Cited by 1,164Regulation of Appetite and ObesityHypothalamic control of reproductive hormonesNeuropeptides and Animal Physiology

The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons

Hahn, Tina M., Breininger, John F., Baskin, Denis G., Schwartz, Michael W.·1998·Nature Neuroscience

DOI 10.1038/1082

Open this paper in CoChat — free account

Integrity signals

Registry

Crossref · 10.1038/1082

Cites

15 of 15 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Targeted disruption of the melanocortin-4 receptor results in obesity in mice
Huszar, D., Lynch, C. A., Fairchild-Huntress, V., Dunmore, J. H., Fang, Q., Berkemeier, L. R., Gu, W., Kesterson, R. A., Boston, B. A., Cone, R. D., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)81865-6 · Cited by 3,030
Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
Fan, W., Boston, B. A., Kesterson, R. A., Hruby, V. J., & Cone, R. D. (1997) · Nature · doi:10.1038/385165a0 · Cited by 1,924
Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein
Ollmann, M. M., Wilson, B. D., Yang, Y.-K., Kerns, J. A., Chen, Y., Gantz, I., & Barsh, G. S. (1997) · Science · doi:10.1126/science.278.5335.135 · Cited by 1,881
The role of neuropeptide Y in the antiobesity action of the obese gene product
Stephens, T. W., Basinski, M., Bristow, P. K., Bue-Valleskey, J. M., Burgett, S. G., Craft, L., Hale, J., Hoffmann, J., Hsiung, H. M., Kriauciunas, A., et al. (1995) · Nature · doi:10.1038/377530a0 · Cited by 1,498
Specificity of Leptin Action on Elevated Blood Glucose Levels and Hypothalamic Neuropeptide Y Gene Expression in ob/ob Mice
Schwartz, M. W., Baskin, D. G., Bukowski, T. R., Kuijper, J. L., Foster, D., Lasser, G., Prunkard, D. E., Porte, D., Woods, S. C., Seeley, R. J., et al. (1996) · Diabetes · doi:10.2337/diab.45.4.531 · Cited by 904
Self-citation
Leptin Increases Hypothalamic Pro-opiomelanocortin mRNA Expression in the Rostral Arcuate Nucleus
Schwartz, M. W., Seeley, R. J., Woods, S. C., Weigle, D. S., Campfield, L. A., Burn, P., & Baskin, D. G. (1997) · Diabetes · doi:10.2337/diab.46.12.2119 · Cited by 879
Self-citation
Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity
Glenn Stanley, B., Kyrkouli, S. E., Lampert, S., & Leibowitz, S. F. (1986) · Peptides · doi:10.1016/0196-9781(86)90149-x · Cited by 849
Proopiomelanocortin Neurons Are Direct Targets for Leptin in the Hypothalamus
Cheung, C. C., Clifton, D. K., & Steiner, R. A. (1997) · Endocrinology · doi:10.1210/endo.138.10.5570 · Cited by 769
Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice.Preprint
Shutter, J. R., Graham, M., Kinsey, A. C., Scully, S. A., Lüthy, R., & Stark, K. L. (1997) · Genes & Development · doi:10.1101/gad.11.5.593 · Cited by 672
Altered Expression of Hypothalamic Neuropeptide mRNAs in Food-Restricted and Food-Deprived Rats
Brady, L. S., Smith, M. A., Gold, P. W., & Herkenham, M. A. (2008) · Neuroendocrinology · doi:10.1159/000125626 · Cited by 641

Flagged first, then by citations

Show all 15 references

Sorted by citations

Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451
Self-citation
A role for ghrelin in the central regulation of feeding
Nakazato, M., Murakami, N., Date, Y., Kojima, M., Matsuo, H., Kangawa, K., & Matsukura, S. (2001) · Nature · doi:10.1038/35051587 · Cited by 3,443
The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis
Cowley, M. A., Smith, R. G., Diano, S., Tschöp, M., Pronchuk, N., Grove, K. L., Strasburger, C. J., Bidlingmaier, M., Esterman, M., Heiman, M. L., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00063-1 · Cited by 1,679
Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight
Kalra, S. P., Dube, M. G., Pu, S., Xu, B., Horváth, T. L., & Kalra, P. S. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.1.0357 · Cited by 1,564
From Lesions to Leptin
Elmquist, J. K., Elias, C. F., & Saper, C. B. (1999) · Neuron · doi:10.1016/s0896-6273(00)81084-3 · Cited by 1,160
NPY/AgRP Neurons Are Essential for Feeding in Adult Mice but Can Be Ablated in Neonates
Luquet, S. H., Perez, F. A., Hnasko, T. S., & Palmiter, R. D. (2005) · Science · doi:10.1126/science.1115524 · Cited by 1,150
The Need to Feed
Saper, C. B., Chou, T. C., & Elmquist, J. K. (2002) · Neuron · doi:10.1016/s0896-6273(02)00969-8 · Cited by 1,120
STAT3 signalling is required for leptin regulation of energy balance but not reproduction
Bates, S. H., Stearns, W. H., Dundon, T. A., Schubert, M., Tso, A. W. K., Wang, Y., Banks, A. S., Lavery, H. J., Haq, A. K., Maratos-Flier, E., et al. (2003) · Nature · doi:10.1038/nature01388 · Cited by 1,010
Self-citation
Rapid Rewiring of Arcuate Nucleus Feeding Circuits by Leptin
Pinto, S., Roseberry, A. G., Liu, H., Diano, S., Shanabrough, M., Cai, X., Friedman, J. M., & Horvath, T. L. (2004) · Science · doi:10.1126/science.1089459 · Cited by 987
Leptin Differentially Regulates NPY and POMC Neurons Projecting to the Lateral Hypothalamic Area
Elias, C. F., Aschkenasi, C., Lee, C., Kelly, J., Ahima, R. S., Bjorbæk, C., Flier, J. S., Saper, C. B., & Elmquist, J. K. (1999) · Neuron · doi:10.1016/s0896-6273(01)80035-0 · Cited by 924
Ghrelin, an Endogenous Growth Hormone Secretagogue, Is a Novel Orexigenic Peptide That Antagonizes Leptin Action Through the Activation of Hypothalamic Neuropeptide Y/Y1 Receptor Pathway
Shintani, M., Ogawa, Y., Ebihara, K., Aizawa‐Abe, M., Miyanaga, F., Takaya, K., Hayashi, T., Inoue, G., Hosoda, K., Kojima, M., et al. (2001) · Diabetes · doi:10.2337/diabetes.50.2.227 · Cited by 848
A molecular census of arcuate hypothalamus and median eminence cell types
Campbell, J. N., Macosko, E. Z., Fenselau, H., Pers, T. H., Lyubetskaya, A., Tenen, D., Goldman, M., Verstegen, A. M. J., Resch, J. M., McCarroll, S. A., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4495 · Cited by 817
Leptin Activates Hypothalamic CART Neurons Projecting to the Spinal Cord
Elias, C. F., Lee, C., Kelly, J., Aschkenasi, C. J., Ahima, R. S., Couceyro, P. R., Kuhar, M. J., Saper, C. B., & Elmquist, J. K. (1998) · Neuron · doi:10.1016/s0896-6273(00)80656-x · Cited by 809
The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice
Broberger, C., Johansen, J., Johansson, C., Schalling, M., & Hökfelt, T. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.15043 · Cited by 798
Leptin Regulation of Neuroendocrine Systems
Ahima, R. S., Saper, C. B., Flier, J. S., & Elmquist, J. K. (2000) · Frontiers in Neuroendocrinology · doi:10.1006/frne.2000.0197 · Cited by 767
Neurobiology of food intake in health and disease
Morton, G. J., Meek, T. H., & Schwartz, M. W. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3745 · Cited by 748
Self-citation
Orexigenic Action of Peripheral Ghrelin Is Mediated by Neuropeptide Y and Agouti-Related Protein
Chen, H. Y., Trumbauer, M. E., Chen, A. S., Weingarth, D. T., Adams, J. R., Frazier, E. G., Shen, Z., Marsh, D. J., Feighner, S. D., Guan, X.-M., et al. (2004) · Endocrinology · doi:10.1210/en.2003-1596 · Cited by 685
Sensory Detection of Food Rapidly Modulates Arcuate Feeding Circuits
Chen, Y., Lin, Y.-C., Kuo, T.-W., & Knight, Z. A. (2015) · Cell · doi:10.1016/j.cell.2015.01.033 · Cited by 660
Chronic Central Infusion of Ghrelin Increases Hypothalamic Neuropeptide Y and Agouti-Related Protein mRNA Levels and Body Weight in Rats
Kamegai, J., Tamura, H., Shimizu, T., Ishii, S., Sugihara, H., & Wakabayashi, I. (2001) · Diabetes · doi:10.2337/diabetes.50.11.2438 · Cited by 624
Toward a Wiring Diagram Understanding of Appetite Control
Andermann, M. L., & Lowell, B. B. (2017) · Neuron · doi:10.1016/j.neuron.2017.06.014 · Cited by 633
An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger
Krashes, M. J., Shah, B. P., Madara, J. C., Olson, D. P., Strochlic, D. E., Garfield, A. S., Vong, L., Pei, H., Watabe-Uchida, M., Uchida, N., et al. (2014) · Nature · doi:10.1038/nature12956 · Cited by 603
The hypothalamus and the control of energy homeostasis
Williams, G., Bing, C., Cai, X., Harrold, J. A., King, P., & Liu, X. H. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00612-6 · Cited by 573
Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat
Kishi, T., Aschkenasi, C. J., Lee, C. E., Mountjoy, K. G., Saper, C. B., & Elmquist, J. K. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10454 · Cited by 581
Minireview: Ghrelin and the Regulation of Energy Balance--A Hypothalamic Perspective
Horváth, T. L., Diano, S., Sótonyi, P., Heiman, M. L., & Tschöp, M. H. (2001) · Endocrinology · doi:10.1210/endo.142.10.8490 · Cited by 573
Leptin Signaling in the Central Nervous System and the Periphery
Bjørbæk, C. (2004) · Recent Progress in Hormone Research · doi:10.1210/rp.59.1.305 · Cited by 559
Response of melanocortin–4 receptor–deficient mice to anorectic and orexigenic peptides
Marsh, D. J., Hollopeter, G., Huszar, D., Laufer, R., Yagaloff, K. A., Fisher, S. L., Burn, P., & Palmiter, R. D. (1999) · Nature Genetics · doi:10.1038/5070 · Cited by 547
The Melanocortin-4 Receptor: Physiology, Pharmacology, and Pathophysiology
Tao, Y.-X. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0037 · Cited by 531
Unraveling the central nervous system pathways underlying responses to leptin
Elmquist, J. K., Maratos-Flier, E., Saper, C. B., & Flier, J. S. (1998) · Nature Neuroscience · doi:10.1038/2164 · Cited by 520
Genetic identification of vagal sensory neurons that control feeding
Bai, L., Mesgarzadeh, S., Ramesh, K. S., Huey, E. L., Liu, Y., Gray, L. A., Aitken, T. J., Chen, Y., Beutler, L. R., Ahn, J. S., et al. (2019) · Cell · doi:10.1016/j.cell.2019.10.031 · Cited by 494
The cellular and molecular bases of leptin and ghrelin resistance in obesity
Cui, H., López, M., & Rahmouni, K. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.222 · Cited by 498
Recent advances in understanding leptin signaling and leptin resistance
Morris, D. L., & Rui, L. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00274.2009 · Cited by 484
Ghrelin-Induced Food Intake Is Mediated via the Orexin Pathway
Toshinai, K., Date, Y., Murakami, N., Shimada, M., Mondal, M. S., Shimbara, T., Guan, J., Wang, Q., Funahashi, H., Sakurai, T., et al. (2003) · Endocrinology · doi:10.1210/en.2002-220788 · Cited by 470
Role of neuropeptides in appetite regulation and obesity – A review
Arora, S., & Anubhuti, A. (2006) · Neuropeptides · doi:10.1016/j.npep.2006.07.001 · Cited by 471
Appetite control
Wynne, K., Stanley, S., McGowan, B. M., & Bloom, S. R. (2005) · Journal of Endocrinology · doi:10.1677/joe.1.05866 · Cited by 478
Hunger States Switch a Flip-Flop Memory Circuit via a Synaptic AMPK-Dependent Positive Feedback Loop
Yang, Y., Atasoy, D., Su, H. H., & Sternson, S. M. (2011) · Cell · doi:10.1016/j.cell.2011.07.039 · Cited by 431
Neither Agouti-Related Protein nor Neuropeptide Y Is Critically Required for the Regulation of Energy Homeostasis in Mice
Qian, S., Chen, H., Weingarth, D. T., Trumbauer, M. E., Novi, D. E., Guan, X.-M., Yu, H., Shen, Z., Feng, Y., Frazier, E. G., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.14.5027-5035.2002 · Cited by 430
Serotonin Reciprocally Regulates Melanocortin Neurons to Modulate Food Intake
Heisler, L. K., Jobst, E. E., Sutton, G. M., Zhou, L., Borók, E., Thornton-Jones, Z. D., Liu, H. Y., Zigman, J. M., Balthasar, N., Kishi, T., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.06.004 · Cited by 433
Anatomy of an Endogenous Antagonist: Relationship between Agouti-Related Protein and Proopiomelanocortin in Brain
Bagnol, D., Lu, X.-Y., Kaelin, C. B., Day, H. E. W., Ollmann, M., Gantz, I., Akil, H., Barsh, G. S., & Watson, S. J. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-18-j0004.1999 · Cited by 425
A missense variant of the porcine melanocortin-4 receptor (MC4R) gene is associated with fatness, growth, and feed intake traits
Kim, K., Larsen, N., Short, T. H., Plastow, G. S., & Rothschild, M. F. (2000) · Mammalian Genome · doi:10.1007/s003350010025 · Cited by 415
Genetic approaches to studying energy balance: perception and integration
Barsh, G. S., & Schwartz, M. W. (2002) · Nature Reviews Genetics · doi:10.1038/nrg862 · Cited by 438
Self-citation
Overlapping Brain Circuits for Homeostatic and Hedonic Feeding
Rossi, M. A., & Stuber, G. D. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2017.09.021 · Cited by 415
Leptin signaling and leptin resistance
Zhou, Y., & Rui, L. (2013) · Frontiers of Medicine · doi:10.1007/s11684-013-0263-5 · Cited by 358
AgRP(83-132) Acts as an Inverse Agonist on the Human-Melanocortin-4 Receptor
Nijenhuis, W. A. J., Oosterom, J., & Adan, R. A. H. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.1.0578 · Cited by 408
Role of the gut microbiota in host appetite control: bacterial growth to animal feeding behaviour
Fetissov, S. O. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.150 · Cited by 403
Insulin and leptin: dual adiposity signals to the brain for the regulation of food intake and body weight
Baskin, D. G., Lattemann, D. F., Seeley, R. J., Woods, S. C., Porte, D., & Schwartz, M. W. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01974-5 · Cited by 401
Self-citation
Ghrelin: An orexigenic and somatotrophic signal from the stomach
Inui, A. (2001) · Nature reviews. Neuroscience · doi:10.1038/35086018 · Cited by 397
The Neuroanatomical Axis for Control of Energy Balance
Grill, H. J., & Kaplan, J. M. (2002) · Frontiers in Neuroendocrinology · doi:10.1006/frne.2001.0224 · Cited by 395
Minireview: From Anorexia to Obesity—The Yin and Yang of Body Weight Control
Zigman, J. M., & Elmquist, J. K. (2003) · Endocrinology · doi:10.1210/en.2003-0241 · Cited by 382
Transgenic Mice Expressing Green Fluorescent Protein under the Control of the Melanocortin-4 Receptor Promoter
Liu, H., Kishi, T., Roseberry, A. G., Cai, X., Lee, C. E., Montez, J. M., Friedman, J. M., & Elmquist, J. K. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-18-07143.2003 · Cited by 379
Genetics and Pathophysiology of Human Obesity
Cummings, D. E., & Schwartz, M. W. (2003) · Annual Review of Medicine · doi:10.1146/annurev.med.54.101601.152403 · Cited by 375
Self-citation
Hormonal regulation of food intake
Stanley, S., Wynne, K., McGowan, B., & Bloom, S. (2005) · Physiological Reviews · doi:10.1152/physrev.00015.2004 · Cited by 372
The neurocircuitry and receptor subtypes mediating anxiolytic-like effects of neuropeptide Y
Kask, A., Harro, J., von Hörsten, S., Redrobe, J. P., Dumont, Y., & Quirion, R. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(01)00066-5 · Cited by 358
Leptin signaling in the hypothalamus: emphasis on energy homeostasis and leptin resistance
Sahu, A. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2003.10.001 · Cited by 358
Ghrelin in the regulation of body weight and metabolism
Castañeda, T. R., Tong, J., Datta, R., Culler, M. D., & Tschöp, M. H. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.10.008 · Cited by 361
Is the Energy Homeostasis System Inherently Biased Toward Weight Gain?
Schwartz, M. W., Woods, S. C., Seeley, R. J., Barsh, G. S., Baskin, D. G., & Leibel, R. L. (2003) · Diabetes · doi:10.2337/diabetes.52.2.232 · Cited by 352
Self-citation
Neurobiology of Feeding and Energy Expenditure
Gao, Q., & Horvath, T. L. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094324 · Cited by 346
Cancer anorexia-cachexia syndrome: are neuropeptides the key?
Inui, A. (1999) · PubMed · Cited by 338
The TRH neuron: a hypothalamic integrator of energy metabolism
Lechan, R. M., & Fekete, C. (2006) · Progress in brain research · doi:10.1016/s0079-6123(06)53012-2 · Cited by 338
Food Intake and the Regulation of Body Weight
Woods, S. C., Schwartz, M. W., Baskin, D. G., & Seeley, R. J. (2000) · Annual Review of Psychology · doi:10.1146/annurev.psych.51.1.255 · Cited by 335
Self-citation
Role of signal transducer and activator of transcription 3 in regulation of hypothalamic proopiomelanocortin gene expression by leptin
Münzberg, H., Huo, L., Nillni, E. A., Hollenberg, A. N., & Bjørbæk, C. (2003) · Endocrinology · doi:10.1210/en.2002-221037 · Cited by 328
Model for the regulation of energy balance and adiposity by the central nervous system
Schwartz, M. W., Baskin, D. G., Kaiyala, K. J., & Woods, S. C. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.4.584 · Cited by 325
Self-citation
Peripheral ghrelin selectively increases Fos expression in neuropeptide Y – synthesizing neurons in mouse hypothalamic arcuate nucleus
Wang, L., Saint-Pierre, D. H., & Taché, Y. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00241-0 · Cited by 334
Long-term orexigenic effects of AgRP-(83—132) involve mechanisms other than melanocortin receptor blockade
Hagan, M. M., Rushing, P. A., Pritchard, L. M., Schwartz, M. W., Strack, A. M., der Ploeg, L. H. T. V., Woods, S. C., & Seeley, R. J. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.279.1.r47 · Cited by 320
Self-citation
Fasting Induces a Large, Leptin-Dependent Increase in the Intrinsic Action Potential Frequency of Orexigenic Arcuate Nucleus Neuropeptide Y/Agouti-Related Protein Neurons
Takahashi, K. A., & Cone, R. D. (2005) · Endocrinology · doi:10.1210/en.2004-1397 · Cited by 308
Mitochondrial dynamics controlled by mitofusins regulate Agrp neuronal activity and diet-induced obesity
Dietrich, M. O., Liu, Z.-W., & Horvath, T. L. (2013) · Cell · doi:10.1016/j.cell.2013.09.004 · Cited by 306
Differential Distribution and Regulation of OX1 and OX2 Orexin/Hypocretin Receptor Messenger RNA in the Brain upon Fasting
Lu, X., Bagnol, D., Burke, S., Akil, H., & Watson, S. J. (2000) · Hormones and Behavior · doi:10.1006/hbeh.2000.1584 · Cited by 299
Fasting Activation of AgRP Neurons Requires NMDA Receptors and Involves Spinogenesis and Increased Excitatory Tone
Liu, T., Kong, D., Shah, B. P., Ye, C., Koda, S., Saunders, A., Ding, J. B., Yang, Z., Sabatini, B. L., & Lowell, B. B. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.027 · Cited by 296
Regulation of energy homeostasis by the NPY system
Loh, K., Herzog, H., & Shi, Y.-C. (2015) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2015.01.003 · Cited by 293
Agouti-related peptide neural circuits mediate adaptive behaviors in the starved state
Padilla, S. L., Qiu, J., Soden, M. E., Sanz, E., Nestor, C. C., Barker, F. D., Quintana, A., Zweifel, L. S., Rønnekleiv, O. K., Kelly, M. J., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4274 · Cited by 285
Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons
Morton, G. J., Gelling, R. W., Niswender, K. D., Morrison, C. D., Rhodes, C. J., & Schwartz, M. W. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.10.009 · Cited by 292
Self-citation
Neuropeptides, food intake and body weight regulation: a hypothalamic focus
Hillebrand, J. J., de Wied, D., & Adan, R. A. H. (2002) · Peptides · doi:10.1016/s0196-9781(02)00269-3 · Cited by 291
The role of dopamine in motivation for food in humans: implications for obesity
Wang, G.-J., Volkow, N. D., & Fowler, J. S. (2002) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.6.5.601 · Cited by 285
Arcuate Nucleus-Dependent Regulation of Metabolism—Pathways to Obesity and Diabetes Mellitus
Jaïs, A., & Brüning, J. C. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab025 · Cited by 298
Hypothalamic Agrp Neurons Drive Stereotypic Behaviors beyond Feeding
Dietrich, M. O., Zimmer, M. R., Bober, J., & Horváth, T. L. (2015) · Cell · doi:10.1016/j.cell.2015.02.024 · Cited by 271
All Bariatric Surgeries Are Not Created Equal: Insights from Mechanistic Comparisons
Stefater, M. A., Wilson, H., Chambers, A. P., Sandoval, D. A., & Seeley, R. J. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1044 · Cited by 289
Neuropeptide Y in normal eating and in genetic and dietary-induced obesity
Beck, B. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.1855 · Cited by 281
Effects of dietary fat types on body fatness, leptin, and ARC leptin receptor, NPY, and AgRP mRNA expression
Wang, H., Storlien, L. H., & Huang, X. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00230.2001 · Cited by 280
Obesity: The Integrated Roles of Environment and Genetics
Speakman, J. R. (2004) · Journal of Nutrition · doi:10.1093/jn/134.8.2090s · Cited by 275
The melanocortin pathway and control of appetite-progress and therapeutic implications
Baldini, G., & Phelan, K. D. (2019) · Journal of Endocrinology · doi:10.1530/joe-18-0596 · Cited by 300
O-GlcNAc Transferase Enables AgRP Neurons to Suppress Browning of White Fat
Ruan, H.-B., Dietrich, M. O., Liu, Z.-W., Zimmer, M. R., Li, M.-D., Singh, J. P., Zhang, K., Yin, R., Wu, J., Horvath, T. L., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.010 · Cited by 281
Brain serotonin system in the coordination of food intake and body weight
Lam, D. D., Garfield, A. S., Marston, O. J., Shaw, J., & Heisler, L. K. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.09.003 · Cited by 273
Brain regulation of food intake and appetite: molecules and networks
Broberger, C. (2005) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2005.01553.x · Cited by 286
Arcuate NPY Controls Sympathetic Output and BAT Function via a Relay of Tyrosine Hydroxylase Neurons in the PVN
Shi, Y.-C., Lau, J., Lin, Z., Zhang, H., Zhai, L., Sperk, G., Heilbronn, R., Mietzsch, M., Weger, S., Huang, X.-F., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.006 · Cited by 266
The Central Melanocortin System and the Integration of Short- and Long-term Regulators of Energy Homeostasis
Ellacott, K. L. J. (2004) · Recent Progress in Hormone Research · doi:10.1210/rp.59.1.395 · Cited by 260
Peptides and Food Intake
Crespo, C. S., Cachero, A. P., Puebla, L., Barrios, V., & Arilla, E. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00058 · Cited by 274
Fermentable carbohydrate stimulates FFAR2-dependent colonic PYY cell expansion to increase satiety
Brooks, L. J., Viardot, A., Tsakmaki, A., Stolarczyk, É., Howard, J. K., Cani, P. D., Everard, A., Sleeth, M., Psichas, A., Anastasovskaj, J., et al. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.10.011 · Cited by 258
The hardship of obesity: a soft-wired hypothalamus
Horváth, T. L. (2005) · Nature Neuroscience · doi:10.1038/nn1453 · Cited by 256
Agouti-related protein functions as an inverse agonist at a constitutively active brain melanocortin-4 receptor
Haskell‐Luevano, C., & Monck, E. K. (2001) · Regulatory Peptides · doi:10.1016/s0167-0115(01)00234-8 · Cited by 250
Distinct Physiologic and Neuronal Responses to Decreased Leptin and Mild Hyperleptinemia
Ahima, R. S., Kelly, J. F., Elmquist, J. K., & Flier, J. S. (1999) · Endocrinology · doi:10.1210/endo.140.11.7105 · Cited by 267
Regulation of leptin production: sympathetic nervous system interactions
Rayner, D. V., & Trayhurn, P. (2001) · Journal of Molecular Medicine · doi:10.1007/s001090100198 · Cited by 250
Brown fat biology and thermogenesis
Richard, D. (2010) · Frontiers in bioscience · doi:10.2741/3786 · Cited by 251
Role of the melanocortin-4 receptor in metabolic rate and food intake in mice
Chen, A. S., Metzger, J. M., Trumbauer, M. E., Guan, X.-M., Yu, H., Frazier, E. G., Marsh, D. J., Forrest, M. J., Gopal-Truter, S., Fisher, J. K., et al. (2000) · Transgenic Research · doi:10.1023/a:1008983615045 · Cited by 247
Hypothalamic pathways underlying the endocrine, autonomic, and behavioral effects of leptin
Elmquist, J. K. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00613-8 · Cited by 249
Interrelationship between the Novel Peptide Ghrelin and Somatostatin/Growth Hormone-Releasing Hormone in Regulation of Pulsatile Growth Hormone Secretion
Tannenbaum, G. S., Epelbaum, J., & Bowers, C. Y. (2003) · Endocrinology · doi:10.1210/en.2002-220852 · Cited by 248
Important role of hypothalamic Y2 receptors in body weight regulation revealed in conditional knockout mice
Sainsbury, A., Schwarzer, C., Couzens, M., Fetissov, S. O., Fürtinger, S., Jenkins, A. B., Cox, H. M., Sperk, G., Hökfelt, T. G. M., & Herzog, H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.132043299 · Cited by 244
Cell type-specific transcriptomics of hypothalamic energy-sensing neuron responses to weight-loss
Henry, F. E., Sugino, K., Tozer, A., Branco, T., & Sternson, S. M. (2015) · eLife · doi:10.7554/elife.09800 · Cited by 249
Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose‐responsive neurons to regulate Ca2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus
Muroya, S., Funahashi, H., Yamanaka, A., Kohno, D., Uramura, K., Nambu, T., Shibahara, M., Kuramochi, M., Takigawa, M., Yanagisawa, M., et al. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03255.x · Cited by 253
Hypothalamic control of energy balance: different peptides, different functions
LEIBOWITZ, S. F., & Wortley, K. E. (2004) · Peptides · doi:10.1016/j.peptides.2004.02.006 · Cited by 241
Orexin receptor‐1 (OX‐R1) immunoreactivity in chemically identified neurons of the hypothalamus: focus on orexin targets involved in control of food and water intake
Bäckberg, M., Hervieu, G. J., Wilson, S., & Meister, B. (2002) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01859.x · Cited by 235
Postembryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype
Bewick, G. A., Gardiner, J., Dhillo, W. S., Kent, A. S., White, N. E., Webster, Z., Ghatei, M. A., & Bloom, S. R. (2005) · The FASEB Journal · doi:10.1096/fj.04-3434fje · Cited by 253

Authors: Hahn, T. M., Breininger, J. F., Baskin, D. G., & Schwartz, M. W.
Affiliations: University of Washington (US)
Corresponding author: Schwartz, Michael W.
ORCID: Baskin, Denis G.
Schwartz, Michael W.
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 1998-08
Volume: 1
Issue: 4
Pages: 271-272
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/1082
OpenAlex: W1499189927
Semantic Scholar: 5cd16912209995a3a151590004769aad5b81ebd8
Cited by: 1,164
References: 15
Citations by year: 2026: 21 · 2025: 27 · 2024: 31 · 2023: 25 · 2022: 40 · 2021: 36 · 2020: 49 · 2019: 34 · 2018: 36 · 2017: 54 · 2016: 58 · 2015: 49 · 2014: 42 · 2013: 48 · 2012: 61
FWCI: 12.84
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (2r01dk012829-36)
National Institute of Diabetes and Digestive and Kidney Diseases (DK 12829, R01DK052989, DK-52989)
National Institute of Neurological Disorders and Stroke (NS-32273)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: agouti-related protein, neuropeptide Y, proopiomelanocortin, arcuate nucleus, hypothalamic neurons, fasting, food intake regulation, energy homeostasis, melanocortin system
MeSH terms: Animals, Fasting, Hypothalamus, Male, Neurons, Neuropeptide Y, Proteins, RNA, Messenger, In Situ Hybridization, Intercellular Signaling Peptides and Proteins, Mice, Agouti-Related Protein

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks