Selective Antimicrobial Action Is Provided by Phenol-Soluble Modulins Derived from Staphylococcus epidermidis, a Normal Resident of the Skin

Host-Bacterial Mutualism in the Human Intestine

Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277

The global burden of group A streptococcal diseases

Carapetis, J. R., Steer, A. C., Mulholland, E. K., & Weber, M. (2005) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(05)70267-x · Cited by 3,001

[14]Determination and analysis of urea and guanidine hydrochloride denaturation curves

Pace, C. N. (1986) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(86)31045-0 · Cited by 2,267

Innate antimicrobial peptide protects the skin from invasive bacterial infection

Nizet, V., Ohtake, T., Lauth, X., Trowbridge, J., Rudisill, J., Dorschner, R. A., Pestonjamasp, V., Piraino, J., Huttner, K., & Gallo, R. L. (2001) · Nature · doi:10.1038/35106587 · Cited by 1,198

Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA

Wang, R., Braughton, K. R., Kretschmer, D., Bach, T.-H. L., Queck, S. Y., Li, M., Kennedy, A. D., Dorward, D. W., Klebanoff, S. J., Peschel, A., et al. (2007) · Nature Medicine · doi:10.1038/nm1656 · Cited by 1,046

A diversity profile of the human skin microbiotaPreprint

Grice, E. A., Kong, H. H., Renaud, G., Young, A., Bouffard, G. G., Blakesley, R. W., Wolfsberg, T. G., Turner, M. L. C., & Segre, J. A. (2008) · Genome Research · doi:10.1101/gr.075549.107 · Cited by 1,026

Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea

Yamasaki, K., Nardo, A. D., Bardan, A., Murakami, M., Ohtake, T., Coda, A. B., Dorschner, R. A., Bonnart, C., Descargues, P., Hovnanian, A., et al. (2007) · Nature Medicine · doi:10.1038/nm1616 · Cited by 864

Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin

Salzman, N. H., Ghosh, D., Huttner, K. M., Paterson, Y. Y. W., & Bevins, C. L. (2003) · Nature · doi:10.1038/nature01520 · Cited by 765

Staphylococcus epidermidis infections

Vuong, C., & Otto, M. J. (2002) · Microbes and Infection · doi:10.1016/s1286-4579(02)01563-0 · Cited by 710

Molecular analysis of human forearm superficial skin bacterial biota

Gao, Z., Tseng, C., Pei, Z., & Blaser, M. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607077104 · Cited by 660

The skin microbiome

Grice, E. A., & Segre, J. A. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2537 · Cited by 3,143

Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis

Kong, H. H., Oh, J., Deming, C., Conlan, S., Grice, E. A., Beatson, M. A., Nomicos, E., Polley, E. C., Komarow, H. D., Program, N. C. S., et al. (2012) · Genome Research · doi:10.1101/gr.131029.111 · Cited by 1,808

Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis

Nakatsuji, T., Chen, T. H., Narala, S., Chun, K. A., Two, A. M., Yun, T., Shafiq, F., Kotol, P. F., Bouslimani, A., Melnik, A. V., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aah4680 · Cited by 1,095

Epithelial antimicrobial defence of the skin and intestine

Gallo, R. L., & Hooper, L. V. (2012) · Nature reviews. Immunology · doi:10.1038/nri3228 · Cited by 1,020

Skin microbiota–host interactions

Chen, Y. E., Fischbach, M. A., & Belkaid, Y. (2018) · Nature · doi:10.1038/nature25177 · Cited by 815

Staphylococcal Infections: Mechanisms of Biofilm Maturation and Detachment as Critical Determinants of Pathogenicity

Otto, M. J. (2012) · Annual Review of Medicine · doi:10.1146/annurev-med-042711-140023 · Cited by 606

Staphylococcus δ-toxin induces allergic skin disease by activating mast cells

Nakamura, Y., Oscherwitz, J., Cease, K. B., Chan, S. M., Muñoz-Planillo, R., Hasegawa, M., Villaruz, A. E., Cheung, G. Y. C., McGavin, M. J., Travers, J. B., et al. (2013) · Nature · doi:10.1038/nature12655 · Cited by 558

Structure and function of the human skin microbiome

Schommer, N. N., & Gallo, R. L. (2013) · Trends in Microbiology · doi:10.1016/j.tim.2013.10.001 · Cited by 561

Diversity of the human skin microbiome early in life

Capone, K. A., Dowd, S. E., Stamatas, G. N., & Nikolovski, J. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.168 · Cited by 532

Staphylococcus aureus and Atopic Dermatitis: A Complex and Evolving Relationship

Geoghegan, J. A., Irvine, A. D., & Foster, T. J. (2017) · Trends in Microbiology · doi:10.1016/j.tim.2017.11.008 · Cited by 533

Functions of the skin microbiota in health and disease

Sanford, J. A., & Gallo, R. L. (2013) · Seminars in Immunology · doi:10.1016/j.smim.2013.09.005 · Cited by 512

Microbiota-mediated colonization resistance: mechanisms and regulation

Caballero-Flores, G., Pickard, J. M., & Núñez, G. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00833-7 · Cited by 474

Phenol-soluble modulins and staphylococcal infection

Peschel, A., & Otto, M. J. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro3110 · Cited by 455

Activation of TLR2 by a Small Molecule Produced by Staphylococcus epidermidis Increases Antimicrobial Defense against Bacterial Skin Infections

Lai, Y., Cogen, A. L., Radek, K. A., Park, H. J., MacLeod, D. T., Leichtle, A., Ryan, A. F., Di Nardo, A., & Gallo, R. L. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.123 · Cited by 446

Defensive symbioses of animals with prokaryotic and eukaryotic microorganisms

Flórez, L. V., Biedermann, P. H. W., Engl, T., & Kaltenpoth, M. (2015) · Natural Product Reports · doi:10.1039/c5np00010f · Cited by 422

Staphylococcus aureus hemolysins, bi-component leukocidins, and cytolytic peptides: a redundant arsenal of membrane-damaging virulence factors?

Vandenesch, F., Lina, G., & Henry, T. (2012) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2012.00012 · Cited by 405

Gram-Positive Uropathogens, Polymicrobial Urinary Tract Infection, and the Emerging Microbiota of the Urinary Tract

Kline, K. A., & Lewis, A. L. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.uti-0012-2012 · Cited by 397

Antimicrobial Peptides: Old Molecules with New Ideas

Nakatsuji, T., & Gallo, R. L. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.387 · Cited by 411

Microbial Symbiosis with the Innate Immune Defense System of the Skin

Gallo, R. L., & Nakatsuji, T. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.182 · Cited by 387

Rosacea

Two, A. M., Wu, W., Gallo, R. L., & Hata, T. R. (2015) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2014.08.028 · Cited by 388

Functional Amyloids Composed of Phenol Soluble Modulins Stabilize Staphylococcus aureus Biofilms

Schwartz, K., Syed, A. K., Stephenson, R. E., Rickard, A. H., & Boles, B. R. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002744 · Cited by 378

Phenol-soluble modulins – critical determinants of staphylococcal virulence

Cheung, G. Y. C., Joo, H., Chatterjee, S. S., & Otto, M. J. (2013) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12057 · Cited by 395

Staphylococcus aureus Exploits Epidermal Barrier Defects in Atopic Dermatitis to Trigger Cytokine Expression

Nakatsuji, T., Chen, T. H., Two, A. M., Chun, K., Narala, S., Geha, R. S., Hata, T. R., & Gallo, R. L. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.05.127 · Cited by 379

Staphylococcus epidermidis and its dual lifestyle in skin health and infection

Severn, M. M., & Horswill, A. R. (2022) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00780-3 · Cited by 408

Development of a human skin commensal microbe for bacteriotherapy of atopic dermatitis and use in a phase 1 randomized clinical trial

Nakatsuji, T., Hata, T. R., Tong, Y., Cheng, J. Y., Shafiq, F., Butcher, A. M., Salem, S. S., Brinton, S. L., Rudman Spergel, A. K., Johnson, K., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01256-2 · Cited by 333

A commensal strain of Staphylococcus epidermidis protects against skin neoplasia

Nakatsuji, T., Chen, T. H., Butcher, A. M., Trzoss, L., Nam, S., Shirakawa, K. T., Zhou, W. L., Oh, J., Otto, M. J., Fenical, W., et al. (2018) · Science Advances · doi:10.1126/sciadv.aao4502 · Cited by 333

Bacterial skin commensals and their role as host guardians

Christensen, G. J. M., & Brüggemann, H. (2013) · Beneficial Microbes · doi:10.3920/bm2012.0062 · Cited by 327

Skin Barrier Function and the Microbiome

Lee, H.-J., & Kim, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113071 · Cited by 317

Staphylococcus epidermidis in the human skin microbiome mediates fermentation to inhibit the growth of Propionibacterium acnes: implications of probiotics in acne vulgaris

Wang, Y., Kuo, S., Shu, M., Yu, J., Huang, S., Dai, A., Two, A. M., Gallo, R. L., & Huang, C. (2013) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-013-5394-8 · Cited by 299

Microbiome in healthy skin, update for dermatologists

Dréno, B., Araviiskaia, E., Berardesca, E., Gontijo, G., Sanchez Viera, M., Xiang, L. F., Martin, R., & Bieber, T. (2016) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.13965 · Cited by 292

The Innate Immune System in Acute and Chronic Wounds

MacLeod, A. S., & Mansbridge, J. N. (2016) · Advances in Wound Care · doi:10.1089/wound.2014.0608 · Cited by 289

Skin microbiome: genomics-based insights into the diversity and role of skin microbes

Kong, H. H. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.01.013 · Cited by 293

The Skin Microbiota: Balancing Risk and Reward

Flowers, L. J., & Grice, E. A. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.06.017 · Cited by 302

Commensal Staphylococci Influence Staphylococcus aureus Skin Colonization and Disease

Parlet, C. P., Severn, M. M., & Horswill, A. R. (2019) · Trends in Microbiology · doi:10.1016/j.tim.2019.01.008 · Cited by 289

The Role of the Skin Microbiome in Atopic Dermatitis

Williams, M. R., & Gallo, R. L. (2015) · Current Allergy and Asthma Reports · doi:10.1007/s11882-015-0567-4 · Cited by 272

The skin microbiome: Current perspectives and future challenges

Chen, Y. E., & Tsao, H. (2013) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2013.01.016 · Cited by 275

Type 2 Inflammation Contributes to Skin Barrier Dysfunction in Atopic Dermatitis

Beck, L. A., Cork, M. J., Amagai, M., Benedetto, A. D., Kabashima, K., Hamilton, J. D., & Rossi, A. B. (2022) · JID Innovations · doi:10.1016/j.xjidi.2022.100131 · Cited by 268

Staphylococcus epidermidis Antimicrobial δ-Toxin (Phenol-Soluble Modulin-γ) Cooperates with Host Antimicrobial Peptides to Kill Group A Streptococcus

Cogen, A. L., Yamasaki, K., Muto, J., Sanchez, K. M., Crotty Alexander, L., Tanios, J., Lai, Y., Kim, J. E., Nizet, V., & Gallo, R. L. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008557 · Cited by 245

Pathogenic Mechanisms and Host Interactions in Staphylococcus epidermidis Device-Related Infection

Bresco, M. S., Harris, L. G., Thompson, K., Stanić, B., Morgenstern, M., O’Mahony, L., Richards, R. G., & Moriarty, T. F. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01401 · Cited by 256

The cutaneous innate immune response in patients with atopic dermatitis

Kuo, I., Yoshida, T., Benedetto, A. D., & Beck, L. A. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.12.1563 · Cited by 241

What lives on our skin: ecology, genomics and therapeutic opportunities of the skin microbiome

Scharschmidt, T. C., & Fischbach, M. A. (2013) · Drug Discovery Today: Disease Mechanisms · doi:10.1016/j.ddmec.2012.12.003 · Cited by 215

The Cutaneous Microbiome and Wounds: New Molecular Targets to Promote Wound Healing

Johnson, T. R., Gómez, B. I., McIntyre, M. K., Dubick, M. A., Christy, R. J., Nicholson, S. E., & Burmeister, D. M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092699 · Cited by 219

Staphylococcus epidermidis Strategies to Avoid Killing by Human Neutrophils

Cheung, G. Y. C., Rigby, K. M., Wang, R., Queck, S. Y., Braughton, K. R., Whitney, A. R., Teintze, M., DeLeo, F. R., & Otto, M. J. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001133 · Cited by 213

The role of bacterial skin infections in atopic dermatitis: expert statement and review from the International Eczema Council Skin Infection Group

Alexander, H., Paller, A. S., Traidl‐Hoffmann, C., Beck, L. A., Benedetto, A. D., Dhar, S., Girolomoni, G., Irvine, A. D., Spuls, P. I., Su, J. C., et al. (2019) · British Journal of Dermatology · doi:10.1111/bjd.18643 · Cited by 218

Protective Microbiota: From Localized to Long-Reaching Co-Immunity

Chiu, L., Bazin, T., Truchetet, M., Schaeverbeke, T., Delhaès, L., & Pradeu, T. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01678 · Cited by 208

Staphylococcal alpha-phenol soluble modulins contribute to neutrophil lysis after phagocytosis

Surewaard, B. G. J., de Haas, C. J. C., Vervoort, F., Rigby, K. M., DeLeo, F. R., Otto, M. J., van Strijp, J. A. G., & Nijland, R. (2013) · Cellular Microbiology · doi:10.1111/cmi.12130 · Cited by 207

Staphylococcus epidermidis protease EcpA can be a deleterious component of the skin microbiome in atopic dermatitis

Cau, L., Williams, M. R., Butcher, A. M., Nakatsuji, T., Kavanaugh, J. S., Cheng, J. Y., Shafiq, F., Higbee, K., Hata, T. R., Horswill, A. R., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.06.024 · Cited by 193

Essential Staphylococcus aureus toxin export system

Chatterjee, S. S., Joo, H., Duong, A. C., Dieringer, T. D., Tan, V. Y., Song, Y. J., Fischer, E. R., Cheung, G. Y. C., Li, M., & Otto, M. J. (2013) · Nature Medicine · doi:10.1038/nm.3047 · Cited by 181

The Role of Toll-Like Receptors in Skin Host Defense, Psoriasis, and Atopic Dermatitis

Sun, L., Liu, W., & Zhang, L. (2019) · Journal of Immunology Research · doi:10.1155/2019/1824624 · Cited by 187

Transplantation of human skin microbiota in models of atopic dermatitis

Myles, I. A., Williams, K. W., Reckhow, J. D., Jammeh, M. L., Pincus, N. B., Sastalla, I., Saleem, D., Stone, K. D., & Datta, S. K. (2016) · JCI Insight · doi:10.1172/jci.insight.86955 · Cited by 182

Living in Your Skin: Microbes, Molecules, and Mechanisms

Swaney, M. H., & Kalan, L. (2021) · Infection and Immunity · doi:10.1128/iai.00695-20 · Cited by 201

Phenol-soluble modulins

Otto, M. J. (2013) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2013.11.019 · Cited by 175

Impact of prebiotics and probiotics on skin health

Al‐Ghazzewi, F. H., & Tester, R. F. (2014) · Beneficial Microbes · doi:10.3920/bm2013.0040 · Cited by 183

Host-Specific Evolutionary and Transmission Dynamics Shape the Functional Diversification of Staphylococcus epidermidis in Human Skin

Zhou, W. L., Spoto, M., Hardy, R., Guan, C., Fleming, E. S., Larson, P. J., Brown, J. S., & Oh, J. (2020) · Cell · doi:10.1016/j.cell.2020.01.006 · Cited by 169

The role of the skin microbiome in atopic dermatitis

Nakatsuji, T., & Gallo, R. L. (2018) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2018.12.003 · Cited by 167

Curli-Containing Enteric Biofilms Inside and Out: Matrix Composition, Immune Recognition, and Disease Implications

Tursi, S. A., & Tükel, Ç. (2018) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00028-18 · Cited by 171

Antimicrobial Activity of Community-associated Methicillin-resistant Staphylococcus aureus Is Caused by Phenol-soluble Modulin Derivatives

Joo, H., Cheung, G. Y. C., & Otto, M. J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.221382 · Cited by 155

Impact of Staphylococcus aureus on Pathogenesis in Polymicrobial Infections

Nair, N., Biswas, R., Götz, F., & Biswas, L. (2014) · Infection and Immunity · doi:10.1128/iai.00059-14 · Cited by 154

Staphylococci: Colonizers and Pathogens of Human Skin

Coates‐Brown, R., Moran, J. C., & Horsburgh, M. J. (2013) · Future Microbiology · doi:10.2217/fmb.13.145 · Cited by 160

Potential role of microorganisms in the pathogenesis of rosacea

Holmes, A. D. (2013) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2013.08.006 · Cited by 156

Bacterial symbionts and natural products

Crawford, J. M., & Clardy, J. (2011) · Chemical Communications · doi:10.1039/c1cc11574j · Cited by 152

Staphylococcus epidermidis: A Potential New Player in the Physiopathology of Acne?

Claudel, J., Auffret, N., Leccia, M. ‐., Poli, F., Corvec, S., & Dréno, B. (2019) · Dermatology · doi:10.1159/000499858 · Cited by 162

Host–pathogen interactions between the skin and Staphylococcus aureus

Krishna, S. M., & Miller, L. S. (2011) · Current Opinion in Microbiology · doi:10.1016/j.mib.2011.11.003 · Cited by 152

A longitudinal study of the diabetic skin and wound microbiome

Gardiner, M., Vicaretti, M., Sparks, J., Bansal, S., Bush, S., Liu, M., Darling, A. E., Harry, E. J., & Burke, C. (2017) · PeerJ · doi:10.7717/peerj.3543 · Cited by 152

Changing our microbiome: probiotics in dermatology

Yu, Y., Dunaway, S., Champer, J., Kim, J., & Alikhan, A. (2019) · British Journal of Dermatology · doi:10.1111/bjd.18088 · Cited by 152

Lugdunin amplifies innate immune responses in the skin in synergy with host- and microbiota-derived factors

Bitschar, K., Sauer, B., Focken, J., Dehmer, H., Moos, S., Konnerth, M. C., Schilling, N. A., Grond, S., Kalbacher, H., Kurschus, F. C., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10646-7 · Cited by 151

Colonization and Infection of the Skin by S. aureus: Immune System Evasion and the Response to Cationic Antimicrobial Peptides

Ryu, S., Song, P. I., Seo, C., Cheong, H., & Park, Y. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15058753 · Cited by 146

Direct and synergistic hemolysis caused by Staphylococcus phenol-soluble modulins: implications for diagnosis and pathogenesis

Cheung, G. Y. C., Duong, A. C., & Otto, M. J. (2011) · Microbes and Infection · doi:10.1016/j.micinf.2011.11.013 · Cited by 135

The microbiota and autoimmunity: Their role in thyroid autoimmune diseases

Köhling, H.-L., Plummer, S. F., Marchesi, J. R., Davidge, K. S., & Ludgate, M. (2017) · Clinical Immunology · doi:10.1016/j.clim.2017.07.001 · Cited by 139

Host Response to Staphylococcus epidermidis Colonization and Infections

Nguyen, T. D., Park, M. D., & Otto, M. J. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00090 · Cited by 140

The Skin and Intestinal Microbiota and Their Specific Innate Immune Systems

Coates, M., Lee, M. J., Norton, D., & MacLeod, A. S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02950 · Cited by 144

Beyond sepsis: Staphylococcus epidermidis is an underestimated but significant contributor to neonatal morbidity

Dong, Y., Speer, C. P., & Glaser, K. (2018) · Virulence · doi:10.1080/21505594.2017.1419117 · Cited by 128

Oral and Topical Probiotics and Postbiotics in Skincare and Dermatological Therapy: A Concise Review

Almeida, C. V. D., Antiga, E., & Lulli, M. (2023) · Microorganisms · doi:10.3390/microorganisms11061420 · Cited by 141

Innate antimicrobial immunity in the skin: A protective barrier against bacteria, viruses, and fungi

Coates, M., Blanchard, S., & MacLeod, A. S. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1007353 · Cited by 134

Skin barrier in atopic dermatitis: beyond filaggrin

Zaniboni, M. C., ­Samorano, L. P., Orfali, R. L., & Aoki, V. (2016) · Anais Brasileiros de Dermatologia · doi:10.1590/abd1806-4841.20164412 · Cited by 123

Psoriasis and Antimicrobial Peptides

Takahashi, T., & Yamasaki, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186791 · Cited by 128

Inactivation of staphylococcal phenol soluble modulins by serum lipoprotein particles

Surewaard, B. G. J., Nijland, R., Spaan, A. N., Kruijtzer, J. A. W., de Haas, C. J. C., & van Strijp, J. A. G. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002606 · Cited by 117

Staphylococcus epidermidis and Other Coagulase-Negative Staphylococci

Rupp, M. E., & Fey, P. D. (2015) · Elsevier eBooks · doi:10.1016/b978-1-4557-4801-3.00197-1 · Cited by 118

The role of topical probiotics on wound healing: A review of animal and human studies

Knackstedt, R. W., Knackstedt, T., & Gatherwright, J. R. (2020) · International Wound Journal · doi:10.1111/iwj.13451 · Cited by 125

The Human Microbiota and Skin Cancer

Woo, Y. R., Cho, S. H., Lee, J. D., & Kim, H. S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031813 · Cited by 115

Quantitation and Composition of Cutaneous Microbiota in Diabetic and Nondiabetic Men

Redel, H., Gao, Z., Li, H., Alekseyenko, A. V., Zhou, Y., Perez-Perez, G. I., Weinstock, G. M., Sodergren, E. J., & Blaser, M. J. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit005 · Cited by 117

Cutaneous Leishmaniasis Induces a Transmissible Dysbiotic Skin Microbiota that Promotes Skin Inflammation

Gimblet, C., Meisel, J. S., Loesche, M. A., Cole, S. D., Horwinski, J., Novais, F. O., Misic, A. M., Bradley, C. W., Beiting, D. P., Rankin, S. C., et al. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.06.006 · Cited by 114

Neutrophil responses to staphylococcal pathogens and commensals via the formyl peptide receptor 2 relates to phenol‐soluble modulin release and virulence

Rautenberg, M., Joo, H., Otto, M. J., & Peschel, A. (2010) · The FASEB Journal · doi:10.1096/fj.10-175208 · Cited by 116

Skin microbiome transplantation and manipulation: Current state of the art

Callewaert, C., Knödlseder, N., Karoglan, A., Güell, M., & Paetzold, B. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.01.001 · Cited by 116

Research Techniques Made Simple: Bacterial 16S Ribosomal RNA Gene Sequencing in Cutaneous Research

Jo, J., Kennedy, E. A., & Kong, H. H. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.01.005 · Cited by 121

Butyric Acid from Probiotic Staphylococcus epidermidis in the Skin Microbiome Down-Regulates the Ultraviolet-Induced Pro-Inflammatory IL-6 Cytokine via Short-Chain Fatty Acid Receptor

Keshari, S., Balasubramaniam, A., Myagmardoloonjin, B., Herr, D. R., Negari, I. P., & Huang, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184477 · Cited by 111

Staphylococcal LTA-Induced miR-143 Inhibits Propionibacterium acnes-Mediated Inflammatory Response in Skin

Xia, X., Li, Z., Liu, K., Wu, Y., Jiang, D., & Lai, Y. (2015) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2015.12.024 · Cited by 110

The skin surface as antimicrobial barrier: present concepts and future outlooks

Harder, J., Schröder, J., & Gläser, R. (2012) · Experimental Dermatology · doi:10.1111/exd.12046 · Cited by 112

An Update on Clinical Burden, Diagnostic Tools, and Therapeutic Options of Staphylococcus aureus

Reddy, P. N., Srirama, K., & Dirisala, V. R. (2017) · Infectious Diseases Research and Treatment · doi:10.1177/1179916117703999 · Cited by 121

A Novel Lipopeptide from Skin Commensal Activates TLR2/CD36-p38 MAPK Signaling to Increase Antibacterial Defense against Bacterial Infection

Li, D., Lei, H., Li, Z., Li, H., Wang, Y., & Lai, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058288 · Cited by 109

Host- and microbe determinants that may influence the success of S. aureus colonization

Johannessen, M., Sollid, J. E., & Hanssen, A.-M. (2012) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2012.00056 · Cited by 100

Normal Skin Microbiota is Altered in Pre-clinical Hidradenitis Suppurativa

Ring, H. C., Bay, L., Kallenbach, K., Miller, I. M., Prens, E. P., Saunte, D. M. L., Bjarnsholt, T., & Jemec, G. B. E. (2016) · Acta Dermato Venereologica · doi:10.2340/00015555-2503 · Cited by 103

Staphylococcus aureus and the Cutaneous Microbiota Biofilms in the Pathogenesis of Atopic Dermatitis

Domenico, E. G. D., Cavallo, I., Capitanio, B., Ascenzioni, F., Pimpinelli, F., Morrone, A., & Ensoli, F. (2019) · Microorganisms · doi:10.3390/microorganisms7090301 · Cited by 101

Pilot study on novel skin care method by augmentation with Staphylococcus epidermidis, an autologous skin microbe – A blinded randomized clinical trial

Nodake, Y., Matsumoto, S., Miura, R., Honda, H., Ishibashi, G., Matsumoto, S., Dekio, I., & Sakakibara, R. (2015) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2015.05.001 · Cited by 95

Iron Metabolism at the Interface between Host and Pathogen: From Nutritional Immunity to Antibacterial Development

Marchetti, M., Bei, O. D., Bettati, S., Campanini, B., Kovachka, S., Gianquinto, E., Spyrakis, F., & Ronda, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21062145 · Cited by 93

Commensal Bacteria Lipoteichoic Acid Increases Skin Mast Cell Antimicrobial Activity against Vaccinia Viruses

Wang, Z., MacLeod, D. T., & Nardo, A. D. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200471 · Cited by 95

The role of Staphylococcus epidermidis in neonatal sepsis: Guarding angel or pathogenic devil?

Dong, Y., & Speer, C. P. (2014) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2014.04.013 · Cited by 91

Defining motility in the Staphylococci

Pollitt, E. J. G., & Diggle, S. P. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2507-z · Cited by 91

Comparison of Staphylococcus epidermidis isolated from prosthetic joint infections and commensal isolates in regard to antibiotic susceptibility, agr type, biofilm production, and epidemiology

Hellmark, B., Söderquist, B., Unemo, M., & Nilsdotter‐Augustinsson, Å. (2012) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2012.11.001 · Cited by 87

The Environmental Exposures and Inner- and Intercity Traffic Flows of the Metro System May Contribute to the Skin Microbiome and Resistome

Kang, K., Ni, Y., Li, J., Imamovic, L., Sarkar, C., Kobler, M. D., Heshiki, Y., Zheng, T., Kumari, S., Wong, J. C. Y., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.06.109 · Cited by 89

The role of staphylococcus epidermidis in cutaneous defense

Cogen, A. L. (2009) · eScholarship (California Digital Library)

Staphylococcus epidermidis Antimicrobial δ-Toxin (Phenol-Soluble Modulin-γ) Cooperates with Host Antimicrobial Peptides to Kill Group A Streptococcus

Cogen, A. L., Yamasaki, K., Muto, J., Sanchez, K. M., Crotty Alexander, L., Tanios, J., Lai, Y., Kim, J. E., Nizet, V., & Gallo, R. L. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008557 · Cited by 245

Staphylococcus epidermidis Antimicrobial d-Toxin (Phenol-Soluble Modulin-c) Cooperates with Host Antimicrobial Peptides to Kill Group A Streptococcus

Cogen, A. L., Yamasaki, K., Muto, J., Sanchez, K. M., Alex, L. C., Tanios, J., Lai, Y., Kim, J. E., Nizet, V., Gallo, R. L., et al. (2013)

Staphylococcus epidermidis activates keratinocyte cytokine expression and promotes skin inflammation through the production of phenol-soluble modulins

Williams, M. R., Bagood, M. D., Enroth, T. J., Bunch, Z. L., Jiang, N., Liu, E., Almoughrabie, S., Khalil, S., Li, F., Brinton, S. L., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113024 · Cited by 48

Activation of TLR2 by a Small Molecule Produced by Staphylococcus epidermidis Increases Antimicrobial Defense against Bacterial Skin Infections

Lai, Y., Cogen, A. L., Radek, K. A., Park, H. J., MacLeod, D. T., Leichtle, A., Ryan, A. F., Di Nardo, A., & Gallo, R. L. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.123 · Cited by 446