The microenvironment of the tumour–host interface

Carcinoma-associated fibroblasts stimulate tumor progression of initiated human epithelium

Olumi, A., Grossfeld, G., Hayward, S., Carroll, P., Cunha, G., Hein, P., & Tlsty, T. (2000) · Breast Cancer Research · doi:10.1186/bcr138 · Cited by 1,463

MMP-9 Supplied by Bone Marrow–Derived Cells Contributes to Skin Carcinogenesis

Coussens, L. M., Tinkle, C. L., Hanahan, D., & Werb, Z. (2000) · Cell · doi:10.1016/s0092-8674(00)00139-2 · Cited by 1,306

Effector Memory T Cells, Early Metastasis, and Survival in Colorectal Cancer

Pagès, F., Berger, A., Camus, M., Sanchez-Cabo, F., Costes, A., Molidor, R., Mlecnik, B., Kirilovsky, A., Nilsson, M., Damotte, D., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa051424 · Cited by 2,135

Formation and function of the myofibroblast during tissue repair

Hinz, B. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700613 · Cited by 1,658

Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene

Pennacchietti, S., Michieli, P., Galluzzo, M., Mazzone, M., Giordano, S., & Comoglio, P. M. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00085-0 · Cited by 1,311

Role of tissue stroma in cancer cell invasion

De Wever, O., & Mareel, M. (2003) · The Journal of Pathology · doi:10.1002/path.1398 · Cited by 1,042

Multiple myeloma: evolving genetic events and host interactions

Kuehl, W. M., & Bergsagel, P. L. (2002) · Nature Reviews Cancer · doi:10.1038/nrc746 · Cited by 818

Regulation of cancer cell migration and bone metastasis by RANKL.

Jones, D. H., Nakashima, T., Sanchez, O. H., Kozieradzki, I., Komarova, S. V., Sarosi, I., Morony, S., Rubin, E., Sarao, R., Hojilla, C. V., et al. (2006) · Nature · doi:10.1038/nature04524 · Cited by 796

The role of tumor stroma in cancer progression and prognosis: Emphasis on carcinoma-associated fibroblasts and non-small cell lung cancer

Bremnes, R. M., Dønnem, T., Al-Saad, S., Al-Shibli, K., Andersen, S., Sirera, R., Camps, C., Marinez, I., & Busund, L.-T. (2011) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e3181f8a1bd · Cited by 691

Cancer associated fibroblasts (CAFs) in tumor microenvironment

Xing, F. (2010) · Frontiers in Bioscience · doi:10.2741/3613 · Cited by 682

scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila

Brumby, A. M., & Richardson, H. E. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg548 · Cited by 628

Targeting tumor‐associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake

Loeffler, M. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26532 · Cited by 633

Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness

Giannoni, E., Bianchini, F., Masieri, L., Serni, S., Torre, E., Calorini, L., & Chiarugi, P. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0785 · Cited by 596

The Differential Effects of Mutant p53 Alleles on Advanced Murine Lung Cancer

Jackson, E. L., Olive, K. P., Tuveson, D. A., Bronson, R., Crowley, D., Brown, M., & Jacks, T. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-2193 · Cited by 553

Bone marrow contribution to tumor-associated myofibroblasts and fibroblasts

Direkze, N. C., Hodivala-Dilke, K., Jeffery, R., Hunt, T., Poulsom, R., Oukrif, D., Alison, M. R., & Wright, N. A. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1708 · Cited by 530

Cancer and ageing: rival demons?

Campisi, J. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1073 · Cited by 512

Stress hormone-mediated invasion of ovarian cancer cells

Sood, A. K., Bhatty, R., Kamat, A. A., Landen, C. N., Han, L., Thaker, P. H., Li, Y., Gershenson, D. M., Lutgendorf, S., & Cole, S. W. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1698 · Cited by 491

Cancer as a robust system: implications for anticancer therapy

Kitano, H. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1300 · Cited by 456

Cellular senescence: a link between cancer and age-related degenerative disease?

Campisi, J., Andersen, J. K., Kapahi, P., & Melov, S. (2011) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2011.09.001 · Cited by 421

Chemokines: agents for the immunotherapy of cancer?

Homey, B., Müller, A., & Zlotnik, A. (2002) · Nature Reviews Immunology · doi:10.1038/nri748 · Cited by 398

Tenascin-C induced signaling in cancer

Orend, G., & Chiquet-Ehrismann, R. (2006) · Cancer Letters · doi:10.1016/j.canlet.2006.02.017 · Cited by 384

The Carcinoma–Stromal Ratio of Colon Carcinoma Is an Independent Factor for Survival Compared to Lymph Node Status and Tumor Stage

Mesker, W. E., Junggeburt, J. M. C., Szuhai, K., de Heer, P., Morreau, H., Tanke, H. J., & Tollenaar, R. A. E. M. (2007) · Analytical Cellular Pathology · doi:10.1155/2007/175276 · Cited by 354

Pericytes limit tumor cell metastasis

Xian, X. (2006) · Journal of Clinical Investigation · doi:10.1172/jci25705 · Cited by 345

Bone marrow mesenchymal stem cells are abnormal in multiple myeloma

Corre, J., Mahtouk, K., Attal, M., Gadelorge, M., Huynh, A., Fleury-Cappellesso, S., Danho, C., Laharrague, P., Klein, B., Rème, T., et al. (2007) · Leukemia · doi:10.1038/sj.leu.2404621 · Cited by 328

Extracellular vesicles including exosomes are mediators of signal transduction: are they protective or pathogenic?

Gangoda, L., Boukouris, S., Liem, M., Kalra, H., & Mathivanan, S. (2015) · PROTEOMICS · doi:10.1002/pmic.201400234 · Cited by 301

Crosstalk to Stromal Fibroblasts Induces Resistance of Lung Cancer to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors

Wang, W., Li, Q., Yamada, T., Matsumoto, K., Matsumoto, I., Oda, M., Watanabe, G., Kayano, Y., Nishioka, Y., Sone, S., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1001 · Cited by 297

Cancer and aging: a model for the cancer promoting effects of the aging stroma

Krtolica, A., & Campisi, J. (2002) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(02)00053-5 · Cited by 295

Nanoparticles for modulating tumor microenvironment to improve drug delivery and tumor therapy

Yang, S., & Gao, H. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.05.004 · Cited by 256

Stroma-Derived Three-Dimensional Matrices Are Necessary and Sufficient to Promote Desmoplastic Differentiation of Normal Fibroblasts

Amatangelo, M. D., Bassi, D. E., Klein-Szanto, A. J. P., & Cukierman, E. (2005) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)62991-4 · Cited by 248

Stage-specific vascular markers revealed by phage display in a mouse model of pancreatic islet tumorigenesis

Joyce, J. A., Laakkonen, P., Bernasconi, M., Bergers, G., Ruoslahti, E., & Hanahan, D. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00271-x · Cited by 211

The role of cancer-associated fibroblasts, solid stress and other microenvironmental factors in tumor progression and therapy resistance

Kharaishvili, G., Simkova, D., Bouchalova, K., Gachechiladze, M., Narsia, N., & Bouchal, J. (2014) · Cancer Cell International · doi:10.1186/1475-2867-14-41 · Cited by 197

Interleukin-6 in the bone marrow microenvironment promotes the growth and survival of neuroblastoma cells

Ara, T., Song, L., Shimada, H., Keshelava, N., Russell, H. V., Metelitsa, L. S., Groshen, S. G., Seeger, R. C., & DeClerck, Y. A. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-0613 · Cited by 175

The influence of glucocorticoid signaling on tumor progression

Volden, P. A., & Conzen, S. D. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.10.022 · Cited by 163

Cellular Mechanisms for Low-Dose Ionizing Radiation–Induced Perturbation of the Breast Tissue Microenvironment

Tsai, K. K. C., Chuang, E. Y.-Y., Little, J. B., & Yuan, Z.-M. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0703 · Cited by 145

Mounting Pressure in the Microenvironment: Fluids, Solids, and Cells in Pancreatic Ductal Adenocarcinoma

DuFort, C. C., DelGiorno, K. E., & Hingorani, S. R. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.03.040 · Cited by 144

The Heat Shock Protein 90 Inhibitor, 17-Allylamino-17-demethoxygeldanamycin, Enhances Osteoclast Formation and Potentiates Bone Metastasis of a Human Breast Cancer Cell Line

Price, J. T., Quinn, J. M. W., Sims, N. A., Vieusseux, J., Waldeck, K., Docherty, S. E., Myers, D., Nakamura, A., Waltham, M. C., Gillespie, M. T., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4458 · Cited by 142

Dormant cancer cells retrieved from metastasis-free organs regain tumorigenic and metastatic potency

Suzuki, M., Mose, E. S., Montel, V., & Tarin, D. (2006) · The American Journal of Pathology · doi:10.2353/ajpath.2006.060053 · Cited by 136

Cystatin C Antagonizes Transforming Growth Factor β Signaling in Normal and Cancer Cells

Sokol, J. P., & Schiemann, W. P. (2004) · Molecular Cancer Research · doi:10.1158/1541-7786.183.2.3 · Cited by 121

Lack of host SPARC enhances vascular function and tumor spread in an orthotopic murine model of pancreatic carcinoma

Arnold, S. A., Rivera, L. B., Miller, A. F., Carbon, J. G., Dineen, S. P., Xie, Y., Castrillon, D. H., Sage, E. H., Puolakkainen, P., Bradshaw, A. D., et al. (2010) · Disease Models & Mechanisms · doi:10.1242/dmm.003228 · Cited by 118

Cancer‑associated fibroblast regulation of tumor neo‑angiogenesis as a therapeutic target in cancer (Review)

Wang, F., Sun, W., Zhang, J., & Fan, Y. (2019) · Oncology Letters · doi:10.3892/ol.2019.9973 · Cited by 115

Senescent Cells and Their Secretory Phenotype as Targets for Cancer Therapy

Velarde, M. C., Demaria, M., & Campisi, J. (2013) · Interdisciplinary Topics in Gerontology and Geriatrics · doi:10.1159/000343572 · Cited by 112

Fibroblast Hepatocyte Growth Factor Promotes Invasion of Human Mammary Ductal Carcinoma In situ

Jedeszko, C., Victor, B. C., Podgorski, I., & Sloane, B. F. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1043 · Cited by 104

Involvement of Cyr61 in growth, migration, and metastasis of prostate cancer cells

Sun, Z.-J., Wang, Y., Cai, Z., Chen, P.-P., Tong, X.-J., & Xie, D. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604712 · Cited by 95

Laminin-332-rich tumor microenvironment for tumor invasion in the interface zone of breast cancer

Kim, B. G., An, H. J., Kang, S., Choi, Y. P., Gao, M.-Q., Park, H., & Cho, N. H. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2010.11.028 · Cited by 98

Metastatic ability of Drosophila tumors depends on MMP activity

Beaucher, M., Hersperger, E., Page-McCaw, A., & Shearn, A. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2006.12.001 · Cited by 97

Characterization of the tumor microenvironment and tumor–stroma interaction by non-invasive preclinical imaging

Ramamonjisoa, N., & Ackerstaff, E. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00003 · Cited by 93

Flavonoids inhibit melanoma lung metastasis by impairing tumor cells endothelium interactions

Piantelli, M., Rossi, C., Iezzi, M., La Sorda, R., Iacobelli, S., Alberti, S., & Natali, P. G. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20510 · Cited by 85

Cancer-associated fibroblasts promote non-small cell lung cancer cell invasion by upregulation of glucose-regulated protein 78 (GRP78) expression in an integrated bionic microfluidic device

Yu, T., Guo, Z., Fan, H., Song, J., Liu, Y., Gao, Z., & Wang, Q. (2016) · Oncotarget · doi:10.18632/oncotarget.8232 · Cited by 70

Detection of Metabolic Alterations in Non-tumor Gastrointestinal Tissue of the ApcMin/+ Mouse by 1H MAS NMR Spectroscopy

Backshall, A., Alferez, D., Teichert, F., Wilson, I. D., Wilkinson, R. W., Goodlad, R. A., & Keun, H. C. (2009) · Journal of Proteome Research · doi:10.1021/pr800793w · Cited by 42

Exosomes in colorectal carcinoma formation: ALIX under the magnifying glass

Valcz, G., Galamb, O., Krenács, T., Spisák, S., Kalmár, A., Patai, Á. V., Wichmann, B., Dede, K., Tulassay, Z., & Molnár, B. (2016) · Modern Pathology · doi:10.1038/modpathol.2016.72 · Cited by 42

Predictive potential of tumour-stroma ratio on benefit from adjuvant bevacizumab in high-risk stage II and stage III colon cancer

Zunder, S. M., van Pelt, G. W., Gelderblom, H. J., Mancao, C., Putter, H., Tollenaar, R. A., & Mesker, W. E. (2018) · British Journal of Cancer · doi:10.1038/s41416-018-0083-0 · Cited by 36

Genomic and phenotypic analysis reveals a key role for CCN1 (CYR61) in BAG3—modulated adhesion and invasion

Kassis, J. N., Virador, V. M., Guancial, E. A., Kimm, D., Ho, A. S., Mishra, M., Chuang, E. Y., Cook, J., Gius, D., & Kohn, E. C. (2009) · The Journal of Pathology · doi:10.1002/path.2557 · Cited by 34

Desmoplasia: not always a bad thing

Abbas, O., & Mahalingam, M. (2011) · Histopathology · doi:10.1111/j.1365-2559.2010.03617.x · Cited by 32

Stromal organization as predictive biomarker for the treatment of colon cancer with adjuvant bevacizumab; a post-hoc analysis of the AVANT trial

Zunder, S., van der Wilk, P., Gelderblom, H., Dekker, T., Mancao, C., Kiialainen, A., Putter, H., Tollenaar, R., & Mesker, W. (2019) · Cellular Oncology · doi:10.1007/s13402-019-00449-9 · Cited by 9