Direct observation of a free radical interaction between vitamin E and vitamin C

PACKER, J. E., SLATER, T. F., WILLSON, R. L.·1979·Nature

DOI 10.1038/278737a0

Open this paper in CoChat — free account

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/278737a0

Cites

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Exercise-Induced Oxidative Stress: Cellular Mechanisms and Impact on Muscle Force Production
Powers, S. K., & Jackson, M. J. (2008) · Physiological Reviews · doi:10.1152/physrev.00031.2007 · Cited by 2,459
β-Carotene: an Unusual Type of Lipid Antioxidant
Burton, G. W., & Ingold, K. U. (1984) · Science · doi:10.1126/science.6710156 · Cited by 2,150
Strategies of antioxidant defense
SIES, H. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb18025.x · Cited by 1,976
Intracellular Antioxidants: from Chemical to Biochemical Mechanisms
Chaudière, J., & Ferrari-Iliou, R. (1999) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(99)00090-3 · Cited by 671
Carotenoid radical chemistry and antioxidant/pro-oxidant properties
El-Agamey, A., Lowe, G. M., McGarvey, D. J., Mortensen, A., Phillip, D. M., Truscott, T. G., & Young, A. J. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2004.03.007 · Cited by 627
Commentary: Vitamin C: Antioxidant or Pro-Oxidant In Vivo?
Halliwell, B. (1996) · Free Radical Research · doi:10.3109/10715769609149066 · Cited by 531
Vitamin C and Infections
Hemilä, H. (2017) · Nutrients · doi:10.3390/nu9040339 · Cited by 461
Antioxidant defense mechanisms in murine epidermis and dermis and their responses to ultraviolet light
Shindo, Y., Witt, E., & Packer, L. (1993) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12469048 · Cited by 363
Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study: a randomized trial of the effect of vitamins E and C on 3‐year progression of carotid atherosclerosis
Salonen, J. T., Nyyssönen, K., Salonen, R., Lakka, H. ‐., Kaikkonen, J., Porkkala‐Sarataho, E., Voutilainen, S., Lakka, T. A., Rissanen, T., Leskinen, L., et al. (2000) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2000.00752.x · Cited by 327
Protection and Recycling of α-Tocopherol in Human Erythrocytes by Intracellular Ascorbic Acid
May, J. M., Qu, Z.-C., & Mendiratta, S. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1997.0473 · Cited by 316
Aging- and Photoaging-Dependent Changes of Enzymic and Nonenzymic Antioxidants in the Epidermis and Dermis of Human Skin In Vivo
Rhie, G.-E., Shin, M. H., Seo, J. Y., Choi, W. W., Cho, K. H., Kim, K. H., Park, K. C., Eun, H. C., & Chung, J. H. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01469.x · Cited by 274
Protective effect against sunburn of combined systemic ascorbic acid (vitamin C) and d-α-tocopherol (vitamin E)
Eberlein-König, B., Placzek, M., & Przybilla, B. (1998) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(98)70537-7 · Cited by 240
Dose-response effects of acute ultraviolet irradiation on antioxidants and molecular markers of oxidation in murine epidermis and dermis
Shindo, Y., Witt, E., Han, D., & Packer, L. (1994) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12373027 · Cited by 234
Modulation of UV-light-induced skin inflammation by d-alpha-tocopherol and l-ascorbic acid: A clinical study using solar simulated radiation
Fuchs, J., & Kern, H. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00132-4 · Cited by 200
The Pathobiochemistry of Nitrogen Dioxide
Kirsch, M., Korth, H.-G., Sustmann, R., & Groot, H. D. (2002) · Biological Chemistry · doi:10.1515/bc.2002.043 · Cited by 150
Synthetic or food-derived vitamin C—Are they equally bioavailable?
Carr, A., & Vissers, M. (2013) · Nutrients · doi:10.3390/nu5114284 · Cited by 137
Antioxidants, Food Processing and Health
Poljsak, B., Kovač, V., & Milisav, I. (2021) · Antioxidants · doi:10.3390/antiox10030433 · Cited by 133
UVR-induced oxidative stress in human skin in vivo: Effects of oral vitamin C supplementation
McArdle, F., Rhodes, L. E., Parslew, R., Jack, C. I. A., Friedmann, P. S., & Jackson, M. J. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01042-0 · Cited by 132
Ultraviolet B-Induced DNA Damage in Human Epidermis Is Modified by the Antioxidants Ascorbic Acid and D-α-Tocopherol
Placzek, M., Gaube, S., Kerkmann, U., Gilbertz, K.-P., Herzinger, T., Haen, E., & Przybilla, B. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.23560.x · Cited by 123
Interactions between vitamin C and vitamin E are observed in tissues of inherently scorbutic rats
Tanaka, K., Hashimoto, T., Tokumaru, S., Iguchi, H., & Kojo, S. (1997) · The Journal of Nutrition · doi:10.1093/jn/127.10.2060 · Cited by 119
Antioxidant and prooxidant roles for β-carotene, α-tocopherol and ascorbic acid in human lung cells
Zhang, P., & Omaye, S. T. (2001) · Toxicology in Vitro · doi:10.1016/s0887-2333(00)00054-0 · Cited by 119
One-electron oxidation of ergothioneine and analogues investigated by pulse radiolysis: redox reaction involving ergothioneine and vitamin C
ASMUS, K.-D., BENSASSON, R. V., BERNIER, J.-L., HOUSSIN, R., & LAND, E. J. (1996) · Biochemical Journal · doi:10.1042/bj3150625 · Cited by 89
CURCUMIN‐DERIVED TRANSIENTS: A PULSED LASER AND PULSE RADIOLYSIS STUDY
Gorman, A. A., Hamblett, I., Srinivasan, V. S., & Wood, P. D. (1994) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1994.tb05053.x · Cited by 86
Interactions of lipoic acid radical cations with vitamins C and E analogue and hydroxycinnamic acid derivatives
Lu, C., & Liu, Y. (2002) · Archives of Biochemistry and Biophysics · doi:10.1016/s0003-9861(02)00411-3 · Cited by 56
OXIDATIVE STRESS AND THE PATHOGENESIS OF HEART FAILURE
Ball, A. M. M., & Sole, M. J. (1998) · Cardiology Clinics · doi:10.1016/s0733-8651(05)70043-6 · Cited by 53
Skin Redox Balance Maintenance: The Need for an Nrf2-Activator Delivery System
Ben-Yehuda Greenwald, M., Ben-Sasson, S., Bianco-Peled, H., & Kohen, R. (2016) · Cosmetics · doi:10.3390/cosmetics3010001 · Cited by 49
Experimental Vitamin C Depletion and Supplementation in Young Men: Nutrient Interactions and Dental Health Effects
JACOB, R. A., OMAYE, S. T., SKALA, J. H., LEGGOTT, P. J., ROTHMAN, D. L., & MURRAY, P. A. (1987) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1987.tb23772.x · Cited by 48
Antioxidant action of vitamin E in vivo as assessed from its reaction products with multiple biological oxidants
Niki, E., & Noguchi, N. (2021) · Free Radical Research · doi:10.1080/10715762.2020.1866181 · Cited by 47
Vitamin C for preventing and treating pneumonia
Hemilä, H., & Louhiala, P. (2007) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005532.pub2 · Cited by 44
Antioxidant intervention attenuates oxidative stress in children and teenagers with Down syndrome
Parisotto, E. B., Garlet, T. R., Cavalli, V. L. D. L. O., Zamoner, A., da Rosa, J. S., Bastos, J., Micke, G. A., Fröde, T. S., Pedrosa, R. C., & Wilhelm Filho, D. (2014) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2014.03.013 · Cited by 34
Kinetic study of the reaction of vitamin C derivatives with tocopheroxyl (vitamin E radical) and substituted phenoxyl radicals in solution
Mukai, K., Nishimura, M., Nagano, A., Tanaka, K., & Niki, E. (1989) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(89)90159-1 · Cited by 32
In memoriam: Emeritus Professor Robin L. Willson
Davies, M. J., Davies, K. J. A., Halliwell, B., Jackson, M. J., Mann, G. E., Poli, G., Radi, R., Riley, P. A., Sies, H., Ward, J. F., et al. (2022) · Free Radical Research · doi:10.1080/10715762.2022.2140273 · Cited by 1

Authors: PACKER, J. E., SLATER, T. F., & WILLSON, R. L.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1979-04
Volume: 278
Issue: 5706
Pages: 737-738
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/278737a0
OpenAlex: W1963820921
Cited by: 1,470
References: 0
FWCI: 12.35
Type: journal article
Language: en
Open access: closed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review