Silencing of microRNAs in vivo with ‘antagomirs’

Untitled work

Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714

Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets

Lewis, B. P., Burge, C. B., & Bartel, D. P. (2005) · Cell · doi:10.1016/j.cell.2004.12.035 · Cited by 11,855

The functions of animal microRNAs

Ambros, V. (2004) · Nature · doi:10.1038/nature02871 · Cited by 10,728

MicroRNA expression profiles classify human cancers

Lü, J., Getz, G. A., Miska, E. A., Alvarez-Saavedra, E., Lamb, J., Peck, D., Sweet-Cordero, A., Ebert, B. L., Mak, R. H., Ferrando, A. A., et al. (2005) · Nature · doi:10.1038/nature03702 · Cited by 9,637

MicroRNAs: small RNAs with a big role in gene regulation

He, L., & Hannon, G. J. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1379 · Cited by 7,118

Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

Lim, L. P., Lau, N. C., Garrett-Engele, P., Grimson, A., Schelter, J. M., Castle, J., Bartel, D. P., Linsley, P. S., & Johnson, J. M. (2005) · Nature · doi:10.1038/nature03315 · Cited by 4,755

Combinatorial microRNA target predictions

Krek, A., Grün, D., Poy, M. N., Wolf, R., Rosenberg, L., Epstein, E. J., MacMenamin, P., da Piedade, I., Gunsalus, K. C., Stoffel, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1536 · Cited by 4,603

NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins

Pruitt, K. D., Tatusova, T. A., & Maglott, D. R. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl842 · Cited by 4,441

Human MicroRNA Targets

John, B., Enright, A. J., Aravin, A., Tuschl, T., Sander, C., & Marks, D. S. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020363 · Cited by 3,796

A microRNA polycistron as a potential human oncogene

He, L., Thomson, J. M., Hemann, M. T., Hernando, E., Mu, D., Goodson, S. G., Powers, S., Cordon‐Cardo, C., Lowe, S. W., Hannon, G. J., et al. (2005) · Nature · doi:10.1038/nature03552 · Cited by 3,642

The Micro-Ribonucleic Acid (miRNA) miR-206 Targets the Human Estrogen Receptor-α (ERα) and Represses ERα Messenger RNA and Protein Expression in Breast Cancer Cell Lines

Adams, B. D., Furneaux, H., & White, B. A. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0022 · Cited by 484

Muscle-specific microRNAs in skeletal muscle development

Horak, M., Novák, J., & Vašků, J. B. (2015) · Developmental Biology · doi:10.1016/j.ydbio.2015.12.013 · Cited by 485

MicroRNA-122 Inhibits Tumorigenic Properties of Hepatocellular Carcinoma Cells and Sensitizes These Cells to Sorafenib

Bai, S., Nasser, M. W., Wang, B., Hsu, S., Datta, J., Kutay, H., Yadav, A., Nuovo, G. J., Kumar, P., & Ghoshal, K. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.016774 · Cited by 477

p53-Responsive MicroRNAs 192 and 215 Are Capable of Inducing Cell Cycle Arrest

Braun, C. J., Zhang, X., Savelyeva, I., Wolff, S., Moll, U. M., Schepeler, T., Orntoft, T. F., Andersen, C. L., & Dobbelstein, M. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1569 · Cited by 476

Silencing disease genes in the laboratory and the clinic

Watts, J. K., & Corey, D. R. (2011) · The Journal of Pathology · doi:10.1002/path.2993 · Cited by 493

Dynamic regulation of miRNA expression in ordered stages of cellular developmentPreprint

Neilson, J. R., Zheng, G. X. Y., Burge, C. B., & Sharp, P. A. (2007) · Genes & Development · doi:10.1101/gad.1522907 · Cited by 476

Practical Aspects of microRNA Target Prediction

Witkos, T. M., Kościańska, E., & Krzyżosiak, W. J. (2011) · Current Molecular Medicine · doi:10.2174/156652411794859250 · Cited by 485

Targeted Inhibition of miRNA Maturation with Morpholinos Reveals a Role for miR-375 in Pancreatic Islet Development

Kloosterman, W. P., Lagendijk, A. K., Ketting, R. F., Moulton, J. D., & Plasterk, R. H. A. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050203 · Cited by 466

A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans

Li, H., Xie, H., Liu, W., Hu, R., Huang, B., Tan, Y., Liao, E.-Y., Xu, K., Sheng, Z., Zhou, H., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39832 · Cited by 464

MicroRNA expression in the adult mouse central nervous system

Bak, M., Silahtaroglu, A., Møller, M., Christensen, M., Rath, M. F., Skryabin, B., Tommerup, N., & Kauppinen, S. (2008) · RNA · doi:10.1261/rna.783108 · Cited by 463

Natural selection on human microRNA binding sites inferred from SNP data

Chen, K., & Rajewsky, N. (2006) · Nature Genetics · doi:10.1038/ng1910 · Cited by 469

Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects

Jimenez-Mateos, E. M., Engel, T., Merino‐Serrais, P., McKiernan, R. C., Tanaka, K., Mouri, G., Sano, T., O’Tuathaigh, C. M. P., Waddington, J. L., Prenter, S., et al. (2012) · Nature Medicine · doi:10.1038/nm.2834 · Cited by 469

miR-296 Regulates Growth Factor Receptor Overexpression in Angiogenic Endothelial Cells

Würdinger, T., Tannous, B. A., Saydam, O., Skog, J., Grau, S., Soutschek, J., Weissleder, R., Breakefield, X. O., & Krichevsky, A. M. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.10.005 · Cited by 469

Maintenance of muscle stem-cell quiescence by microRNA-489

Cheung, T. H., Quach, N. L., Charville, G. W., Liu, L., Park, L., Edalati, A., Yoo, B., Hoang, P., & Rando, T. A. (2012) · Nature · doi:10.1038/nature10834 · Cited by 461

Rapid Changes in MicroRNA-146a Expression Negatively Regulate the IL-1β-Induced Inflammatory Response in Human Lung Alveolar Epithelial Cells

Perry, M. M., Moschos, S. A., Williams, A. E., Shepherd, N. J., Larner-Svensson, H. M., & Lindsay, M. A. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.8.5689 · Cited by 461

miR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanoma

Luo, M., Wu, L., Zhang, K., Wang, H., Zhang, T., Gutierrez, L., O’Connell, D., Zhang, P., Li, Y., Gao, T., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0053-8 · Cited by 408

MicroRNA regulatory networks in human adipose tissue and obesity

Arner, P., & Kulyté, A. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.25 · Cited by 461

Specificity, duplex degradation and subcellular localization of antagomirs

Krützfeldt, J., Kuwajima, S., Braich, R. S., Rajeev, K. G., Pena, J., Tuschl, T., Manoharan, M., & Stoffel, M. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm024 · Cited by 462

microRNA Therapeutics in Cancer — An Emerging Concept

Shah, M., Ferrajoli, A., Sood, A. K., Lopez‐Berestein, G., & Călin, G. A. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.09.017 · Cited by 461

Alterations of the microRNA network cause neurodegenerative disease

Hébert, S. S., & De Strooper, B. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2008.12.003 · Cited by 452

MicroRNA-328 Contributes to Adverse Electrical Remodeling in Atrial Fibrillation

Lu, Y., Zhang, Y., Wang, N., Pan, Z., Gao, X., Zhang, F., Zhang, Y., Shan, H., Luo, X., Bai, Y., et al. (2010) · Circulation · doi:10.1161/circulationaha.110.958967 · Cited by 450

MicroRNAs 17-5p–20a–106a control monocytopoiesis through AML1 targeting and M-CSF receptor upregulation

Fontana, L., Pelosi, E., Greco, P., Racanicchi, S., Testa, U., Liuzzi, F., Croce, C. M., Brunetti, E., Grignani, F., & Peschle, C. (2007) · Nature Cell Biology · doi:10.1038/ncb1613 · Cited by 384

REV-ERBα Participates in Circadian SREBP Signaling and Bile Acid Homeostasis

Martelot, G. L., Claudel, T., Gatfield, D., Schaad, O., Kornmann, B., Sasso, G. L., Moschetta, A., & Schibler, U. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000181 · Cited by 463

Lipid Metabolism, Apoptosis and Cancer Therapy

Huang, C., & Freter, C. E. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16010924 · Cited by 457

MicroRNAs: Novel regulators in the hallmarks of human cancer

Ruan, K., Fang, X., & Ouyang, G. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.04.031 · Cited by 454

Regulation of Epidermal Growth Factor Receptor Signaling in Human Cancer Cells by MicroRNA-7

Webster, R. J., Giles, K. M., Price, K. J., Zhang, P. M., Mattick, J. S., & Leedman, P. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804280200 · Cited by 450

MicroRNAs in Cardiovascular Disease

Barwari, T., Joshi, A., & Mayr, M. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.09.945 · Cited by 449

The Role of miRNAs in Regulating Gene Expression Networks

Gurtan, A. M., & Sharp, P. A. (2013) · Journal of Molecular Biology · doi:10.1016/j.jmb.2013.03.007 · Cited by 456

MicroRNA—implications for cancer

Sassen, S., Miska, E. A., & Caldas, C. (2007) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-007-0532-2 · Cited by 446

Targeting non-coding RNAs to overcome cancer therapy resistance

Chen, B., Dragomir, M. P., Chen, Y., Li, Q., Horst, D. A., & Călin, G. A. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00975-3 · Cited by 447

Selective stabilization of mammalian microRNAs by 3′ adenylation mediated by the cytoplasmic poly(A) polymerase GLD-2Preprint

Katoh, T., Sakaguchi, Y., Miyauchi, K., Suzuki, T., Kashiwabara, S., Baba, T., & Suzuki, T. (2009) · Genes & Development · doi:10.1101/gad.1761509 · Cited by 438

MicroRNA history: Discovery, recent applications, and next frontiers

Almeida, M. I., Reis, R. M., & Calin, G. A. (2011) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2011.03.009 · Cited by 466

Drosophila microRNAs Are Sorted into Functionally Distinct Argonaute Complexes after Production by Dicer-1

Förstemann, K., Horwich, M. D., Wee, L. M., Tomari, Y., & Zamore, P. D. (2007) · Cell · doi:10.1016/j.cell.2007.05.056 · Cited by 468

MicroRNA identification in plasma and serum: a new tool to diagnose and monitor diseases

Cortez, M. A., & Calin, G. A. (2009) · Expert Opinion on Biological Therapy · doi:10.1517/14712590902932889 · Cited by 445

MicroRNA regulation of Alzheimer's Amyloid precursor protein expression

Hébert, S. S., Horré, K., Nicolaï, L., Bergmans, B., Papadopoulou, A. S., Delacourte, A., & De Strooper, B. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.11.009 · Cited by 436

Chemical modification and design of anti-miRNA oligonucleotides

Lennox, K. A., & Behlke, M. A. (2011) · Gene Therapy · doi:10.1038/gt.2011.100 · Cited by 440

MiR-21 Indicates Poor Prognosis in Tongue Squamous Cell Carcinomas as an Apoptosis Inhibitor

Li, J., Huang, H., Sun, L., Yang, M., Pan, C., Chen, W., Wu, D., Lin, Z., Zeng, C., Yao, Y., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-3053 · Cited by 431

Mechanisms and strategies for effective delivery of antisense and siRNA oligonucleotides

Juliano, R. L., Alam, M. R., Dixit, V., & Kang, H. M. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn342 · Cited by 442

MicroRNA gene expression profile of hepatitis C virus–associated hepatocellular carcinoma†‡

Varnholt, H., Drebber, U., Schulze, F., Wedemeyer, I., Schirmacher, P., Dienes, H., & Odenthal, M. (2008) · Hepatology · doi:10.1002/hep.22158 · Cited by 432

Deadenylation is a widespread effect of miRNA regulation

Eulálio, A., Huntzinger, E., Nishihara, T., Rehwinkel, J., Fauser, M., & Izaurralde, E. (2008) · RNA · doi:10.1261/rna.1399509 · Cited by 429

Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function

Bernardo, B. C., Gao, X., Winbanks, C. E., Boey, E. J. H., Tham, Y. K., Kiriazis, H., Gregorevic, P., Obad, S., Kauppinen, S., Du, X., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206432109 · Cited by 439

microRNAs in Vertebrate Physiology and Human Disease

Chang, T.-C., & Mendell, J. T. (2007) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.8.080706.092351 · Cited by 437

Antagonism of microRNA-126 suppresses the effector function of T H 2 cells and the development of allergic airways disease

Mattes, J., Collison, A., Plank, M. W., Phipps, S., & Foster, P. S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905063106 · Cited by 431

miR-375 Targets 3′-Phosphoinositide–Dependent Protein Kinase-1 and Regulates Glucose-Induced Biological Responses in Pancreatic β-Cells

Ouaamari, A. E., Baroukh, N., Martens, G. A., Lebrun, P., PIPELEERS, D. G., & OBBERGHEN, E. V. (2008) · Diabetes · doi:10.2337/db07-1614 · Cited by 438

The Medicinal Chemistry of Therapeutic Oligonucleotides

Wan, W. B., & Seth, P. P. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b00551 · Cited by 445

MiRNAs and Cancer

Visone, R., & Croce, C. M. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080794 · Cited by 430

Position-Dependent Function for a Tandem MicroRNA miR-122-Binding Site Located in the Hepatitis C Virus RNA Genome

Jopling, C. L., Schütz, S., & Sarnow, P. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.05.013 · Cited by 426

Pharmacology of Antisense Drugs

Bennett, C. F., Baker, B. F., Pham, N. C., Swayze, E. E., & Geary, R. S. (2016) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010716-104846 · Cited by 445

Non-coding RNAs in hepatocellular carcinoma: molecular functions and pathological implications

Wong, C., Tsang, F. H., & Ng, I. O. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.169 · Cited by 427

miR-146a Is Critical for Endotoxin-induced Tolerance

Nahid, M. A., Pauley, K. M., Satoh, M., & Chan, E. K. L. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.056317 · Cited by 423

Improved targeting of miRNA with antisense oligonucleotides

Davis, S. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl183 · Cited by 422

Obesity-associated exosomal miRNAs modulate glucose and lipid metabolism in mice

Castaño, C., Kalko, S. G., Novials, A., & Párrizas, M. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1808855115 · Cited by 429

Optochemical Control of Biological Processes in Cells and Animals

Ankenbruck, N., Courtney, T. M., Naro, Y., & Deiters, A. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201700171 · Cited by 422

MicroRNA-132 Potentiates Cholinergic Anti-Inflammatory Signaling by Targeting Acetylcholinesterase

Shaked, I., Meerson, A., Wolf, Y., Avni, R., Greenberg, D., Gilboa-Geffen, A., & Soreq, H. (2009) · Immunity · doi:10.1016/j.immuni.2009.09.019 · Cited by 366

Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits

DiFiglia, M., Sena‐Esteves, M., Chase, K. O., Sapp, E., Pfister, E., Sass, M., Yoder, J., Reeves, P., Pandey, R. K., Rajeev, K. G., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708285104 · Cited by 433

MicroRNAs As Novel Regulators of Angiogenesis

Suárez, Y., & Sessa, W. C. (2009) · Circulation Research · doi:10.1161/circresaha.108.191270 · Cited by 416

Liver-specific microRNA-122: Biogenesis and function

Jopling, C. L. (2012) · RNA Biology · doi:10.4161/rna.18827 · Cited by 433

Temporal Proteome and Lipidome Profiles Reveal Hepatitis C Virus-Associated Reprogramming of Hepatocellular Metabolism and Bioenergetics

Diamond, D. L., Syder, A. J., Jacobs, J., Sorensen, C. M., Walters, K., Proll, S. C., McDermott, J., Gritsenko, M. A., Zhang, Q., Zhao, R., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000719 · Cited by 429

Inhibition of miR-25 improves cardiac contractility in the failing heart

Wahlquist, C., Jeong, D., Rojas‐Muñoz, A., Kho, C., Lee, A. A., Mitsuyama, S., van Mil, A., Park, W. J., Sluijter, J. P. G., Doevendans, P. A., et al. (2014) · Nature · doi:10.1038/nature13073 · Cited by 412

MicroRNAs: A new class of regulatory genes affecting metabolism

Krützfeldt, J., & Stoffel, M. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.05.009 · Cited by 416

Non-coding RNAs in cardiovascular diseases: diagnostic and therapeutic perspectives

Poller, W. C., Dimmeler, S., Heymans, S. R. B., Zeller, T., Haas, J., Karakas, M., Leistner, D. M., Jakob, P., Nakagawa, S., Blankenberg, S., et al. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehx165 · Cited by 417

Viral and Cellular MicroRNAs as Determinants of Viral Pathogenesis and Immunity

Gottwein, E., & Cullen, B. R. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.05.002 · Cited by 406

Tackling heart failure in the twenty-first century

Mudd, J. O., & Kass, D. A. (2008) · Nature · doi:10.1038/nature06798 · Cited by 417

Virus-encoded microRNAs

Grundhoff, A. T., & Sullivan, C. S. (2011) · Virology · doi:10.1016/j.virol.2011.01.002 · Cited by 416

Viruses and microRNAs

Cullen, B. R. (2006) · Nature Genetics · doi:10.1038/ng1793 · Cited by 411

MicroRNAs as oncogenes

Hammond, S. M. (2005) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2005.12.005 · Cited by 407

The database of experimentally supported targets: a functional update of TarBase

Papadopoulos, G. L., Reczko, M., Simossis, V. A., Sethupathy, P., & Hatzigeorgiou, A. G. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn809 · Cited by 398

Expression of MicroRNA‐146a in osteoarthritis cartilage

Yamasaki, K., Nakasa, T., Miyaki, S., Ishikawa, M., Deie, M., Adachi, N., Yasunaga, Y., Asahara, H., & Ochi, M. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24404 · Cited by 407

MiR-122/Cyclin G1 Interaction Modulates p53 Activity and Affects Doxorubicin Sensitivity of Human Hepatocarcinoma Cells

Fornari, F., Gramantieri, L., Giovannini, C., Veronese, A., Ferracin, M., Sabbioni, S., Calin, G. A., Grazi, G. L., Croce, C. M., Tavolari, S., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4797 · Cited by 400

MicroRNA Replacement Therapy for miR-145 and miR-33a Is Efficacious in a Model of Colon Carcinoma

Ibrahim, A. F., Weirauch, U., Thomas, M., Grünweller, A., Hartmann, R. K., & Aigner, A. M. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-4645 · Cited by 413

Oligonucleotide therapy: An emerging focus area for drug delivery in chronic inflammatory respiratory diseases

Mehta, M., Deeksha, Tewari, D., Gupta, G., Awasthi, R., Singh, H., Pandey, P., Chellappan, D. K., Wadhwa, R., Collet, T., et al. (2019) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2019.05.028 · Cited by 397

MicroRNAs in Disease and Potential Therapeutic Applications

Soifer, H. S., Rossi, J. J., & Sætrom, P. (2007) · Molecular Therapy · doi:10.1038/sj.mt.6300311 · Cited by 402

Integration of microRNA miR-122 in hepatic circadian gene expressionPreprint

Gatfield, D., Martelot, G. L., Vejnar, C. E., Gerlach, D., Schaad, O., Fleury-Olela, F., Ruskeepää, A., Orešič, M., Esau, C., Zdobnov, E. M., et al. (2009) · Genes & Development · doi:10.1101/gad.1781009 · Cited by 393

MicroRNA-1 Negatively Regulates Expression of the Hypertrophy-Associated Calmodulin and Mef2a Genes

Ikeda, S., He, A., Kong, S. W., Lü, J., Bejar, R. L., Bodyak, N. D., Lee, K., Ma, Q., Kang, P. M., Golub, T. R., et al. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01222-08 · Cited by 394

MicroRNA therapeutics

Broderick, J. A., & Zamore, P. D. (2011) · Gene Therapy · doi:10.1038/gt.2011.50 · Cited by 393

Long Noncoding RNAs and MicroRNAs in Cardiovascular Pathophysiology

Thum, T., & Condorelli, G. (2015) · Circulation Research · doi:10.1161/circresaha.116.303549 · Cited by 390

The epigenetics of aging and neurodegeneration

Lardenoije, R., Iatrou, A., Kenis, G., Kompotis, K., Steinbusch, H. W. M., Mastroeni, D., Coleman, P., Lemere, C. A., Hof, P. R., van den Hove, D. L. A., et al. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.05.002 · Cited by 381

Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications

Brown, B. D., & Naldini, L. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2628 · Cited by 336

Antagomir-17-5p Abolishes the Growth of Therapy-Resistant Neuroblastoma through p21 and BIM

Fontana, L., Fiori, M. E., Albini, S., Cifaldi, L., Giovinazzi, S., Forloni, M., Boldrini, R., Donfrancesco, A., Federici, V., Giacomini, P., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002236 · Cited by 394

Expression of miR-33 from an SREBP2 Intron Inhibits Cholesterol Export and Fatty Acid Oxidation*

Gerin, I., Clerbaux, L.-A., Haumont, O., Lanthier, N., Das, A. K., Burant, C. F., Leclercq, I. A., MacDougald, O. A., & Bommer, G. T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.152090 · Cited by 382

microRNAs in Cardiovascular Diseases

Condorelli, G., Latronico, M. V. G., & Cavarretta, E. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.01.050 · Cited by 385

The Promyelocytic Leukemia Zinc Finger–MicroRNA-221/-222 Pathway Controls Melanoma Progression through Multiple Oncogenic Mechanisms

Felicetti, F., Errico, M. C., Bottero, L., Segnalini, P., Stoppacciaro, A., Biffoni, M., Felli, N., Mattia, G., Petrini, M., Colombo, M. P., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2538 · Cited by 382

Distance constraints between microRNA target sites dictate efficacy and cooperativity

Sætrom, P., Heale, B. S. E., Snøve, O., Aagaard, L., Alluin, J. V., & Rossi, J. J. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm133 · Cited by 400

miR-122, a paradigm for the role of microRNAs in the liver

Girard, M., Jacquemin, E., Münnich, A., Lyonnet, S., & Henrion‐Caude, A. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.01.019 · Cited by 383

Toward MicroRNA–Based Therapeutics for Heart Disease

van Rooij, E., Marshall, W. S., & Olson, E. N. (2008) · Circulation Research · doi:10.1161/circresaha.108.183426 · Cited by 383

The emerging role of miR-200 family of MicroRNAs in epithelial-mesenchymal transition and cancer metastasis

Korpal, M., & Kang, Y. (2008) · RNA Biology · doi:10.4161/rna.5.3.6558 · Cited by 383

MicroRNA Expression in Squamous Cell Carcinoma and Adenocarcinoma of the Esophagus: Associations with Survival

Mathé, E. A., Nguyen, G. H., Bowman, E. D., Zhao, Y., Budhu, A., Schetter, A. J., Braun, R., Reimers, M., Kumamoto, K., Hughes, D., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1467 · Cited by 375

Micro RNA s in metabolism

Vienberg, S. G., Geiger, J., Madsen, S., & Dalgaard, L. T. (2016) · Acta Physiologica · doi:10.1111/apha.12681 · Cited by 385

MicroRNAs: novel regulators in cardiac development and disease

Thum, T., Catalucci, D., & Bauersachs, J. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn137 · Cited by 377

Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92

Matsubara, H., Takeuchi, T., Nishikawa, E., Yanagisawa, K., Hayashita, Y., Ebi, H., Yamada, H., Suzuki, M., Nagino, M., Nimura, Y., et al. (2007) · Oncogene · doi:10.1038/sj.onc.1210425 · Cited by 369

Inhibiting MicroRNA-192 Ameliorates Renal Fibrosis in Diabetic Nephropathy

Putta, S., Lanting, L. L., Sun, G., Lawson, G. W., Kato, M. V., & Natarajan, R. D. (2012) · Journal of the American Society of Nephrology · doi:10.1681/asn.2011050485 · Cited by 374

MicroRNAs and the hallmarks of cancer

Dalmay, T., & Edwards, D. R. (2006) · Oncogene · doi:10.1038/sj.onc.1209911 · Cited by 374

MicroRNA-mediated regulation of glucose and lipid metabolism

Agbu, P., & Carthew, R. W. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00354-w · Cited by 376

miR‐210: The Master Hypoxamir

Chan, Y. C., Banerjee, J., Choi, S. Y., & Sen, C. K. (2011) · Microcirculation · doi:10.1111/j.1549-8719.2011.00154.x · Cited by 370

Miravirsen (SPC3649) can inhibit the biogenesis of miR-122

Gebert, L. F. R., Rebhan, M. A. E., Crivelli, S. E. M., Denzler, R., Stoffel, M., & Hall, J. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt852 · Cited by 376

Members of the microRNA-17-92 cluster exhibit a cell-intrinsic antiangiogenic function in endothelial cells

Doebele, C., Bonauer, A., Fischer, A., Scholz, A., Reiss, Y., Urbich, C., Hofmann, W., Zeiher, A. M., & Dimmeler, S. (2010) · Blood · doi:10.1182/blood-2010-01-264812 · Cited by 362

Molecular characterization of human Argonaute-containing ribonucleoprotein complexes and their bound target mRNAs

Landthaler, M., Gaidatzis, D., Rothballer, A., Chen, P., Soll, S. J., Dinic, L., Ojo, T., Hafner, M., Zavolan, M., & Tuschl, T. (2008) · RNA · doi:10.1261/rna.1351608 · Cited by 370

Controlling cholesterol synthesis beyond 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR)

Sharpe, L. J., & Brown, A. J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.r113.479808 · Cited by 382

p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC

Christoffersen, N. R., Shalgi, R., Frankel, L. B., Leucci, E., Lees, M., Klausen, M., Pilpel, Y., Nielsen, F. C., Oren, M., & Lund, A. H. (2010) · Cell Death & Differentiation · doi:10.1038/cdd.2009.109 · Cited by 352

The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development

Hornstein, E., Mansfield, J. H., Yekta, S., Hu, J. K., Harfe, B. D., McManus, M. T., Baskerville, S., Bartel, D. P., & Tabin, C. J. (2005) · Nature · doi:10.1038/nature04138 · Cited by 396

Antagomirzymes: Oligonucleotide Enzymes That Specifically Silence MicroRNA Function

Jadhav, V., Scaria, V., & Maiti, S. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200805521 · Cited by 56

In Brief

(2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1825

Lentivirus-mediated antagomir expression for specific inhibition of miRNA function

Scherr, M., Venturini, L., Battmer, K., Schaller-Schoenitz, M., Schaefer, D., Dallmann, I., Ganser, A., & Eder, M. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm971 · Cited by 190

Lentivirus-Mediated Antagomir Expression

Surdziel, E., Eder, M., & Scherr, M. (2010) · Methods in molecular biology · doi:10.1007/978-1-60761-811-9_16 · Cited by 10