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Cited by 286

The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.

Genome-wide association scan for five major dimensions of personality

Open access
Terracciano, A, Sanna, S, Uda, M, Deiana, B, Usala, G, Busonero, F, Maschio, A, Scally, M, Patriciu, N, Chen, W-M, Distel, M A, Slagboom, E P, Boomsma, D I, Villafuerte, S, Śliwerska, E, Burmeister, M, Amin, N, Janssens, A C J W, van Duijn, C M, Schlessinger, D, Abecasis, G R, Costa, P T·2010·Molecular Psychiatry
DOI 10.1038/mp.2008.113
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Abstract

Personality traits are summarized by five broad dimensions with pervasive influences on major life outcomes, strong links to psychiatric disorders and clear heritable components. To identify genetic variants associated with each of the five dimensions of personality we performed a genome-wide association (GWA) scan of 3972 individuals from a genetically isolated population within Sardinia, Italy. On the basis of the analyses of 362 129 single-nucleotide polymorphisms we found several strong signals within or near genes previously implicated in psychiatric disorders. They include the association of neuroticism with SNAP25 (rs362584, P=5 × 10−5), extraversion with BDNF and two cadherin genes (CDH13 and CDH23; Ps<5 × 10−5), openness with CNTNAP2 (rs10251794, P=3 × 10−5), agreeableness with CLOCK (rs6832769, P=9 × 10−6) and conscientiousness with DYRK1A (rs2835731, P=3 × 10−5). Effect sizes were small (less than 1% of variance), and most failed to replicate in the follow-up independent samples (N up to 3903), though the association between agreeableness and CLOCK was supported in two of three replication samples (overall P=2 × 10−5). We infer that a large number of loci may influence personality traits and disorders, requiring larger sample sizes for the GWA approach to confidently identify associated genetic variants.

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Metadata

Authors
Terracciano, A., Sanna, S., Uda, M., Deiana, B., Usala, G., Busonero, F., Maschio, A., Scally, M., Patriciu, N., Chen, W.-M., Distel, M. A., Slagboom, E. P., Boomsma, D. I., Villafuerte, S., Śliwerska, E., Burmeister, M., Amin, N., Janssens, A. C. J. W., van Duijn, C. M., Schlessinger, D., Abecasis, G. R., & Costa, P. T.
Venue
Molecular Psychiatry
Publisher
Springer Science and Business Media LLC
Published
2008-10-28
Volume
15
Issue
6
Pages
647-656
ISSN
  • 1359-4184 (ISSN-L)
  • 1476-5578
DOI
10.1038/mp.2008.113
OpenAlex
W2104766386
Cited by
286
References
99
FWCI
11.25
Type
journal article
Language
en
Open access
green

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