Cited by 405Neurogenesis and neuroplasticity mechanismsCardiovascular and exercise physiologyBarrier Structure and Function Studies

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Exercise and the Brain: Angiogenesis in the Adult Rat Cerebellum after Vigorous Physical Activity and Motor Skill Learning

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Isaacs, Krystyna R., Anderson, Brenda J., Alcantara, Adriana A., Black, James E., Greenough, William T.·1992·Journal of Cerebral Blood Flow & Metabolism

DOI 10.1038/jcbfm.1992.14

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Abstract

This study compared the morphology of cerebellar cortex in adult female rats exposed for 1 month to repetitive exercise, motor learning, or an inactive condition. In the exercise conditions, rats that were run on a treadmill or housed with access to a running wheel had a shorter diffusion distance from blood vessels in the molecular layer of the paramedian lobule when compared to rats housed individually or rats that participated in a motor skill learning task. Rats taught complex motor skills substantially increased the volume of the molecular layer per Purkinje neuron and increased blood vessel number sufficiently to maintain the diffusion distance. These results dissociate angiogenesis associated with increased neuropil volume (as seen in the motor learning group) from angiogenesis associated with increased metabolic demands (as seen in the exercise groups). While the volume fraction of mitochondria did not differ among groups, the mitochondrial volume fraction per Purkinje cell was significantly increased in the motor skill rats. This appears to parallel the previously reported increase in synapses and associated neuropil volume change.

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Angiogenic factors.
Folkman, J., & Klagsbrun, M. (1987) · Science · doi:10.1126/science.2432664 · Cited by 3,491
The new stereological tools: Disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis
Gundersen, H. J. G., Bagger, P. V., Bendtsen, T. F., Evans, S. M., Korbo, L., Marcussen, N., Møller, A., Nielsen, K. N., Nyengaard, J. R., Pakkenberg, B., et al. (1988) · Apmis · doi:10.1111/j.1699-0463.1988.tb00954.x · Cited by 2,480
Cerebellar Cortex
Palay, S. L., & Chan‐Palay, V. (1974) · Springer eBooks · doi:10.1007/978-3-642-65581-4 · Cited by 2,468
The cerebellum and neural control
Ito, M. (1984) · Cited by 2,314
The cerebellum and neural control
Tindall, S. C. (1985) · Surgical Neurology · doi:10.1016/0090-3019(85)90320-9 · Cited by 1,760
Cerebellar Cortex: Cytology and Organization
Palay, S. L., & Chan‐Palay, V. (1974) · Medical Entomology and Zoology · Cited by 1,679
Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis
Ausprunk, D. H., & Folkman, J. (1977) · Microvascular Research · doi:10.1016/0026-2862(77)90141-8 · Cited by 1,290
Stereological Methods
Cowden, R. R., & Weibel, E. R. (1982) · Transactions of the American Microscopical Society · doi:10.2307/3225581 · Cited by 1,196
Learning causes synaptogenesis, whereas motor activity causes angiogenesis, in cerebellar cortex of adult rats.
Black, J. E., Isaacs, K. R., Anderson, B. J., Alcantara, A. A., & Greenough, W. T. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.14.5568 · Cited by 1,161
Self-citation
Chemical and Anatomical Plasticity of Brain
Bennett, E. L., Diamond, M. C., Krech, D., & Rosenzweig, M. R. (1964) · Science · doi:10.1126/science.146.3644.610 · Cited by 769

Flagged first, then by citations

Show all 62 references

Research works printed but not linked: 7

Alcantara AA, 1990, Soc Neurosci Abstr, 16, 1164
Brodal A, 1981, Neurological anatomy
Gyllensten L, 1959, Acta Morphol Neerl Scand, 2, 289
Opitz E, 1951, Exp Med Surg, 9, 389
Petrén T, 1938, Morphol Jahrb, 82, 554
Ter Haar MB, 1972, Horm Behav, 36, 991
Wang GH, 1923, Comp Psychol Monogr, 2, 1

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Self-citation
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Self-citation
Quantitative proton MR spectroscopic findings of cortical reorganization in the auditory cortex of musicians.
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Rapid laminar-dependent changes in GFAP immunoreactive astrocytes in the visual cortex of rats reared in a complex environment
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Self-citation
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Functional Genomics meets neurodegenerative disorders
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Functional improvement after motor training is correlated with synaptic plasticity in rat thalamus
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Recruitment of the prefrontal cortex and cerebellum in Parkinsonian rats following skilled aerobic exercise
Wang, Z., Guo, Y., Myers, K. G., Heintz, R., & Holschneider, D. P. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.02.020 · Cited by 42
Mechanisms of neuronal cell death
Morrison, R. S., Kinoshita, Y., Xiang, H., Johnson, M. D., Kuntz, C., Ghatan, S., Ho, J. T., & Schwartzkroin, P. A. (1998) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/(sici)1098-2779(1998)4:3 · Cited by 15
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Correlation of local changes in cerebral blood flow, capillary density, and cytochrome oxidase during development
Tuor, U. I., Kurpita, G., & Simone, C. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903420310 · Cited by 40
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Wang, Y., Li, M., Dong, F., Zhang, J., & Zhang, F. (2015) · PubMed Central · Cited by 36
Enhanced apoptosis from early physical exercise rehabilitation following ischemic stroke
Li, F., Shi, W., Zhao, E. Y., Geng, X., Li, X., Peng, C., Shen, J., Wang, S., & Ding, Y. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23890 · Cited by 36
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Ambrose, C. T. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.03.005 · Cited by 37
Conjugated Linoleic Acid (CLA) inhibits new vessel growth in the mammalian brain
Sikorski, A. M., Hebert, N., & Swain, R. A. (2008) · Brain Research · doi:10.1016/j.brainres.2008.01.096 · Cited by 35
Fish oil supplementation and physical exercise program: Distinct effects on different memory tasks
Rachetti, A. L. F., Arida, R. M., Patti, C. L., Zanin, K. A., Fernandes‐Santos, L., Frussa‐Filho, R., da Silva, S. G., Scorza, F. A., & Cysneiros, R. M. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.09.048 · Cited by 36
Exercise-induced changes of the capillaries in the cortex of middle-aged rats
Huang, C., Qiu, X., Wang, S., Wu, H., Xia, L., Li, C., Gao, Y., Zhang, L., Xiu, Y., Fu, C., et al. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2012.12.046 · Cited by 34
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Motor Performance Improved by Exercises in Cerebral Ischemic Rats
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The beta-thymosins, small actin-binding peptides widely expressed in the developing and adult cerebellum
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Authors: Isaacs, K. R., Anderson, B. J., Alcantara, A. A., Black, J. E., & Greenough, W. T.
Affiliations: University of Illinois Urbana-Champaign (US)
ORCID: Black, James E.
Venue: Journal of Cerebral Blood Flow & Metabolism
Publisher: SAGE Publications
Published: 1992-01
Volume: 12
Issue: 1
Pages: 110-119
ISSN: 0271-678X (ISSN-L)
1559-7016
DOI: 10.1038/jcbfm.1992.14
OpenAlex: W2010856791
Cited by: 405
References: 62
Citations by year: 2026: 3 · 2025: 11 · 2024: 7 · 2023: 10 · 2022: 12 · 2021: 14 · 2020: 11 · 2019: 20 · 2018: 12 · 2017: 17 · 2016: 15 · 2015: 17 · 2014: 12 · 2013: 22 · 2012: 22
FWCI: 1.43
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Cerebral Blood Flow & Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation
National Institutes of Health (5t32mh018412-02)
University of Illinois at Urbana-Champaign
U.S. Public Health Service (43830)
National Institute of Mental Health (MH-18882, MH18412)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD07333, T32HD007333)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Keywords: physical activity, angiogenesis, cerebellum, motor skill learning, Purkinje cells, molecular layer, blood vessel density, mitochondrial volume fraction, treadmill running, running wheel, brain vascularization
MeSH terms: Animals, Capillaries, Cerebellum, Physical Exertion, Female, Learning, Motor Skills, Neovascularization, Pathologic, Rats

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Exercise and the Brain: Angiogenesis in the Adult Rat Cerebellum after Vigorous Physical Activity and Motor Skill Learning

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