Genome-wide association study of severity in multiple sclerosis
Open accessAbstract
Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system with a strong genetic component. Several lines of evidence support a strong role for genetic factors influencing both disease susceptibility and clinical outcome in MS. Identification of genetic variants that distinguish particular disease subgroups and/or predict a severe clinical outcome is critical to further our understanding of disease mechanisms and guide development of effective therapeutic approaches. We studied 1470 MS cases and performed a genome-wide association study of more than 2.5 million single-nucleotide polymorphisms to identify loci influencing disease severity, measured using the MS severity score (MSSS), a measure of clinical disability. Of note, no single result achieved genome-wide significance. Furthermore, variants within previously confirmed MS susceptibility loci do not appear to influence severity. Although bioinformatic analyses highlight certain pathways that are over-represented in our results, we conclude that the genetic architecture of disease severity is likely polygenic and comprised of modest effects, similar to what has been described for MS susceptibility, to date. However, a role for major effects of rare variants cannot be excluded. Importantly, our results also show the MSSS, when considered as a binary or continuous phenotype variable is by comparison a stable outcome.
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Published efforts to systematically interrogate MS severity have only involved modest numbers of cases and have not identified any convincingly associated genetic variants.
“published efforts to systematically interrogate severity have, thus far, only involved modest numbers of cases, and unanimously fall short of identifying any convincingly associated genetic variants5,10,11.”
From Locus for severity implicates CNS resilience in progression of multiple sclerosis (2023) · cites this paper as [10]
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An Introduction to the Bootstrap
Efron, B., & Tibshirani, R. J. (1994) · doi:10.1201/9780429246593 · Cited by 40,500 · see citing works
KEGG: Kyoto Encyclopedia of Genes and Genomes
Kanehisa, M. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.1.27 · Cited by 37,077 · see citing works
KEGG: Kyoto Encyclopedia of Genes and Genomes
Ogata, H., Goto, S., Sato, K., Fujibuchi, W., Bono, H., & Kanehisa, M. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.1.29 · Cited by 31,232 · see citing works
An Introduction to the Bootstrap
Efron, B., & Tibshirani, R. J. (1993) · doi:10.1007/978-1-4899-4541-9 · Cited by 21,230 · see citing works
McDonald, W. I., Compston, A., Edan, G., Goodkin, D., Hartung, H., Lublin, F. D., McFarland, H. F., Paty, D. W., Polman, C. H., Reingold, S. C., et al. (2001) · Annals of Neurology · doi:10.1002/ana.1032 · Cited by 6,969 · see citing works
From genomics to chemical genomics: new developments in KEGG
Kanehisa, M. I. (2005) · Nucleic Acids Research · doi:10.1093/nar/gkj102 · Cited by 3,126 · see citing works
KEGG for representation and analysis of molecular networks involving diseases and drugs
Kanehisa, M., Goto, S., Furumichi, M., Tanabe, M., & Hirakawa, M. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkp896 · Cited by 2,322 · see citing works
WebGestalt: an integrated system for exploring gene sets in various biological contexts
Zhang, B., Kirov, S. A., & Snoddy, J. R. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki475 · Cited by 1,801 · see citing works
Risk Alleles for Multiple Sclerosis Identified by a Genomewide Study
(2007) · New England Journal of Medicine · doi:10.1056/nejmoa073493 · Cited by 1,746 · see citing works
Multiple Sclerosis Severity Score: Using disability and disease duration to rate disease severity
Roxburgh, R. H. S. R., Seaman, S. R., Masterman, T., Hensiek, A. E., Sawcer, S. J., Vukusic, S., Achiti, I., Confavreux, C., Coustans, M., le Page, E., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000156155.19270.f8 · Cited by 963 · see citing works
International MS Genetics Consortium, De Jager, P. L., Jia, X., Wang, J., de Bakker, P. I. W., Ottoboni, L., Aggarwal, N. T., Piccio, L., Raychaudhuri, S., Tran, D., et al. (2009) · Nature Genetics · doi:10.1038/ng.401 · Cited by 800 · see citing works
Self-citationNMDA receptors are expressed in oligodendrocytes and activated in ischaemia
Káradóttir, R. T., Cavelier, P., Bergersen, L. H., & Attwell, D. (2005) · Nature · doi:10.1038/nature04302 · Cited by 773 · see citing works
The epidemiology of multiple sclerosis in Europe
Pugliatti, M., Rosati, G., Carton, H., Riise, T., Drulovic, J., Vécsei, L., & Milanov, I. (2006) · European Journal of Neurology · doi:10.1111/j.1468-1331.2006.01342.x · Cited by 654 · see citing works
Differential regulation of central nervous system autoimmunity by TH1 and TH17 cells
Stromnes, I. M., Cerretti, L., Liggitt, D., Harris, R. A., & Goverman, J. M. (2008) · Nature Medicine · doi:10.1038/nm1715 · Cited by 626 · see citing works
NMDA receptors are expressed in developing oligodendrocyte processes and mediate injury
Salter, M. G., & Fern, R. F. (2005) · Nature · doi:10.1038/nature04301 · Cited by 556 · see citing works
NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia
Micu, I., Jiang, Q., Coderre, E., Ridsdale, A., Zhang, L., Woulfe, J., Yin, X., Trapp, B. D., McRory, J. E., Rehak, R., et al. (2005) · Nature · doi:10.1038/nature04474 · Cited by 504 · see citing works
Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis
Baranzini, S. E., Wang, J., Gibson, R. A., Galwey, N., Naegelin, Y., Barkhof, F., Radue, E.-W., Lindberg, R. L. P., Uitdehaag, B. M. G., Johnson, M. R., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddn388 · Cited by 476 · see citing works
Self-citationNMDA receptor surface mobility depends on NR2A-2B subunits
Groc, L., Heine, M., Cousins, S. L., Stephenson, F. A., Lounis, B., Cognet, L., & Choquet, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605238103 · Cited by 376 · see citing works
Heterogeneity in Meta-Analyses of Genome-Wide Association Investigations
Ioannidis, J. P. A., Patsopoulos, N. A., & Εvangelou, Ε. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000841 · Cited by 332 · see citing works
Clinical characteristics of African Americans vs Caucasian Americans with multiple sclerosis
Cree, B., Khan, O., BOURDETTE, D. N., Goodin, D., Cohen, J. A., Marrie, R. A., Glidden, D. V., Weinstock‐Guttman, B., Reich, D., Patterson, N. J., et al. (2004) · Neurology · doi:10.1212/01.wnl.0000145762.60562.5d · Cited by 302 · see citing works
Self-citationImpaired learning with enhanced hippocampal long‐term potentiation in PTPδ‐deficient mice
Uetani, N., Kato, K., Ogura, H., Mizuno, K., Kawano, K., Mikoshiba, K., Yakura, H., Asano, M., & Iwakura, Y. (2000) · The EMBO Journal · doi:10.1093/emboj/19.12.2775 · Cited by 250 · see citing works
Laurie, D., Bartke, I., Schoepfer, R., Naujoks, K., & Seeburg, P. H. (1997) · Molecular Brain Research · doi:10.1016/s0169-328x(97)00206-4 · Cited by 224 · see citing works
Multicenter Case-Control Study on Restless Legs Syndrome in Multiple Sclerosis: the REMS Study
The Italian REMS Study Group, Manconi, M., Ferini‐Strambi, L., Filippi, M., Bonanni, E., Iudice, A., Murri, L., Gigli, G. L., Fratticci, L., Merlino, G., et al. (2008) · SLEEP · doi:10.5665/sleep/31.7.944 · Cited by 211 · see citing works
Jen, Y., Manova, K., & Benezra, R. (1997) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(199701)208:1 · Cited by 210 · see citing works
A human vascular disorder, supravalvular aortic stenosis, maps to chromosome 7.
Ewart, A. K., Morris, C. A., Ensing, G. J., Loker, J., Moore, C. A., Leppert, M., & Keating, M. T. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.8.3226 · Cited by 182 · see citing works
Barnby, G., Abbott, A., Sykes, N., Morris, A. P., Weeks, D. E., Mott, R., Lamb, J. A., Bailey, A. J., & Monaco, A. P. (2005) · The American Journal of Human Genetics · doi:10.1086/430454 · Cited by 180 · see citing works
Kwon, S., Woo, J., Kim, S., Kim, H., & Kim, E. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.061127 · Cited by 163 · see citing works
Genetic basis for clinical expression in multiple sclerosis
The Multiple Sclerosis Genetics Group, Barcellos, L. F., Oksenberg, J. R., Green, A. J., Bucher, P., Rimmler, J. B., Schmidt, S., Garcia, M., Lincoln, R., Pericak‐Vance, M. A., et al. (2002) · Brain · doi:10.1093/brain/awf009 · Cited by 154 · see citing works
Self-citationMultiple sclerosis genetics—is the glass half full, or half empty?
Oksenberg, J., & Baranzini, S. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.91 · Cited by 152 · see citing works
Self-citationBalaštík, M., Ferraguti, F., Pires‐daSilva, A., Lee, T. H., Álvarez-Bolado, G., Lu, K. P., & Gruß, P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802261105 · Cited by 151 · see citing works
High prevalence of restless legs syndrome in multiple sclerosis
Manconi, M., Fabbrini, M., Bonanni, E., Filippi, M., Rocca, M. A., Murri, L., & Ferini‐Strambi, L. (2007) · European Journal of Neurology · doi:10.1111/j.1468-1331.2007.01740.x · Cited by 136 · see citing works
DeLuca, G. C., Ramagopalan, S. V., Herrera, B. M., Dyment, D. A., Lincoln, M. R., Montpetit, A., Pugliatti, M., Barnardo, M., RISCH, N. J., Sadovnick, A. D., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707731105 · Cited by 135 · see citing works
Mammalian Motoneuron Axon Targeting Requires Receptor Protein Tyrosine Phosphatases σ and δ
Uetani, N., Chagnon, M. J., Kennedy, T. E., Iwakura, Y., & Tremblay, M. L. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0386-06.2006 · Cited by 133 · see citing works
Multiple sclerosis susceptibility alleles in African Americans
Johnson, B. A., Wang, J., Taylor, E. M., Caillier, S. J., Herbert, J., Khan, O. A., Cross, A. H., Jager, P. L. D., Gourraud, P., Cree, B., et al. (2009) · Genes and Immunity · doi:10.1038/gene.2009.81 · Cited by 126 · see citing works
Self-citationMultiple sclerosis genetics: leaving no stone unturned
Oksenberg, J. R., & Barcellos, L. F. (2005) · Genes and Immunity · doi:10.1038/sj.gene.6364237 · Cited by 123 · see citing works
Self-citationNR2A and NR2B receptor gene variations modify age at onset in Huntington disease
Arning, L., Kraus, P. H., Valentin, S., Carsten Saft, C., Andrich, J., & Epplen, J. T. (2004) · Neurogenetics · doi:10.1007/s10048-004-0198-8 · Cited by 113 · see citing works
Okonkwo, D. O., Pettus, E. H., Moroi, J., & Povlishock, J. T. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01075-5 · Cited by 109 · see citing works
Butterfield, R. J., Blankenhorn, E. P., Roper, R. J., Zachary, J. F., Doerge, R. W., & Teuscher, C. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64574-9 · Cited by 106 · see citing works
The International Multiple Sclerosis Genetics Consortium (IMSGC), McCauley, J. L., Zuvich, R. L., Beecham, A. H., De Jager, P. L., Konidari, I., Whitehead, P. L., Aubin, C., Ban, M., Pobywajlo, S., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddp542 · Cited by 106 · see citing works
Self-citationWang, J., & Bixby, J. L. (1999) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1999.0789 · Cited by 105 · see citing works
Genetics and pathogenesis of multiple sclerosis
Zuvich, R. L., McCauley, J. L., Pericak‐Vance, M. A., & Haines, J. L. (2009) · Seminars in Immunology · doi:10.1016/j.smim.2009.08.003 · Cited by 98 · see citing works
Turic, D., Langley, K., Mills, S., Stephens, M., Lawson, D. C., Govan, C., Williams, N. M., van den Bree, M. V. D., Craddock, N., Kent, L., et al. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001387 · Cited by 91 · see citing works
Familial effects on the clinical course of multiple sclerosis
Hensiek, A. E., Seaman, S. R., Barcellos, L. F., Oturai, A. B., Eraksoi, M., Cocco, E. E., Vécsei, L., Stewart, G. J., Dubois, B., Bellman-Strobl, J., et al. (2007) · Neurology · doi:10.1212/01.wnl.0000252822.53506.46 · Cited by 90 · see citing works
Self-citationAPOE epsilon variation in multiple sclerosis susceptibility and disease severity
Burwick, R. M., Ramsay, P. P., Haines, J. L., Hauser, S. L., Oksenberg, J. R., Pericak‐Vance, M. A., Schmidt, S., Compston, A., Sawcer, S. J., Cittadella, R., et al. (2006) · Neurology · doi:10.1212/01.wnl.0000210531.19498.3f · Cited by 90 · see citing works
Self-citationAndresen, J. M., Gayán, J., Cherny, S. S., Brocklebank, D., Alkorta‐Aranburu, G., Addis, E. A., Cardon, L. R., Housman, D. E., & Wexler, N. S. (2006) · Journal of Medical Genetics · doi:10.1136/jmg.2006.045153 · Cited by 87 · see citing works
MGAT5 alters the severity of multiple sclerosis
Brynedal, B., Wojcik, J., Esposito, F., Debailleul, V., Yaouanq, J., Boneschi, F. M., Edan, G., Comı, G., Hillert, J. A., & Abderrahim, H. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.01.003 · Cited by 85 · see citing works
Familial factors influence disability in MS multiplex families
Brassat, D., Vuillemin-Azaïs, C., Yaouanq, J., Sémana, G., Reboul, J., Cournu‐Rebeix, I., Mertens, C., Edan, G., Lyon‐Caen, O., Clanet, M., et al. (1999) · Neurology · doi:10.1212/wnl.52.8.1632 · Cited by 84 · see citing works
IL12A, MPHOSPH9/CDK2AP1 and RGS1 are novel multiple sclerosis susceptibility loci
(IMSGC), T. I. M. S. G. C. (2010) · Genes and Immunity · doi:10.1038/gene.2010.28 · Cited by 82 · see citing works
Glutamate Receptors in Neuroinflammatory Demyelinating Disease
Bolton, C., & Paul, C. (2006) · Mediators of Inflammation · doi:10.1155/mi/2006/93684 · Cited by 78 · see citing works
Watanabe, M., Isobe, T., Ichimura, T., Kuwano, R., Takahashi, Y., & Kondo, H. (1993) · Molecular Brain Research · doi:10.1016/0169-328x(93)90082-z · Cited by 78 · see citing works
Schaapveld, R. Q. J., Schepens, J. T. G., Bächner, D., Attema, J., Wieringa, B., Jap, P. H. K., & Hendriks, W. J. A. J. (1998) · Mechanisms of Development · doi:10.1016/s0925-4773(98)00119-1 · Cited by 67 · see citing works
Arning, L., Carsten Saft, C., Wieczorek, S., Andrich, J., Kraus, P. H., & Epplen, J. T. (2007) · Human Genetics · doi:10.1007/s00439-007-0393-4 · Cited by 62 · see citing works
Jensen, C., Stankovich, J. M., van der Walt, A., Bahlo, M., Taylor, B. V., van der Mei, I. A. F., Foote, S. J., Kilpatrick, T. J., Johnson, L., Wilkins, E. J., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010003 · Cited by 53 · see citing works
The multiple sclerosis severity score (MSSS) predicts disease severity over time
Pachner, A. R., & Steiner, I. (2009) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2008.11.020 · Cited by 52 · see citing works
The E3‐ubiquitin ligase TRIM2 regulates neuronal polarization
Khazaei, M. R., Bunk, E. C., Hillje, A., Jahn, H. M., Riegler, E. M., Knoblich, J. A., Young, P., & Schwamborn, J. C. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06971.x · Cited by 51 · see citing works
Tang, J., Chen, X., Xu, X., Wu, R., Zhao, J., Hu, Z., & Xia, K. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.09.022 · Cited by 48 · see citing works
Silencing neuroglobin enhances neuronal vulnerability to oxidative injury by down-regulating 14-3-3γ
Ye, S., Zhou, X., Lai, X., Li, Z., & Chen, X. (2009) · Acta Pharmacologica Sinica · doi:10.1038/aps.2009.70 · Cited by 41 · see citing works
Zebrafish gene knockdowns imply roles for human YWHAG in infantile spasms and cardiomegaly
Komoike, Y., Fujii, K., Nishimura, A., Hiraki, Y., Hayashidani, M., Shimojima, K. Y., Nishizawa, T., Higashi, K., Yasukawa, K., Saitsu, H., et al. (2010) · genesis · doi:10.1002/dvg.20607 · Cited by 40 · see citing works
The association of 14-3-3γ and actin plays a role in cell division and apoptosis in astrocytes
Chen, X., & Yu, A. C. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00895-1 · Cited by 39 · see citing works
Polanczyk, M. J., Yellayi, S., Zamora, A., Subramanian, S., Tovey, M., Vandenbark, A. A., Offner, H., Zachary, J. F., Fillmore, P. D., Blankenhorn, E. P., et al. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63752-2 · Cited by 38 · see citing works
Mohrmann, R., Hatt, H. H., & Gottmann, K. (2000) · Neuroreport · doi:10.1097/00001756-200004270-00012 · Cited by 32 · see citing works
14-3-3γ and Neuroglobin are New Intrinsic Protective Factors for Cerebral Ischemia
Dong, Y., Zhao, R., Chen, X., & Yu, A. C. (2010) · Molecular Neurobiology · doi:10.1007/s12035-010-8142-4 · Cited by 31 · see citing works
Prognosis of the individual course of disease: the elements of time, hetereogeneity and precision
Däumer, M., Neuhaus, A., Herbert, J., & Ebers, G. C. (2009) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(09)71301-2 · Cited by 30 · see citing works
Peláez, I. M., Vogler, S., Strauß, U., Wernhoff, P., Pahnke, J., Brockmann, G. A., Moch, H., Thiesen, H., Rolfs, A., & Ibrahim, S. M. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi203 · Cited by 30 · see citing works
Shyur, S., Wang, J., Lin, C. G.-J., Hsiao, Y.-H., Liou, Y.-H., Wu, Y.-J., & Wu, L. S.-H. (2008) · European Journal of Human Genetics · doi:10.1038/ejhg.2008.79 · Cited by 16 · see citing works
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Friese, M. A., Schattling, B., & Fugger, L. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.37 · Cited by 628 · see citing works
Nylander, A., & Hafler, D. A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci58649 · Cited by 495 · see citing works
Sawcer, S. J., Franklin, R. J. M., & Ban, M. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70041-9 · Cited by 404 · see citing works
The immunology of multiple sclerosis
Attfield, K. E., Jensen, L. T., Kaufmann, M., Friese, M. A., & Fugger, L. (2022) · Nature Reviews Immunology · doi:10.1038/s41577-022-00718-z · Cited by 380 · see citing works
Zhang, M. J., Hou, K., Dey, K. K., Sakaue, S., Jagadeesh, K. A., Weinand, K., Taychameekiatchai, A., Rao, P., Pisco, A. O., Zou, J., et al. (2022) · Nature Genetics · doi:10.1038/s41588-022-01167-z · Cited by 302 · see citing works
The genetics of multiple sclerosis: an up‐to‐date review
Gourraud, P., Harbo, H. F., Hauser, S. L., & Baranzini, S. E. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01134.x · Cited by 278 · see citing works
Locus for severity implicates CNS resilience in progression of multiple sclerosis
International Multiple Sclerosis Genetics Consortium, Harroud, A., Stridh, P., McCauley, J. L., Saarela, J., van den Bosch, A. M. R., Engelenburg, H. J., Beecham, A. H., Alfredsson, L., Alikhani, K., et al. (2023) · Nature · doi:10.1038/s41586-023-06250-x · Cited by 243 · see citing works
Self-citationThe neuropathobiology of multiple sclerosis
Woo, M. S., Engler, J. B., & Friese, M. A. (2024) · Nature reviews. Neuroscience · doi:10.1038/s41583-024-00823-z · Cited by 194 · see citing works
Disability in multiple sclerosis
Kister, I., Chamot, E., Salter, A. R., Cutter, G., Bacon, T. E., & Herbert, J. (2013) · Neurology · doi:10.1212/wnl.0b013e3182872855 · Cited by 176 · see citing works
Age Related Multiple Sclerosis Severity Score: Disability ranked by age
Manouchehrinia, A., Westerlind, H., Kingwell, E., Zhu, F., Carruthers, R., Ramanujam, R., Ban, M., Glaser, A., Sawcer, S., Tremlett, H., et al. (2017) · Multiple Sclerosis Journal · doi:10.1177/1352458517690618 · Cited by 174 · see citing works
Genetics of Multiple Sclerosis: An Overview and New DirectionsPreprint
Patsopoulos, N. A. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a028951 · Cited by 177 · see citing works
Changes in Gut Microbiota and Multiple Sclerosis: A Systematic Review
Ordoñez-Rodriguez, A., Román, P., Rueda‐Ruzafa, L., Campos-Ríos, A., & Cardona, D. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20054624 · Cited by 138 · see citing works
Gut microbiome of treatment-naïve MS patients of different ethnicities early in disease course
Ventura, R. E., Iizumi, T., Battaglia, T., Liu, M., Perez-Perez, G. I., Herbert, J., & Blaser, M. J. (2019) · Scientific Reports · doi:10.1038/s41598-019-52894-z · Cited by 104 · see citing works
Genome‐wide association studies of multiple sclerosis
Cotsapas, C., & Mitrovic, M. (2018) · Clinical & Translational Immunology · doi:10.1002/cti2.1018 · Cited by 89 · see citing works
DNA methylation signatures of monozygotic twins clinically discordant for multiple sclerosis
Souren, N. Y., Gerdes, L. A., Lutsik, P., Gasparoni, G., Beltrán, E., Salhab, A., Kümpfel, T., Weichenhan, D., Plass, C., Hohlfeld, R., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09984-3 · Cited by 83 · see citing works
Multiple sclerosis risk loci and disease severity in 7,125 individuals from 10 studies
George, M. F., Briggs, F. B. S., Shao, X., Gianfrancesco, M. A., Kockum, I., Harbo, H. F., Celius, E. G., Bos, S. D., Hedström, A., Shen, L., et al. (2016) · Neurology Genetics · doi:10.1212/nxg.0000000000000087 · Cited by 86 · see citing works
Self-citationLiu, G., Jiang, Y., Wang, P., Feng, R., Jiang, N., Chen, X., Song, H., & Chen, Z. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07547.x · Cited by 83 · see citing works
Cotsapas, C. J., Mitrovič, M., & Hafler, D. A. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64076-5.00046-6 · Cited by 83 · see citing works
Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis
Ponath, G. D., Lincoln, M. R., Levine-Ritterman, M., Park, C., Dahlawi, S., Mubarak, M., Sumida, T. S., Airas, L. M., Zhang, S., Isitan, C., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07785-8 · Cited by 80 · see citing works
Bove, R. M., Secor, E. A., Healy, B. C., Musallam, A., Vaughan, T. E., Glanz, B. I., Greeke, E. E., Weiner, H. L., Chitnis, T., Wicks, P. J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059707 · Cited by 68 · see citing works
Cree, B. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52001-2.00009-1 · Cited by 58 · see citing works
The Efficacy of Cannabis on Multiple Sclerosis-Related Symptoms
Haddad, F., Dokmak, G., & Karaman, R. (2022) · Life · doi:10.3390/life12050682 · Cited by 58 · see citing works
Revisiting the Pathoetiology of Multiple Sclerosis: Has the Tail Been Wagging the Mouse?
Sen, M. K., Almuslehi, M. S. M., Shortland, P. J., Coorssen, J. R., & Mahns, D. A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.572186 · Cited by 55 · see citing works
Neuronal metabotropic glutamate receptor 8 protects against neurodegeneration in CNS inflammation
Woo, M. S., Ufer, F., Rothammer, N., Liberto, G. D., Binkle-Ladisch, L., Haferkamp, U., Sonner, J. K., Engler, J. B., Hornig, S., Bauer, S., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20201290 · Cited by 53 · see citing works
Caminero, A. B., Comabella, M., & Montalbán, X. (2011) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2011.04484.x · Cited by 54 · see citing works
Genetics of multiple sclerosis
Baranzini, S. E., & Nickles, D. (2012) · Current Opinion in Neurology · doi:10.1097/wco.0b013e3283533a93 · Cited by 52 · see citing works
Not all roads lead to the immune system: the genetic basis of multiple sclerosis severity
Jokubaitis, V., Campagna, M. P., Ibrahim, O., Stankovich, J. M., Kleinová, P., Matesanz, F., Hui, D., Eichau, S., Slee, M., Lechner‐Scott, J., et al. (2022) · Brain · doi:10.1093/brain/awac449 · Cited by 60 · see citing works
Recent Advances and Future Challenges in the Genetics of Multiple Sclerosis
Lill, C. M. (2014) · Frontiers in Neurology · doi:10.3389/fneur.2014.00130 · Cited by 51 · see citing works
Hecker, M., Bühring, J., Fitzner, B., Rommer, P. S., & Zettl, U. K. (2021) · Biomolecules · doi:10.3390/biom11101510 · Cited by 48 · see citing works
Epigenetic insights into multiple sclerosis disease progression
Kular, L., & Jagodic, M. (2020) · Journal of Internal Medicine · doi:10.1111/joim.13045 · Cited by 46 · see citing works
Wang, H., Zhong, X., Wang, K., Qiu, W., Li, J., Dai, Y., & Hu, X. (2011) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2011.11.005 · Cited by 45 · see citing works
Rockowitz, S., & Zheng, D. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv514 · Cited by 42 · see citing works
Hughes, S., Spelman, T., Trojano, M., Lugaresi, A., Izquierdo, G., Grand’Maison, F., Duquette, P., Girard, M., Grammond, P., Oreja-Guevara, C., et al. (2012) · Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) · doi:10.1136/jnnp-2011-301051 · Cited by 43 · see citing works
Ten years of proteomics in multiple sclerosis
Farias, A. S., Pradella, F., Schmitt, A., Santos, L. M. B., & Martins‐de‐Souza, D. (2014) · PROTEOMICS · doi:10.1002/pmic.201300268 · Cited by 40 · see citing works
McGowan, L. M., Smith, G. D., Gaunt, T. R., & Richardson, T. G. (2019) · Human Molecular Genetics · doi:10.1093/hmg/ddz155 · Cited by 40 · see citing works
Epistasis and immunity: the role of genetic interactions in autoimmune diseases
Rose, A. M., & Bell, L. C. K. (2012) · Immunology · doi:10.1111/j.1365-2567.2012.03623.x · Cited by 38 · see citing works
Clinical relevance and functional consequences of the TNFRSF1A multiple sclerosis locus
Ottoboni, L., Frohlich, I. Y., Lee, M. H., Healy, B. C., Keenan, B. T., Xia, Z., Chitnis, T., Guttmann, C. R. G., Khoury, S. J., Weiner, H. L., et al. (2013) · Neurology · doi:10.1212/01.wnl.0000436612.66328.8a · Cited by 36 · see citing works
Post‐mortem multiple sclerosis lesion pathology is influenced by single nucleotide polymorphisms
Fransen, N. L., Crusius, J. B. A., Smolders, J., Mizee, M. R., van Eden, C. G., Luchetti, S., Remmerswaal, E. B. M., Hamann, J., Mason, M. R. J., & Huitinga, I. (2020) · Brain Pathology · doi:10.1111/bpa.12760 · Cited by 37 · see citing works
Watanabe, M., Nakamura, Y., Sato, S., Niino, M., Fukaura, H., Tanaka, M., Ochi, H., Kanda, T., Takeshita, Y., Yokota, T., et al. (2021) · Scientific Reports · doi:10.1038/s41598-020-79833-7 · Cited by 39 · see citing works
Association of SNPs of CD40 Gene with Multiple Sclerosis in Russians
Sokolova, E. А., Malkova, N. A., Korobko, D. S., Rozhdestvenskiĭ, A. S., Kakulya, A. V., Ханох, Е. В., Ra, D., Платонов, Ф. А., Popova, T., Геннадьевна, А. Е., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061032 · Cited by 36 · see citing works
Tyro3, Axl, Mertk receptor-mediated efferocytosis and immune regulation in the tumor environment
Zhou, L., & Matsushima, G. K. (2021) · International review of cytology · doi:10.1016/bs.ircmb.2021.02.002 · Cited by 35 · see citing works
Self-reported levels of education and disability progression in multiple sclerosis
D'hooghe, M. B., Haentjens, P., Van Remoortel, A., De Keyser, J., & Nagels, G. (2016) · Acta Neurologica Scandinavica · doi:10.1111/ane.12555 · Cited by 35 · see citing works
Stem Cells as Potential Targets of Polyphenols in Multiple Sclerosis and Alzheimer’s Disease
Tandon, A., Singh, S. J., & Chaturvedi, R. K. (2018) · BioMed Research International · doi:10.1155/2018/1483791 · Cited by 35 · see citing works
Genetics and functional genomics of multiple sclerosis
Kim, W., & Patsopoulos, N. A. (2022) · Seminars in Immunopathology · doi:10.1007/s00281-021-00907-3 · Cited by 34 · see citing works
Genome-wide association studies in neurology.
Tan, M., Jiang, T., Tan, L., & Yu, J. (2014) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2305-5839.2014.11.12 · Cited by 33 · see citing works
Li, C. F., Zhou, R. W., Mkhikian, H., Newton, B. L., Yu, Z., & Demetriou, M. (2013) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2012.12.008 · Cited by 33 · see citing works
Mahurkar, S., Moldovan, M., Suppiah, V., & O'Doherty, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057655 · Cited by 22 · see citing works
de Boer, A., van den Bosch, A. M. R., Mekkes, N., Fransen, N. L., Dagkesamanskaia, E., Hoekstra, E., Hamann, J., Smolders, J., Huitinga, I., & Holtman, I. R. (2024) · Acta Neuropathologica · doi:10.1007/s00401-024-02742-w · Cited by 29 · see citing works
Crielaard, L., Kavaliūnas, A., Ramanujam, R., Olsson, T. P., Hillert, J. A., Stridh, P., Kockum, I. S., & Manouchehrinia, A. (2019) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2018-319913 · Cited by 30 · see citing works
Genetic predictors of relapse rate in pediatric MS
Graves, J. S., Barcellos, L. F., Shao, X., Noble, J. A., Mowry, E. M., Quach, H., Belman, A. L., Casper, T. C., Krupp, L., & Waubant, E. L. (2016) · Multiple Sclerosis Journal · doi:10.1177/1352458515624269 · Cited by 28 · see citing works
Self-citationGenetic variation in the geneLRP2increases relapse risk in multiple sclerosis
Zhou, Y., Graves, J. S., Simpson, S., Charlesworth, J., van der Mei, I. A. F., Waubant, E. L., Barcellos, L. F., Belman, A. L., Krupp, L., Lucas, R. M., et al. (2017) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2017-315971 · Cited by 28 · see citing works
Self-citationCalvier, L., Demuth, G., Manouchehri, N., Wong, C. H. Y., Sacharidou, A., Mineo, C., Shaul, P. W., Monson, N. L., Kounnas, M. Z., Stüve, O., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aay7675 · Cited by 30 · see citing works
TRPV1 Gates Tissue Access and Sustains Pathogenicity in Autoimmune Encephalitis
Paltser, G., Liu, X. J., Yantha, J., Winer, S., Tsui, H., Wu, P., Maezawa, Y., Cahill, L. S., Laliberté, C. L., Ramagopalan, S. V., et al. (2013) · Molecular Medicine · doi:10.2119/molmed.2012.00329 · Cited by 26 · see citing works
Next generation sequencing for neurological diseases: New hope or new hype?
Keogh, M. J., & Chinnery, P. F. (2012) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2012.09.030 · Cited by 25 · see citing works
Giacalone, G., Clarelli, F., Osiceanu, A. M., Guaschino, C., Brambilla, P., Sorosina, M., Liberatore, G., Zauli, A., Esposito, F., Rodegher, M., et al. (2015) · Multiple Sclerosis Journal · doi:10.1177/1352458514564590 · Cited by 25 · see citing works
Acquired channelopathies as contributors to development and progression of multiple sclerosis
Schattling, B., Eggert, B., & Friese, M. A. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2013.12.006 · Cited by 24 · see citing works
A genetic basis for multiple sclerosis severity: Red herring or real?
Jokubaitis, V., & Butzkueven, H. (2016) · Molecular and Cellular Probes · doi:10.1016/j.mcp.2016.08.007 · Cited by 22 · see citing works
Involvement of Genetic Factors in Multiple Sclerosis
Ferrè, L., Filippi, M., & Esposito, F. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.612953 · Cited by 22 · see citing works
Relevance of Multiple Sclerosis Severity Genotype in Predicting Disease Course: A Real‐World Cohort
Kreft, K. L., Uzochukwu, E., Loveless, S., Willis, M., Wynford‐Thomas, R., Harding, K. E., Holmans, P., Lawton, M., Tallantyre, E. C., & Robertson, N. P. (2023) · Annals of Neurology · doi:10.1002/ana.26831 · Cited by 22 · see citing works
Kalinčík, T., Guttmann, C. R. G., Krásenský, J., Vaněčková, M., Lelková, P., Týblová, M., Seidl, Z., Jager, P. L. D., Havrdová, E., & Horáková, D. (2013) · Genes and Immunity · doi:10.1038/gene.2013.17 · Cited by 21 · see citing works
RESTREPO, N. A., Butkiewicz, M., McGrath, J. A., & Crawford, D. C. (2016) · Frontiers in Genetics · doi:10.3389/fgene.2016.00185 · Cited by 21 · see citing works
Gene variants of adhesion molecules act as modifiers of disease severity in MS
Dardiotis, E., Panayiotou, E., Provatas, A., Christodoulou, K., Hadjisavvas, A., Antoniades, A., Lourbopoulos, A., Pantzaris, M., Grigoriadis, N., Hadjigeorgiou, G., et al. (2017) · Neurology: Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000350 · Cited by 20 · see citing works
Feasibility study for remote assessment of cognitive function in multiple sclerosis
Barcellos, L. F. (2016) · Journal of Neurology and Neuromedicine · doi:10.29245/2572.942x/2016/8.1084 · Cited by 21 · see citing works
Self-citationGraves, J. S., Barcellos, L. F., Simpson, S., Belman, A. L., Lin, R., Taylor, B. V., Ponsonby, A., Dwyer, T., Krupp, L., Waubant, E. L., et al. (2017) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2017.10.008 · Cited by 21 · see citing works
Self-citationA higher burden of multiple sclerosis genetic risk confers an earlier onset
Misicka, E., Davis, M. F., Kim, W., Brugger, S. W., Beales, J. T., Loomis, S. J., Bronson, P. G., & Briggs, F. B. S. (2021) · Multiple Sclerosis Journal · doi:10.1177/13524585211053155 · Cited by 20 · see citing works
Self-citationPredicting onset of secondary-progressive multiple sclerosis using genetic and non-genetic factors
Misicka, E., Sept, C. E., & Briggs, F. B. S. (2020) · Journal of Neurology · doi:10.1007/s00415-020-09850-z · Cited by 20 · see citing works
Self-citationWang, E., Zhao, Y., Monaco, A., Uccellini, L., Kirkwood, J. M., Spyropoulou‐Vlachou, M., Panelli, M. C., Marincola, F. M., & Gogas, H. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040805 · Cited by 18 · see citing works
Reilly, G. D., Mahkawnghta, A. S., Jelinek, P. L., Livera, A. M. D., Weiland, T. J., Brown, C. R., Taylor, K. L., Neate, S. L., Jelinek, G. A., & Marck, C. H. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00229 · Cited by 18 · see citing works
Shepard, C. J., Cline, S. G., Hinds, D., Jahanbakhsh, S., & Prokop, J. W. (2019) · Physiological Genomics · doi:10.1152/physiolgenomics.00120.2018 · Cited by 17 · see citing works
van Rensburg, S. J., Peeters, A. V., van Toorn, R., Schoeman, J. F., Moremi, K. E., Heerden, C. J. V., & Kotze, M. J. (2019) · Molecular Genetics and Metabolism Reports · doi:10.1016/j.ymgmr.2019.100465 · Cited by 15 · see citing works
Genome-Wide Multiple Sclerosis Association Data and Coagulation
Starza, S. L., Ferraldeschi, M., Buscarinu, M. C., Romano, S., Fornasiero, A., Mechelli, R., Umeton, R., Ristori, G., & Salvetti, M. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00095 · Cited by 14 · see citing works
Ferrè, L., Clarelli, F., Pignolet, B., Mascia, E., Frasca, M., Santoro, S., Sorosina, M., Bucciarelli, F., Moiola, L., Martinelli, V., et al. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13010122 · Cited by 14 · see citing works
Kolić, I., Stojković, L., Stanković, A., Stefanović, M., Dinčić, E., & Živković, M. (2021) · Gene · doi:10.1016/j.gene.2021.145422 · Cited by 13 · see citing works
Contribution of common risk variants to multiple sclerosis in Orkney and Shetland
Barnes, C. L. K., Hayward, C., Porteous, D. J., Campbell, H. J., Joshi, P. K., & Wilson, J. F. (2021) · European Journal of Human Genetics · doi:10.1038/s41431-021-00914-w · Cited by 12 · see citing works
The role of the Epstein–Barr Virus receptor CD21 in Multiple Sclerosis
Toepfner, N., Cepok, S., Grummel, V., & Hemmer, B. (2011) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2011.11.002 · Cited by 12 · see citing works
Javor, J., Shawkatová, I., Ďurmanová, V., Párnická, Z., Čierný, D., Michalík, J., Čopíková‐Cudráková, D., Smahová, B., Gmitterová, K., Peterajová, Ľ., et al. (2018) · International Journal of Immunogenetics · doi:10.1111/iji.12388 · Cited by 14 · see citing works
Perdaens, O., & Pesch, V. V. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312637 · Cited by 11 · see citing works
Functional relevance for multiple sclerosis-associated genetic variants
Lin, X., Deng, F., Mo, X., Wu, L., & Lei, S. (2014) · Immunogenetics · doi:10.1007/s00251-014-0803-4 · Cited by 10 · see citing works
Jokubaitis, V., Ibrahim, O., Stankovich, J. M., Kleinová, P., Matesanz, F., Hui, D., Eichau, S., Slee, M., Lechner‐Scott, J., Lea, R. A., et al. (2022) · medRxiv · doi:10.1101/2022.02.04.22270362 · Cited by 10 · see citing works
Unlocking Multiple Sclerosis Genetics
Sahi, N., Ciccarelli, O., Houlden, H., & Chard, D. (2025) · Neurology · doi:10.1212/wnl.0000000000214141 · Cited by 9 · see citing works
Quantitative MRI phenotypes capture biological heterogeneity in multiple sclerosis patients
Smets, I., Goris, A., Vandebergh, M., Demeestere, J., Sunaert, S. G., Dupont, P. J., & Dubois, B. (2021) · Scientific Reports · doi:10.1038/s41598-021-81035-8 · Cited by 8 · see citing works
Role of Socioeconomic Position in Multiple Sclerosis Etiology
Briggs, F. B. S., Green, M. C., & Weintraub, M. R. (2015) · Neurodegenerative Disease Management · doi:10.2217/nmt.15.22 · Cited by 8 · see citing works
Self-citationMultiple Sclerosis: Individualized Disease Susceptibility and Therapy Response
Pravica, V., Marković, M., Cupic, M. D., Savić, E., Popadic, D. M., Drulovic, J. S., & Mostarica‐Stojković, M. (2013) · Biomarkers in Medicine · doi:10.2217/bmm.12.113 · Cited by 7 · see citing works
Interferon beta treatment of multiple sclerosis increases serum interleukin-7
Lundström, W., Hermanrud, C. E., Sjöstrand, M., Brauner, S., Wahren‐Herlenius, M., Olsson, T. P., Karrenbauer, V. D., Hillert, J. A., & Fogdell‐Hahn, A. (2014) · Multiple Sclerosis Journal · doi:10.1177/1352458514532700 · Cited by 7 · see citing works
Lee, S., Park, B., Hong, K., & Jung, D. (2022) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd9040104 · Cited by 8 · see citing works
Ricigliano, V. A. G., Umeton, R., Germinario, L., Alma, E., Briani, M., Segni, N. D., Montesanti, D., Pierelli, G., Cancrini, F., Lomonaco, C., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071198 · Cited by 7 · see citing works
Loomis, S. J., Sadhu, N., Fisher, E., Gafson, A., Huang, Y., Yang, C., Hughes, E. E., Marshall, E., Herman, A. H., John, S., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-41099-0 · Cited by 7 · see citing works
Кулакова, О. Г., Bashinskaya, V. V., Tsareva, E., Boyko, A. N., Favorova, O. O., & Gusev, E. I. (2016) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro201611610210-15 · Cited by 7 · see citing works
Almsned, F. M., Lipsky, R. H., & Jafri, M. S. (2021) · Informatics in Medicine Unlocked · doi:10.1016/j.imu.2021.100563 · Cited by 6 · see citing works
The “6B” Strategy: Build Back a Better Blood–Brain Barrier
Calvier, L., Alexander, A., & Herz, J. (2022) · Immuno · doi:10.3390/immuno2030032 · Cited by 6 · see citing works
Genetic Predisposition, Humans
Jordan, M. A., Field, J., Butzkueven, H., & Baxter, A. G. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-384929-8.00026-5 · Cited by 6 · see citing works
Genotype–phenotype correlation for non-HLA disease associated risk alleles in multiple sclerosis
Harding, K. E., Ingram, G., Cossburn, M., Hirst, C. L., Pickersgill, T. P., Ben‐Shlomo, Y., & Robertson, N. P. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.06.040 · Cited by 5 · see citing works
Is There a Genetic Correlation between Multiple Sclerosis and Cerebral Aneurysms?
Albrekkan, F. M., Bachir, S., Jumaa, M. A., Zaidi, S. F., & Medhkour, A. (2016) · World Neurosurgery · doi:10.1016/j.wneu.2016.04.027 · Cited by 5 · see citing works
Genetic Predisposition, Humans
Jordan, M. A., & Baxter, A. G. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-812102-3.00023-3 · Cited by 4 · see citing works
Lewis, P. A., & Spillane, J. E. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811069-0.00007-0 · Cited by 4 · see citing works
Roostaei, T., & Jager, P. L. D. (2019) · Current clinical neurology · doi:10.1007/978-3-030-24436-1_4 · Cited by 4 · see citing works
The Genetics of Multiple Sclerosis
Miner, A. E., Dastgheyb, N., Palomino, M. M., & Graves, J. S. (2021) · Springer eBooks · doi:10.1007/978-3-030-61883-4_11 · Cited by 3 · see citing works
Ferrari, M., Vecchio, D., D’Alfonso, S., Gemma, A., Marino, F., Comi, C., & Cosentino, M. (2024) · Genes · doi:10.3390/genes15060736 · Cited by 3 · see citing works
Role of Genetic Factors in Pathophysiology of Multiple Sclerosis
Goris, A., Dubois, B., & Hilven, K. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800763-1.00008-7 · Cited by 3 · see citing works
Contribution of genomic variation to the severity of multiple sclerosis
Кулакова, О. Г., Matveeva, N. A., Сергеевич, К. И., Boyko, A. N., & Favorova, O. O. (2025) · Neurology neuropsychiatry Psychosomatics · doi:10.14412/2074-2711-2025-1-78-84 · Cited by 2 · see citing works
- Authors
- International Multiple Sclerosis Genetics Consortium, Briggs, F. B. S., Shao, X., Goldstein, B. A., Oksenberg, J. R., Barcellos, L. F., & De Jager, P. L.
- Venue
- Genes & Immunity
- Published
- 2011-06-09
- Volume
- 12
- Issue
- 8
- Pages
- 615-625
- ISSN
- 1466-4879 (ISSN-L)
- 1476-5470
- PMC
- PMC3640650
- OpenAlex
- W32848451
- Cited by
- 120
- References
- 65
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 4 · 2023: 6 · 2022: 8 · 2021: 12 · 2020: 5 · 2019: 11 · 2018: 9 · 2017: 6 · 2016: 8 · 2015: 4 · 2014: 9 · 2013: 13 · 2012: 12
- FWCI
- 8.55
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Genes and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Wellcome Trust (084702/Z/08/Z)
- Ministère de la Santé et des Services sociaux
- National Institute for Health and Care Research
- National Institutes of Health
- National Institute of Mental Health (T32MH065215, MH065215)
- National Institute of Allergy and Infectious Diseases (AI076544, R01AI076544)
- National Institute of Neurological Disorders and Stroke (NS067305, NS032830, NS049477, R01NS032830, R01NS067305, R01NS049477)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- multiple sclerosis, disease severity, clinical disability, genetic susceptibility loci, polygenic architecture, rare variants, single nucleotide polymorphisms, disease outcome prediction, gene pathways
- MeSH terms
- Female, Humans, Male, Multiple Sclerosis, Severity of Illness Index, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Genome-Wide Association Study
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