Calreticulin exposure is required for the immunogenicity of γ-irradiation and UVC light-induced apoptosis

Calreticulin exposure dictates the immunogenicity of cancer cell death

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The cornified envelope: a model of cell death in the skin

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Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death

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Cell-Surface Calreticulin Initiates Clearance of Viable or Apoptotic Cells through trans-Activation of LRP on the Phagocyte

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Classification of cell death: recommendations of the Nomenclature Committee on Cell Death

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Cell death modalities: classification and pathophysiological implications

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Strategies for optimizing combinations of molecularly targeted anticancer agents

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Why is cancer drug discovery so difficult?

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Immunogenicity of Apoptotic Cells In Vivo: Role of Antigen Load, Antigen-Presenting Cells, and Cytokines

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Quantitation of mitochondrial alterations associated with apoptosis

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Apoptotic Cells Deliver Processed Antigen to Dendritic Cells for Cross-Presentation

Blachère, N. E., Darnell, R. B., & Albert, M. L. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030185 · Cited by 153 · see citing works

Immune Response Against Dying Tumor Cells

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Successful combination of local CpG‐ODN and radiotherapy in malignant glioma

Meng, Y., Carpentier, A. F., Chen, L., Boisserie, G., Simon, J.-M., Mazeron, J., & Delattre, J. (2005) · International Journal of Cancer · doi:10.1002/ijc.21131 · Cited by 105 · see citing works

Calreticulin exposure increases cancer immunogenicity

Clarke, C., & Smyth, M. J. (2007) · Nature Biotechnology · doi:10.1038/nbt0207-192 · Cited by 82 · see citing works

A Better Way for a Cancer Cell to Die

Lake, R., & van der Most, R. (2006) · New England Journal of Medicine · doi:10.1056/nejmcibr061443 · Cited by 64 · see citing works

Calreticulin Promotes Folding of Functional Human Leukocyte Antigen Class I Molecules in Vitro

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A 'good death' for tumor immunology

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Calreticulin: Raising awareness of apoptosis

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Immunogenic Cell Death in Cancer Therapy

Kroemer, G., Galluzzi, L., Kepp, O., & Zitvogel, L. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-100008 · Cited by 3,303 · see citing works

Immunogenic cell death in cancer and infectious disease

Galluzzi, L., Buqué, A., Kepp, O., Zitvogel, L., & Kroemer, G. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2016.107 · Cited by 3,119 · see citing works

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

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Immunological aspects of cancer chemotherapy

Zitvogel, L., Apetoh, L., Ghiringhelli, F., & Kroemer, G. (2008) · Nature Reviews Immunology · doi:10.1038/nri2216 · Cited by 1,712 · see citing works

Fractionated but Not Single-Dose Radiotherapy Induces an Immune-Mediated Abscopal Effect when Combined with Anti–CTLA-4 Antibody

Dewan, M. Z., Galloway, A. E., Kawashima, N., Dewyngaert, J. K., Babb, J. S., Formenti, S. C., & Demaria, S. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-0265 · Cited by 1,678 · see citing works

Immunostimulation with chemotherapy in the era of immune checkpoint inhibitors

Galluzzi, L., Humeau, J., Buqué, A., Zitvogel, L., & Kroemer, G. (2020) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0413-z · Cited by 1,349 · see citing works

Immunogenic and tolerogenic cell death

Green, D. R., Ferguson, T., Zitvogel, L., & Kroemer, G. (2009) · Nature Reviews Immunology · doi:10.1038/nri2545 · Cited by 1,176 · see citing works

Harnessing innate immunity in cancer therapy

Demaria, O., Cornen, S., Daëron, M., Morel, Y., Medzhitov, R., & Vivier, E. (2019) · Nature · doi:10.1038/s41586-019-1593-5 · Cited by 957 · see citing works

Mechanisms of pre‐apoptotic calreticulin exposure in immunogenic cell death

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Calreticulin Is the Dominant Pro-Phagocytic Signal on Multiple Human Cancers and Is Counterbalanced by CD47

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Induction of Immunological Tolerance by Apoptotic Cells Requires Caspase-Dependent Oxidation of High-Mobility Group Box-1 Protein

Kazama, H., Ricci, J.-E., Herndon, J. M., Hoppe, G., Green, D. R., & Ferguson, T. A. (2008) · Immunity · doi:10.1016/j.immuni.2008.05.013 · Cited by 627 · see citing works

Molecular mechanisms of ATP secretion during immunogenic cell death

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An Immunosurveillance Mechanism Controls Cancer Cell Ploidy

Senovilla, L., Vitale, I., Martins, I., Tailler, M., Pailleret, C., Michaud, M., Galluzzi, L., Adjemian, S., Kepp, O., Niso-Santano, M., et al. (2012) · Science · doi:10.1126/science.1224922 · Cited by 436 · see citing works

Endoplasmic Reticulum Stress Signaling in Cancer Cells

Oakes, S. A. (2020) · The American Journal of Pathology · doi:10.1016/j.ajpath.2020.01.010 · Cited by 397 · see citing works

Molecular Mechanisms of Radiation-Induced Cancer Cell Death: A Primer

Sia, J., Szmyd, R., Hau, E., & Gee, H. E. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00041 · Cited by 378 · see citing works

The co-translocation of ERp57 and calreticulin determines the immunogenicity of cell death

Panaretakis, T., Joza, N., Modjtahedi, N., Tesniere, A., Vitale, I., Durchschlag, M., Fimia, G. M., Kepp, O., Piacentini, M., Froehlich, K.-U., et al. (2008) · Cell Death & Differentiation · doi:10.1038/cdd.2008.67 · Cited by 344 · see citing works

Radiation therapy and anti-tumor immunity: exposing immunogenic mutations to the immune system

Lhuillier, C., Rudqvist, N.-P., Elemento, O., Formenti, S. C., & Demaria, S. (2019) · Genome Medicine · doi:10.1186/s13073-019-0653-7 · Cited by 276 · see citing works

Immunostimulatory nanomedicines synergize with checkpoint blockade immunotherapy to eradicate colorectal tumors

Duan, X., Chan, C., Han, W., Guo, N., Weichselbaum, R. R., & Lin, W. (2019) · Nature Communications · doi:10.1038/s41467-019-09221-x · Cited by 256 · see citing works

Ecto‐calreticulin in immunogenic chemotherapy

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Physical modalities inducing immunogenic tumor cell death for cancer immunotherapy

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Autophagy within the antigen donor cell facilitates efficient antigen cross-priming of virus-specific CD8+ T cells

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Regulation of efferocytosis as a novel cancer therapy

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Immunogenic Cell Death-Based Cancer Vaccines

Jin, M.-Z., & Wang, X.-P. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.697964 · Cited by 99 · see citing works

Induction of immunogenic apoptosis by blockade of epidermal growth factor receptor activation with a specific antibody

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Resistance to anticancer vaccination effect is controlled by a cancer cell-autonomous phenotype that disrupts immunogenic phagocytic removal

Garg, A. D., Elsen, S., Krysko, D. V., Vandenabeele, P., de Witte, P., & Agostinis, P. (2015) · Oncotarget · doi:10.18632/oncotarget.4754 · Cited by 87 · see citing works

Immune system and intestinal microbiota determine efficacy of androgen deprivation therapy against prostate cancer

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Western Blot을 이용한 대장암과 대장선종의 Calreticulin 단백 발현 연구

금보라, 진윤태, 박상훈, et al. (2006)

Leveraging the Immune System during Chemotherapy: Moving Calreticulin to the Cell Surface Converts Apoptotic Death from “Silent” to Immunogenic

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[Calreticulin, Ca2+-binding chaperon of the endoplasmic reticulum].

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Antibodies to calnexin and mutated calreticulin are common in human sera

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Calreticulin recognizes misfolded HLA-A2 heavy chains

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