Cited by 327Oral microbiology and periodontitis researchGut microbiota and healthGenomics and Phylogenetic Studies

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Community-wide transcriptome of the oral microbiome in subjects with and without periodontitis

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Duran-Pinedo, Ana E, Chen, Tsute, Teles, Ricardo, Starr, Jacqueline R, Wang, Xiaoshan, Krishnan, Keerthana, Frias-Lopez, Jorge·2014·The ISME Journal

DOI 10.1038/ismej.2014.23PMC PMC4817619

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Abstract

Despite increasing knowledge on phylogenetic composition of the human microbiome, our understanding of the in situ activities of the organisms in the community and their interactions with each other and with the environment remains limited. Characterizing gene expression profiles of the human microbiome is essential for linking the role of different members of the bacterial communities in health and disease. The oral microbiome is one of the most complex microbial communities in the human body and under certain circumstances, not completely understood, the healthy microbial community undergoes a transformation toward a pathogenic state that gives rise to periodontitis, a polymicrobial inflammatory disease. We report here the in situ genome-wide transcriptome of the subgingival microbiome in six periodontally healthy individuals and seven individuals with periodontitis. The overall picture of metabolic activities showed that iron acquisition, lipopolysaccharide synthesis and flagellar synthesis were major activities defining disease. Unexpectedly, the vast majority of virulence factors upregulated in subjects with periodontitis came from organisms that are not considered major periodontal pathogens. One of the organisms whose gene expression profile was characterized was the uncultured candidate division TM7, showing an upregulation of putative virulence factors in the diseased community. These data enhance understanding of the core activities that are characteristic of periodontal disease as well as the role that individual organisms in the subgingival community play in periodontitis.

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See all 327

Authors: Duran-Pinedo, A. E., Chen, T., Teles, R., Starr, J. R., Wang, X., Krishnan, K., & Frias-Lopez, J.
Affiliations: The Forsyth Institute (US)
Harvard University (US)
Department of Microbiology, Forsyth Institute , Cambridge, MA, USA
ORCID: Duran-Pinedo, Ana E
Chen, Tsute
Teles, Ricardo
Starr, Jacqueline R
Krishnan, Keerthana
Venue: The ISME Journal
Publisher: Oxford University Press (OUP)
Published: 2014-03-06
Volume: 8
Issue: 8
Pages: 1659-1672
ISSN: 1751-7362 (ISSN-L)
1751-7370
DOI: 10.1038/ismej.2014.23
PMC: PMC4817619
OpenAlex: W2080580603
Cited by: 327
References: 92
Citations by year: 2026: 15 · 2025: 19 · 2024: 17 · 2023: 21 · 2022: 36 · 2021: 42 · 2020: 38 · 2019: 26 · 2018: 25 · 2017: 28 · 2016: 21 · 2015: 26 · 2014: 12
FWCI: 38.27
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The ISME Journal (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Dental and Craniofacial Research (DE021127, U01DE021127, DE021553, R01DE021553)
Topics: Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
Keywords: periodontitis, oral microbiota, subgingival microbiota, microbial gene expression, virulence factors, iron acquisition, lipopolysaccharide biosynthesis, flagellar synthesis, polymicrobial disease, microbial interactions
MeSH terms: Adult, Bacteria, Humans, Periodontitis, Phylogeny, Virulence Factors, Metagenome, Transcriptome, Microbiota

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Community-wide transcriptome of the oral microbiome in subjects with and without periodontitis

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