, Y., & Liang, X.-J. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0207-x · Cited by 1,586
Self-citationpH-Sensitive nano-systems for drug delivery in cancer therapy
Liu, J., Huang, Y., Kumar, A., Tan, A., Jin, S., Mozhi, A., & Liang, X.-J. (2014) · Biotechnology Advances · doi:10.1016/j.biotechadv.2013.11.009 · Cited by 1,121
Self-citationVarious methods of gold nanoparticles (GNPs) conjugation to antibodies
Jazayeri, M. H., Amani, H., Pourfatollah, A. A., Pazoki-Toroudi, H., & Sedighimoghaddam, B. (2016) · Sensing and Bio-Sensing Research · doi:10.1016/j.sbsr.2016.04.002 · Cited by 528
Gold Nanoparticles for Nucleic Acid Delivery
Ding, Y., Jiang, Z., Saha, K., Kim, C. S., Kim, S. T., Landis, R. F., & Rotello, V. M. (2014) · Molecular Therapy · doi:10.1038/mt.2014.30 · Cited by 521
The challenge and prospect of mRNA therapeutics landscape
Weng, Y., Li, C., Yang, T., Hu, B., Zhang, M., Guo, S., Xiao, H., Liang, X.-J., & Huang, Y. (2020) · Biotechnology Advances · doi:10.1016/j.biotechadv.2020.107534 · Cited by 417
Self-citation
Metadata
- Authors
- Guo, S., Huang, Y., Jiang, Q., Sun, Y., Deng, L., Liang, Z., Du, Q., Xing, J., Zhao, Y., Wang, P. C., Dong, A., & Liang, X.-J.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-08-13
- Volume
- 4
- Issue
- 9
- Pages
- 5505-5511
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2141839114
- Cited by
- 401
- References
- 30
- FWCI
- 9.92
- Type
- journal article
- Language
- en
- Open access
- green
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