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Microbiome and Human Aging: Probiotic and Prebiotic Potentials in Longevity, Skin Health and Cellular Senescence

Boyajian, Jacqueline Lena, Ghebretatios, Merry, Schaly, Sabrina, Islam, Paromita, Prakash, Satya·2021·Nutrients
DOI 10.3390/nu13124550PMC PMC8705837
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Abstract

The role of the microbiome in human aging is important: the microbiome directly impacts aging through the gastrointestinal system. However, the microbial impact on skin has yet to be fully understood. For example, cellular senescence is an intrinsic aging process that has been recently associated with microbial imbalance. With age, cells become senescent in response to stress wherein they undergo irreversible growth arrest while maintaining high metabolic activity. An accumulation of senescent cells has been linked to various aging and chronic pathologies due to an overexpression of the senescence-associated secretory phenotype (SASP) comprised of proinflammatory cytokines, chemokines, growth factors, proteases, lipids and extracellular matrix components. In particular, dermatological disorders may be promoted by senescence as the skin is a common site of accumulation. The gut microbiota influences cellular senescence and skin disruption through the gut-skin axis and secretion of microbial metabolites. Metabolomics can be used to identify and quantify metabolites involved in senescence. Moreover, novel anti-senescent therapeutics are warranted given the poor safety profiles of current pharmaceutical drugs. Probiotics and prebiotics may be effective alternatives, considering the relationship between the microbiome and healthy aging. However, further research on gut composition under a senescent status is needed to develop immunomodulatory therapies.

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Metadata

Authors
Boyajian, J. L., Ghebretatios, M., Schaly, S., Islam, P., & Prakash, S.
Venue
Nutrients
Publisher
MDPI AG
Published
2021-12-18
Volume
13
Issue
12
Pages
4550
ISSN
2072-6643
DOI
10.3390/nu13124550
PMC
PMC8705837
Cited by
115
References
30
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
Natural Sciences and Engineering Research Council (RGPIN/06596-2019)

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