Cited by 710Cell death mechanisms and regulationImmune Response and InflammationNF-κB Signaling Pathways

Necrosis, a well-orchestrated form of cell demise: Signalling cascades, important mediators and concomitant immune response

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Festjens, Nele, Vanden Berghe, Tom, Vandenabeele, Peter·2006·Biochimica et Biophysica Acta (BBA) - Bioenergetics

Abstract

Necrosis has long been described as a consequence of physico-chemical stress and thus accidental and uncontrolled. Recently, it is becoming clear that necrotic cell death is as well controlled and programmed as caspase-dependent apoptosis, and that it may be an important cell death mode that is both pathologically and physiologically relevant. Necrotic cell death is not the result of one well-described signalling cascade but is the consequence of extensive crosstalk between several biochemical and molecular events at different cellular levels. Recent data indicate that serine/threonine kinase RIP1, which contains a death domain, may act as a central initiator. Calcium and reactive oxygen species (ROS) are main players during the propagation and execution phases of necrotic cell death, directly or indirectly provoking damage to proteins, lipids and DNA, which culminates in disruption of organelle and cell integrity. Necrotically dying cells initiate pro-inflammatory signalling cascades by actively releasing inflammatory cytokines and by spilling their contents when they lyse. Unravelling the signalling cascades contributing to necrotic cell death will permit us to develop tools to specifically interfere with necrosis at certain levels of signalling. Necrosis occurs in both physiological and pathophysiological processes, and is capable of killing tumour cells that have developed strategies to evade apoptosis. Thus detailed knowledge of necrosis may be exploited in therapeutic strategies.

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Crossref · 10.1016/j.bbabio.2006.06.014

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  • Evidence is accumulating that necrotic cell death may be regulated by signal transduction pathways and catabolic mechanisms.

    “Nonetheless, evidence is accumulating that the execution of necrotic cell death may be subtly regulated by a set of signal transduction pathways and catabolic mechanisms 111,112.”

    From Immunogenic and tolerogenic cell death (2009) · cites this paper as [112]

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Authors
Festjens, N., Vanden Berghe, T., & Vandenabeele, P.
Affiliations
Vlaams Instituut voor Biotechnologie (BE)
Corresponding author
Vandenabeele, Peter
Venue
Biochimica et Biophysica Acta (BBA) - Bioenergetics
Publisher
Elsevier BV
Published
2006-09
Volume
1757
Issue
9-10
Pages
1371-1387
ISSN
0005-2728 (ISSN-L)
OpenAlex
W2130407823
Cited by
710
References
248
Citations by year
2026: 17 · 2025: 31 · 2024: 30 · 2023: 33 · 2022: 20 · 2021: 44 · 2020: 23 · 2019: 27 · 2018: 31 · 2017: 30 · 2016: 37 · 2015: 36 · 2014: 40 · 2013: 52 · 2012: 42
FWCI
3.44
Type
journal article
Language
en
Open access
Locations
  • Biochimica et Biophysica Acta (BBA) - Bioenergetics (publishedVersion)
  • PubMed (publishedVersion)
  • Ghent University Academic Bibliography (Ghent University) (submittedVersion)
Funders
  • Universiteit Gent
  • Vlaamse regering
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords
necrosis, programmed cell death, RIP1 kinase, death domain, calcium signaling, reactive oxygen species, pro-inflammatory signaling, inflammatory cytokines, cell lysis, tumor cell killing, apoptosis evasion, signaling crosstalk
MeSH terms
Animals, Cytoskeleton, Humans, Necrosis, Signal Transduction, Cell Death, Reactive Oxygen Species, Inflammation Mediators

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