Cited by 405Neurogenesis and neuroplasticity mechanismsCardiovascular and exercise physiologyBarrier Structure and Function Studies

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Exercise and the Brain: Angiogenesis in the Adult Rat Cerebellum after Vigorous Physical Activity and Motor Skill Learning

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Isaacs, Krystyna R., Anderson, Brenda J., Alcantara, Adriana A., Black, James E., Greenough, William T.·1992·Journal of Cerebral Blood Flow & Metabolism

DOI 10.1038/jcbfm.1992.14

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Abstract

This study compared the morphology of cerebellar cortex in adult female rats exposed for 1 month to repetitive exercise, motor learning, or an inactive condition. In the exercise conditions, rats that were run on a treadmill or housed with access to a running wheel had a shorter diffusion distance from blood vessels in the molecular layer of the paramedian lobule when compared to rats housed individually or rats that participated in a motor skill learning task. Rats taught complex motor skills substantially increased the volume of the molecular layer per Purkinje neuron and increased blood vessel number sufficiently to maintain the diffusion distance. These results dissociate angiogenesis associated with increased neuropil volume (as seen in the motor learning group) from angiogenesis associated with increased metabolic demands (as seen in the exercise groups). While the volume fraction of mitochondria did not differ among groups, the mitochondrial volume fraction per Purkinje cell was significantly increased in the motor skill rats. This appears to parallel the previously reported increase in synapses and associated neuropil volume change.

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Self-citation
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Authors: Isaacs, K. R., Anderson, B. J., Alcantara, A. A., Black, J. E., & Greenough, W. T.
Affiliations: University of Illinois Urbana-Champaign (US)
ORCID: Black, James E.
Venue: Journal of Cerebral Blood Flow & Metabolism
Publisher: SAGE Publications
Published: 1992-01
Volume: 12
Issue: 1
Pages: 110-119
ISSN: 0271-678X (ISSN-L)
1559-7016
DOI: 10.1038/jcbfm.1992.14
OpenAlex: W2010856791
Cited by: 405
References: 62
Citations by year: 2026: 3 · 2025: 11 · 2024: 7 · 2023: 10 · 2022: 12 · 2021: 14 · 2020: 11 · 2019: 20 · 2018: 12 · 2017: 17 · 2016: 15 · 2015: 17 · 2014: 12 · 2013: 22 · 2012: 22
FWCI: 1.43
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Cerebral Blood Flow & Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation
National Institutes of Health (5t32mh018412-02)
University of Illinois at Urbana-Champaign
U.S. Public Health Service (43830)
National Institute of Mental Health (MH-18882, MH18412)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD07333, T32HD007333)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Keywords: physical activity, angiogenesis, cerebellum, motor skill learning, Purkinje cells, molecular layer, blood vessel density, mitochondrial volume fraction, treadmill running, running wheel, brain vascularization
MeSH terms: Animals, Capillaries, Cerebellum, Physical Exertion, Female, Learning, Motor Skills, Neovascularization, Pathologic, Rats

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Exercise and the Brain: Angiogenesis in the Adult Rat Cerebellum after Vigorous Physical Activity and Motor Skill Learning

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