Cited by 233Skin Protection and AgingGenetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Fifty years of skin aging

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Yaar, Mina, Eller, Mark S., Gilchrest, Barbara A.·2002·Journal of Investigative Dermatology Symposium Proceedings

Abstract

In developed countries, interest in cutaneous aging is in large part the result of a progressive, dramatic rise over the past century in the absolute number and the proportion of the population who are elderly (Smith et al, 2001). The psychosocial as well as physiologic effects of skin aging on older individuals have created a demand for better understanding of the process and particularly for effective interventions. Skin aging is a complex process determined by the genetic endowment of the individual as well as by environmental factors. The appearance of old skin and the clinical consequences of skin aging have been well known for centuries, but only in the past 50 y have mechanisms and mediators been systematically pursued. Still, within this relatively short time there has been tremendous progress, a progress greatly enhanced by basic gerontologic research employing immunologic, biochemical, and particularly molecular biologic approaches (Figs 1, 2).

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Crossref · 10.1046/j.1523-1747.2002.19636.x

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Authors
Yaar, M., Eller, M. S., & Gilchrest, B. A.
Affiliations
Boston University (US)
Corresponding author
Gilchrest, Barbara A.
Venue
Journal of Investigative Dermatology Symposium Proceedings
Publisher
Elsevier BV
Published
2002-12
Volume
7
Issue
1
Pages
51-58
ISSN
1087-0024 (ISSN-L)
OpenAlex
W2000936610
Cited by
233
References
132
Citations by year
2026: 5 · 2025: 5 · 2024: 8 · 2023: 14 · 2022: 10 · 2021: 11 · 2020: 15 · 2019: 17 · 2018: 12 · 2017: 14 · 2016: 27 · 2015: 10 · 2014: 11 · 2013: 8 · 2012: 10
FWCI
21.57
Type
conference paper
Language
en
Open access
Locations
  • Journal of Investigative Dermatology Symposium Proceedings (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
Keywords
skin aging, aging mechanisms, genetic factors, environmental factors, older adults, aging interventions
MeSH terms
Animals, Dermatology, Humans, Skin Physiological Phenomena, Skin Aging, Gene Expression, Telomere, Oxidative Stress

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