Depression, daily stressors and inflammatory responses to high-fat meals: when stress overrides healthier food choices
Open accessAbstract
Depression, stress and diet can all alter inflammation. This double-blind, randomized crossover study addressed the impact of daily stressors and a history of major depressive disorder (MDD) on inflammatory responses to high-fat meals. During two separate 9.5 h admissions, 58 healthy women (38 breast cancer survivors and 20 demographically similar controls), mean age 53.1 years, received either a high saturated fat meal or a high oleic sunflower oil meal. The Daily Inventory of Stressful Events assessed prior day stressors and the Structured Clinical Interview for DSM-IV evaluated MDD. As expected, for a woman with no prior day stressors, C-reactive protein (CRP), serum amyloid A (SAA), intercellular adhesion molecule-1 (sICAM-1) and vascular cell adhesion molecule-1 (sVCAM-1) were higher following the saturated fat meal than the high oleic sunflower oil meal after controlling for pre-meal measures, age, trunk fat and physical activity. But if a woman had prior day stressors, these meal-related differences disappeared-because the stressors heightened CRP, SAA, sICAM-1 and sVCAM-1 responses to the sunflower oil meal, making it look more like the responses to the saturated fat meal. In addition, women with an MDD history had higher post-meal blood pressure responses than those without a similar history. These data show how recent stressors and an MDD history can reverberate through metabolic alterations, promoting inflammatory and atherogenic responses.
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Stressors experienced the previous day, or a personal history of major depressive disorders, may cancel out the beneficial effects of healthy food choices on inflammation and mood.
“For example, recent clinical research has observed that stressors experienced the previous day, or a personal history of major depressive disorders, may cancel out the beneficial effects of healthy food choices on inflammation and mood.22”
From Food and mood: How do diet and nutrition affect mental wellbeing? (2020) · cites this paper as [22]
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Food and mood: How do diet and nutrition affect mental wellbeing?
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- Authors
- Kiecolt-Glaser, J. K., Fagundes, C. P., Andridge, R., Peng, J., Malarkey, W. B., Habash, D., & Belury, M. A.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- The Ohio State University (US)
- The Ohio State University Wexner Medical Center (US)
- Venue
- Molecular Psychiatry
- Published
- 2016-09-20
- Volume
- 22
- Issue
- 3
- Pages
- 476-482
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- PMC
- PMC5508550
- OpenAlex
- W2523234092
- Cited by
- 54
- References
- 69
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 6 · 2023: 3 · 2022: 7 · 2021: 3 · 2020: 11 · 2019: 2 · 2018: 7 · 2017: 4 · 2015: 1
- FWCI
- 1.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Jiangsu National Synergistic Innovation Center for Advanced Materials
- National Institutes of Health
- National Cancer Institute (K05CA172296, R21CA154054, R21CA158868, P30CA016058)
- National Center for Research Resources (UL1RR025755)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- depression, major depressive disorder, daily hassles, inflammation, high-fat meal, saturated fat, oleic acid, sunflower oil, C-reactive protein, serum amyloid A, ICAM-1, VCAM-1, postprandial blood pressure, breast cancer survivors, women, food choice
- MeSH terms
- Serum Amyloid A Protein, C-Reactive Protein, Depression, Major Depressive Disorder, Diet, Dietary Fats, Double-Blind Method, Female, Food Preferences, Humans, Inflammation, Middle Aged, Stress, Psychological, Triglycerides, Cross-Over Studies, Intercellular Adhesion Molecule-1, Vascular Cell Adhesion Molecule-1, Postprandial Period, Diet, High-Fat
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