Effect of Lactobacillus plantarum 299v on Colonic Fermentation and Symptoms of Irritable Bowel Syndrome

Sen, S.; Mullan, M.M.; Parker, T.J.; Woolner, J.T.; Tarry, S.A.; Hunter, J.O.

doi:10.1023/a:1020597001460

Cited by 245Gastrointestinal motility and disordersProbiotics and Fermented FoodsGut microbiota and health

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

Effect of Lactobacillus plantarum 299v on Colonic Fermentation and Symptoms of Irritable Bowel Syndrome

Sen, S., Mullan, M.M., Parker, T.J., Woolner, J.T., Tarry, S.A., Hunter, J.O.·2002·Digestive Diseases and Sciences

DOI 10.1023/a:1020597001460

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Abstract

A number of recent clinical trials have promoted the use of probiotic bacteria as a treatment for irritable bowel syndrome (IBS). The recent demonstration of abnormal colonic fermentation in some patients with this condition provides an opportunity for the objective assessment of the therapeutic value of these bacteria. This study was designed to investigate the effects of Lactobacillus plantarum 299V on colonic fermentation. We conducted a double-blind, placebo-controlled, cross-over, four-week trial of Lactobacillus plantarum 299V in 12 previously untreated patients with IBS. Symptoms were assessed daily by a validated composite score and fermentation by 24-hr indirect calorimetry in a 1.4-m3 canopy followed by breath hydrogen determination for 3 hr after 20 ml of lactulose. On placebo, the median symptom score was 8.5 [6.25-11.25 interquartile range (IQR)], the median maximum rate of gas production was 0.55 ml/min (0.4-1.1 IQR), and the median hydrogen production was 189.7 ml/24 hr (118.3-291.1 IQR). On Lactobacillus plantarum 299V the median symptom score was 8 (6.75-13.5 IQR), the median maximum rate of gas production 0.92 ml/min (0.45-1.5 IQR), and the median hydrogen production 208.2 ml/24 hr (146-350.9 IQR). There was no significant difference. Breath hydrogen excretion after lactulose was reduced by the probiotic (median at 120 min, 6 ppm; placebo, 17 ppm; P = 0.019). In conclusion, Lactobacillus plantarum 299V in this study did not appear to alter colonic fermentati…

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Two studies reported no difference between specific probiotic treatments and placebo, and one study reported a significant worsening of diarrhoea with the specific probiotic treatment compared with placebo.
“Two studies reported no difference between specific probiotic treatments and placebo,28–37 and one study reported a significant worsening of diarrhoea with the specific probiotic treatment compared with placebo.59”
From Systematic review: probiotics in the management of lower gastrointestinal symptoms in clinical practice - an evidence-based international guide (2013) · cites this paper as [30]
Twelve studies evaluated abdominal pain as a secondary end point only, with mixed results: one reported a negative effect, eight reported no significant effect, and three reported a significant beneficial effect.
“Twelve studies evaluated abdominal pain as a secondary end point only. Results from these studies were mixed: one reported a negative effect of the specific probiotic treatment,59 eight (examining six different probiotics) reported no significant effect28–38 and three reported a significant beneficial effect of three different probiotics35,39”
From Systematic review: probiotics in the management of lower gastrointestinal symptoms in clinical practice - an evidence-based international guide (2013) · cites this paper as [30]
All three studies that examined flatus as a primary end point, and four of seven studies in which flatus was a secondary end point only, showed no significant difference between seven specific probiotic treatments and control.
“all three studies that examined flatus as a primary end point,30,57 and four of seven studies in which flatus was a secondary end point only,28–38 showed no significant difference between seven specific probiotic treatments and control.”
From Systematic review: probiotics in the management of lower gastrointestinal symptoms in clinical practice - an evidence-based international guide (2013) · cites this paper as [30]
Probiotics tested to date do not help reduce flatus in patients with IBS, with low grade of evidence.
“Probiotics tested to date do not help reduce flatus in patients with IBS Low [147,149-150,156,168,174-175, 178-179,184]”
From Gut microbiota role in irritable bowel syndrome: New therapeutic strategies (2016) · cites this paper as [178]

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A controlled, double-blind, randomized study on the efficacy of Lactobacillus plantarum 299V in patients with irritable bowel syndrome
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Role of Lactobacillus plantarum 299v versus Placebo in symptomatic improvement of irritable bowel syndrome patients
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WITHDRAWN: A Double Blind Randomized Clinical Trail: Comparing Lactobacillus plantarum 299v with Placebo in treating irritable bowel syndrome patientsPreprint
haq, M.-U., Ullah, F., Hassan, M., Babar, A. N., & Ullah, A. (2020) · Research Square · doi:10.21203/rs.2.23376/v1

Authors: Sen, S., Mullan, M. M., Parker, T. J., Woolner, J. T., Tarry, S. A., & Hunter, J. O.
Affiliations: Addenbrooke's Hospital (GB)
ORCID: Parker, T.J.
Venue: Digestive Diseases and Sciences
Publisher: Springer Science and Business Media LLC
Published: 2002-11
Volume: 47
Issue: 11
Pages: 2615-2620
ISSN: 0163-2116 (ISSN-L)
1573-2568
DOI: 10.1023/a:1020597001460
OpenAlex: W2059455849
Cited by: 245
References: 25
Citations by year: 2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 5 · 2017: 8 · 2016: 7 · 2015: 2 · 2014: 16 · 2013: 12 · 2012: 17
FWCI: 10.86
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Digestive Diseases and Sciences (publishedVersion)
PubMed (publishedVersion)
Funders: Lunds Universitet
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: Lactobacillus plantarum 299v, irritable bowel syndrome, probiotics, colonic fermentation, breath hydrogen, lactulose breath test, gas production, IBS symptoms, indirect calorimetry
MeSH terms: Adult, Breath Tests, Calorimetry, Indirect, Colon, Colonic Diseases, Functional, Double-Blind Method, Female, Fermentation, Humans, Hydrogen, Lactobacillus, Male, Middle Aged, Avena, Cross-Over Studies, Probiotics

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Effect of Lactobacillus plantarum 299v on Colonic Fermentation and Symptoms of Irritable Bowel Syndrome

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