SIRT1 and CLOCK 3111T>C combined genotype is associated with evening preference and weight loss resistance in a behavioral therapy treatment for obesity
Open accessAbstract
Background A new negative feedback loop has been proposed, which suggests connections between the circadian clock and SIRTUIN1 (SIRT1)-dependent functions associated with cell survival, development and metabolism.Objective To develop a SIRT1 and circadian locomotor output cycles kaput (CLOCK) combined genotype and to assess its associations with the chronotype of subjects and their potential resistance to weight loss in a behavioral treatment for obesity based on a Mediterranean diet.Design Overweight /obese subjects (n=1465), aged 20-65 years, who attended outpatient obesity clinics, were genotyped for SIRT1 (rs1467568) and CLOCK (3111T>C, rs1801260). Anthropometric, biochemical and dietary-intake variables were analyzed. Effectiveness of the program and weight loss progression during 30 weeks of treatment was assessed.Results We found highly consistent associations between the morning/evening questionnaires across the different genotype categories. Subjects carrying minor alleles at SIRT1 and CLOCK loci (R group) displayed a higher resistance to weight loss and a lower weekly weight loss rate as compared with homozygotes for both major alleles (P group). Significant differences were found across genotypes in weight loss progression during the 30 weeks of treatment (P=0.039). Dietary habits indicated that R carriers had a lower intake of total carbohydrates and monounsaturated fats, and a higher intake of saturated fats than those carrying the intermediate (M) and the P genotype (P=0.02). Plasma ghrelin concentrations were also significantly higher in subjects carrying the R genotype.Conclusion Variants of both SIRT1 and CLOCK have an additive effect on resistance to weight loss that could be related to the chronotype of the subject, higher plasma levels of ghrelin and less adherence to Mediterranean diet patterns.
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There is evidence that people carrying minor alleles at both SIRT1 and CLOCK loci had significantly weight loss resistance associated with late evening preference.
“There is evidence that people carrying minor alleles at both the SIRT1 and CLOCK loci had a significantly weight loss resistance which is associated with late evening preference (31) .”
From Effects of consuming later evening meal<i>v</i>. earlier evening meal on weight loss during a weight loss diet: a randomised clinical trial (2021) · cites this paper as [31]
The SIRT1-rs1467568 and CLOCK-rs1801260 SNPs have an additive effect on resistance to weight loss.
“In this study, carried out in subjects attending the same outpatient obesity clinics, we analyzed the combined effects of the SIRT1-rs1467568 and the CLOCK-rs1801260 SNPs on the effectiveness of the weight-loss program and demonstrated that SIRT1 and CLOCK SNPs have an additive effect on resistance to weight loss that could be driven by effects on chronotype, plasma ghrelin concentrations, and”
From Circadian rhythms, metabolism, and chrononutrition in rodents and humans (2016) · cites this paper as [61]
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A self-assessment questionnaire to determine morningness- eveningness in human circadian rhythms
Home, J. K. (1976) · Medical Entomology and Zoology · Cited by 4,783 · see citing works
(1976) · PubMed · Cited by 3,979 · see citing works
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
Cantó, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., Milne, J. C., Elliott, P. J., Puigserver, P., & Auwerx, J. (2009) · Nature · doi:10.1038/nature07813 · Cited by 3,300 · see citing works
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160 · see citing works
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
Picard, F., Kurtev, M. V., Chung, N., Topark‐Ngarm, A., Senawong, T., de Oliveira, R. M., Leid, M. E., McBurney, M. W., & Guarente, L. (2004) · Nature · doi:10.1038/nature02583 · Cited by 1,943 · see citing works
Nakahata, Y., Kaluzova, M., Grimaldi, B., Sahar, S., Hirayama, J., Chen, D., Guarente, L. P., & Sassone-Corsi, P. (2008) · Cell · doi:10.1016/j.cell.2008.07.002 · Cited by 1,427 · see citing works
Hypothalamic mTOR Signaling Regulates Food Intake
Cota, D., Proulx, K., Smith, K. A. B., Kozma, S. C., Thomas, G., Woods, S. C., & Seeley, R. J. (2006) · Science · doi:10.1126/science.1124147 · Cited by 1,278 · see citing works
Circadian Control of the NAD <sup>+</sup> Salvage Pathway by CLOCK-SIRT1
Nakahata, Y., Sahar, S., Astarita, G., Kaluzova, M., & Sassone-Corsi, P. (2009) · Science · doi:10.1126/science.1170803 · Cited by 1,198 · see citing works
Circadian Regulator CLOCK Is a Histone Acetyltransferase
Doi, M., Hirayama, J., & Sassone‐Corsi, P. (2006) · Cell · doi:10.1016/j.cell.2006.03.033 · Cited by 890 · see citing works
Polymorphisms Associated with Cholesterol and Risk of Cardiovascular Events
Kathiresan, S., Melander, O., Anevski, D., Guiducci, C., Burtt, N. P., Roos, C., Hirschhorn, J. N., Berglund, G., Hedblad, B., Groop, L., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0706728 · Cited by 696 · see citing works
Metabolic adaptations through the PGC‐1α and SIRT1 pathways
Rodgers, J. T., Lerín, C., Gerhart‐Hines, Z., & Puigserver, P. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.11.034 · Cited by 599 · see citing works
Ghrelin?a hormone with multiple functions
Korbonits, M. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.03.002 · Cited by 593 · see citing works
Frescas, D., Valenti, L. V. C., & Accili, D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412357200 · Cited by 528 · see citing works
Circadian Rhythms and Metabolic Syndrome
Maury, E., Ramsey, K. M., & Bass, J. T. (2010) · Circulation Research · doi:10.1161/circresaha.109.208355 · Cited by 502 · see citing works
Xue, B., & Kahn, B. B. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.113217 · Cited by 338 · see citing works
Taillard, J., Philip, P., Chastang, J., & Bioulac, B. H. (2004) · Journal of Biological Rhythms · doi:10.1177/0748730403259849 · Cited by 327 · see citing works
Brain SIRT1: Anatomical Distribution and Regulation by Energy Availability
Ramadori, G., Lee, C. E., Bookout, A. L., Lee, S., Williams, K. W., Anderson, J. G., Elmquist, J. K., & Coppari, R. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3257-08.2008 · Cited by 311 · see citing works
Morrison, A. C., Bare, L. A., Chambless, L. E., Ellis, S. G., Malloy, M. J., Kane, J. P., Pankow, J. S., Devlin, J. J., Willerson, J. T., & Boerwinkle, E. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm060 · Cited by 280 · see citing works
Sookoian, S. C., Gemma, C., Gianotti, T. F., Burgueño, A. L., Castaño, G. O., & Pirola, C. J. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.6.1606 · Cited by 262 · see citing works
PERIOD3, circadian phenotypes, and sleep homeostasis
Dijk, D., & Archer, S. N. (2009) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2009.07.002 · Cited by 246 · see citing works
Mishima, K., Tozawa, T., Satoh, K., Saito, H., & Mishima, Y. (2004) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30110 · Cited by 240 · see citing works
High-fat feeding alters the clock synchronization to light
Mendoza, J., Pévet, P., & Challet, E. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.159566 · Cited by 213 · see citing works
Mediobasal Hypothalamic p70 S6 Kinase 1 Modulates the Control of Energy Homeostasis
Blouet, C., Ono, H., & Schwartz, G. J. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.10.004 · Cited by 197 · see citing works
Hypothalamic Sirt1 Regulates Food Intake in a Rodent Model System
Çakır, I., Perelló, M., Lansari, O., Messier, N. J., Vaslet, C. A., & Nillni, E. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008322 · Cited by 195 · see citing works
Chronobiological aspects of nutrition, metabolic syndrome and obesity
Garaulet, M., & Madrid, J. A. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.05.005 · Cited by 177 · see citing works
The expression of SIRT1 in nonalcoholic fatty liver disease induced by high‐fat diet in rats
Deng, X., Chen, L., & Li, N. (2007) · Liver International · doi:10.1111/j.1478-3231.2007.01497.x · Cited by 174 · see citing works
CLOCK genetic variation and metabolic syndrome risk: modulation by monounsaturated fatty acids
Garaulet, M., Lee, Y.-C., Shen, J., Parnell, L. D., Arnett, D. K., Tsai, M. Y., Lai, C.-Q., & Ordovas, J. M. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27536 · Cited by 172 · see citing works
Self-citationGaraulet, M., Corbalán-Tutau, M. D., Madrid, J. A., Morales, E., Baraza, J. C., Lee, Y. C., & Ordovás, J. M. (2010) · International Journal of Obesity · doi:10.1038/ijo.2009.255 · Cited by 142 · see citing works
SIRT1 Genetic Variation Is Related to BMI and Risk of Obesity
Zillikens, M. C., van Meurs, J. B. J., Rivadeneira, F., Amin, N., Albert Hofman, D., Oostra, B. A., Sijbrands, E. J. G., Witteman, J. C. M., Pols, H. A. P., van Duijn, C. M., et al. (2009) · Diabetes · doi:10.2337/db09-0536 · Cited by 138 · see citing works
Ghrelin, sleep reduction and evening preference: relationships to CLOCK 3111 T/C SNP and weight loss
Garaulet, M., Sánchez-Moreno, C., Smith, C. E., Lee, Y.-C., Nicolás, F., & Ordovás, J. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017435 · Cited by 132 · see citing works
Disruption of the Circadian Timing Systems
Mendlewicz, J. (2009) · CNS Drugs · doi:10.2165/11318630-000000000-00000 · Cited by 122 · see citing works
Serra‐Majem, L., & Bartrina, J. A. (2001) · Public Health Nutrition · doi:10.1079/phn2001229 · Cited by 91 · see citing works
Lee, K. Y., Song, J. Y., Kim, S. H., Kim, S. C., Joo, E.-J., Ahn, Y. M., & Kim, Y. S. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.06.010 · Cited by 79 · see citing works
Corbalán-Tutau, M. D., Morales, E. M., Canteras, M., Espallardo, A., Hernández, T., & Garaulet, M. (2009) · Nutrition · doi:10.1016/j.nut.2009.02.013 · Cited by 76 · see citing works
Nocturnal eating: Association with binge eating, obesity, and psychological distress
Striegel‐Moore, R. H., Rosselli, F., Wilson, G. T., Perrin, N., Harvey, K., & DeBar, L. (2009) · International Journal of Eating Disorders · doi:10.1002/eat.20735 · Cited by 68 · see citing works
Fourier analysis of human soft tissue facial shape: sex differences in normal adults.
Ferrario, V. F., Sforza, C., Jh, S., Miani, A., & Taroni, G. (1995) · Europe PMC (PubMed Central) · Cited by 56 · see citing works
Eng, S., Wagstaff, D. A., & Kranz, S. (2009) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/1479-5868-6-27 · Cited by 46 · see citing works
Bechtold, D. A. (2008) · Journal of Genetics · doi:10.1007/s12041-008-0067-6 · Cited by 42 · see citing works
A Circadian Loop asSIRTs Itself
Wijnen, H. (2009) · Science · doi:10.1126/science.1174132 · Cited by 37 · see citing works
Genetic Predisposition, Nongenetic Risk Factors, and Coronary Infarct
Trichopoulou, A., Yiannakouris, N., Bamia, C., Benetou, V., Trichopoulos, D., & Ordovás, J. M. (2008) · Archives of Internal Medicine · doi:10.1001/archinte.168.8.891 · Cited by 34 · see citing works
Pérez‐Llamas, F., Garaulet, M., Sanz, F., Palma, J. T., de Heredia, F. P., Marı́n, R., & Zamora, S. (2004) · Hispana · Cited by 29 · see citing works
Garaulet, M., Pérez‐Llamas, F., Zamora, S., & Tébar, F. J. (1999) · Journal of Human Nutrition and Dietetics · doi:10.1046/j.1365-277x.1999.00163.x · Cited by 27 · see citing works
Pérez‐Llamas, F., Garaulet, M., Herrero, F., Jt, P., de Heredia, F. P., Marı́n, R., & Zamora, S. (2004) · PubMed · Cited by 23 · see citing works
Tables of composition of foods.
Donath, W. F., Langen, & Lichtenstein (1932) · Cited by 4 · see citing works
[Tables on the composition of food].
Randoin, L., Le Gallic, P., & Causeret, J. (1950) · PubMed · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Garvey, W. T., Mechanick, J. I., Brett, E. M., Garber, A. J., Hurley, D. L., Jastreboff, A. M., Nadolsky, K., Pessah-Pollack, R., & Plodkowski, R. (2016) · Endocrine Practice · doi:10.4158/ep161365.gl · Cited by 1,914 · see citing works
Timing of food intake predicts weight loss effectiveness
Garaulet, M., Gómez-Abellán, P., Alburquerque-Béjar, J. J., Lee, Y.-C., Ordovás, J. M., & Scheer, F. A. J. L. (2013) · International Journal of Obesity · doi:10.1038/ijo.2012.229 · Cited by 639 · see citing works
The Influence of Meal Frequency and Timing on Health in Humans: The Role of Fasting
Paoli, A., Tinsley, G. M., Bianco, A., & Moro, T. (2019) · Nutrients · doi:10.3390/nu11040719 · Cited by 381 · see citing works
Timing of food intake and obesity: a novel association
Garaulet, M., & Gómez-Abellán, P. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.01.001 · Cited by 362 · see citing works
Reutrakul, S., & Van Cauter, E. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12355 · Cited by 321 · see citing works
Health Consequences of Circadian Disruption in Humans and Animal Models
Evans, J. A., & Davidson, A. J. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-396971-2.00010-5 · Cited by 291 · see citing works
Chronotype is independently associated with glycemic control in type 2 diabetes
Reutrakul, S., Hood, M. M., Crowley, S. J., Morgan, M. K., Teodori, M., Knutson, K. L., & Van Cauter, E. (2013) · Diabetes Care · doi:10.2337/dc12-2697 · Cited by 285 · see citing works
Lucassen, E. A., Zhao, X., Rother, K. I., Mattingly, M. S., Courville, A. B., de Jonge, L., Csako, G., Cizza, G., & for the Sleep Extension Study Group (2013) · PLoS ONE · doi:10.1371/journal.pone.0056519 · Cited by 264 · see citing works
Circadian rhythms, metabolism, and chrononutrition in rodents and humans
Johnston, J. D., Ordovás, J. M., Scheer, F. A., & Turek, F. W. (2016) · Advances in Nutrition · doi:10.3945/an.115.010777 · Cited by 258 · see citing works
Timing of breakfast, lunch, and dinner. Effects on Obesity and Metabolic Risk
Lopez-Minguez, J., Gómez-Abellán, P., & Garaulet, M. (2019) · Nutrients · doi:10.3390/nu11112624 · Cited by 201 · see citing works
Jenwitheesuk, A., Nopparat, C., Mukda, S., Wongchitrat, P., & Govitrapong, P. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150916848 · Cited by 163 · see citing works
Circadian rhythms and obesity: Timekeeping governs lipid metabolism
Li, Y., Ma, J., Kang, Y., Su, W., Tan, B., Wu, X., Huang, X., Li, T., Yin, Y., Tosini, G., et al. (2020) · Journal of Pineal Research · doi:10.1111/jpi.12682 · Cited by 159 · see citing works
Physiological responses to food intake throughout the day
Johnston, J. D. (2014) · Nutrition Research Reviews · doi:10.1017/s0954422414000055 · Cited by 158 · see citing works
Chrono-Nutrition: Circadian Rhythm and Personalized Nutrition
Franzago, M., Alessandrelli, E., Notarangelo, S., Stuppia, L., & Vitacolonna, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032571 · Cited by 172 · see citing works
Circadian Rhythms in Diet-Induced Obesity
Engin, A. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-48382-5_2 · Cited by 144 · see citing works
Factors affecting weight loss variability in obesity
Dent, R., McPherson, R., & Harper, M.-E. (2020) · Metabolism · doi:10.1016/j.metabol.2020.154388 · Cited by 131 · see citing works
Circadian rhythms, food timing and obesity
Lopez-Minguez, J., Gómez-Abellán, P., & Garaulet, M. (2016) · Proceedings of the Nutrition Society · doi:10.1017/s0029665116000628 · Cited by 113 · see citing works
Ruiz-Lozano, T., Vidal, J., de Hollanda, A., Canteras, M., Garaulet, M., & Izquierdo-Pulido, M. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.116 · Cited by 96 · see citing works
Teixeira, G. P., Mota, M. C., & Crispim, C. A. (2017) · Chronobiology International · doi:10.1080/07420528.2017.1407778 · Cited by 89 · see citing works
Mealtime: A circadian disruptor and determinant of energy balance?
Ruddick-Collins, L. C., Morgan, P. J., & Johnstone, A. M. (2020) · Journal of Neuroendocrinology · doi:10.1111/jne.12886 · Cited by 74 · see citing works
García‐Ríos, A., Gómez-Delgado, F., Garaulet, M., Alcala-Diaz, J. F., Delgado‐Lista, J., Marı́n, C., Rangel-Zúñiga, O. A., Rodríguez-Cantalejo, F., Gómez-Luna, P., Ordovás, J. M., et al. (2013) · Chronobiology International · doi:10.3109/07420528.2013.864300 · Cited by 73 · see citing works
Circadian gene variants and breast cancer
Reszka, E., Lesicka, M., Muurlink, O. T., & Pepłońska, B. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.01.012 · Cited by 70 · see citing works
Chrononutrition—When We Eat Is of the Essence in Tackling Obesity
Ahluwalia, M. K. (2022) · Nutrients · doi:10.3390/nu14235080 · Cited by 72 · see citing works
Successful weight loss maintenance associated with morning chronotype and better sleep quality
Ross, K. M., Thomas, J. G., & Wing, R. R. (2015) · Journal of Behavioral Medicine · doi:10.1007/s10865-015-9704-8 · Cited by 63 · see citing works
Association between genetic variants of the clock gene and obesity and sleep duration
Valladares, M., Obregón, A. M., & Chaput, J. (2015) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-015-0447-3 · Cited by 61 · see citing works
Regulation of the clock gene expression in human adipose tissue by weight loss
Pivovarova‐Ramich, O., Gögebakan, Ö., Sucher, S., Groth, J., Murahovschi, V., Kessler, K., Osterhoff, M., Rudovich, N. N., Kramer, A., & Pfeiffer, A. F. H. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.34 · Cited by 59 · see citing works
Smoliga, J. M., Colombo, E. S., & Campen, M. J. (2013) · Aging · doi:10.18632/aging.100579 · Cited by 58 · see citing works
Circadian clock genes as promising therapeutic targets for autoimmune diseases
Xiang, K., Xu, Z., Hu, Y., He, Y.-S., Wu, G., Li, T., Wang, X., Ding, L., Zhang, Q., Tao, S., et al. (2021) · Autoimmunity Reviews · doi:10.1016/j.autrev.2021.102866 · Cited by 57 · see citing works
Kline, C. E., Chasens, E. R., Bizhanova, Z., Sereika, S. M., Buysse, D. J., Imes, C. C., Kariuki, J. K., Mendez, D. D., Cajita, M. I., Rathbun, S. L., et al. (2021) · International Journal of Obesity · doi:10.1038/s41366-020-00728-8 · Cited by 56 · see citing works
López‐Guimerà, G., Dashti, H. S., Smith, C. E., Sánchez‐Carracedo, D., Ordovás, J. M., & Garaulet, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099152 · Cited by 55 · see citing works
The relationship between chronotype and obesity: A systematic review
ERİM, S. E., & Sert, H. (2023) · Chronobiology International · doi:10.1080/07420528.2023.2180385 · Cited by 53 · see citing works
Riestra, P., Gebreab, S. Y., Xu, R., Khan, R., Gaye, A., Correa, A., Min, Y., Sims, M., & Davis, S. (2017) · BMC Genetics · doi:10.1186/s12863-017-0522-6 · Cited by 53 · see citing works
Gómez-Delgado, F., García‐Ríos, A., Alcala-Diaz, J. F., Rangel-Zúñiga, O. A., Delgado‐Lista, J., Yubero‐Serrano, E. M., López-Moreno, J., Tinahones, F. J., Ordovás, J. M., Garaulet, M., et al. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500375 · Cited by 47 · see citing works
Sleep, circadian dysrhythmia, obesity and diabetes
Sridhar, G. R., & Sanjana, N. S. N. (2016) · World Journal of Diabetes · doi:10.4239/wjd.v7.i19.515 · Cited by 44 · see citing works
Covassin, N., Singh, P., & Somers, V. K. (2016) · Hypertension · doi:10.1161/hypertensionaha.116.06588 · Cited by 44 · see citing works
Garaulet, M., Martínez-Nicolás, A., Ruiz, J. R., Konstabel, K., Labayen, I., González‐Gross, M., Marcos, A., Molnár, D., Widhalm, K., Casajús, J. A., et al. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.09.026 · Cited by 43 · see citing works
Chedraui, P. A., & Pérez-López, F. R. (2013) · Climacteric · doi:10.3109/13697137.2013.802884 · Cited by 39 · see citing works
Samblas, M., Milagro, F. I., Gómez-Abellán, P., Martínez, J. A., & Garaulet, M. (2016) · Journal of Biological Rhythms · doi:10.1177/0748730416629247 · Cited by 37 · see citing works
Maciukiewicz, M., Dmitrzak‐Węglarz, M., Pawlak, J., Leszczyńska-Rodziewicz, A., Zaremba, D., Skibińska, M., & Hauser, J. (2014) · Chronobiology International · doi:10.3109/07420528.2014.899244 · Cited by 36 · see citing works
NAMPT-dependent NAD + biosynthesis controls circadian metabolism in a tissue-specific manner
Basse, A. L., Nielsen, K. N., Karavaeva, I. E., Ingerslev, L. R., Ma, T., Havelund, J. F., Nielsen, T. S., Frost, M., Peics, J., Dalbram, E., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2220102120 · Cited by 36 · see citing works
Induction of NAFLD with Increased Risk of Obesity and Chronic Diseases in Developed Countries
Martins, I. J. (2014) · Open Journal of Endocrine and Metabolic Diseases · doi:10.4236/ojemd.2014.44011 · Cited by 35 · see citing works
Reeves, S., Huber, J., Halsey, L. G., Horabady-Farahani, Y., Ijadi, M., & Smith, T. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.05.015 · Cited by 35 · see citing works
Galbete, C., Contreras, R., Martínez, J. A., Martínez‐González, M. Á., Guillén‐Grima, F., & Martí, A. (2012) · Chronobiology International · doi:10.3109/07420528.2012.728657 · Cited by 35 · see citing works
Lifestyle mediators of associations among siestas, obesity, and metabolic health
Vizmanos-Lamotte, B., Cascales, A. I., Rodríguez‐Martín, M., Salmerón, D., Morales, E., Alonso, A. A., Scheer, F. A. J. L., & Garaulet, M. (2023) · Obesity · doi:10.1002/oby.23765 · Cited by 34 · see citing works
Madjd, A., Taylor, M. A., Delavari, A., Malekzadeh, R., Macdonald, I. A., & Farshchi, H. R. (2021) · British Journal of Nutrition · doi:10.1017/s0007114520004456 · Cited by 34 · see citing works
MELATONIN: NEUROPHYSIOLOGICAL AND NEUROENDOCRINE ASPECTS
Romanchuk, N., & Pyatin, V. F. (2019) · Bulletin of Science and Practice · doi:10.33619/2414-2948/44/08 · Cited by 31 · see citing works
Misalignment of Circadian Rhythms in Diet-Induced Obesity
Engin, A. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-63657-8_2 · Cited by 33 · see citing works
Garaulet, M., & Gómez-Abellán, P. (2013) · PubMed · doi:10.3305/nh.2013.28.sup5.6926 · Cited by 32 · see citing works
Rahati, S., Qorbani, M., Naghavi, A., Nia, M. H., & Pishva, H. (2022) · BMC Endocrine Disorders · doi:10.1186/s12902-022-01063-x · Cited by 28 · see citing works
Genetics of weight loss: A basis for personalized obesity management
Martínez, J. A., & Milagro, F. I. (2015) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2014.12.007 · Cited by 27 · see citing works
Nutritional genomics, inflammation and obesity
Corrêa, T. A. F., Quintanilha, B. J., Norde, M. M., Pinhel, M. A. D. S., Nonino, C. B., & Rogero, M. M. (2020) · Archives of Endocrinology and Metabolism · doi:10.20945/2359-3997000000255 · Cited by 30 · see citing works
Magnesium Therapy Prevents Senescence with the Reversal of Diabetes and Alzheimer’s Disease
Martins, I. J. (2016) · Health · doi:10.4236/health.2016.87073 · Cited by 21 · see citing works
Sirtuins-Mediators of Maternal Obesity-Induced Complications in Offspring?
Nguyen, L. T., Chen, H., Pollock, C. A., & Saad, S. (2016) · The FASEB Journal · doi:10.1096/fj.15-280743 · Cited by 19 · see citing works
Martins, I. J., Wilson, A. C., Lim, W. L. F., Laws, S. M., Fuller, S. J., & Martins, R. N. (2012) · Health · doi:10.4236/health.2012.412a209 · Cited by 16 · see citing works
Chronodisruption and cardiovascular disease
García‐Ríos, A., & Ordovás, J. M. (2022) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/j.arteri.2021.12.004 · Cited by 15 · see citing works
Sex modifies the association between the CLOCK variant rs1801260 and BMI in school-age children
Meng, Y., Lohse, B., & Cunningham-Sabo, L. D. (2020) · PLoS ONE · doi:10.1371/journal.pone.0236991 · Cited by 15 · see citing works
Clock Gene Modulates Roles of OXTR and AVPR1b Genes in Prosociality
Ci, H., Wu, N., & Su, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109086 · Cited by 14 · see citing works
Are Owls and Larks Different When it Comes to Aggression? Genetics, Neurobiology, and Behavior
Deibel, S. H., McDonald, R. J., & Kolla, N. J. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.00039 · Cited by 13 · see citing works
Pelczyńska, M., Moszak, M., Wojciechowska, J., Płócienniczak, A., Potocki, J., Blok, J., Balcerzak, J., Zblewski, M., & Bogdański, P. (2024) · Nutrients · doi:10.3390/nu17010080 · Cited by 13 · see citing works
Németh, Z., Kiss, É., & Takács, I. (2022) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2709253 · Cited by 12 · see citing works
Clinical Implications of Impaired Sleep
Terre, L. (2014) · American Journal of Lifestyle Medicine · doi:10.1177/1559827614521955 · Cited by 12 · see citing works
da Fonseca, A. C. P., Assis, I. S. D. S., Salum, K. C. R., Palhinha, L., Abreu, G. D. M., Zembrzuski, V. M., Campos, M., Nogueira-Neto, J. F., Cambraia, A., Souza, M. L. F., et al. (2024) · Frontiers in Genetics · doi:10.3389/fgene.2024.1363417 · Cited by 11 · see citing works
Lo, M.-T., Bandín, C., Yang, H.-W., Scheer, F. A. J. L., Hu, K., & Garaulet, M. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.168 · Cited by 10 · see citing works
Jankovic, N., Schmitting, S., Stutz, B., Krüger, B., Buyken, A. E., & Alexy, U. (2023) · European Journal of Nutrition · doi:10.1007/s00394-023-03259-w · Cited by 10 · see citing works
Higashibata, T., Wakai, K., Naito, M., Morita, E., Hishida, A., Hamajima, N., Hara, M., Suzuki, S., Hosono, S., Takashima, N., et al. (2016) · Gene · doi:10.1016/j.gene.2016.08.051 · Cited by 9 · see citing works
Kim, S., Lee, H. S., Park, H.-K., Linton, J. A., Lee, J., & Lee, H. (2017) · Chronobiology International · doi:10.1080/07420528.2017.1337780 · Cited by 9 · see citing works
Yang, H.-W., Garaulet, M., Li, P., Bandín, C., Lin, C., Lo, M., & Hu, K. (2021) · Nutrients · doi:10.3390/nu13072463 · Cited by 8 · see citing works
The EASO New Investigator Award in Clinical Research 2021: Role of Chronotype in Obesity
Muscogiuri, G. (2022) · Obesity Facts · doi:10.1159/000527691 · Cited by 9 · see citing works
Garaulet, M., & Madrid, J. A. (2015) · PubMed · doi:10.3305/nh.2015.31.sup3.8776 · Cited by 9 · see citing works
Infancy and Childhood Obesity Grade Predicts Weight Loss in Adulthood: The ONTIME Study
Morales, E., Torres‐Castillo, N., & Garaulet, M. (2021) · Nutrients · doi:10.3390/nu13072132 · Cited by 8 · see citing works
[Measurement units used in treatments to reduce weight and obesity. Systematic review].
Gutiérrez-Hervás, A., García-Galbis, M. R., Baeza, M. R., Cortés‐Castell, E., Villar, N. M., & Cordero, M. J. A. (2014) · PubMed · doi:10.3305/nh.2014.30.3.7619 · Cited by 6 · see citing works
Saetung, S., Nimitphong, H., Siwasaranond, N., Manodpitipong, A., Crowley, S. J., Hood, M. M., & Reutrakul, S. (2017) · Behavioral Sleep Medicine · doi:10.1080/15402002.2017.1342169 · Cited by 8 · see citing works
Ren, X., Zhang, M., Sun, X., Zheng, L., Bi, Y., Li, Q., Sun, L., Di, F., Xu, Y., Zhu, D., et al. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06870-z · Cited by 7 · see citing works
Tangestani, H., Emamat, H., Yekaninejad, M. S., Alipour, M., Keshavarz, S. A., & Mirzaei, K. (2022) · International Journal of Preventive Medicine · doi:10.4103/ijpvm.ijpvm_352_20 · Cited by 5 · see citing works
Valladares, M., Chaput, J., Vásquez, S. R., Pino-Astorga, C., & Obregón, A. M. (2019) · Annals of Human Biology · doi:10.1080/03014460.2019.1706764 · Cited by 5 · see citing works
From clock genes to exercise: shaping the field of Exercise Chronophysiology
Ciorciari, A. M., & Lamia, K. A. (2025) · Current Opinion in Physiology · doi:10.1016/j.cophys.2025.100835 · Cited by 4 · see citing works
Rahati, S., Qorbani, M., Naghavi, A., & Pishva, H. (2024) · Clinical Nutrition · doi:10.1016/j.clnu.2024.12.021 · Cited by 4 · see citing works
Semenova, N. V., Михайловна, М. И., Kolesnikov, S. I., Rychkova, L. V., Bairova, T. A., Darenskaya, M. A., & Kolesnikova, L. I. (2020) · Pathophysiology · doi:10.3390/pathophysiology28010001 · Cited by 4 · see citing works
Huang, J., Zheng, Q., Wang, S., Zhang, Q., Jiang, L., Hao, R., Li, F., & Ma, Y. (2017) · Archives animal breeding/Archiv für Tierzucht · doi:10.5194/aab-60-357-2017 · Cited by 4 · see citing works
Drozdovska, S., Валеріївна, А. О., Orlenko, V., Andrieiev, I., Pastukhova, V., Mazur, I. I., Hurenko, O. O., & Nahorna, A. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.105094 · Cited by 3 · see citing works
The Mediterranean Diet and Obesity from a Nutrigenetic and Epigenetics Perspective
Garaulet, M. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-407849-9.00022-1 · Cited by 2 · see citing works
Savini, I., Gasperi, V., & Catani, M. V. (2016) · Wiley eBooks · doi:10.1002/9780470015902.a0021028 · Cited by 2 · see citing works
Genetics in Chronobiology and Obesity
Garaulet, M., & Ordovás, J. M. (2012) · Springer eBooks · doi:10.1007/978-1-4614-5082-5_8 · Cited by 1 · see citing works
Chronodisruption and cardiovascular disease
García‐Ríos, A., & Ordovás, J. M. (2022) · Clínica e Investigación en Arteriosclerosis (English Edition) · doi:10.1016/j.artere.2022.07.003 · Cited by 1 · see citing works
The Use of Chrono Nutrition in Precision Nutrition
Ordovás, J. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-15315-0.00014-6 · Cited by 1 · see citing works
Викторовна, С. Н., Mel'nichenko, G. A., Poluektov, M. G., Савельева, Л. В., Katsiya, G. V., & Goncharov, N. P. (2014) · Obesity and metabolism · doi:10.14341/omet2014323-30 · Cited by 1 · see citing works
CLOCK GENES, CIRCADIAN RHYTHMS, AND MOOD DISORDERS: THE ROLE OF POSITIVE AFFECT
Miller, M. A. (2014) · D-Scholarship@Pitt (University of Pittsburgh)
Chronotype Is Independently Associated WithGlycemicControl inType2Diabetes
Reutrakul, S., Hood, M. M., Crowley, S. J., Morgan, M. K., Teodori, M., Knutson, K. L., & Cauter, E. V. (2016)
8 Integrative Nutritional Therapy for Cardiovascular Disease
Guarneri, M., & Bradley, R. D. (2017) · CRC Press eBooks · doi:10.1201/b22342-8
Exercise, Diet, and Obese Adolescents
Gómez-Abellán, P., & Garaulet, M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-420168-2.00009-0
Association Between Sleep Pattern, Anthropometric Indicators, and Metabolic Risk Factors
Yari, Z., & Rabiei, S. (2021) · Sleep and Vigilance · doi:10.1007/s41782-021-00177-x
Integrative Nutritional Therapy for Cardiovascular Disease
Guarneri, M., & Bradley, R. D. (2015) · CRC Press eBooks · doi:10.1201/b18833-9
Rahati, S., Qorbani, M., Naghavi, A., & Pishva, H. (2023) · Research Square · doi:10.21203/rs.3.rs-2958003/v1
Lai, C., Parnell, L. D., Li, Z., Noel, S. E., Bhupathiraju, S. N., Tucker, K. L., & Ordovás, J. M. (2025) · Metabolites · doi:10.3390/metabo15110697
Rahati, S., Qorbani, M., Naghavi, A., Nia, M. H., & Pishva, H. (2022) · Figshare · doi:10.6084/m9.figshare.19976900
Bmal2, a circadian-related gene as candidate in obesity and diabetes
Philippe, M. (2023) · theses.fr (ABES) · doi:10.70675/0649c89czc015z4d7fz8832z596152e96dc1
- Authors
- Garaulet, M., Esteban Tardido, A., Lee, Y.-C., Smith, C. E., Parnell, L. D., & Ordovás, J. M.
- Affiliations
- Universidad de Murcia (ES)
- Tufts University (US)
- Corresponding author
- Garaulet, M
- Venue
- International Journal of Obesity
- Published
- 2012-02-07
- Volume
- 36
- Issue
- 11
- Pages
- 1436-1441
- ISSN
- 0307-0565 (ISSN-L)
- 1476-5497
- PMC
- PMC4428942
- OpenAlex
- W2076855437
- Cited by
- 98
- References
- 45
- Citations by year
- 2025: 3 · 2024: 4 · 2023: 8 · 2022: 9 · 2021: 5 · 2020: 8 · 2019: 4 · 2017: 11 · 2016: 13 · 2015: 8 · 2014: 14 · 2013: 8 · 2012: 3
- FWCI
- 6.36
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- International Journal of Obesity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL54776, R01HL054776)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-075030, R01DK075030)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- SIRT1, clock genes, circadian clock, chronotype, obesity, weight loss resistance, behavior therapy, Mediterranean diet, dietary adherence, ghrelin, genetic susceptibility, circadian rhythm
- MeSH terms
- Adult, Aged, Behavior Therapy, Circadian Rhythm, Feeding Behavior, Female, Genotype, Humans, Male, Middle Aged, Obesity, Surveys and Questionnaires, Spain, Genetic Variation, Weight Loss, Body Mass Index, Diet, Mediterranean, Ghrelin, Sirtuin 1, CLOCK Proteins
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