Hippocampal lesions cause learning deficits in inbred mice in the Morris water maze and conditioned-fear task

Place navigation impaired in rats with hippocampal lesions

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Impaired Learning and Motor Behavior in Heterozygous Pafah1b1 (Lis1) Mutant MicePreprint

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Contextual and cued fear conditioning in C57BL/6J and DBA/2J mice: Context discrimination and the effects of retention interval.

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Inbred strain variation in contextual and cued fear conditioning behavior

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Quantification of swim patterns in the morris water maze

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Cued and Contextual Fear Conditioning in Mice

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Different rankings of inbred mouse strains on the Morris maze and a refined 4-arm water escape task

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The Relationship between Acute Glucocorticoid Levels and Hippocampal Function Depends upon Task Aversiveness and Memory Processing Stage

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Gadd45b knockout mice exhibit selective deficits in hippocampus-dependent long-term memoryPreprint

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Developmental effects of acute, chronic, and withdrawal from chronic nicotine on fear conditioning

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Behavioral validation of the Ts65Dn mouse model for Down syndrome of a genetic background free of the retinal degeneration mutation Pde6brd1

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Decreased motivation to eat in µ‐opioid receptor‐deficient mice

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Nicotine Enhances Contextual Fear Conditioning and Ameliorates Ethanol-Induced Deficits in Contextual Fear Conditioning.

Gould, T. J., & Lommock, J. A. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.6.1276 · Cited by 80

Experimental parameters affecting the Morris water maze performance of a mouse model of Down syndrome

Stasko, M. R., & Costa, A. C. S. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.01.012 · Cited by 83

Consolidation and translation regulation: Figure 1.Preprint

Gal-Ben-Ari, S., Kenney, J. W., Ounalla-Saad, H., Taha, E., David, O., Levitan, D., Gildish, I., Panja, D., Pai, B., Wibrand, K., et al. (2012) · Learning & Memory · doi:10.1101/lm.026849.112 · Cited by 80

The effects of DHBE and MLA on nicotine-induced enhancement of contextual fear conditioning in C57BL/6 mice

Davis, J. A., & Gould, T. J. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0047-y · Cited by 78

Hippocampal gene expression profiling across eight mouse inbred strains: towards understanding the molecular basis for behaviour

Fernandes, C., Paya-Cano, J., Sluyter, F., D'Souza, U., Plomin, R., & Schalkwyk, L. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03358.x · Cited by 94

Nicotine enhances trace cued fear conditioning but not delay cued fear conditioning in C57BL/6 mice

Gould, T. J., Feiro, O., & Moore, D. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.04.009 · Cited by 78

Conditioned response suppression in the IntelliCage: assessment of mouse strain differences and effects of hippocampal and striatal lesions on acquisition and retention of memory

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Neuroprotective role of taurine during aging

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4′-Demethylnobiletin, a Bioactive Metabolite of Nobiletin Enhancing PKA/ERK/CREB Signaling, Rescues Learning Impairment Associated with NMDA Receptor Antagonism via Stimulation of the ERK Cascade

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Terminalia chebula extract prevents scopolamine-induced amnesia via cholinergic modulation and anti-oxidative effects in mice

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Identification of quantitative trait loci involved in contextual and auditory-cued fear conditioning in BXD recombinant inbred strains.

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Nicotine, adolescence, and stress: A review of how stress can modulate the negative consequences of adolescent nicotine abuse

Holliday, E. D., & Gould, T. J. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.04.003 · Cited by 78

Minocycline, a second-generation tetracycline, as a neuroprotective agent in an animal model of schizophrenia

Levkovitz, Y., Levi, U., Braw, Y., & Cohen, H. (2007) · Brain Research · doi:10.1016/j.brainres.2007.03.080 · Cited by 74

Deficits in Trace Cued Fear Conditioning in Galanin-Treated Rats and Galanin-Overexpressing Transgenic MicePreprint

Kinney, J. W., Starosta, G., Holmes, A., Wrenn, C. C., Yang, R. J., Harris, A. P., Long, K. C., & Crawley, J. N. (2002) · Learning & Memory · doi:10.1101/m.49502 · Cited by 74

Long‐term monitoring of hippocampus‐dependent behavior in naturalistic settings: Mutant mice lacking neurotrophin receptor TrkB in the forebrain show spatial learning but impaired behavioral flexibility

Vyssotski, A. L., Dell'Omo, G., Poletaeva, I. I., Vyssotski, D. L., Minichiello, L., Klein, R., Wolfer, D. P., & Lipp, H. (2002) · Hippocampus · doi:10.1002/hipo.10002 · Cited by 72

SNAP‐25 in hippocampal CA1 region is involved in memory consolidation

Hou, Q., Gao, X., Zhang, X., Kong, L., Wang, X., Bian, W., Tu, Y., Jin, M., Zhao, G., Li, B., et al. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03600.x · Cited by 75

β2 subunit-containing nicotinic receptors mediate the enhancing effect of nicotine on trace cued fear conditioning in C57BL/6 mice

Davis, J. A., & Gould, T. J. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0624-8 · Cited by 72

Atp8a1 deficiency is associated with phosphatidylserine externalization in hippocampus and delayed hippocampus‐dependent learning

Levano, K. S., Punia, V., Raghunath, M., Debata, P. R., Curcio, G. M., Mogha, A., Purkayastha, S., McCloskey, D. P., Fata, J. E., & Banerjee, P. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07543.x · Cited by 71

Two Genes on A/J Chromosome 18 Are Associated with Susceptibility to Staphylococcus aureus Infection by Combined Microarray and QTL Analyses

Ahn, S. H., Deshmukh, H. S., Johnson, N. V., Cowell, L. G., Rude, T. H., Scott, W. K., Nelson, C. L., Zaas, A. K., Marchuk, D. A., Keum, S., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001088 · Cited by 71

Nobiletin, a Citrus Flavonoid, Reverses Learning Impairment Associated with N-Methyl-D-aspartate Receptor Antagonism by Activation of Extracellular Signal-Regulated Kinase Signaling

Nakajima, A., Yamakuni, T., Matsuzaki, K., Nakata, N., Onozuka, H., Yokosuka, A., Sashida, Y., Mimaki, Y., & Ohizumi, Y. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.117010 · Cited by 71

Autism-like behaviours and enhanced memory formation and synaptic plasticity in Lrfn2/SALM1-deficient mice

Morimura, N., Yasuda, H., Yamaguchi, K., Katayama, K.-I., Hatayama, M., Tomioka, N. H., Odagawa, M., Kamiya, A., Iwayama, Y., Maekawa, M., et al. (2017) · Nature Communications · doi:10.1038/ncomms15800 · Cited by 73

Ca-Stimulated Type 8 Adenylyl Cyclase Is Required for Rapid Acquisition of Novel Spatial Information and for Working/Episodic-Like Memory

Zhang, M., Moon, C., Chan, G. C.-K., Yang, L., Zheng, F., Conti, A. C., Muglia, L., Muglia, L. J., Storm, D. R., & Wang, H. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1177-08.2008 · Cited by 67

Cellular, molecular, and genetic substrates underlying the impact of nicotine on learning

Gould, T. J., & Leach, P. T. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.08.004 · Cited by 72

Loss of the tailless gene affects forebrain development and emotional behavior

ROY, K., Thiels, E., & Monaghan, A. P. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00902-2 · Cited by 67

Gravin Orchestrates Protein Kinase A and β2-Adrenergic Receptor Signaling Critical for Synaptic Plasticity and Memory

Havekes, R., Canton, D. A., Park, A. J., Huang, T., Nie, T., Day, J. P., Guercio, L. A., Grimes, Q., Luczak, V., Gelman, I. H., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3612-12.2012 · Cited by 68

β2 subunit containing acetylcholine receptors mediate nicotine withdrawal deficits in the acquisition of contextual fear conditioning

Portugal, G. S., Kenney, J. W., & Gould, T. J. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.05.002 · Cited by 66

Nicotinic receptors in the dorsal and ventral hippocampus differentially modulate contextual fear conditioning

Kenney, J. W., Raybuck, J. D., & Gould, T. J. (2012) · Hippocampus · doi:10.1002/hipo.22003 · Cited by 70

Alcohol‐induced memory impairment in trace fear conditioning: A hippocampus‐specific effect

Weitemier, A. Z., & Ryabinin, A. E. (2003) · Hippocampus · doi:10.1002/hipo.10063 · Cited by 66

Mutant mice lacking ryanodine receptor type 3 exhibit deficits of contextual fear conditioning and activation of calcium/calmodulin-dependent protein kinase II in the hippocampus

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Nicotine enhances both foreground and background contextual fear conditioning

Davis, J. A., Porter, J., & Gould, T. J. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2005.10.026 · Cited by 65

Nicotine addiction and psychiatric disorders

Kutlu, M. G., Parikh, V., & Gould, T. J. (2015) · International Review of Neurobiology · doi:10.1016/bs.irn.2015.08.004 · Cited by 65

Combining two repurposed drugs as a promising approach for Alzheimer's disease therapy

Chumakov, I. M., Nabirotchkin, S., Cholet, N., Milet, A., Boucard, A., Toulorge, D., Pereira, Y., Graudens, E., Traoré, S., Foucquier, J., et al. (2015) · Scientific Reports · doi:10.1038/srep07608 · Cited by 66

Multidisciplinary approaches for investigating the mechanisms of hippocampus-dependent memory: a focus on inbred mouse strains

Schimanski, L. A., & Nguyen, P. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.04.002 · Cited by 66

Ethanol disrupts fear conditioning in C57BL/6 mice

Gould, T. J. (2003) · Journal of Psychopharmacology · doi:10.1177/0269881103017001702 · Cited by 64

Fear conditioning increases NREM sleep.

Hellman, K., & Abel, T. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.2.310 · Cited by 62

Nicotine and Hippocampus-Dependent Learning: Implications for Addiction

Gould, T. J. (2006) · Molecular Neurobiology · doi:10.1385/mn:34:2:93 · Cited by 61

Acute Ethanol Has Biphasic Effects on Short‐ and Long‐Term Memory in Both Foreground and Background Contextual Fear Conditioning in C57BL/6 Mice

Gulick, D., & Gould, T. J. (2007) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00458.x · Cited by 61

Hippocampal nAChRs mediate nicotine withdrawal-related learning deficits

Davis, J. A., & Gould, T. J. (2009) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2009.02.003 · Cited by 60

Progression of multiple behavioral deficits with various ages of onset in a murine model of Hurler syndrome

Pan, D., Sciascia, A., Vorhees, C. V., & Williams, M. T. (2007) · Brain Research · doi:10.1016/j.brainres.2007.10.036 · Cited by 60

MK-801 disrupts acquisition of contextual fear conditioning but enhances memory consolidation of cued fear conditioning

Gould, T. J., McCarthy, M. M., & Keith, R. A. (2002) · Behavioural Pharmacology · doi:10.1097/00008877-200207000-00005 · Cited by 59

Absence of carboxypeptidase E leads to adult hippocampal neuronal degeneration and memory deficits

Woronowicz, A., Koshimizu, H., Chang, S., Cawley, N. X., Hill, J. M., Rodriguiz, R. M., Abebe, D. T., Dorfman, C. S., Senatorov, V. V., Zhou, A., et al. (2008) · Hippocampus · doi:10.1002/hipo.20462 · Cited by 60

Remodeling of hippocampal mossy fibers is selectively induced seven days after the acquisition of a spatial but not a cued reference memory taskPreprint

Rekart, J. L., Sandoval, C. J., Bermúdez‐Rattoni, F., & Routtenberg, A. (2007) · Learning & Memory · doi:10.1101/lm.516507 · Cited by 58

Synapsin III: Role in neuronal plasticity and disease

Porton, B., Wetsel, W. C., & Kao, H. (2011) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2011.07.007 · Cited by 58

Quantitative Genetics and Mouse Behavior

Wehner, J. M., Radcliffe, R. A., & Bowers, B. J. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.845 · Cited by 58

The duration of nicotine withdrawal-associated deficits in contextual fear conditioning parallels changes in hippocampal high affinity nicotinic acetylcholine receptor upregulation

Gould, T. J., Portugal, G. S., André, J. M., Tadman, M. P., Marks, M. J., Kenney, J. W., Yildirim, E., & Adoff, M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.01.003 · Cited by 56

Age-related deficits in the retention of memories for cued fear conditioning are reversed by galantamine treatment

Gould, T. J., & Feiro, O. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.06.040 · Cited by 56

Survey of embryonic stem cell line source strains in the water maze reveals superior reversal learning of 129S6/SvEvTac mice

Clapcote, S. J. (2003) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.09.030 · Cited by 56

NMDA receptor blockade and hippocampal neuronal loss impair fear conditioning and position habit reversal in C57Bl/6 mice

Bardgett, M. E., Boeckman, R., Krochmal, D. J., Fernando, H., Ahrens, R. C., & Csernansky, J. G. (2003) · Brain Research Bulletin · doi:10.1016/s0361-9230(03)00023-6 · Cited by 56

Differential impairment of auditory and contextual fear conditioning by protein synthesis inhibition in C57BL/6N mice.

Stiedl, O., Palve, M., Radulović, J., Birkenfeld, K., & Spiess, J. (1999) · Behavioral Neuroscience · doi:10.1037//0735-7044.113.3.496 · Cited by 56

Search strategy analysis of Tg4-42 Alzheimer Mice in the Morris Water Maze reveals early spatial navigation deficits

Curdt, N., Schmitt, F. W., Bouter, C., Iseni, T., Weile, H. C., Altunok, B., Beindorff, N., Bayer, T. A., Cooke, M. B., & Bouter, Y. (2022) · Scientific Reports · doi:10.1038/s41598-022-09270-1 · Cited by 63

Neural mechanisms underlying the deficit of learning and memory by exposure to Di(2-ethylhexyl) phthalate in rats

Ran, D., Luo, Y., Gan, Z., Liu, J., & Yang, J. (2019) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2019.02.043 · Cited by 54

Hippocampal dysfunction and behavioral deficit in the water maze in mice: An unresolved issue?

Gerlai, R. T., McNamara, A., Williams, S. P., & PHILLIPS, H. S. (2002) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00630-x · Cited by 54

Nicotine withdrawal‐induced deficits in trace fear conditioning in C57BL / 6 mice – a role for high‐affinity β2 subunit‐containing nicotinic acetylcholine receptors

Raybuck, J. D., & Gould, T. J. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06580.x · Cited by 53

Atomoxetine Reverses Nicotine Withdrawal-Associated Deficits in Contextual Fear Conditioning

Davis, J. A., & Gould, T. J. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301315 · Cited by 52

Behavioral Deficits in Animal Models of Blast Traumatic Brain Injury

Aravind, A., Ravula, A. R., Chandra, N., & Pfister, B. J. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00990 · Cited by 53

Comparison of neurobehavioral changes in three inbred strains of mice prenatally exposed to methylmercury

Kim, C.-Y., Nakai, K., Kasanuma, Y., & Satoh, H. (2000) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(99)00077-x · Cited by 53

Altered navigational strategy use and visuospatial deficits in hAPP transgenic mice

Deipolyi, A. R., Fang, S., Palop, J. J., Yu, G.-Q., Wang, X., & Mucke, L. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.10.021 · Cited by 52

Bupropion dose-dependently reverses nicotine withdrawal deficits in contextual fear conditioning

Portugal, G. S., & Gould, T. J. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2007.08.004 · Cited by 52

NIH Swiss and Black Swiss mice have retinal degeneration and performance deficits in cognitive tests.

Clapcote, S. J., Lazar, N. L., Bechard, A. R., Wood, G. A., & Roder, J. (2005) · PubMed · Cited by 51

Mice lacking synapsin III show abnormalities in explicit memory and conditioned fear

Porton, B., Rodriguiz, R. M., Phillips, L. E., Gilbert, J. W., Feng, J., Greengard, P., Kao, H., & Wetsel, W. C. (2009) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2009.00555.x · Cited by 51

Blastomere biopsy influences epigenetic reprogramming during early embryo development, which impacts neural development and function in resulting mice

Wu, Y., Lv, Z., Yang, Y., Dong, G., Yu, Y., Cui, Y., Tong, M., Wang, L., Zhou, Z., Zhu, H., et al. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1466-2 · Cited by 50

Deficits in spatial learning and motor coordination in ADAM11-deficient mice

Takahashi, E., Sagane, K., Oki, T., Yamazaki, K., Nagasu, T., & Kuromitsu, J. (2006) · BMC Neuroscience · doi:10.1186/1471-2202-7-19 · Cited by 50

Fear conditioning in C57/BL/6 and DBA/2 mice: variability in nucleus accumbens function according to the strain predisposition to show contextual- or cue-based responding

Ammassari‐Teule, M., Passino, E., Restivo, L., & Marsanich, B. D. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.01333.x · Cited by 49

Low doses of interleukin-1β improve the leverpress avoidance performance of Sprague–Dawley rats

Brennan, F. X., Beck, K. D., & Servatius, R. J. (2003) · Neurobiology of Learning and Memory · doi:10.1016/s1074-7427(03)00060-1 · Cited by 50

Alterations in hippocampal GAP-43 phosphorylation and protein level following contextual fear conditioning

Young, E. A., Owen, E. H., Meiri, K. F., & Wehner, J. M. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02021-7 · Cited by 51

Assessing cognitive function in animal models of mental retardation

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Deficits in Adult Neurogenesis, Contextual Fear Conditioning, and Spatial Learning in aGfapMutant Mouse Model of Alexander Disease

Hagemann, T. L., Paylor, R. E., & Messing, A. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3693-13.2013 · Cited by 51

Associative Learning, the Hippocampus, and Nicotine Addiction

Gould, T. J., & Davis, J. A. (2008) · Current Drug Abuse Reviews · doi:10.2174/1874473710801010009 · Cited by 49

Enhancement of contextual fear-conditioning by putative (±)-α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor modulators and N-methyl-d-aspartate (NMDA) receptor antagonists in DBA/2J mice

Lü, Y., & Wehner, J. M. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00644-6 · Cited by 48

Interactive effects of ethanol and nicotine on learning in C57BL/6J mice depend on both dose and duration of treatment

Gulick, D., & Gould, T. J. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0982-x · Cited by 49

Changes in protein kinase C (PKC) activity, isozyme translocation, and GAP‐43 phosphorylation in the rat hippocampal formation after a single‐trial contextual fear conditioning paradigm

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Effects of hippocampal lesions on patterned motor learning in the rat

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