Prediction of Response to Medication and Cognitive Therapy in the Treatment of Moderate to Severe Depression.

Fournier, Jay C.; DeRubeis, Robert J.; Shelton, Richard C.; Hollon, Steven D.; Amsterdam, Jay D.; Gallop, Robert

doi:10.1037/a0015401

Cited by 340Psychotherapy Techniques and ApplicationsTreatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Prediction of Response to Medication and Cognitive Therapy in the Treatment of Moderate to Severe Depression.

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Fournier, Jay C., DeRubeis, Robert J., Shelton, Richard C., Hollon, Steven D., Amsterdam, Jay D., Gallop, Robert·2009·Journal of Consulting and Clinical Psychology

DOI 10.1037/a0015401PMC PMC2810269

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Abstract

A recent randomized controlled trial found nearly equivalent response rates for antidepressant medications and cognitive therapy in a sample of moderate to severely depressed outpatients. In this article, the authors seek to identify the variables that were associated with response across both treatments as well as variables that predicted superior response in one treatment over the other. The sample consisted of 180 depressed outpatients: 60 of whom were randomly assigned to cognitive therapy; 120 were assigned to antidepressant medications. Treatment was provided for 16 weeks. Chronic depression, older age, and lower intelligence each predicted relatively poor response across both treatments. Three prescriptive variables-marriage, unemployment, and having experienced a greater number of recent life events-were identified, and each predicted superior response to cognitive therapy relative to antidepressant medications. Thus, 6 markers of treatment outcome were identified, each of which might be expected to carry considerable clinical utility. The 3 prognostic variables identify subgroups that might benefit from alternative treatment strategies; the 3 prescriptive variables identify groups who appear to respond particularly well to cognitive therapy.

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Adults with resistant depressive disorders may display traits of overcontrol, such as heightened self-criticism, diminished autonomy, rigid internalized expectations, heightened control over spontaneous emotions, and a fear of making mistakes.
“Adults with resistant depressive disorders may display traits of overcontrol, such as heightened self-criticism, diminished autonomy, rigid internalized expectations, heightened control over spontaneous emotions, and a fear of making mistakes [28–30].”
From Dialectical Behavior Therapy as an intervention for Treatment Resistant Depression in adults: A protocol for systematic review and meta-analysis (2024) · cites this paper as [29]
The Methods > Potential Predictors section (page unavailable) includes perfectionism, need for approval, and self-esteem among variables assessed in depressed outpatients, which overlaps with the claimed traits. It does not establish that adults with treatment-resistant depression display the listed pattern of overcontrol, including reduced autonomy, emotional restraint, or fear of mistakes. The Methods > Participants section (page unavailable) describes a moderate-to-severe depression sample, not a treatment-resistant sample. (LLM, conf=0.78)
Experimental — accuracy not yet measured
These maladaptive responses can prolong depressive symptoms.
“These maladaptive responses can prolong depressive symptoms [29,30].”
From Dialectical Behavior Therapy as an intervention for Treatment Resistant Depression in adults: A protocol for systematic review and meta-analysis (2024) · cites this paper as [29]
The Methods section lists cognitive variables such as attributional style and perfectionism, but does not say that maladaptive responses prolong depression. The Discussion reports that patients with chronic depression had less symptom relief during treatment, without attributing that persistence to maladaptive responses. Searches for maladaptive coping, rumination, and symptom persistence found no passage making the claimed link. (LLM, conf=0.74)
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Does pretreatment severity moderate the efficacy of psychological treatment of adult outpatient depression? A meta-analysis.
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Self-citation
Using patient self-reports to study heterogeneity of treatment effects in major depressive disorder
Kessler, R. C., van Loo, H. M., Wardenaar, K. J., Bossarte, R. M., Brenner, L. A., Ebert, D. D., de Jonge, P., Nierenberg, A. A., Rosellini, A. J., Sampson, N. A., et al. (2016) · Epidemiology and Psychiatric Sciences · doi:10.1017/s2045796016000020 · Cited by 193 · see citing works
Schema Theory and Schema Therapy in Mood and Anxiety Disorders: A Review
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Pretreatment Rostral Anterior Cingulate Cortex Theta Activity in Relation to Symptom Improvement in Depression: A Randomized Clinical Trial
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Moderators and non-specific predictors of treatment outcome for anxiety disorders: A comparison of cognitive behavioral therapy to acceptance and commitment therapy
Wolitzky-Taylor, K. B., Arch, J. J., Rosenfield, D., & Craske, M. G. (2012) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0029418 · Cited by 185 · see citing works
Preferences for positive psychology exercises
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Guided self-help works: randomized waitlist controlled trial of pacifica, a mobile app integrating cognitive behavioral therapy and mindfulness for stress, anxiety, and depression
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Who gets the most out of cognitive behavioral therapy for anxiety disorders? The role of treatment dose and patient engagement.
Glenn, D., Golinelli, D., Rose, R. D., Roy-Byrne, P., Stein, M. B., Sullivan, G., Bystritksy, A., Sherbourne, C., & Craske, M. G. (2013) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0033403 · Cited by 166 · see citing works
Personalized prediction of antidepressant v. placebo response: evidence from the EMBARC study
Webb, C. A., Trivedi, M. H., Cohen, Z. D., Dillon, D. G., Fournier, J. C. J., Goer, F., D, M. F. M., McGrath, P. J., Weissman, M. M., Parsey, R. V., et al. (2018) · Psychological Medicine · doi:10.1017/s0033291718001708 · Cited by 172 · see citing works
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GENDER AS PREDICTOR AND MODERATOR OF OUTCOME IN COGNITIVE BEHAVIOR THERAPY AND PHARMACOTHERAPY FOR ADULT DEPRESSION: AN “INDIVIDUAL PATIENT DATA” META-ANALYSIS: Research Article: Gender as Moderator of Treatment Outcome
Cuijpers, P., Weitz, E., Twisk, J., Kuehner, C., Cristea, I., David, D., DeRubeis, R. J., Dimidjian, S., Dunlop, B. W., Faramarzi, M., et al. (2014) · Depression and Anxiety · doi:10.1002/da.22328 · Cited by 158 · see citing works
Self-citation
Genetic and clinical characteristics of treatment-resistant depression using primary care records in two UK cohorts
Fabbri, C., Hagenaars, S. P., John, C., Williams, A. T., Shrine, N. R. G., Moles, L., Hanscombe, K. B., Serretti, A., Shepherd, D. J., Free, R. C., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01062-9 · Cited by 156 · see citing works
Psychotherapy for depression: A randomized clinical trial comparing schema therapy and cognitive behavior therapy
Carter, J. D., McIntosh, V. V. W., Jordan, J., Porter, R., FRAMPTON, C. M. A., & Joyce, P. R. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.06.034 · Cited by 152 · see citing works
Predictors and moderators of time to remission of major depression with interpersonal psychotherapy and SSRI pharmacotherapy
Frank, E., Cassano, G., Rucci, P., Thompson, W. K., KRAEMER, H. C., Fagiolini, A. M., Maggi, L., Kupfer, D. J., Shear, M. K., Houck, P. R., et al. (2010) · Psychological Medicine · doi:10.1017/s0033291710000553 · Cited by 151 · see citing works
Predicting Optimal Outcomes in Cognitive Therapy or Interpersonal Psychotherapy for Depressed Individuals Using the Personalized Advantage Index Approach
Huibers, M. J. H., Cohen, Z. D., Lemmens, L. H. J. M., Arntz, A., Peeters, F. P. M. L., Cuijpers, P., & DeRubeis, R. J. (2015) · PLOS ONE · doi:10.1371/journal.pone.0140771 · Cited by 215 · see citing works
Case studies within a mixed methods paradigm: Toward a resolution of the alienation between researcher and practitioner in psychotherapy research.
Dattilio, F. M., Edwards, D. J. A., & Fishman, D. B. (2010) · Psychotherapy · doi:10.1037/a0021181 · Cited by 144 · see citing works
Sustained effectiveness and cost-effectiveness of the Healthy Activity Programme, a brief psychological treatment for depression delivered by lay counsellors in primary care: 12-month follow-up of a randomised controlled trial
Weobong, B., Weiss, H. A., McDaid, D., Singla, D. R., Hollon, S. D., Nadkarni, A., Park, A.-L., Bhat, B., Katti, B., Anand, A., et al. (2017) · PLOS Medicine · doi:10.1371/journal.pmed.1002385 · Cited by 135 · see citing works
Effects of Patient Preferences on Outcomes in the Predictors of Remission in Depression to Individual and Combined Treatments (PReDICT) Study
Dunlop, B. W., Kelley, M. E., Aponte‐Rivera, V., Mletzko, T., Kinkead, B. L., Ritchie, J., Nemeroff, C. B., Craighead, W. E., Mayberg, H. S., & for the PReDICT Team (2017) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2016.16050517 · Cited by 140 · see citing works
Cognitive behavioral therapy is effective in misophonia: An open trial
Schröder, A. E., Vulink, N. C., van Loon, A. J., & Denys, D. A. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.04.017 · Cited by 139 · see citing works
PSYCHOLOGICAL TREATMENT OF DEPRESSION IN COLLEGE STUDENTS: A METAANALYSIS: Review: Treatment of Depression in Students
Cuijpers, P., Cristea, I. A., Ebert, D. D., Koot, H. M., Auerbach, R. P., Bruffaerts, R., & Kessler, R. C. (2016) · Depression and Anxiety · doi:10.1002/da.22461 · Cited by 137 · see citing works
Intranasal Oxytocin to Prevent Posttraumatic Stress Disorder Symptoms: A Randomized Controlled Trial in Emergency Department Patients
van Zuiden, M., Frijling, J. L., Nawijn, L., Koch, S. B. J., Goslings, J. C., Luitse, J. S., Biesheuvel, T. H., Honig, A., Veltman, D. J., & Olff, M. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.11.012 · Cited by 134 · see citing works
Predictors of response to an attention modification program in generalized social phobia.
Amir, N., Taylor, C. T., & Donohue, M. (2011) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0023808 · Cited by 130 · see citing works
Combination Psychotherapy and Antidepressant Medication Treatment for Depression: For Whom, When, and How
Craighead, W. E., & Dunlop, B. W. (2011) · Annual Review of Psychology · doi:10.1146/annurev.psych.121208.131653 · Cited by 129 · see citing works
Neuroimaging-based biomarkers for treatment selection in major depressive disorder
Dunlop, B. W., & Mayberg, H. S. (2014) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2014.16.4/bdunlop · Cited by 127 · see citing works
Clinical effectiveness and cost-effectiveness of cognitive behavioural therapy as an adjunct to pharmacotherapy for treatment-resistant depression in primary care: the CoBalT randomised controlled trial
Wiles, N., Thomas, L., Abel, A., Barnes, M., Carroll, F., Ridgway, N., Sherlock, S., Turner, N., Button, K., Odondi, L., et al. (2014) · Health Technology Assessment · doi:10.3310/hta18310 · Cited by 127 · see citing works
Associations between socioeconomic status and psychological therapy outcomes: A systematic review and meta‐analysis
Finegan, M., Firth, N., Wojnarowski, C., & Delgadillo, J. (2018) · Depression and Anxiety · doi:10.1002/da.22765 · Cited by 123 · see citing works
Intensive prolonged exposure therapy for chronic PTSD patients following multiple trauma and multiple treatment attempts
Hendriks, L., Kleine, R. A. D., Broekman, T. G., Hendriks, G.-J., & Minnen, A. V. (2018) · European Journal of Psychotraumatology · doi:10.1080/20008198.2018.1425574 · Cited by 121 · see citing works
Neurocognitive Functioning in Depressed Young People: A Systematic Review and Meta-Analysis
Goodall, J., Fisher, C. A., Hetrick, S. E., Phillips, L., Parrish, E. M., & Allott, K. (2018) · Neuropsychology Review · doi:10.1007/s11065-018-9373-9 · Cited by 122 · see citing works
A demonstration of a multi-method variable selection approach for treatment selection: Recommending cognitive–behavioral versus psychodynamic therapy for mild to moderate adult depression
Cohen, Z. D., Kim, T. T., Van, H. L., Dekker, J., & Driessen, E. (2019) · Psychotherapy Research · doi:10.1080/10503307.2018.1563312 · Cited by 122 · see citing works
Predictors and Moderators of Response to Internet-Delivered Interpersonal Psychotherapy and Cognitive Behavior Therapy for Depression
Donker, T., Batterham, P. J., Warmerdam, L., Bennett, K., Bennett, A., Cuijpers, P., Griffiths, K. M., & Christensen, H. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.06.020 · Cited by 115 · see citing works
Cognitive-behavioral analysis system of psychotherapy, drug, or their combination for persistent depressive disorder: personalizing the treatment choice using individual participant data network metaregression.
Furukawa, T. A., Efthimiou, O., Weitz, E. S., Cipriani, A., Keller, M. B., Kocsis, J. H., Klein, D. N., Michalak, J., Salanti, G., Cuijpers, P., et al. (2018) · Psychotherapy and Psychosomatics · doi:10.1159/000489227 · Cited by 109 · see citing works
A systematic review of digital and face-to-face cognitive behavioral therapy for depression
Kambeitz-Ilankovic, L., Rzayeva, U., Völkel, L., Wenzel, J., Weiske, J., Jessen, F., Reininghaus, U., Uhlhaas, P. J., Alvarez-Jimenez, M., & Kambeitz, J. (2022) · npj Digital Medicine · doi:10.1038/s41746-022-00677-8 · Cited by 103 · see citing works
Predictors of Symptomatic Change and Adherence in Internet-Based Cognitive Behaviour Therapy for Social Anxiety Disorder in Routine Psychiatric Care
El Alaoui, S., Ljótsson, B., Hedman, E., Kaldo, V., Andersson, E., Rück, C., Andersson, G., & Lindefors, N. (2015) · PLOS ONE · doi:10.1371/journal.pone.0124258 · Cited by 98 · see citing works
“[27] was followed where predictor domains (socio-demographic variables, clinical variables, family history and treatment factors) were first examined separately.”
Method
The dynamic interplay between negative and positive emotions in daily life predicts response to treatment in depression: A momentary assessment study
Wichers, M., Lothmann, C., Simons, C. J. P., Nicolson, N. A., & Peeters, F. (2012) · British Journal of Clinical Psychology · doi:10.1111/j.2044-8260.2011.02021.x · Cited by 89 · see citing works
An update on the efficacy of psychological treatments for obsessive-compulsive disorder in adults
Ponniah, K., Magiati, I., & Hollon, S. D. (2013) · Journal of Obsessive-Compulsive and Related Disorders · doi:10.1016/j.jocrd.2013.02.005 · Cited by 79 · see citing works
“Such indices could be used for treatment selection if they predicted differential response to different interventions (moderation) (Fournier et al., 2009).”
Background
Mental health and unemployment: A systematic review and meta-analysis of interventions to improve depression and anxiety outcomes
Arena, A. F. A., Mobbs, S., Sanatkar, S., Williams, D. O., Collins, D., Harris, M., Harvey, S. B., & Deady, M. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.05.027 · Cited by 85 · see citing works
Acceptance and commitment therapy group for treatment-resistant participants: a randomized controlled trial
Clarke, S., Kingston, J., James, K., Bolderston, H., & Remington, B. (2014) · Journal of Contextual Behavioral Science · doi:10.1016/j.jcbs.2014.04.005 · Cited by 79 · see citing works
Effectiveness of cognitive behavioral group therapy for depression in routine practice
Thimm, J. C., & Antonsen, L. (2014) · BMC Psychiatry · doi:10.1186/s12888-014-0292-x · Cited by 77 · see citing works
Precision medicine for long-term depression outcomes using the Personalized Advantage Index approach: cognitive therapy or interpersonal psychotherapy?
van Bronswijk, S. C., DeRubeis, R. J., Lemmens, L. H. J. M., Peeters, F. P. M. L., Keefe, J. R., Cohen, Z. D., & Huibers, M. J. H. (2021) · Psychological Medicine · doi:10.1017/s0033291719003192 · Cited by 75 · see citing works
Predictors of PTSD symptoms in adults admitted to a Level I trauma center: A prospective analysis
Powers, M. B., Warren, A. M., Rosenfield, D., Roden-Foreman, K., Bennett, M., Reynolds, M. C., Davis, M. L., Foreman, M. L., Petrey, L. B., & Smits, J. A. J. (2014) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2014.01.003 · Cited by 72 · see citing works
Pre-treatment predictors of dropout from prolonged exposure therapy in patients with chronic posttraumatic stress disorder and comorbid substance use disorders
Belleau, E. L., Chin, E. G., Wanklyn, S. G., Zambrano-Vazquez, L., Schumacher, J. A., & Coffey, S. F. (2017) · Behaviour Research and Therapy · doi:10.1016/j.brat.2017.01.011 · Cited by 71 · see citing works
The contribution of depressive ‘disorder characteristics’ to determinations of prognosis for adults with depression: an individual patient data meta-analysis
Buckman, J. E. J., Saunders, R., Cohen, Z. D., Barnett, P., Clarke, K., Ambler, G., DeRubeis, R. J., Gilbody, S. M., Hollon, S. D., Kendrick, T., et al. (2021) · Psychological Medicine · doi:10.1017/s0033291721001367 · Cited by 70 · see citing works
The effectiveness and cost-effectiveness of lay counsellor-delivered psychological treatments for harmful and dependent drinking and moderate to severe depression in primary care in India: PREMIUM study protocol for randomized controlled trials
Patel, V., Weobong, B., Nadkarni, A., Weiss, H. A., Anand, A., Naik, S., Bhat, B., Pereira, J., Araya, R., Dimidjian, S., et al. (2014) · Trials · doi:10.1186/1745-6215-15-101 · Cited by 66 · see citing works
Self-citation
Factors associated with differential response to online cognitive behavioural therapy
Button, K. S., Wiles, N. J., Lewis, G., Peters, T. J., & Kessler, D. (2012) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-011-0389-1 · Cited by 69 · see citing works
Continuation of Antidepressants vs Sequential Psychological Interventions to Prevent Relapse in Depression
Breedvelt, J., Warren, F. C., Segal, Z. V., Kuyken, W., & Bockting, C. (2021) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2021.0823 · Cited by 65 · see citing works
Benefits of Sequentially Adding Cognitive-Behavioral Therapy or Antidepressant Medication for Adults With Nonremitting Depression
Dunlop, B. W., LoParo, D., Kinkead, B. L., Mletzko, T., Cole, S. P., Nemeroff, C. B., Mayberg, H. S., & Craighead, W. E. (2019) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2018.18091075 · Cited by 65 · see citing works
Monotherapy Insufficient in Severe Anxiety? Predictors and Moderators in the Child/Adolescent Anxiety Multimodal Study
Taylor, J. H., Lebowitz, E. R., Jakubovski, E., Coughlin, C. G., Silverman, W. K., & Bloch, M. H. (2018) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2017.1371028 · Cited by 63 · see citing works
Moderators of remission with interpersonal counselling or drug treatment in primary care patients with depression: randomised controlled trial
Menchetti, M., Rucci, P., Bortolotti, B., Bombi, A., Scocco, P., KRAEMER, H. C., Berardi, D., & the DEPICS group (2013) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.112.122663 · Cited by 62 · see citing works
Personalized Medicine and Cognitive Behavioral Therapies for Depression: Small Effects, Big Problems, and Bigger Data
Lorenzo‐Luaces, L., Peipert, A., Jesús-Romero, R. D., Rutter, L. A., & Rodríguez‐Quintana, N. (2020) · International Journal of Cognitive Therapy · doi:10.1007/s41811-020-00094-3 · Cited by 62 · see citing works
Improving outcome for mental disorders by enhancing memory for treatment
Harvey, A. G., Lee, J., Smith, R. L., Gumport, N. B., Hollon, S. D., Rabe‐Hesketh, S., Hein, K., Dolsen, E. A., Haman, K., Kanady, J. C., et al. (2016) · Behaviour Research and Therapy · doi:10.1016/j.brat.2016.03.007 · Cited by 60 · see citing works
Shared and Unique Changes in Brain Connectivity Among Depressed Patients After Remission With Pharmacotherapy Versus Psychotherapy
Dunlop, B. W., Cha, J., Choi, K. S., Rajendra, J. K., Nemeroff, C. B., Craighead, W. E., & Mayberg, H. S. (2023) · American Journal of Psychiatry · doi:10.1176/appi.ajp.21070727 · Cited by 56 · see citing works
Predicting Outcome in Internet-Based Cognitive Behaviour Therapy for Major Depression: A Large Cohort Study of Adult Patients in Routine Psychiatric Care
El Alaoui, S., Ljótsson, B., Hedman, E., Svanborg, C., Kaldo, V., & Lindefors, N. (2016) · PLOS ONE · doi:10.1371/journal.pone.0161191 · Cited by 51 · see citing works
Concurrent treatment of posttraumatic stress disorder and alcohol dependence: Predictors and moderators of outcome.
Zandberg, L. J., Rosenfield, D., McLean, C. P., Powers, M. B., Asnaani, A., & Foa, E. B. (2015) · Journal of Consulting and Clinical Psychology · doi:10.1037/ccp0000052 · Cited by 56 · see citing works
To each his own well-being boosting intervention: using preference to guide selection
Schueller, S. (2011) · The Journal of Positive Psychology · doi:10.1080/17439760.2011.577092 · Cited by 55 · see citing works
Cognitive Behavioral Therapy for Depression
Sudak, D. M. (2011) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2011.10.001 · Cited by 53 · see citing works
Therapist effects and the outcome–alliance correlation in cognitive behavioral therapy for panic disorder with agoraphobia
Huppert, J. D., Kivity, Y., Barlow, D. H., Gorman, J. M., Shear, M. K., & Woods, S. W. (2013) · Behaviour Research and Therapy · doi:10.1016/j.brat.2013.11.001 · Cited by 51 · see citing works
Prospective Service Use and Health Care Costs of Medicaid Beneficiaries with Treatment-Resistant Depression
Olfson, M., Amos, T. B., Benson, C., McRae, J., & Marcus, S. C. (2018) · Journal of Managed Care & Specialty Pharmacy · doi:10.18553/jmcp.2018.24.3.226 · Cited by 48 · see citing works
Acute phase cognitive therapy for recurrent major depressive disorder: Who drops out and how much do patient skills influence response?
Jarrett, R. B., Minhajuddin, A., Kangas, J. L., Friedman, E. S., Callan, J. A., & Thase, M. E. (2013) · Behaviour Research and Therapy · doi:10.1016/j.brat.2013.01.006 · Cited by 48 · see citing works
Lower versus higher frequency of sessions in starting outpatient mental health care and the risk of a chronic course; a naturalistic cohort study
Tiemens, B. G., Kloos, M., Spijker, J., Ingenhoven, T., Kampman, M., & Hendriks, G. (2019) · BMC Psychiatry · doi:10.1186/s12888-019-2214-4 · Cited by 48 · see citing works
Effectiveness of cognitive–behavioural therapy for depression in advanced cancer: CanTalk randomised controlled trial
Serfaty, M., King, M., Nazareth, I., Moorey, S., Aspden, T., Mannix, K., Davis, S., Wood, J., & Jones, L. (2020) · The British Journal of Psychiatry · doi:10.1192/bjp.2019.207 · Cited by 47 · see citing works
APPLYING NEPALI ETHNOPSYCHOLOGY TO PSYCHOTHERAPY FOR THE TREATMENT OF MENTAL ILLNESS AND PREVENTION OF SUICIDE AMONG BHUTANESE REFUGEES
Kohrt, B. A., Maharjan, S. M., Timsina, D., & Griffith, J. L. (2012) · Annals of Anthropological Practice · doi:10.1111/j.2153-9588.2012.01094.x · Cited by 47 · see citing works
D-cycloserine augmentation of cognitive behavioral group therapy of social anxiety disorder: Prognostic and prescriptive variables.
Smits, J. A. J., Hofmann, S. G., Rosenfield, D., Hopkins, L. B., Costa, P. T., Simon, N. M., O’Cleirigh, C. M., Meuret, A. E., Marques, L. M., Otto, M. W., et al. (2013) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0034120 · Cited by 46 · see citing works
Dismantling, personalising and optimising internet cognitive–behavioural therapy for depression: a study protocol for individual participant data component network meta-analysis
Furukawa, T. A., Karyotaki, E., Suganuma, A. M., Pompoli, A., Ostinelli, E. G., Cipriani, A., Cuijpers, P. J., & Efthimiou, O. (2018) · BMJ Open · doi:10.1136/bmjopen-2018-026137 · Cited by 46 · see citing works
Reward related ventral striatal activity and differential response to sertraline versus placebo in depressed individuals
Greenberg, T., Fournier, J. C. J., Stiffler, R. S., Chase, H. W., Almeida, J., Aslam, H. A., Deckersbach, T., Cooper, C. M., Toups, M. S. P., Carmody, T., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0490-5 · Cited by 46 · see citing works
Self-citation
The history, current status, and possible future of precision mental health
DeRubeis, R. J. (2019) · Behaviour Research and Therapy · doi:10.1016/j.brat.2019.103506 · Cited by 46 · see citing works
Predictors of dropout in concurrent treatment of posttraumatic stress disorder and alcohol dependence: rate of improvement matters
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A RANDOMIZED-CONTROLLED TRIAL OF AN INTERVENTION TO IMPROVE ANTIDEPRESSANT ADHERENCE AMONG LATINOS WITH DEPRESSION
Interian, A., Lewis‐Fernández, R., Gara, M. A., & Escobar, J. I. (2013) · Depression and Anxiety · doi:10.1002/da.22052 · Cited by 43 · see citing works
Manualised cognitive-behavioural therapy in treating depression in advanced cancer: the CanTalk RCT.
Serfaty, M., King, M., Nazareth, I., Moorey, S., Aspden, T., Tookman, A., Mannix, K., Gola, A., Davis, S., Wood, J., et al. (2019) · Health Technology Assessment · doi:10.3310/hta23190 · Cited by 37 · see citing works
Effectiveness of Cognitive Behavioral Therapy in Public Mental Health: Comparison to Treatment as Usual for Treatment-Resistant Depression
Lopez, M. A., & Basco, M. A. (2015) · Administration and Policy in Mental Health and Mental Health Services Research · doi:10.1007/s10488-014-0546-4 · Cited by 42 · see citing works
Towards personalising treatment: a systematic review and meta-analysis of face-to-face efficacy moderators of cognitive-behavioral therapy and interpersonal psychotherapy for major depressive disorder
Whiston, A., Bockting, C., & Semkovska, M. (2019) · Psychological Medicine · doi:10.1017/s0033291719002812 · Cited by 42 · see citing works
Identifying moderators of the adherence-outcome relation in cognitive therapy for depression
Sasso, K. E., Strunk, D. R., Braun, J. D., DeRubeis, R. J., & Brotman, M. A. (2015) · Journal of Consulting and Clinical Psychology · doi:10.1037/ccp0000045 · Cited by 40 · see citing works
Self-citation
Predictive Neuroimaging Markers of Psychotherapy Response: A Systematic Review
Chakrabarty, T., Ogrodniczuk, J. S., & Hadjipavlou, G. A. (2016) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000132 · Cited by 40 · see citing works
Using Socratic Questioning to promote cognitive change and achieve depressive symptom reduction: Evidence of cognitive change as a mediator
Vittorio, L. N., Murphy, S. T., Braun, J. D., & Strunk, D. R. (2022) · Behaviour Research and Therapy · doi:10.1016/j.brat.2022.104035 · Cited by 40 · see citing works
A Systematic Review of Cognitive Behavioral Therapy for Depression in Veterans
Hundt, N. E., Fletcher, T. L., Robinson, A. J., & Cully, J. A. (2014) · Military Medicine · doi:10.7205/milmed-d-14-00128 · Cited by 46 · see citing works
PREDICTING OUTCOME OF DEPRESSION USING THE DEPRESSIVE SYMPTOM PROFILE: THE LEIDEN ROUTINE OUTCOME MONITORING STUDY
van Noorden, M. S., van Fenema, E. M., van der Wee, N. J. A., Zitman, F. G., & Giltay, E. J. (2012) · Depression and Anxiety · doi:10.1002/da.21958 · Cited by 39 · see citing works
Refractory depression—Mechanisms and efficacy of radically open dialectical behaviour therapy (RefraMED): Findings of a randomised trial on benefits and harms.
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Moderators of LGBQ-affirmative cognitive behavioral therapy: ESTEEM is especially effective among Black and Latino sexual minority men.
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Predictors of response to medication and cognitive therapy in the treatment of moderate to severe depression
Fournier, J. C. (2010) · ScholarlyCommons (University of Pennsylvania)
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Authors: Fournier, J. C., DeRubeis, R. J., Shelton, R. C., Hollon, S. D., Amsterdam, J. D., & Gallop, R.
Affiliations: University of Pennsylvania (US)
Vanderbilt University Medical Center (US)
Vanderbilt University (US)
West Chester University (US)
ORCID: Fournier, Jay C.
DeRubeis, Robert J.
Shelton, Richard C.
Hollon, Steven D.
Gallop, Robert
Venue: Journal of Consulting and Clinical Psychology
Publisher: American Psychological Association (APA)
Published: 2009
Volume: 77
Issue: 4
Pages: 775-787
ISSN: 0022-006X (ISSN-L)
1939-2117
DOI: 10.1037/a0015401
PMC: PMC2810269
OpenAlex: W2085575985
Cited by: 340
References: 68
Citations by year: 2026: 14 · 2025: 7 · 2024: 13 · 2023: 16 · 2022: 21 · 2021: 43 · 2020: 17 · 2019: 29 · 2018: 20 · 2017: 19 · 2016: 23 · 2015: 27 · 2014: 22 · 2013: 20 · 2012: 16
FWCI: 16.95
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Journal of Consulting and Clinical Psychology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (MH55877 (R10); MH55875 (R10); MH01697 (K02); MH01741 (K24))
Topics: Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords: depression, antidepressants, cognitive therapy, treatment response prediction, prognostic factors, chronic depression, old age, intelligence, marital status, unemployment, life events, outpatients, treatment selection
MeSH terms: Adult, Antidepressive Agents, Chronic Disease, Combined Modality Therapy, Major Depressive Disorder, Female, Humans, Male, Middle Aged, Personality Inventory, Prognosis, Recurrence, Cognitive Behavioral Therapy, Randomized Controlled Trials as Topic, Age of Onset, Dysthymic Disorder

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Prediction of Response to Medication and Cognitive Therapy in the Treatment of Moderate to Severe Depression.

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