CoChat
Sign Up
Cited by 102Sodium Intake and HealthBlood Pressure and Hypertension StudiesNitric Oxide and Endothelin Effects

Low-sodium DASH reduces oxidative stress and improves vascular function in salt-sensitive humans

Open access
Al-Solaiman, Y, Jesri, A, Zhao, Y, Morrow, J D, Egan, B M·2009·Journal of Human Hypertension
DOI 10.1038/jhh.2009.32PMC PMC2783838
Open this paper in CoChat — free account

Abstract

Salt induces oxidative stress in salt-sensitive (SS) animals and man. It is not known whether in SS subjects the low-sodium dietary approaches to stop hypertension (LS-DASH) reduces oxidative stress more than DASH, which is high in antioxidants. To assess the effects of DASH and LS-DASH on oxidative stress, 19 volunteers were studied after 3 weeks of a standardized usual low fruits and vegetables diet (ULFV), followed by 3 weeks on DASH (both diets approximately 120 mmol Na(+) per day), then 3 weeks on LS-DASH (60 mmol Na(+) per day). SS was defined as systolic blood pressure >or=5 mm Hg lower on LS-DASH than DASH. In SS subjects (N=9), systolic blood pressure was lower on LS-DASH (111.0+/-2.0 mm Hg) than DASH (118.0+/-2.2, P<0.01) and ULFV (122.3+/-2.7, P=0.002). In salt-resistant (SR) volunteers (N=10), systolic blood pressure was lower on DASH (113.0+/-1.6) than ULFV (119.0+/-1.8, P<0.05) but not LS-DASH (115.7+/-1.8). Urine F2-isoprostanes, a marker of oxidative stress, were lower in SS subjects on LS-DASH (1.69+/-0.24) than ULFV (3.09+/-0.50, P<0.05) and marginally lower than DASH (2.46+/-0.44, P<0.20). F2-isoprostanes were not different among the three diets in SR volunteers (2.18+/-0.29, 2.06+/-0.29, 2.27+/-0.53, respectively). Aortic augmentation index, a measure of vascular stiffness, was lower in SS subjects on LS-DASH than either DASH or ULFV, and lower on DASH than ULFV in SR volunteers. In SS but not SR subjects, LS-DASH is associated with lower values for F2-isoprostanes and the aortic augmentation index. The results suggest that LS-DASH decreases oxidative stress, improves vascular function and lowers blood pressure in SS but not SR volunteers.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/jhh.2009.32

Cites

64 of 64 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The spontaneously hypertensive stroke-prone rat (SHRSP), the most relevant experimental model of sporadic SVD, has multiple modest endothelial and perivascular tissue defects in early life, including impaired endothelial tight junctions, poor myelination, overactive microglia, and a tendency to glial scarring detectable in protein expression.

    “the most relevant experimental model of sporadic SVD, the spontaneously-hypertensive stroke prone rat (SHRSP),21,22,135 has multiple modest endothelial and perivascular tissue defects in early life,21 including impaired endothelial tight junctions, poor myelination, overactive microglia, and tendency to glial scarring detectable in protein expression.134”

    From Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging (2013) · cites this paper as [134]

  • In an animal model of spontaneous SVD, even modest short-term salt exposure exacerbated inflammation, oxidative stress and small vessel pathology, and to a lesser but measurable extent in control rats without raising blood pressure.

    “In an animal model of spontaneous SVD, even modest short term salt exposure exacerbated inflammation, oxidative stress and small vessel pathology and to a lesser but nonetheless measureable extent in control rats without raising BP.134,135”

    From Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging (2013) · cites this paper as [134]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 3

  1. [23]Van DeWater JM Miller TW Vogel RL Mount BE Dalton ML Impedance Cardiography. The next vital sign technology? Chest 2003 123 2028 2033 12796185
  2. [33]Chen PY Gladish RD Sanders PW Vascular smooth muscle nitric oxide synthase anomalies in Dahl/Rapp salt-sensitive rats Hypertension 1998 31 918 924 9535415
  3. [36]Bragulat E de la Sierra A Antonio MT Coca A Endothelial dysfunction in salt-sensitive essential hypertension Hypertension 2001 37 444 448 11230316

Cited by

Sorted by citations

Related

Authors
Al-Solaiman, Y., Jesri, A., Zhao, Y., Morrow, J. D., & Egan, B. M.
Affiliations
  • Medical University of South Carolina (US)
  • Vanderbilt University (US)
Corresponding author
Egan, B M
ORCID
Venue
Journal of Human Hypertension
Publisher
Springer Science and Business Media LLC
Published
2009-04-30
Volume
23
Issue
12
Pages
826-835
ISSN
  • 0950-9240 (ISSN-L)
  • 1476-5527
DOI
10.1038/jhh.2009.32
PMC
PMC2783838
OpenAlex
W2009794559
Cited by
102
References
64
Citations by year
2026: 1 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 6 · 2020: 7 · 2019: 5 · 2018: 7 · 2017: 5 · 2016: 7 · 2015: 10 · 2014: 12 · 2013: 11 · 2012: 6
FWCI
5.16
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Human Hypertension (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Medical University of South Carolina
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (HL04290, K24HL004290, R01HL058794, HL 58794)
  • National Institute of General Medical Sciences (GM 15431, P50GM015431, P01GM015431)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK 48831, R01DK048831)
  • National Center on Minority Health and Health Disparities
  • National Center for Research Resources (M01RR001070, RR-01070)
  • National Institute on Minority Health and Health Disparities (P60MD000267, MD00267)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Keywords
salt-sensitive hypertension, oxidative stress, F2-isoprostanes, vascular function, aortic augmentation index, vascular stiffness, systolic blood pressure, dietary sodium reduction, antioxidants, hypertension prevention, dietary intervention, blood pressure reduction
MeSH terms
Adult, Aldosterone, Aorta, Blood Pressure, Cardiac Output, Diet, Sodium-Restricted, Elasticity, Electrolytes, Female, Heart Rate, Humans, Hypertension, Insulin, Lipids, Male, Middle Aged, Phenols, Plant Extracts, Potassium Chloride, Renin, Sodium Chloride, Vascular Resistance, Oxidative Stress, F2-Isoprostanes, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review