The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Abstract reward and punishment representations in the human orbitofrontal cortex
Abstract
The orbitofrontal cortex (OFC) is implicated in emotion and emotion-related learning. Using event-related functional magnetic resonance imaging (fMRI), we measured brain activation in human subjects doing an emotion-related visual reversal-learning task in which choice of the correct stimulus led to a probabilistically determined 'monetary' reward and choice of the incorrect stimulus led to a monetary loss. Distinct areas of the OFC were activated by monetary rewards and punishments. Moreover, in these areas, we found a correlation between the magnitude of the brain activation and the magnitude of the rewards and punishments received. These findings indicate that one emotional involvement of the human orbitofrontal cortex is its representation of the magnitudes of abstract rewards and punishments, such as receiving or losing money.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Altered cortical midline activation, particularly in the vmPFC, has been associated with judgements of selfrelevance (Phan et al., 2004), as well as appreciation of emotional valence, ranging from simple sensory to more complex and abstract events (O' Doherty et al., 2001;Anderson et al., 2003;Cunningham et al., 2004).”
From Attending to the present: mindfulness meditation reveals distinct neural modes of self-reference (2007) · cites this paper as O' Doherty et al., 2001
In the citing paper
“The OFC, a highly evolved brain region, is associated with increasing positive mood and altering the contextualization of arising sensory events.35,85,88,94”
From The neural mechanisms of mindfulness-based pain relief: a functional magnetic resonance imaging-based review and primer (2019) · cites this paper as [85]
In the citing paper
“the human lateral OFC is activated when a reward is not obtained in a visual discrimination reversal task (Kringelbach and Rolls, 2003) (Fig. 4A), and when money is not received in a monetary reward task (O’Doherty et al., 2001; Xie et al., 2020), and in a one-trial rule-based reward reversal task (Rolls et al., 2020b).”
From The orbitofrontal cortex: reward, emotion and depression (2020) · cites this paper as O’Doherty et al., 2001
In the citing paper
“Given that the activations of the lateral and medial OFC often appear to be reciprocally related (O’Doherty et al., 2001; Rolls et al., 2003a; Xie et al., 2020), the other part of the theory is that in depression there may be underactivity, under-sensitivity or under-connectivity of the (reward-related) medial OFC in depression (Rolls, 2016a, 2018a).”
From The orbitofrontal cortex: reward, emotion and depression (2020) · cites this paper as O’Doherty et al., 2001
Citations
Cites
Co-Planar Stereotaxic Atlas of the Human Brain
Talairach, J., & Tournoux, P. (1988) · Medical Entomology and Zoology · Cited by 11,798
Co-planar stereotaxic atlas of the human brain
Laitinen, L. (1989) · Clinical Neurology and Neurosurgery · doi:10.1016/0303-8467(89)90128-5 · Cited by 7,565
Insensitivity to future consequences following damage to human prefrontal cortex
Bechara, A., Damasio, A. R., Damasio, H., & Anderson, S. W. (1994) · Cognition · doi:10.1016/0010-0277(94)90018-3 · Cited by 6,128
Deciding advantageously before knowing the advantageous strategy
Bechara, A., Damasio, H., Tranel, D., & Damasio, A. R. (1997) · Science · doi:10.1126/science.275.5304.1293 · Cited by 3,547
Stuss, D. T., & Benson, D. F. (1986) · Raven Press eBooks · Cited by 2,102
The Orbitofrontal Cortex and Reward
Rolls, E. T. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.284 · Cited by 1,595
Self-citationImpairment of social and moral behavior related to early damage in human prefrontal cortex
Anderson, S. W., Bechara, A., Damasio, H., Tranel, D., & Damasio, A. R. (1999) · Nature Neuroscience · doi:10.1038/14833 · Cited by 1,539
Dissociation in prefrontal cortex of affective and attentional shifts
Dias, R., Robbins, T. W., & Roberts, A. C. (1996) · Nature · doi:10.1038/380069a0 · Cited by 1,527
Anterior cerebral asymmetry and the nature of emotion
Davidson, R. J. (1992) · Brain and Cognition · doi:10.1016/0278-2626(92)90065-t · Cited by 1,381
Relative reward preference in primate orbitofrontal cortex
Tremblay, L., & Schultz, W. (1999) · Nature · doi:10.1038/19525 · Cited by 1,314
Rolls, E. T. (1998) · doi:10.1093/oso/9780198524649.001.0001 · Cited by 1,314
Self-citationLimbic connections of the orbital and medial prefrontal cortex in macaque monkeys
Carmichael, S. T., & Price, J. L. (1995) · Journal of Comparative Neurology · doi:10.1002/cne.903630408 · Cited by 1,197
Rolls, E. T., Hornak, J., Wade, D., & McGrath, J. (1994) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.57.12.1518 · Cited by 1,005
Self-citationMiezin, F. M., Maccotta, L., Ollinger, J. M., Petersen, S. E., & Buckner, R. L. (2000) · NeuroImage · doi:10.1006/nimg.2000.0568 · Cited by 961
The Anatomical Connections of the Macaque Monkey Orbitofrontal Cortex. A Review
Cavada, C. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.220 · Cited by 917
Elliott, R. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.308 · Cited by 887
Limbic lesions and the problem of stimulus--reinforcement associations.
Jones, B., & Mishkin, M. (1972) · Experimental Neurology · doi:10.1016/0014-4886(72)90030-1 · Cited by 864
Iversen, S., & Mishkin, M. (1970) · Experimental Brain Research · doi:10.1007/bf00237911 · Cited by 765
A direct quantitative relationship between the functional properties of human and macaque V5
Rees, G. E., Friston, K. J., & Koch, C. (2000) · Nature Neuroscience · doi:10.1038/76673 · Cited by 650
Gustatory, olfactory, and visual convergence within the primate orbitofrontal cortex
Rolls, E., & Baylis, L. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-09-05437.1994 · Cited by 587
Self-citationCytoarchitecture and neural afferents of orbitofrontal cortex in the brain of the monkey
Morecraft, R. J., Geula, C., & Mesulam, M. ‐. (1992) · Journal of Comparative Neurology · doi:10.1002/cne.903230304 · Cited by 539
Sparseness of the neuronal representation of stimuli in the primate temporal visual cortex
Rolls, E. T., & Tovée, M. J. (1995) · Journal of Neurophysiology · doi:10.1152/jn.1995.73.2.713 · Cited by 500
Self-citationSensory-specific satiety-related olfactory activation of the human orbitofrontal cortex
OʼDoherty, J., Rolls, E. T., Francis, S., Bowtell, R., McGlone, F., Kobal, G., Renner, B., & Ahne, G. (2000) · NeuroReport · doi:10.1097/00001756-200002070-00035 · Cited by 482
Self-citationFrancis, S., Rolls, E. T., Bowtell, R. W., McGlone, F. P., O’Doherty, J. P., Browning, A., Clare, S., & Smith, E. (1999) · Neuroreport · doi:10.1097/00001756-199902250-00003 · Cited by 421
Self-citationTransient activation of inferior prefrontal cortex during cognitive set shifting
Konishi, S., Nakajima, K., Uchida, I., Kameyama, M., Nakahara, K., Sekihara, K., & Miyashita, Y. (1998) · Nature Neuroscience · doi:10.1038/283 · Cited by 401
Orbitofrontal cortex neurons: role in olfactory and visual association learning
Rolls, E. T., Critchley, H. D., Mason, R., & Wakeman, E. A. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.75.5.1970 · Cited by 398
Self-citationKonishi, S., Nakajima, K., Uchida, I., Sekihara, K., & Miyashita, Y. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00167.x · Cited by 386
Sensory-specific satiety-related olfactory activation of the human orbitofrontal cortex
OʼDoherty, J., Rolls, E. T., Francis, S., Bowtell, R., McGlone, F., Kobal, G., Renner, B., & Ahne, G. (2000) · NeuroReport · doi:10.1097/00001756-200003200-00046 · Cited by 361
Self-citationMeunier, M. (1997) · Neuropsychologia · doi:10.1016/s0028-3932(97)00027-4 · Cited by 348
Functional–Anatomic Study of Episodic Retrieval Using fMRI
Buckner, R. L., Koutstaal, W., Schacter, D. L., Wagner, A. D., & Rosen, B. R. (1998) · NeuroImage · doi:10.1006/nimg.1998.0327 · Cited by 296
Gustatory responses of single neurons in the caudolateral orbitofrontal cortex of the macaque monkey
Rolls, E. T., Yaxley, S., & Sienkiewicz, Z. J. (1990) · Journal of Neurophysiology · doi:10.1152/jn.1990.64.4.1055 · Cited by 282
Self-citationBuckner, R. L., Koutstaal, W., Schacter, D., Dale, A., Rotte, M., & Rosen, B. (1998) · NeuroImage · doi:10.1006/nimg.1998.0328 · Cited by 274
Activation of the human brain by monetary reward
Thut, G., Schultz, W., Roelcke, U., Nienhusmeier, M., Missimer, J. H., Maguire, R. P., & Leenders, K. L. (1997) · Neuroreport · doi:10.1097/00001756-199703240-00033 · Cited by 273
Differential neural response to positive and negative feedback in planning and guessing tasks
Elliott, R., Frith, C., & Dolan, R. J. (1997) · Neuropsychologia · doi:10.1016/s0028-3932(97)00055-9 · Cited by 192
Orbitofrontal function, object alternation and perseveration
Freedman, M. (1998) · Cerebral Cortex · doi:10.1093/cercor/8.1.18 · Cited by 165
Connectional networks within the orbital and medial prefrontal cortex of macaque monkeys
Carmichael, S. T., & Price, J. L. (1996) · Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19960722)371:2
Research works printed but not linked: 1
- Damasio, A. R. Descartes' Error (Putnam, New York, 1994).
Cited by
Sorted by citations
The reward circuit: linking primate anatomy and human imaging
Haber, S. N., & Knutson, B. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.129 · Cited by 3,718
Functional neuroanatomy of emotion: A meta-analysis of emotion activation studies in PET and fMRI
Phan, K. L., Wager, T., Taylor, S. F., & Liberzon, I. (2002) · NeuroImage · doi:10.1006/nimg.2002.1087 · Cited by 3,502
Casey, B. J., Jones, R. M., & Hare, T. A. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1440.010 · Cited by 3,345
The role of the medial frontal cortex in cognitive control
Ridderinkhof, K. R., Ullsperger, M., Crone, E. A., & Nieuwenhuis, S. (2004) · Science · doi:10.1126/science.1100301 · Cited by 2,974
Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications
Goldstein, R. Z., & Volkow, N. D. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3119 · Cited by 2,749
Metadata
- Authors
- O'Doherty, J., Kringelbach, M. L., Rolls, E. T., Hornak, J., & Andrews, C.
- Affiliations
- John Radcliffe Hospital (GB)
- University of Oxford (GB)
- Corresponding author
- Rolls, E. T.
- Venue
- Nature Neuroscience
- Published
- 2001-01
- Volume
- 4
- Issue
- 1
- Pages
- 95-102
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W1499836032
- Cited by
- 2,003
- References
- 38
- Citations by year
- 2026: 20 · 2025: 36 · 2024: 61 · 2023: 50 · 2022: 62 · 2021: 70 · 2020: 57 · 2019: 74 · 2018: 54 · 2017: 62 · 2016: 87 · 2015: 90 · 2014: 95 · 2013: 92 · 2012: 99
- Type
- conference abstract
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Decision Sciences › General Decision Sciences › Decision-Making and Behavioral Economics
- Keywords
- orbitofrontal cortex, reward representation, monetary rewards, financial losses, reversal learning, emotions, emotional learning, reward magnitude, brain activation
- MeSH terms
- Adult, Brain Mapping, Emotions, Female, Frontal Lobe, Gambling, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Punishment, Reversal Learning, Reward
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
