Extended treatment with bupropion SR for cigarette smoking cessation

Killen, Joel D.; Fortmann, Stephen P.; Murphy, Greer M.; Hayward, Chris; Arredondo, Christina; Cromp, DeAnn; Celio, Maria; Abe, Laurie; Wang, Yun; Schatzberg, Alan F.

doi:10.1037/0022-006x.74.2.286

Cited by 80Smoking Behavior and CessationSubstance Abuse Treatment and OutcomesPrenatal Substance Exposure Effects

Extended treatment with bupropion SR for cigarette smoking cessation

Killen, Joel D., Fortmann, Stephen P., Murphy, Greer M., Hayward, Chris, Arredondo, Christina, Cromp, DeAnn, Celio, Maria, Abe, Laurie +2 more·2006·Journal of Consulting and Clinical Psychology

DOI 10.1037/0022-006x.74.2.286

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Abstract

The authors present results of a randomized clinical trial of the efficacy of extended treatment with bupropion SR in producing longer term cigarette smoking cessation. Adult smokers (N = 362) received open-label treatment (11 weeks) that combined relapse prevention training, bupropion SR, and nicotine patch followed by extended treatment (14 weeks) with bupropion SR or matching placebo. Abstinence percentages were relatively high (week 11: 52%; week 25: bupropion, 42%; placebo, 38%; week 52: bupropion, 33%; placebo, 34%), but bupropion SR did not surpass placebo. Gender and baseline craving level were identified as significant, independent moderators of treatment response. Men were more likely to abstain than women (week 11: 59% vs. 43%, p = .001; week 25: 48% vs. 31%, p = .001; week 52: 39% vs. 27%, p = .01). Because most smokers suffer relapse with any current cessation treatment, the comparatively high abstinence percentages achieved in this trial are of interest.

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No differences were observed between bupropion versus placebo both during and after relapse prevention intervention in other studies.
“In other studies, no differences were observed between bupropion versus placebo both during and after relapse prevention intervention (117, 118).”
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Bupropion for Smoking Cessation
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Authors: Killen, J. D., Fortmann, S. P., Murphy, G. M., Hayward, C., Arredondo, C., Cromp, D., Celio, M., Abe, L., Wang, Y., & Schatzberg, A. F.
Affiliations: Stanford Medicine (US)
ORCID: Fortmann, Stephen P.
Wang, Yun
Schatzberg, Alan F.
Venue: Journal of Consulting and Clinical Psychology
Publisher: American Psychological Association (APA)
Published: 2006
Volume: 74
Issue: 2
Pages: 286-294
ISSN: 0022-006X (ISSN-L)
1939-2117
DOI: 10.1037/0022-006x.74.2.286
OpenAlex: W1994470828
Cited by: 80
References: 53
Citations by year: 2025: 1 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 2 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 6 · 2012: 7
FWCI: 6.85
Type: journal article
Language: en
Open access: closed
Locations: Journal of Consulting and Clinical Psychology (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (CA 090300)
Topics: Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Keywords: bupropion sustained release, smoking cessation, extended treatment, relapse prevention training, nicotine patch, smoking abstinence, gender differences, treatment moderators, nicotine dependence
MeSH terms: Adolescent, Adult, Aged, Delayed-Action Preparations, Female, Humans, Male, Middle Aged, Smoking, Smoking Cessation, Bupropion

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Extended treatment with bupropion SR for cigarette smoking cessation

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