The DOI matches its Crossref record; 25 of the 27 references it cites were found in a registry or an index.
Silencing of microRNAs in vivo with ‘antagomirs’
Abstract
MicroRNAs (miRNAs) are an abundant class of non-coding RNAs that are believed to be important in many biological processes through regulation of gene expression. The precise molecular function of miRNAs in mammals is largely unknown and a better understanding will require loss-of-function studies in vivo. Here we show that a novel class of chemically engineered oligonucleotides, termed 'antagomirs', are efficient and specific silencers of endogenous miRNAs in mice. Intravenous administration of antagomirs against miR-16, miR-122, miR-192 and miR-194 resulted in a marked reduction of corresponding miRNA levels in liver, lung, kidney, heart, intestine, fat, skin, bone marrow, muscle, ovaries and adrenals. The silencing of endogenous miRNAs by this novel method is specific, efficient and long-lasting. The biological significance of silencing miRNAs with the use of antagomirs was studied for miR-122, an abundant liver-specific miRNA. Gene expression and bioinformatic analysis of messenger RNA from antagomir-treated animals revealed that the 3' untranslated regions of upregulated genes are strongly enriched in miR-122 recognition motifs, whereas downregulated genes are depleted in these motifs. Analysis of the functional annotation of downregulated genes specifically predicted that cholesterol biosynthesis genes would be affected by miR-122, and plasma cholesterol measurements showed reduced levels in antagomir-122-treated mice. Our findings show that antagomirs are powerful tools to silence specific miRNAs in vivo and may represent a therapeutic strategy for silencing miRNAs in disease.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Methods have been developed to manipulate miRNA function pharmacologically, facilitating the development of new cancer therapeutic strategies (Hutvagner et al., 2004; Krutzfeldt et al., 2005).”
From Modulation of K-Ras-Dependent Lung Tumorigenesis by MicroRNA-21 (2010) · cites this paper as Krutzfeldt et al., 2005
Citations
Cites
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
Lewis, B. P., Burge, C. B., & Bartel, D. P. (2005) · Cell · doi:10.1016/j.cell.2004.12.035 · Cited by 11,855
The functions of animal microRNAs
Ambros, V. (2004) · Nature · doi:10.1038/nature02871 · Cited by 10,728
MicroRNA expression profiles classify human cancers
Lü, J., Getz, G. A., Miska, E. A., Alvarez-Saavedra, E., Lamb, J., Peck, D., Sweet-Cordero, A., Ebert, B. L., Mak, R. H., Ferrando, A. A., et al. (2005) · Nature · doi:10.1038/nature03702 · Cited by 9,637
MicroRNAs: small RNAs with a big role in gene regulation
He, L., & Hannon, G. J. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1379 · Cited by 7,118
Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
Lim, L. P., Lau, N. C., Garrett-Engele, P., Grimson, A., Schelter, J. M., Castle, J., Bartel, D. P., Linsley, P. S., & Johnson, J. M. (2005) · Nature · doi:10.1038/nature03315 · Cited by 4,755
Combinatorial microRNA target predictions
Krek, A., Grün, D., Poy, M. N., Wolf, R., Rosenberg, L., Epstein, E. J., MacMenamin, P., da Piedade, I., Gunsalus, K. C., Stoffel, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1536 · Cited by 4,603
Self-citationPruitt, K. D., Tatusova, T. A., & Maglott, D. R. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl842 · Cited by 4,441
John, B., Enright, A. J., Aravin, A., Tuschl, T., Sander, C., & Marks, D. S. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020363 · Cited by 3,796
Self-citationA microRNA polycistron as a potential human oncogene
He, L., Thomson, J. M., Hemann, M. T., Hernando, E., Mu, D., Goodson, S. G., Powers, S., Cordon‐Cardo, C., Lowe, S. W., Hannon, G. J., et al. (2005) · Nature · doi:10.1038/nature03552 · Cited by 3,642
Cited by
Sorted by citations
Items 401–500 of 1,017
Long Noncoding RNAs in Cardiovascular Pathology, Diagnosis, and Therapy
Bär, C., Chatterjee, S., & Thum, T. (2016) · Circulation · doi:10.1161/circulationaha.116.023686 · Cited by 270
MicroRNA and cancer: Current status and prospective
Wu, W., Sun, M., Zou, G.-M., & Chen, J. (2006) · International Journal of Cancer · doi:10.1002/ijc.22454 · Cited by 266
MyomiR-133 regulates brown fat differentiation through Prdm16
Trajkovski, M., Ahmed, K., Esau, C., & Stoffel, M. (2012) · Nature Cell Biology · doi:10.1038/ncb2612 · Cited by 263
Self-citationLiao, B., Bao, X., Liu, L., Feng, S., Zovoilis, A., Liu, W., Xue, Y., Cai, J., Guo, X., Qin, B., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.c111.235960 · Cited by 263
Liu, T., Zhang, X., Du, L., Wang, Y., Liu, X., Tian, H., Wang, L., Li, P., Zhao, Y., Duan, W., et al. (2019) · Molecular Cancer · doi:10.1186/s12943-019-0981-7 · Cited by 266
RetractedRole of microRNAs in diabetes and its cardiovascular complications
Shantikumar, S., Caporali, A., & Emanueli, C. (2012) · Cardiovascular Research · doi:10.1093/cvr/cvr300 · Cited by 263
MicroRNA Therapeutics: the Next Magic Bullet?
Simonson, B., & Das, S. (2015) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557515666150324123208 · Cited by 266
Gong, Y., Renigunta, V., Himmerkus, N., Zhang, J., Renigunta, A., Bleich, M., & Hou, J. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.49 · Cited by 258
MicroRNA replacement therapy in cancer
Mollaei, H., Safaralizadeh, R., & Rostami, Z. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28058 · Cited by 265
Nutrition, Epigenetics, and Metabolic Syndrome
Wang, J., Wu, Z., Li, D., Li, N., Dindot, S. V., Satterfield, M. C., Bazer, F. W., & Wu, G. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4381 · Cited by 266
Devulapally, R., Sekar, N. M., Sekar, T. V., Foygel, K., Massoud, T. F., Willmann, J. K., & Paulmurugan, R. (2015) · ACS Nano · doi:10.1021/nn507465d · Cited by 260
Wang, S., Qiu, L., Yan, X., Jin, W., Wang, Y., Chen, L., Wu, E., Ye, X., Gao, G. F., Wang, F., et al. (2011) · Hepatology · doi:10.1002/hep.24809 · Cited by 258
Yu, Z., Li, Z., Jolicoeur, N., Zhang, L., Fortin, Y., Wang, E., Wu, M., & Shen, S. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm480 · Cited by 259
Inhibition of microRNA with antisense oligonucleotides
Esau, C. (2007) · Methods · doi:10.1016/j.ymeth.2007.11.001 · Cited by 260
MicroRNAs in Metabolic Disease
Fernández-Hernando, C., Ramírez, C. M., Goedeke, L., & Suárez, Y. (2013) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.112.300144 · Cited by 257
Triplet-repeat oligonucleotide-mediated reversal of RNA toxicity in myotonic dystrophy
Mulders, S. A. M., van den Broek, W. J. A. A., Wheeler, T. M., Croes, H. J. E., van Kuik‐Romeijn, P., de Kimpe, S. J., Furling, D., Platenburg, G. J., Gourdon, G., Thornton, C. A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905780106 · Cited by 257
Strategies to determine the biological function of microRNAs
Krützfeldt, J., Poy, M. N., & Stoffel, M. (2006) · Nature Genetics · doi:10.1038/ng1799 · Cited by 259
Self-citationDrummond, M. J., McCarthy, J. J., Fry, C. S., Esser, K. A., & Rasmussen, B. B. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90562.2008 · Cited by 268
Role of miR-21 in the pathogenesis of atrial fibrosis
Adam, O., Löhfelm, B., Thum, T., Gupta, S. K., Puhl, S., Schäfers, H., Böhm, M., & Laufs, U. (2012) · Basic Research in Cardiology · doi:10.1007/s00395-012-0278-0 · Cited by 257
Melo, S. A., Villanueva, A., Moutinho, C., Dávalos, V., Spizzo, R., Ivan, C., Rossi, S., Setién, F., Casanovas, O., Simó‐Riudalbas, L., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014720108 · Cited by 255
Willeit, P., Skroblin, P., Moschen, A. R., Yin, X., Kaudewitz, D., Zampetaki, A., Barwari, T., Whitehead, M., Ramírez, C. M., Goedeke, L., et al. (2016) · Diabetes · doi:10.2337/db16-0731 · Cited by 257
MicroRNA-based therapeutics in central nervous system injuries
Sun, P., Liu, D. Z., Jickling, G. C., Sharp, F. R., & Yin, K.-J. (2018) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x18773871 · Cited by 228
MicroRNAs as Therapeutic Targets and Biomarkers of Cardiovascular Disease
Olson, E. N. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009008 · Cited by 255
Fabani, M. M., & Gait, M. J. (2007) · RNA · doi:10.1261/rna.844108 · Cited by 253
MiRNAs as biomarkers and therapeutic targets in cancer
Heneghan, H., Miller, N., & Kerin, M. J. (2010) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2010.05.010 · Cited by 259
Ebert, P. J. R., Jiang, S., Xie, J., Li, Q.-J., & Davis, M. M. (2009) · Nature Immunology · doi:10.1038/ni.1797 · Cited by 251
Micro‐RNA‐155 inhibits IFN‐γ signaling in CD4 + T cells
Banerjee, A., Schambach, F., DeJong, C. S., Hammond, S. M., & Reiner, S. L. (2009) · European Journal of Immunology · doi:10.1002/eji.200939381 · Cited by 252
Recent developments in oligonucleotide conjugation
Singh, Y., Murat, P., & Defrancq, É. (2010) · Chemical Society Reviews · doi:10.1039/b911431a · Cited by 263
Roles for miRNA-378/378* in adipocyte gene expression and lipogenesis
Gerin, I., Bommer, G. T., McCoin, C. S., Sousa, K. M., Krishnan, V., & MacDougald, O. A. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00179.2010 · Cited by 256
Microrna Let-7: An Emerging Next-Generation Cancer Therapeutic
Barh, D., Malhotra, R., Ravi, B., & Sindhurani, P. (2010) · Current Oncology · doi:10.3747/co.v17i1.356 · Cited by 256
Modulation of miRNA activity in human cancer: a new paradigm for cancer gene therapy?
Tong, A. W., & Nemunaitis, J. J. (2008) · Cancer Gene Therapy · doi:10.1038/cgt.2008.8 · Cited by 251
Mercatelli, N., Coppola, V., Bonci, D., Miele, F., Costantini, A., Guadagnoli, M., Bonanno, E., Muto, G., Frajese, G. V., Maria, R. D., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0004029 · Cited by 250
Targeting microRNA expression to regulate angiogenesis
Kuehbacher, A., Urbich, C., & Dimmeler, S. (2007) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2007.10.014 · Cited by 249
Sun, L., Yao, Y., Liu, B., Lin, Z., Lin, L., Yang, M., Zhang, W., Chen, W., Pan, C., Liu, Q., et al. (2011) · Oncogene · doi:10.1038/onc.2011.263 · Cited by 249
Akat, K. M., Moore-McGriff, D., Morozov, P., Brown, M., Gogakos, T., Correa Da Rosa, J., Mihailovic, A., Sauer, M., Ji, R., Ramarathnam, A., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1401724111 · Cited by 254
Self-citationmiR-24 Regulates Apoptosis by Targeting the Open Reading Frame (ORF) Region of FAF1 in Cancer Cells
Qin, W., Shi, Y., Zhao, B., Yao, C., Jin, L., Ma, J., & Jin, Y. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009429 · Cited by 250
Non-coding RNAs in Cardiac Remodeling and Heart Failure
Kumarswamy, R., & Thum, T. (2013) · Circulation Research · doi:10.1161/circresaha.113.300226 · Cited by 250
Therapeutic targeting of non-coding RNAs in cancer
Slabý, O., Laga, R., & Sedláček, O. (2017) · Biochemical Journal · doi:10.1042/bcj20170079 · Cited by 252
MicroRNAs transfer from human macrophages to hepato-carcinoma cells and inhibit proliferation
Aucher, A., Rudnicka, D., & Davis, D. M. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301728 · Cited by 247
Diosdado, B., van de Wiel, M. A., Droste, J. S. T. S., Mongera, S., Postma, C., Meijerink, W. J. H. J., Carvalho, B. G., & Meijer, G. A. (2009) · British Journal of Cancer · doi:10.1038/sj.bjc.6605037 · Cited by 250
The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice
Castoldi, M., Spasić, M. V., Altamura, S., Elmén, J., Lindow, M., Kiss, J., Stolte, J., Sparla, R., D’Alessandro, L. A., Klingmüller, U., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44883 · Cited by 248
The involvement of microRNAs in neurodegenerative diseases
Maciotta, S., Meregalli, M., & Torrente, Y. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00265 · Cited by 260
Stable RNA nanoparticles as potential new generation drugs for cancer therapy
Shu, Y., Pi, F., Sharma, A. K., Rajabi, M., Haque, F., Shu, D., Leggas, M. L., Evers, B. M., & Guo, P. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.11.006 · Cited by 247
MicroRNAs in Vascular and Metabolic Disease
Zampetaki, A., & Mayr, M. (2012) · Circulation Research · doi:10.1161/circresaha.111.247445 · Cited by 247
MicroRNAs regulating oxidative stress and inflammation in relation to obesity and atherosclerosis
Hulsmans, M., Keyzer, D. D., & Holvoet, P. (2011) · The FASEB Journal · doi:10.1096/fj.11-181149 · Cited by 244
HCV-Induced miR-21 Contributes to Evasion of Host Immune System by Targeting MyD88 and IRAK1
Chen, Y., Chen, J., Wang, H., Shi, J., Wu, K., Liu, S., Liu, Y., & Wu, J. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003248 · Cited by 243
Ramirez, C. M., Dávalos, A., Goedeke, L., Salerno, A. G., Warrier, N., Cirera-Salinas, D., Suárez, Y., & Fernández-Hernando, C. (2011) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.111.232066 · Cited by 242
miRNAs and NAFLD: from pathophysiology to therapy
Gjorgjieva, M., Sobolewski, C., Dolicka, D., de Sousa, M. C., & Foti, M. (2019) · Gut · doi:10.1136/gutjnl-2018-318146 · Cited by 220
MicroRNAs: Control and Loss of Control in Human Physiology and Disease
Li, M., Marín‐Müller, C., Bharadwaj, U., Chow, K.-H., Yao, Q. C., & Chen, C. (2008) · World Journal of Surgery · doi:10.1007/s00268-008-9836-x · Cited by 247
Hairpin RNA: a secondary structure of primary importance
Svoboda, P., & Cara, A. D. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5558-5 · Cited by 241
miRNA sponges: soaking up miRNAs for regulation of gene expression
Bak, R. O., & Mikkelsen, J. G. (2013) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1213 · Cited by 241
Yang, Y.-P., Chien, Y., Chiou, G., Cherng, J., Wang, M., Lo, W., Chang, Y.-L., Huang, P., Chen, Y., Shih, Y., et al. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.10.071 · Cited by 238
MicroRNAs in biological processes and carcinogenesis
Osada, H., & Takahashi, T. (2006) · Carcinogenesis · doi:10.1093/carcin/bgl185 · Cited by 241
Drosophila lacking microRNA miR-278 are defective in energy homeostasisPreprint
Teleman, A. A., & Cohen, S. M. (2006) · Genes & Development · doi:10.1101/gad.374406 · Cited by 240
MicroRNAs in human cancer: from research to therapy
Negrini, M., Ferracin, M., Sabbioni, S., & Croce, C. M. (2007) · Journal of Cell Science · doi:10.1242/jcs.03450 · Cited by 241
Cheng, M., Yang, J., Zhao, X., Zhang, E., Zeng, Q., Yu, Y., Liu, Y., Wu, B., Yi, G., Mao, X., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08895-7 · Cited by 240
The ZSWIM8 ubiquitin ligase mediates target-directed microRNA degradation
Shi, C. Y., Kingston, E. R., Kleaveland, B., Lin, D. H., Stubna, M. W., & Bartel, D. P. (2020) · Science · doi:10.1126/science.abc9359 · Cited by 246
Li, M., Lee, K. F., Lu, Y., Clarke, I. D., Shih, D. J. H., Eberhart, C. G., Collins, V. P., Meter, T. E. V., Picard, D. J., Zhou, L., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.10.025 · Cited by 239
Kato, M. V., Arce, L., Wang, M., Putta, S., Lanting, L. L., & Natarajan, R. D. (2011) · Kidney International · doi:10.1038/ki.2011.43 · Cited by 238
Osteoporosis pathogenesis and treatment: existing and emerging avenues
Liang, B., Burley, G., Lin, S., & Shi, Y. (2022) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-022-00371-3 · Cited by 250
Microrna-27b Is a Regulatory Hub in Lipid Metabolism and Is Altered in Dyslipidemia
Vickers, K. C., Shoucri, B. M., Levin, M. G., Wu, H., Pearson, D. S., Osei-Hwedieh, D. O., Collins, F. S., Remaley, A. T., & Sethupathy, P. (2012) · Hepatology · doi:10.1002/hep.25846 · Cited by 239
microRNA: A Master Regulator of Cellular Processes for Bioengineering Systems
Sun, W., Li, Y.-S. J., Huang, H., Shyy, J. Y.-J., & Chien, S. (2010) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-070909-105314 · Cited by 242
Thakral, S., & Ghoshal, K. (2015) · Current Gene Therapy · doi:10.2174/1566523214666141224095610 · Cited by 241
Xiao, J., Luo, X., Lin, H., Zhang, Y., Lu, Y., Wang, N., Zhang, Y., Yang, B., & Wang, Z. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.c700015200 · Cited by 233
RetractedThe Spectrum of Achalasia: Lessons From Studies of Pathophysiology and High-Resolution Manometry
Kahrilas, P. J., & Boeckxstaens, G. E. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.08.038 · Cited by 236
Asl, E. R., Amini, M. A., Najafi, S., Mansoori, B., Mokhtarzadeh, A., Mohammadi, A., Lotfinejad, P., Bagheri, M., Shirjang, S., Lotfi, Z., et al. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119499 · Cited by 236
Wei, Y., Nazari-Jahantigh, M., Chan, L., Zhu, M., Heyll, K., Corbalán-Campos, J., Hartmann, P., Thiemann, A., Weber, C., & Schober, A. (2013) · Circulation · doi:10.1161/circulationaha.112.000736 · Cited by 235
MicroRNAs in inflammation and immune responses
Contreras, J., & Rao, D. S. (2011) · Leukemia · doi:10.1038/leu.2011.356 · Cited by 237
MicroRNA-146a expresses in interleukin-17 producing T cells in rheumatoid arthritis patients
Niimoto, T., Nakasa, T., Ishikawa, M., Okuhara, A., Izumi, B., Deie, M., Suzuki, O., Adachi, N., & Ochi, M. (2010) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-11-209 · Cited by 235
MicroRNA-27a/b controls endothelial cell repulsion and angiogenesis by targeting semaphorin 6A
Urbich, C., Kaluza, D., Frömel, T., Knau, A., Bennewitz, K., Boon, R. A., Bonauer, A., Doebele, C., Boeckel, J., Hergenreider, E., et al. (2011) · Blood · doi:10.1182/blood-2011-08-373886 · Cited by 236
Hepatocellular carcinoma and microRNA: New perspectives on therapeutics and diagnostics
Yang, N., Ekanem, N. R., Sakyi, C. A., & Ray, S. D. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.10.029 · Cited by 231
Ottosen, S., Parsley, T. B., Yang, L., Zeh, K., van Doorn, L., van der Veer, E., Raney, A. K., Hodges, M. R., & Patick, A. K. (2014) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.04220-14 · Cited by 231
The New State of the Art: Cas9 for Gene Activation and Repression
Russa, M. F. L., & Qi, L. S. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.00512-15 · Cited by 241
Jung, M., Mollenkopf, H., Grimm, C., Wagner, I., Albrecht, M., Waller, T., Pilarsky, C., Johannsen, M., Stephan, C., Lehrach, H., et al. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00705.x · Cited by 249
MicroRNAs in development and disease
Erson-Bensan, A. E., & Petty, E. (2008) · Clinical Genetics · doi:10.1111/j.1399-0004.2008.01076.x · Cited by 235
A three-step pathway comprising PLZF/miR-146a/CXCR4 controls megakaryopoiesis
Labbaye, C., Spinello, I., Quaranta, M. T., Pelosi, E., Pasquini, L., Petrucci, E., Biffoni, M., Nuzzolo, E. R., Billi, M., Foà, R., et al. (2008) · Nature Cell Biology · doi:10.1038/ncb1741 · Cited by 230
Inhibition of MicroRNA-17 Improves Lung and Heart Function in Experimental Pulmonary Hypertension
Pullamsetti, S. S., Doebele, C., Fischer, A., Savai, R., Kojonazarov, B. K., Dahal, B. K., Ghofrani, H. A., Weißmann, N., Grimminger, F., Bonauer, A., et al. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201106-1093oc · Cited by 228
DNA Computation in Mammalian Cells: MicroRNA Logic Operations
Hemphill, J., & Deiters, A. (2013) · Journal of the American Chemical Society · doi:10.1021/ja404350s · Cited by 232
miRNA Therapeutics: A New Class of Drugs with Potential Therapeutic Applications in the Heart
Bernardo, B. C., Ooi, J. Y. Y., Lin, R. C. Y., & McMullen, J. R. (2015) · Future Medicinal Chemistry · doi:10.4155/fmc.15.107 · Cited by 232
Yan, S., Xu, Z., Lou, F., Zhang, L., Fang, K., Bai, J., Liu, Z., Liu, J., Wang, H., Zhu, H., et al. (2015) · Nature Communications · doi:10.1038/ncomms8652 · Cited by 227
A Comprehensive Review of Cancer MicroRNA Therapeutic Delivery Strategies
Forterre, A. V., Komuro, H., Aminova, S., & Harada, M. (2020) · Cancers · doi:10.3390/cancers12071852 · Cited by 233
Chemical contrast for imaging living systems: molecular vibrations drive CARS microscopy
Pezacki, J. P., Blake, J. A., Foss, D. V., Kennedy, D. C., Lyn, R. K., & Singaravelu, R. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.525 · Cited by 229
Collison, A., Mattes, J., Plank, M. W., & Foster, P. S. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.04.005 · Cited by 225
Testa, R., Bonfigli, A. R., Prattichizzo, F., Sala, L. L., Nigris, V. D., & Ceriello, A. (2017) · Nutrients · doi:10.3390/nu9050437 · Cited by 239
MicroRNAs in neurodegenerative diseases and their therapeutic potential
Junn, E., & Mouradian, M. M. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.10.002 · Cited by 186
MicroRNA networks direct neuronal development and plasticity
Loohuis, N. F. M. O., Kos, A., Martens, G. J. M., van Bokhoven, H., Kasri, N. N., & Aschrafi, A. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0788-1 · Cited by 231
Biogenesis of mammalian microRNAs by a non-canonical processing pathway
Havens, M. A., Reich, A. A., Duelli, D. M., & Hastings, M. L. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks026 · Cited by 243
Zhang, W., Dahlberg, J. E., & Tam, W. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.070070 · Cited by 221
Diagnostic, functional, and therapeutic roles of microRNA in allergic diseases
Lu, T. X., & Rothenberg, M. E. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.04.039 · Cited by 222
The peripheral blood mononuclear cell microRNA signature of coronary artery disease
Hoekstra, M., van der Lans, C. A. C., Halvorsen, B. L., Gullestad, L. L., Kuiper, J., Aukrust, P., van Berkel, T. J. C., & Biessen, E. A. L. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.03.075 · Cited by 221
Kato, M. V., Wang, M., Chen, Z., Bhatt, K. S., Oh, H. J., Lanting, L. L., Deshpande, S., Jia, Y., Lai, J. Y., O'Connor, C. L., et al. (2016) · Nature Communications · doi:10.1038/ncomms12864 · Cited by 222
Li, Y., Fan, L., Liu, S., Liu, W., Zhang, H., Zhou, T., Wu, D., Yang, P., Shen, L., Chen, J., et al. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.03.052 · Cited by 220
Subcellular Fate and Off-Target Effects of siRNA, shRNA, and miRNA
Singh, S. P., Narang, A. S., & Mahato, R. I. (2011) · Pharmaceutical Research · doi:10.1007/s11095-011-0608-1 · Cited by 228
Host-virus interaction: a new role for microRNAs
Scaria, V., Hariharan, M., Maiti, S., Pillai, B., & Brahmachari, S. K. (2006) · Retrovirology · doi:10.1186/1742-4690-3-68 · Cited by 221
miR-221 Silencing Blocks Hepatocellular Carcinoma and Promotes Survival
Park, J. K., Kogure, T., Nuovo, G. J., Jiang, J., He, L., Kim, J. H., Phelps, M. A., Papenfuss, T. L., Croce, C. M., Patel, T. C., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-1144 · Cited by 219
Seto, E., Moosmann, A., Grömminger, S., Walz, N., Grundhoff, A. T., & Hammerschmidt, W. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001063 · Cited by 224
Virus-specific mechanisms of carcinogenesis in hepatitis C virus associated liver cancer
McGivern, D. R., & Lemon, S. M. (2011) · Oncogene · doi:10.1038/onc.2010.594 · Cited by 232
Liver-Specific MicroRNA miR-122 Enhances the Replication of Hepatitis C Virus in Nonhepatic Cells
Chang, J., Guo, J., Jiang, D., Guo, H., Taylor, J. M., & Block, T. M. (2008) · Journal of Virology · doi:10.1128/jvi.02575-07 · Cited by 228
Genome-wide Dissection of MicroRNA Functions and Cotargeting Networks Using Gene Set Signatures
Tsang, J. S., Ebert, M. S., & van Oudenaarden, A. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.03.007 · Cited by 226
CHANGES IN microRNA (miR) PROFILE AND EFFECTS OF miR‐320 IN INSULIN‐RESISTANT 3T3‐L1 ADIPOCYTES
Ling, H., Ou, H., Feng, S., Zhang, X., Tuo, Q., Chen, L., Zhu, B., Gao, Z., Tang, C., Yin, W., et al. (2009) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2009.05207.x · Cited by 221
Metadata
- Authors
- Krützfeldt, J., Rajewsky, N., Braich, R., Rajeev, K. G., Tuschl, T., Manoharan, M., & Stoffel, M.
- Affiliations
- Rockefeller University (US)
- New York University (US)
- Alnylam Pharmaceuticals (United States) (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Stoffel, Markus
- ORCID
- Venue
- Nature
- Published
- 2005-10-30
- Volume
- 438
- Issue
- 7068
- Pages
- 685-689
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2161693225
- Cited by
- 3,949
- References
- 27
- Citations by year
- 2026: 51 · 2025: 75 · 2024: 98 · 2023: 109 · 2022: 138 · 2021: 148 · 2020: 155 · 2019: 135 · 2018: 169 · 2017: 169 · 2016: 210 · 2015: 249 · 2014: 326 · 2013: 329 · 2012: 318
- FWCI
- 52.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Bern Open Repository and Information System (University of Bern) (submittedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- Funders
- Bristol-Myers Squibb
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Keywords
- microRNA, antagomir, microRNA silencing, in vivo gene regulation, miR-122, miR-16, miR-192, miR-194, miR-196, Hoxb8, Sonic hedgehog, embryonic development, non-coding RNA, oligonucleotide therapeutics
- MeSH terms
- Antagomirs, Animals, Cholesterol, Oligonucleotides, Sensitivity and Specificity, Substrate Specificity, Time Factors, Down-Regulation, Up-Regulation, RNA, Complementary, Computational Biology, 3' Untranslated Regions, Gene Silencing, MicroRNAs, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review