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Double dissociation of function within the hippocampus: A comparison of dorsal, ventral, and complete hippocampal cytotoxic lesions
Abstract
Rats with complete cytotoxic hippocampal lesions exhibited spatial memory impairments in both the water maze and elevated T maze. They were hyperactive in photocell cages; swam faster in the water maze; and were less efficient on a nonspatial, differential reinforcement of low rates (DRL) task. Performance on both spatial tasks was also impaired by selective dorsal but not ventral lesions; swim speed was increased by ventral but not dorsal lesions. Both partial lesions caused a comparable reduction in DRL efficiency, although these effects were smaller than those of complete lesions. Neither partial lesion induced hyperactivity when rats were tested in photocell cages, although both complete and ventral lesion groups showed increased activity after footshock in other studies (Richmond et al., 1999). These results demonstrate possible functional dissociations along the septotemporal axis of the hippocampus.
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“bilateral lesions of this area have been shown to reduce anxiety-like behavior in rodents (13–15)”
From Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity (2019) · cites this paper as [13]
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Are the Dorsal and Ventral Hippocampus Functionally Distinct Structures?
Fanselow, M. S., & Dong, H.-W. (2010) · Neuron · doi:10.1016/j.neuron.2009.11.031 · Cited by 3,358
Regional dissociations within the hippocampus-memory and anxiety
Bannerman, D. M., Rawlins, J. N. P., McHugh, S. B., Deacon, R. M. J., Yee, B. K., Bast, T., Zhang, W.-N., Pothuizen, H. H. J., & Feldon, J. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.03.004 · Cited by 1,462
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Differential Control of Learning and Anxiety along the Dorsoventral Axis of the Dentate Gyrus
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Hippocampal synaptic plasticity, spatial memory and anxiety
Bannerman, D. M., Sprengel, R., Sanderson, D. J., McHugh, S. B., Rawlins, J. N. P., Monyer, H., & Seeburg, P. H. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3677 · Cited by 688
Metadata
- Authors
- Bannerman, D. M., Yee, B. K., Good, M. A., Heupel, M. J., Iversen, S. D., & Rawlins, J. N. P.
- Affiliations
- University of Oxford (GB)
- Venue
- Behavioral Neuroscience
- Published
- 1999
- Volume
- 113
- Issue
- 6
- Pages
- 1170-1188
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W2037522799
- Cited by
- 397
- References
- 50
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 5 · 2023: 6 · 2022: 10 · 2021: 11 · 2020: 12 · 2019: 17 · 2018: 19 · 2017: 18 · 2016: 15 · 2015: 16 · 2014: 24 · 2013: 22 · 2012: 20
- FWCI
- 5.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- hippocampus, double dissociation, dorsal hippocampus, ventral hippocampus, cytotoxic lesions, spatial memory, water maze, elevated T-maze, hyperactivity, differential reinforcement of low rates, footshock, septotemporal axis, rats
- MeSH terms
- Analysis of Variance, Animals, Hippocampus, Hyperkinesis, Locomotion, Male, Microinjections, Rats, Inbred Strains, Space Perception, N-Methylaspartate, Excitatory Amino Acid Antagonists, Maze Learning, Rats
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