Cited by 3,949MicroRNA in disease regulationRNA Interference and Gene DeliveryPlant Molecular Biology Research

The DOI matches its Crossref record; 25 of the 27 references it cites were found in a registry or an index.

Silencing of microRNAs in vivo with ‘antagomirs’

Krützfeldt, Jan, Rajewsky, Nikolaus, Braich, Ravi, Rajeev, Kallanthottathil G., Tuschl, Thomas, Manoharan, Muthiah, Stoffel, Markus·2005·Nature

DOI 10.1038/nature04303

Open this paper in CoChat — free account

Abstract

MicroRNAs (miRNAs) are an abundant class of non-coding RNAs that are believed to be important in many biological processes through regulation of gene expression. The precise molecular function of miRNAs in mammals is largely unknown and a better understanding will require loss-of-function studies in vivo. Here we show that a novel class of chemically engineered oligonucleotides, termed 'antagomirs', are efficient and specific silencers of endogenous miRNAs in mice. Intravenous administration of antagomirs against miR-16, miR-122, miR-192 and miR-194 resulted in a marked reduction of corresponding miRNA levels in liver, lung, kidney, heart, intestine, fat, skin, bone marrow, muscle, ovaries and adrenals. The silencing of endogenous miRNAs by this novel method is specific, efficient and long-lasting. The biological significance of silencing miRNAs with the use of antagomirs was studied for miR-122, an abundant liver-specific miRNA. Gene expression and bioinformatic analysis of messenger RNA from antagomir-treated animals revealed that the 3' untranslated regions of upregulated genes are strongly enriched in miR-122 recognition motifs, whereas downregulated genes are depleted in these motifs. Analysis of the functional annotation of downregulated genes specifically predicted that cholesterol biosynthesis genes would be affected by miR-122, and plasma cholesterol measurements showed reduced levels in antagomir-122-treated mice. Our findings show that antagomirs are powerful tools to silence specific miRNAs in vivo and may represent a therapeutic strategy for silencing miRNAs in disease.

Integrity signals

Registry

Crossref · 10.1038/nature04303

Cites

25 of 25 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Untitled work
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets
Lewis, B. P., Burge, C. B., & Bartel, D. P. (2005) · Cell · doi:10.1016/j.cell.2004.12.035 · Cited by 11,855
The functions of animal microRNAs
Ambros, V. (2004) · Nature · doi:10.1038/nature02871 · Cited by 10,728
MicroRNA expression profiles classify human cancers
Lü, J., Getz, G. A., Miska, E. A., Alvarez-Saavedra, E., Lamb, J., Peck, D., Sweet-Cordero, A., Ebert, B. L., Mak, R. H., Ferrando, A. A., et al. (2005) · Nature · doi:10.1038/nature03702 · Cited by 9,637
MicroRNAs: small RNAs with a big role in gene regulation
He, L., & Hannon, G. J. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1379 · Cited by 7,118
Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
Lim, L. P., Lau, N. C., Garrett-Engele, P., Grimson, A., Schelter, J. M., Castle, J., Bartel, D. P., Linsley, P. S., & Johnson, J. M. (2005) · Nature · doi:10.1038/nature03315 · Cited by 4,755
Combinatorial microRNA target predictions
Krek, A., Grün, D., Poy, M. N., Wolf, R., Rosenberg, L., Epstein, E. J., MacMenamin, P., da Piedade, I., Gunsalus, K. C., Stoffel, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1536 · Cited by 4,603
Self-citation
NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins
Pruitt, K. D., Tatusova, T. A., & Maglott, D. R. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl842 · Cited by 4,441
Human MicroRNA Targets
John, B., Enright, A. J., Aravin, A., Tuschl, T., Sander, C., & Marks, D. S. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020363 · Cited by 3,796
Self-citation
A microRNA polycistron as a potential human oncogene
He, L., Thomson, J. M., Hemann, M. T., Hernando, E., Mu, D., Goodson, S. G., Powers, S., Cordon‐Cardo, C., Lowe, S. W., Hannon, G. J., et al. (2005) · Nature · doi:10.1038/nature03552 · Cited by 3,642

Show all 27 references

Sorted by citations

Items 601–700 of 1,017

MicroRNAs
Fabbri, M., Croce, C. M., & Calin, G. A. (2008) · The Cancer Journal · doi:10.1097/ppo.0b013e318164145e · Cited by 181
miR-204 targets Bcl-2 expression and enhances responsiveness of gastric cancer
Sacconi, A., Biagioni, F., Canu, V., Mori, F., Benedetto, A. D., Lorenzon, L., Ercolani, C., Agostino, S. D., Cambria, A., Germoni, S., et al. (2012) · Cell Death and Disease · doi:10.1038/cddis.2012.160 · Cited by 180
Down-regulated miR-9 and miR-433 in human gastric carcinoma
Luo, H., Zhang, H., Zhang, Z., Zhang, X., Ning, B., Guo, J., Nie, N., Liu, B., & Wu, X. (2009) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-28-82 · Cited by 180
MicroRNA regulation in angiogenesis
Caporali, A., & Emanueli, C. (2011) · Vascular Pharmacology · doi:10.1016/j.vph.2011.06.006 · Cited by 182
The MUC1 and Galectin-3 Oncoproteins Function in a MicroRNA-Dependent Regulatory Loop
Ramasamy, S., Duraisamy, S., Barbashov, S. F., Kawano, T., Kharbanda, S. M., & Kufe, D. W. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.07.031 · Cited by 181
3′ UTR shortening represses tumor-suppressor genes in trans by disrupting ceRNA crosstalk
Park, H. J., Ji, P., Kim, S., Xia, Z., Rodriguez, B. A. T., Li, L., Su, J., Chen, K., Masamha, C. P., Baillat, D., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0118-8 · Cited by 178
Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis
Chen, Z. B., Lai, T., Jan, Y., Lin, F., Wang, W.-C., Xiao, H., Wang, Y., Sun, W., Cui, X., Li, Y.-S., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci65344 · Cited by 180
Oxidative Stress-Responsive MicroRNAs in Heart Injury
Kura, B., Bačová, B. S., Kaločayová, B., Sýkora, M., & Slezák, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21010358 · Cited by 184
Role of miR-10b in breast cancer metastasis
Ma, L. (2010) · Breast Cancer Research · doi:10.1186/bcr2720 · Cited by 182
Merkel cell polyomavirus encodes a microRNA with the ability to autoregulate viral gene expression
Seo, G. J., Chen, C., & Sullivan, C. S. (2008) · Virology · doi:10.1016/j.virol.2008.11.001 · Cited by 178
miR-143 and miR-145 synergistically regulate ERBB3 to suppress cell proliferation and invasion in breast cancer
Yan, X., Chen, X., Liang, H., Deng, T., Chen, W., Zhang, S., Liu, M., Gao, X., Liu, Y., Zhao, C., et al. (2014) · Molecular Cancer · doi:10.1186/1476-4598-13-220 · Cited by 180
Defective erythroid differentiation in miR-451 mutant mice mediated by 14-3-3ζPreprint
Patrick, D. M., Zhang, C. C., Tao, Y., Yao, H., Qi, X., Schwartz, R. J., Huang, L. J.-S., & Olson, E. N. (2010) · Genes & Development · doi:10.1101/gad.1942810 · Cited by 178
Systematic identification of mRNAs recruited to argonaute 2 by specific microRNAs and corresponding changes in transcript abundance
Hendrickson, D. G., Hogan, D. J., Herschlag, D., Ferrell, J. E., & Brown, P. O. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002126 · Cited by 178
MicroRNAs in diabetic nephropathy: functions, biomarkers, and therapeutic targets
Kato, M. V., & Natarajan, R. D. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12758 · Cited by 182
Therapeutic MicroRNA Strategies in Human Cancer
Li, C., Feng, Y., Coukos, G., & Zhang, L. (2009) · The AAPS Journal · doi:10.1208/s12248-009-9145-9 · Cited by 179
Down-regulation of miR-1/miR-133 Contributes to Re-expression of Pacemaker Channel Genes HCN2 and HCN4 in Hypertrophic Heart*
Luo, X., Lin, H., Pan, Z., Xiao, J., Zhang, Y., Lu, Y., Yang, B., & Wang, Z. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801035200 · Cited by 177
Retracted
The Role of Hypoxia-Induced miR-210 in Cancer Progression
Dang, K., & Myers, K. A. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16036353 · Cited by 181
A Resource for the Conditional Ablation of microRNAs in the Mouse
Park, C. Y., Jeker, L. T., Carver-Moore, K., Oh, A., Liu, H. J., Cameron, R., Richards, H. W., Li, Z., Adler, D., Yoshinaga, Y., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.02.008 · Cited by 177
The Tuberculosis Drug Streptomycin as a Potential Cancer Therapeutic: Inhibition of miR‐21 Function by Directly Targeting Its Precursor
Bose, D., Jayaraj, G. G., Suryawanshi, H., Agarwala, P., Pore, S. K., Banerjee‬‬‬‬‬‬‬‬‬, R., & Maiti, S. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201106455 · Cited by 180
miR-19a promotes colorectal cancer proliferation and migration by targeting TIA1
Liu, Y., Liu, R., Yang, F., Cheng, R., Chen, X., Cui, S., Gu, Y., Sun, W., You, C., 刘志坚, et al. (2017) · Molecular Cancer · doi:10.1186/s12943-017-0625-8 · Cited by 178
Deregulation of miR‐92a expression is implicated in hepatocellular carcinoma development
Shigoka, M., Tsuchida, A., Matsudo, T., Nagakawa, Y., Saitô, H., Suzuki, Y., Aoki, T., Murakami, Y., Toyoda, H., Kumada, T., et al. (2010) · Pathology International · doi:10.1111/j.1440-1827.2010.02526.x · Cited by 175
Cell penetrating peptide conjugates of steric block oligonucleotides
Lebleu, B., Moulton, H. M., Abes, R., Ivanova, G. D., Abes, S., Stein, D. A., Iversen, P. L., Arzumanov, A. A., & Gait, M. J. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.09.002 · Cited by 183
Chromosomal rearrangements and microRNAs: a new cancer link with clinical implications
Calin, G. A., & Croce, C. M. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32577 · Cited by 175
The Role of microRNAs in Inflammation
Das, K., & Rao, L. V. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415479 · Cited by 181
The biogenesis and regulation of animal microRNAs
Kim, H., Lee, Y.-Y., & Kim, V. N. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00805-0 · Cited by 201
microRNA: Emerging therapeutic targets in acute ischemic diseases
Fasanaro, P., Greco, S., Ivan, M., Capogrossi, M. C., & Martelli, F. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.10.003 · Cited by 175
MicroRNAs in adipose tissue: their role in adipogenesis and obesity
Hilton, C., Neville, M. J., & Karpe, F. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.59 · Cited by 177
microRNA miR-275 is indispensable for blood digestion and egg development in the mosquito Aedes aegypti
Bryant, B., Macdonald, W., & Raikhel, A. S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016230107 · Cited by 179
Targeting MicroRNAs in Cancer Gene Therapy
Ji, W., Sun, B., & Su, C. (2017) · Genes · doi:10.3390/genes8010021 · Cited by 181
MicroRNAs Impair MET-Mediated Invasive Growth
Migliore, C., Petrelli, A., Ghiso, E., Corso, S., Capparuccia, L., Eramo, A., Comoglio, P. M., & Giordano, S. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2148 · Cited by 178
Chitosan for Gene Delivery and Orthopedic Tissue Engineering Applications
Raftery, R. M., O’Brien, F. J., & Cryan, S. (2013) · Molecules · doi:10.3390/molecules18055611 · Cited by 180
MicroRNAs – micro in size but macro in function
Singh, S. K., Bhadra, M. P., Girschick, H. J., & Bhadra, U. (2008) · FEBS Journal · doi:10.1111/j.1742-4658.2008.06624.x · Cited by 179
microRNA-103a Functions as a Mechanosensitive microRNA to Inhibit Bone Formation Through Targeting Runx2
Zuo, B., Zhu, J., Li, J., Wang, C., Zhao, X., Cai, G., Li, Z., Peng, J., Wang, P., Shen, C., et al. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2352 · Cited by 175
MicroRNA: an Emerging Therapeutic Target and Intervention Tool
Liu, Z., Sall, A., & Yang, D. (2008) · International Journal of Molecular Sciences · doi:10.3390/ijms9060978 · Cited by 175
Liver microRNA-21 is overexpressed in non-alcoholic steatohepatitis and contributes to the disease in experimental models by inhibiting PPARα expression
Loyer, X., Paradis, V., Hénique, C., Vion, A.-C., Colnot, N., Guérin, C. L., Devue, C., On, S., Scetbun, J., Romain, M., et al. (2015) · Gut · doi:10.1136/gutjnl-2014-308883 · Cited by 174
Hepatic and serum levels of miR-122 after chronic HCV-induced fibrosis
Trebicka, J., Anadol, E., Elfimova, N., Strack, I., Roggendorf, M., Viazov, S. O., Wedemeyer, I., Drebber, U., Rockstroh, J. K., Sauerbruch, T., et al. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.10.015 · Cited by 174
miR-23a regulation of X-linked inhibitor of apoptosis (XIAP) contributes to sex differences in the response to cerebral ischemia
Siegel, C. S., Li, J., Liu, F., Benashski, S. E., & McCullough, L. D. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102635108 · Cited by 175
Nucleoside, nucleotide and oligonucleotide based amphiphiles: a successful marriage of nucleic acids with lipids
Gissot, A., Camplo, M., Grinstaff, M. W., & Barthélémy, P. (2008) · Organic & Biomolecular Chemistry · doi:10.1039/b719280k · Cited by 171
Non-coding RNAs: the new central dogma of cancer biology
Saw, P. E., Xu, X., Chen, J., & Song, E. (2020) · Science China Life Sciences · doi:10.1007/s11427-020-1700-9 · Cited by 180
Biogenesis and mechanisms of microRNA‐mediated gene regulation
Rani, V., & Sengar, R. S. (2022) · Biotechnology and Bioengineering · doi:10.1002/bit.28029 · Cited by 172
Systems biology-based investigation of cooperating microRNAs as monotherapy or adjuvant therapy in cancer
Lai, X., Eberhardt, M., Schmitz, U., & Vera, J. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz638 · Cited by 170
MicroRNAs in non-alcoholic fatty liver disease: Progress and perspectives
Hochreuter, M. Y., Dall, M., Treebak, J. T., & Barrès, R. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101581 · Cited by 180
Microvesicles/exosomes as potential novel biomarkers of metabolic diseases
ller, G. M. A. U. (2012) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s32923 · Cited by 178
Liver tumorigenicity promoted by microRNA-221 in a mouse transgenic model
Callegari, E., Elamin, B. K., Giannone, F. A., Milazzo, M., Altavilla, G., Fornari, F., Giacomelli, L., D’Abundo, L., Ferracin, M., Bassi, C., et al. (2012) · Hepatology · doi:10.1002/hep.25747 · Cited by 170
Stress-induced Reversal of MicroRNA Repression and mRNA P-body Localization in Human CellsPreprint
Bhattacharyya, S. N., Habermacher, R., Martiné, U., Closs, E. I., & Filipowicz, W. (2006) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2006.71.038 · Cited by 178
MiR-122 Inhibits Cell Proliferation and Tumorigenesis of Breast Cancer by Targeting IGF1R
Wang, B., Wang, H., & Yang, Z. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047053 · Cited by 169
Epigenetic aberrations during oncogenesis
Hatziapostolou, M., & Iliopoulos, D. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0624-z · Cited by 173
High‐throughput screens identify microRNAs essential for HER2 positive breast cancer cell growth
Leivonen, S., Sahlberg, K. K., Mäkelä, R., Due, E. U., Kallioniemi, O., Børresen‐Dale, A., & Perälä, M. (2013) · Molecular Oncology · doi:10.1016/j.molonc.2013.10.001 · Cited by 169
Trends in microRNA detection
Cissell, K. A., & Deo, S. K. (2009) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-009-2744-6 · Cited by 174
MicroRNAs and cancer
Cowland, J. B., Hother, C. E., & Grønbæk, K. (2007) · Apmis · doi:10.1111/j.1600-0463.2007.apm_775.xml.x · Cited by 171
Good guy or bad guy: the opposing roles of microRNA 125b in cancer
Banzhaf‐Strathmann, J., & Edbauer, D. (2014) · Cell Communication and Signaling · doi:10.1186/1478-811x-12-30 · Cited by 172
MicroRNA expression dynamics during murine and human erythroid differentiation
Zhan, M., Miller, C. P., Papayannopoulou, T., Stamatoyannopoulos, G., & Song, C.-Z. (2007) · Experimental Hematology · doi:10.1016/j.exphem.2007.03.014 · Cited by 172
Circulating microRNAs as Biomarkers, Therapeutic Targets, and Signaling Molecules
Ajit, S. K. (2012) · Sensors · doi:10.3390/s120303359 · Cited by 168
RNAi-based nanomedicines for targeted personalized therapy
Daka, A., & Peer, D. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.08.014 · Cited by 169
MicroRNAs as regulators of brain function and targets for treatment of epilepsy
Brennan, G. P., & Henshall, D. C. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-020-0369-8 · Cited by 169
RNA Interference and Cancer Therapy
Wang, Z., Rao, D. D., Senzer, N. N., & Nemunaitis, J. J. (2011) · Pharmaceutical Research · doi:10.1007/s11095-011-0604-5 · Cited by 171
Isolation of microRNA targets using biotinylated synthetic microRNAs.
Ørom, U. A., & Lund, A. (2007) · Methods · doi:10.1016/j.ymeth.2007.04.007 · Cited by 186
MicroRNA-regulated, Systemically Delivered rAAV9: A Step Closer to CNS-restricted Transgene Expression
Xie, J., Xie, Q., Zhang, H., Ameres, S. L., Hung, J., Su, Q., He, R., Mu, X. N., Ahmed, S. S., Park, S., et al. (2010) · Molecular Therapy · doi:10.1038/mt.2010.279 · Cited by 169
miRNA cargo within exosome‐like vesicle transfer influences metastatic bone colonization
Valencia, K., Luis-Ravelo, D., Bovy, N., Antón, I., Martínez-Canarias, S., Zandueta, C., Ormazabal, C., Struman, I., Tabruyn, S. P., Rebmann, V., et al. (2014) · Molecular Oncology · doi:10.1016/j.molonc.2014.01.012 · Cited by 168
Reciprocal Effects of Micro-RNA-122 on Expression of Heme Oxygenase-1 and Hepatitis C Virus Genes in Human Hepatocytes
Shan, Y., Zheng, J., Lambrecht, R. W., & Bonkovsky, H. L. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.08.002 · Cited by 162
Recent advances in pharmacotherapy for hypertriglyceridemia
Sahebkar, A., Chew, G. T., & Watts, G. F. (2014) · Progress in Lipid Research · doi:10.1016/j.plipres.2014.07.002 · Cited by 166
Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance
Bhat, A. A., Younes, S. N., Raza, S. S., Zarif, L., Nisar, S., Ahmed, I., Mir, R., Kumar, S., Sharawat, S. K., Hashem, S., et al. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01175-9 · Cited by 172
Regulatory mechanisms of microRNAs involvement in cancer
Fabbri, M., Ivan, M., Cimmino, A., Negrini, M., & Calin, G. A. (2007) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.7.7.1009 · Cited by 167
microRNAs in heart disease: putative novel therapeutic targets?
Condorelli, G., Latronico, M. V. G., & Dorn, G. W. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehp573 · Cited by 162
MicroRNAs in liver cancer: a model for investigating pathogenesis and novel therapeutic approaches
Callegari, E., Gramantieri, L., Domenicali, M., D’Abundo, L., Sabbioni, S., & Negrini, M. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.136 · Cited by 167
Antisense oligonucleotides: treating neurodegeneration at the level of RNA
DeVos, S. L., & Miller, T. M. (2013) · Neurotherapeutics · doi:10.1007/s13311-013-0194-5 · Cited by 164
Regulation of ABCG2 Expression at the 3′ Untranslated Region of Its mRNA through Modulation of Transcript Stability and Protein Translation by a Putative MicroRNA in the S1 Colon Cancer Cell Line
To, K. K. W., Zhan, Z., Litman, T., & Bates, S. E. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00331-08 · Cited by 165
MicroRNA degradation and turnover: regulating the regulators
Zhang, Z., Yong-wen, Q. I. N., Brewer, G., & Jing, Q. (2012) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1114 · Cited by 169
Gfi1 regulates miR-21 and miR-196b to control myelopoiesis
Velu, C. S., Baktula, A. M., & Grimes, H. L. (2009) · Blood · doi:10.1182/blood-2008-11-190215 · Cited by 136
Zebrafish miR-1 and miR-133 shape muscle gene expression and regulate sarcomeric actin organizationPreprint
Mishima, Y., Abreu‐Goodger, C., Staton, A. A., Stahlhut, C. E., Shou, C., Cheng, C., Gerstein, M., Enright, A. J., & Giráldez, A. J. (2009) · Genes & Development · doi:10.1101/gad.1760209 · Cited by 165
MicroRNAs , transforming growth factor beta‐1, and tissue fibrosis
Bowen, T., Jenkins, R. L., & Fraser, D. J. (2012) · The Journal of Pathology · doi:10.1002/path.4119 · Cited by 166
MicroRNA Regulation of Cancer Stem Cells and Therapeutic Implications
DeSano, J. T., & Xu, L. (2009) · The AAPS Journal · doi:10.1208/s12248-009-9147-7 · Cited by 160
MiR-146a/b: a family with shared seeds and different roots
Paterson, M. R., & Kriegel, A. J. (2017) · Physiological Genomics · doi:10.1152/physiolgenomics.00133.2016 · Cited by 177
MiRNA-20 and mirna-106a regulate spermatogonial stem cell renewal at the post-transcriptional level via targeting STAT3 and Ccnd1
He, Z., Jiang, J., Kokkinaki, M., Tang, L., Zeng, W., Gallicano, G. I., Dobrinski, I., & Dym, M. (2013) · Stem Cells · doi:10.1002/stem.1474 · Cited by 162
Regulation of immune responses and tolerance: the micro RNA perspective
Chen, C., Schaffert, S. A., Fragoso, R., & Loh, C. (2013) · Immunological Reviews · doi:10.1111/imr.12060 · Cited by 167
Ectopic expression of miR-126*, an intronic product of the vascular endothelial EGF-like 7 gene, regulates prostein translation and invasiveness of prostate cancer LNCaP cells
Musiyenko, A., Bitko, V., & Barik, S. (2008) · Journal of Molecular Medicine · doi:10.1007/s00109-007-0296-9 · Cited by 164
miR-10 in development and cancer
Lund, A. H. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.58 · Cited by 165
MicroRNAs: critical mediators of differentiation, development and disease
Friedman, J. M., & Jones, P. (2009) · Swiss Medical Weekly · doi:10.4414/smw.2009.12794 · Cited by 161
MicroRNAs: Opening a New Vein in Angiogenesis Research
Fish, J. E., & Srivastava, D. (2009) · Science Signaling · doi:10.1126/scisignal.252pe1 · Cited by 160
Miravirsen dosing in chronic hepatitis C patients results in decreased micro RNA ‐122 levels without affecting other micro RNA s in plasma
van der Ree, M. H., van der Meer, A. J., van Nuenen, A. C., de Bruijne, J., Ottosen, S., Janssen, H. L. A., Kootstra, N. A., & Reesink, H. W. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13432 · Cited by 171
microRNAs and muscle disorders
Chen, J., Callis, T. E., & Wang, D. (2008) · Journal of Cell Science · doi:10.1242/jcs.041723 · Cited by 163
microRNA and stem cell function
Hatfield, S. D., & Ruohola‐Baker, H. (2007) · Cell and Tissue Research · doi:10.1007/s00441-007-0530-3 · Cited by 160
Identification and characterization of microRNAs from the bovine adipose tissue and mammary gland
Gu, Z., Eleswarapu, S., & Jiang, H. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.01.081 · Cited by 158
MicroRNAs and Their Role in Progressive Kidney Diseases
Kato, M. V., Arce, L., & Natarajan, R. D. (2009) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.00520109 · Cited by 162
Diagnostic and prognostic significance of miRNA signatures in tissues and plasma of endometrioid endometrial carcinoma patients
Torres, A., Torres, K., Pesci, A., Ceccaroni, M., Paszkowski, T., Cassandrini, P. A., Zamboni, G., & Maciejewski, R. (2012) · International Journal of Cancer · doi:10.1002/ijc.27840 · Cited by 158
miRGator: an integrated system for functional annotation of microRNAs
Nam, S., Kim, B. S., Shin, S., & Lee, S. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm829 · Cited by 162
MicroRNA-Based Therapeutics for Cancer
Wang, V., & Wu, W. (2009) · BioDrugs · doi:10.2165/00063030-200923010-00002 · Cited by 161
Oncogenic effects of miR-10b in glioblastoma stem cells
Guessous, F., Alvarado‐Velez, M., Marcinkiewicz, L., Zhang, Y., Kim, J., Heister, S., Kefas, B. A., Godlewski, J. A., Schiff, D., Purow, B. W., et al. (2013) · Journal of Neuro-Oncology · doi:10.1007/s11060-013-1047-0 · Cited by 165
miR-29b sensitizes multiple myeloma cells to bortezomib-induced apoptosis through the activation of a feedback loop with the transcription factor Sp1
Amodio, N., Martino, M. T. D., Foresta, U., Leone, E., Lionetti, M., Leotta, M., Gullà, A., Pitari, M. R., Conforti, F. S., Rossi, M., et al. (2012) · Cell Death and Disease · doi:10.1038/cddis.2012.175 · Cited by 162
Profiling olfactory stem cells from living patients identifies miRNAs relevant for autism pathophysiology
Nguyen, L. S., Lepleux, M., Makhlouf, M., Martin, C., Fregeac, J., Siquier-Pernet, K., Philippe, A., Feron, F. P., Gepner, B., Rougeulle, C., et al. (2016) · Molecular Autism · doi:10.1186/s13229-015-0064-6 · Cited by 162
MicroRNAs as stress regulators in pancreatic beta cells and diabetes
LaPierre, M. P., & Stoffel, M. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.06.020 · Cited by 160
Self-citation
Chemical modifications of nucleic acid drugs and their delivery systems for gene‐based therapy
Chen, C., Yang, Z., & Tang, X. (2018) · Medicinal Research Reviews · doi:10.1002/med.21479 · Cited by 164
RNA Therapeutics in Cardiovascular Disease
Lucas, T., Bonauer, A., & Dimmeler, S. (2018) · Circulation Research · doi:10.1161/circresaha.117.311311 · Cited by 162
miR-125a-5p ameliorates hepatic glycolipid metabolism disorder in type 2 diabetes mellitus through targeting of STAT3
Xu, L., Li, Y., Yin, L., Qi, Y., Sun, H., Sun, P., Xu, M. Q., Tang, Z., & Peng, J. (2018) · Theranostics · doi:10.7150/thno.27425 · Cited by 157
The emerging role of miRNAs in inflammatory bowel disease: a review
Chapman, C. G., & Pekow, J. R. (2014) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x14547360 · Cited by 165
MiR-27 orchestrates the transcriptional regulation of brown adipogenesis
Sun, L., & Trajkovski, M. (2013) · Metabolism · doi:10.1016/j.metabol.2013.10.004 · Cited by 159
Small RNA molecules in the regulation of spermatogenesis
He, Z., Kokkinaki, M., Pant, D., Gallicano, G. I., & Dym, M. (2009) · Reproduction · doi:10.1530/rep-08-0494 · Cited by 160
Emerging roles of microRNAs as molecular switches in the integrated circuit of the cancer cell
Sotiropoulou, G., Pampalakis, G., Lianidou, E. S., & Mourelatos, Z. (2009) · RNA · doi:10.1261/rna.1534709 · Cited by 158
Circulating microRNAs as novel biomarkers for bone diseases – Complex signatures for multifactorial diseases?
Hackl, M., Heilmeier, U., Weilner, S., & Grillari, J. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.10.015 · Cited by 161
MicroRNA delivery for regenerative medicine
Peng, B., Chen, Y., & Leong, K. W. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.05.014 · Cited by 159

Authors: Krützfeldt, J., Rajewsky, N., Braich, R., Rajeev, K. G., Tuschl, T., Manoharan, M., & Stoffel, M.
Affiliations: Rockefeller University (US)
New York University (US)
Alnylam Pharmaceuticals (United States) (US)
Howard Hughes Medical Institute (US)
Corresponding author: Stoffel, Markus
ORCID: Krützfeldt, Jan
Rajewsky, Nikolaus
Rajeev, Kallanthottathil G.
Tuschl, Thomas
Manoharan, Muthiah
Stoffel, Markus
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2005-10-30
Volume: 438
Issue: 7068
Pages: 685-689
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature04303
OpenAlex: W2161693225
Cited by: 3,949
References: 27
Citations by year: 2026: 51 · 2025: 75 · 2024: 98 · 2023: 109 · 2022: 138 · 2021: 148 · 2020: 155 · 2019: 135 · 2018: 169 · 2017: 169 · 2016: 210 · 2015: 249 · 2014: 326 · 2013: 329 · 2012: 318
FWCI: 52.66
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Bern Open Repository and Information System (University of Bern) (submittedVersion)
MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
Funders: Bristol-Myers Squibb
National Institutes of Health
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Keywords: microRNA, antagomir, microRNA silencing, in vivo gene regulation, miR-122, miR-16, miR-192, miR-194, miR-196, Hoxb8, Sonic hedgehog, embryonic development, non-coding RNA, oligonucleotide therapeutics
MeSH terms: Antagomirs, Animals, Cholesterol, Oligonucleotides, Sensitivity and Specificity, Substrate Specificity, Time Factors, Down-Regulation, Up-Regulation, RNA, Complementary, Computational Biology, 3' Untranslated Regions, Gene Silencing, MicroRNAs, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Silencing of microRNAs in vivo with ‘antagomirs’

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks