Influence of Shock Training and Explicit Fear-Conditioned Cues on Sleep Architecture in Mice: Strain Comparison

Sanford, Larry D.; Tang, Xiangdong; Ross, Richard J.; Morrison, Adrian R.

doi:10.1023/a:1021051516829

Cited by 108Sleep and Wakefulness ResearchMemory and Neural MechanismsSleep and related disorders

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Influence of Shock Training and Explicit Fear-Conditioned Cues on Sleep Architecture in Mice: Strain Comparison

Sanford, Larry D., Tang, Xiangdong, Ross, Richard J., Morrison, Adrian R.·2003·Behavior Genetics

DOI 10.1023/a:1021051516829

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Abstract

Fear conditioning is thought to model anticipatory anxiety. Inbred mouse strains exhibit different levels of reactivity to aversive environmental stimuli, which may reflect anxiety. We examined the effects of fear conditioning on sleep in mouse strains that differ on behavioral measures of anxiety. Mice (BALB/cJ [C], C57BL/6J [B6], CB6F1/J [CB6], n = 7-10 per strain) were implanted with transmitters for recording sleep by telemetry. Baseline sleep was recorded, and the mice were trained to associate a cue (tone) with footshock (15 cue-shock pairings on 4 consecutive days). Sleep was recorded after shock training and again 4 to 5 days later after presentation of the cue alone. Shock training produced a relatively selective suppression of rapid eye movement sleep (REM) that was greater in the C strain compared to the B6 and CB6 mice. Post-training exposure to the cue alone suppressed REM in all strains. The C strain exhibited a relatively greater immediate suppression of REM, and the CB6 hybrid mice showed the greatest overall suppression of REM. These data demonstrate that stimuli associated with an aversive event can alter sleep and suppress REM in much the same way as exposure to the event itself. Fear conditioning may provide a model for examining genetic and neural mechanisms underlying the influence of anxiety on sleep.

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“Baseline sleep (Tang and Sanford, 2002) and sleep after footshock training (Sanford et al., 2003a,b,c) in BALB/cJ mice have been described in a number of previous papers and these data are not included here.”
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Authors: Sanford, L. D., Tang, X., Ross, R. J., & Morrison, A. R.
Affiliations: Eastern Virginia Medical School (US)
University of Pennsylvania (US)
Corresponding author: Sanford, Larry D.
ORCID: Sanford, Larry D.
Tang, Xiangdong
Ross, Richard J.
Venue: Behavior Genetics
Publisher: Springer Science and Business Media LLC
Published: 2003-01
Volume: 33
Issue: 1
Pages: 43-58
ISSN: 0001-8244 (ISSN-L)
1573-3297
DOI: 10.1023/a:1021051516829
OpenAlex: W139460844
Cited by: 106
References: 35
Citations by year: 2026: 1 · 2025: 1 · 2024: 1 · 2023: 4 · 2022: 5 · 2021: 3 · 2020: 1 · 2019: 4 · 2018: 3 · 2017: 3 · 2016: 6 · 2015: 6 · 2014: 2 · 2013: 6 · 2012: 6
FWCI: 2.45
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Behavior Genetics (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute for Health and Care Research
National Institutes of Health (5r01ns036694-04)
National Institute of Mental Health (R01MH061716, MH64827, MH 61716, R01MH064827)
National Institute of Neurological Disorders and Stroke (NS36694)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords: fear conditioning, sleep architecture, REM sleep suppression, anticipatory anxiety, inbred mouse strains, BALB/cJ, C57BL/6J mice, hybrid mice, aversive stimuli, footshock
MeSH terms: Analysis of Variance, Animals, Conditioning, Psychological, Cues, Electroshock, Fear, Genetics, Behavioral, Hybridization, Genetic, Male, Mice, Inbred BALB C, Mice, Inbred C57BL, Sleep, Sleep, REM, Reflex, Startle, Telemetry, Time Factors, Mice

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Influence of Shock Training and Explicit Fear-Conditioned Cues on Sleep Architecture in Mice: Strain Comparison

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