Autophagy fights disease through cellular self-digestion

Autophagy in the Pathogenesis of Disease

Levine, B., & Kroemer, G. (2008) · Cell · doi:10.1016/j.cell.2007.12.018 · Cited by 7,069

p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy

Pankiv, S., Clausen, T. H., Lamark, T., Brech, A., Bruun, J.-A., Outzen, H., Øvervatn, A., Bjørkøy, G., & Johansen, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702824200 · Cited by 4,578

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

Hara, T., Nakamura, K., Matsui, M., Yamamoto, A., Nakahara, Y., Suzuki-Migishima, R., Yokoyama, M., Mishima, K., Saito, I., Okano, H., et al. (2006) · Nature · doi:10.1038/nature04724 · Cited by 3,882

Self-eating and self-killing: crosstalk between autophagy and apoptosis

Maiuri, M. C., Zalckvar, E., Kimchi, A., & Kroemer, G. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2239 · Cited by 3,638

Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy

Pattingre, S., Tassa, A., Qu, X., Garuti, R., Liang, X. H., Mizushima, N., Packer, M., Schneider, M. D., & Levine, B. (2005) · Cell · doi:10.1016/j.cell.2005.07.002 · Cited by 3,536

Loss of autophagy in the central nervous system causes neurodegeneration in mice

Komatsu, M., Waguri, S., Chiba, T., Murata, S., Iwata, J.-I., Tanida, I., Ueno, T., Koike, M., Uchiyama, Y., Kominami, E., et al. (2006) · Nature · doi:10.1038/nature04723 · Cited by 3,500

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

Bjørkøy, G., Lamark, T., Brech, A., Outzen, H., Perander, M., Øvervatn, A., Stenmark, H., & Johansen, T. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200507002 · Cited by 3,276

The role of autophagy during the early neonatal starvation period

Kuma, A., Hatano, M., Matsui, M., Yamamoto, A., Nakaya, H., Yoshimori, T., Ohsumi, Y., Tokuhisa, T., & Mizushima, N. (2004) · Nature · doi:10.1038/nature03029 · Cited by 2,865

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Ravikumar, B., Vacher, C., Berger, Z., Davies, J. E., Luo, S., Oroz, L. G., Scaravilli, F., Easton, D. F., Duden, R., O'Kane, C. J., et al. (2004) · Nature Genetics · doi:10.1038/ng1362 · Cited by 2,347

Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice

Ni, H., McGill, M. R., Chao, X., Du, K., Williams, J. A. R., Xie, Y., Jaeschke, H., & Ding, W. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.04.025 · Cited by 233

STING signalling is terminated through ESCRT-dependent microautophagy of vesicles originating from recycling endosomes

Kuchitsu, Y., Mukai, K., Uematsu, R., Takaada, Y., Shinojima, A., Shindo, R., Shoji, T., Hamano, S., Ogawa, E., Sato, R., et al. (2023) · Nature Cell Biology · doi:10.1038/s41556-023-01098-9 · Cited by 233

Nrf2-mediated induction of p62 controls Toll-like receptor-4–driven aggresome-like induced structure formation and autophagic degradation

Fujita, K.-I., Maeda, D., Xiao, Q., & Srinivasula, S. M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014156108 · Cited by 232

Chloroquine and hydroxychloroquine for cancer therapy

Manic, G., Obrist, F., Kroemer, G., Vitale, I., & Galluzzi, L. (2014) · Molecular & Cellular Oncology · doi:10.4161/mco.29911 · Cited by 231

NOD2, an intracellular innate immune sensor involved in host defense and Crohn's disease

Strober, W., & Watanabe, T. (2011) · Mucosal Immunology · doi:10.1038/mi.2011.29 · Cited by 231

Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives

Anguiano, J., Garner, T. P., Mahalingam, M., Das, B. C., Gavathiotis, E., & Cuervo, A. M. (2013) · Nature Chemical Biology · doi:10.1038/nchembio.1230 · Cited by 232

Autophagy Is Required for Activation of Pancreatic Stellate Cells, Associated With Pancreatic Cancer Progression and Promotes Growth of Pancreatic Tumors in Mice

Endo, S., Nakata, K., Ohuchida, K., Takesue, S., Nakayama, H., Abe, T., Koikawa, K., Okumura, T., Sada, M., Horioka, K., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.01.010 · Cited by 231

Autophagy variation within a cell population determines cell fate through selective degradation of Fap-1

Gump, J. M., Staskiewicz, L., Morgan, M. J., Bamberg, A., Riches, D. W. H., & Thorburn, A. (2014) · Nature Cell Biology · doi:10.1038/ncb2886 · Cited by 230

Age related macular degeneration and drusen: Neuroinflammation in the retina

Buschini, E., Piras, A., Nuzzi, R., & Vercelli, A. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.05.011 · Cited by 230

Resveratrol induces apoptosis via ROS-triggered autophagy in human colon cancer cells

Miki, H., Uehara, N., Kimura, A., Sasaki, T., Yuri, T., Yoshizawa, K., & Tsubura, A. (2012) · International Journal of Oncology · doi:10.3892/ijo.2012.1325 · Cited by 230

Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal storage and associated synaptic impairments in neurons

Zhang, X., Wei, M., Fan, J., Yan, W., Zha, X., Song, H., Wan, R., Yin, Y., & Wang, W. (2020) · Autophagy · doi:10.1080/15548627.2020.1840796 · Cited by 230

A small‐molecule enhancer of autophagy decreases levels of Aβ and APP‐CTF via Atg5‐dependent autophagy pathway

Tian, Y., Bustos, V., Flajolet, M., & Greengard, P. (2011) · The FASEB Journal · doi:10.1096/fj.10-175158 · Cited by 229

Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy

Eng, C. H., Wang, Z., Tkach, D., Toral‐Barza, L., Ugwonali, S., Liu, S., Fitzgerald, S., George, E., Frias, E., Cochran, N. R., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1515617113 · Cited by 229

Autophagy Signaling Through Reactive Oxygen Species

Huang, J., Lam, G. Y., & Brumell, J. H. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3554 · Cited by 228

Regulation of lipid droplets by autophagy

Dong, H., & Czaja, M. J. (2011) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2011.02.003 · Cited by 197

Autophagy Attenuates Diabetic Glomerular Damage through Protection of Hyperglycemia-Induced Podocyte Injury

Fang, L., Zhou, Y., Cao, H., Wen, P., Jiang, L., He, W., Dai, C., & Yang, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060546 · Cited by 227

Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice.

Ozcelik, S., Fraser, G., Castets, P., Schaeffer, V., Skachokova, Z., Breu, K., Clavaguera, F., Sinnreich, M., Kappos, L., Goedert, M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062459 · Cited by 226

A photoconvertible fluorescent reporter to track chaperone-mediated autophagy

Koga, H., Martínez‐Vicente, M., Macián, F., Verkhusha, V. V., & Cuervo, A. M. (2011) · Nature Communications · doi:10.1038/ncomms1393 · Cited by 226

AMPK-dependent phosphorylation of ULK1 regulates ATG9 localization

Mack, H. I. D., Zheng, B., Asara, J. M., & Thomas, S. Μ. (2012) · Autophagy · doi:10.4161/auto.20586 · Cited by 227

Vesicular trafficking and autophagosome formation

Longatti, A., & Tooze, S. A. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.39 · Cited by 226

PGC1‐α over‐expression prevents metabolic alterations and soleus muscle atrophy in hindlimb unloaded mice

Cannavino, J., Brocca, L., Sandri, M., Bottinelli, R., & Pellegrino, M. A. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.275545 · Cited by 227

AMPK Activation Stimulates Autophagy and Ameliorates Muscular Dystrophy in the mdx Mouse Diaphragm

Pauly, M., Daussin, F., Burelle, Y., Li, T., Godin, R., Fauconnier, J., Koechlin-Ramonatxo, C., Hugon, G., Lacampagne, A., Coisy-Quivy, M., et al. (2012) · The American Journal of Pathology · doi:10.1016/j.ajpath.2012.04.004 · Cited by 225

Autophagy and cancer – issues we need to digest

Liu, E. Y., & Ryan, K. M. (2012) · Journal of Cell Science · doi:10.1242/jcs.093708 · Cited by 225

Autophagy Regulates Endoplasmic Reticulum Homeostasis and Calcium Mobilization in T Lymphocytes

Jia, W., Pua, H. H., Li, Q.-J., & He, Y.-W. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001822 · Cited by 224

D-limonene exhibits antitumor activity by inducing autophagy and apoptosis in lung cancer

Yu, X., Lin, H., Wang, Y., Lv, W., Zhang, S., Qian, Y., Deng, X., Feng, N., Yu, H., & Qian, B. (2018) · OncoTargets and Therapy · doi:10.2147/ott.s155716 · Cited by 224

Concise Review: Mesenchymal Stem Cells in Neurodegenerative Diseases

Volkman, R., & Offen, D. (2017) · Stem Cells · doi:10.1002/stem.2651 · Cited by 222

Zinc oxide nanoparticles induce apoptosis by enhancement of autophagy via PI3K/Akt/mTOR inhibition

Roy, R., Singh, S. K., Chauhan, L. K. S., Das, M., Tripathi, A., & Dwivedi, P. D. (2014) · Toxicology Letters · doi:10.1016/j.toxlet.2014.02.024 · Cited by 222

Starvation-induced Hyperacetylation of Tubulin Is Required for the Stimulation of Autophagy by Nutrient Deprivation

Geeraert, C., Ratier, A., Pfisterer, S. G., Perdiz, D., Cantaloube, I., Rouault, A., Pattingre, S., Proikas‐Cezanne, T., Codogno, P., & Poüs, C. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.091553 · Cited by 222

Serotonin promotes tumor growth in human hepatocellular cancer†

Soll, C., Jang, J. H., Riener, M., Moritz, W., Wild, P. J., Graf, R., & Clavien, P. (2009) · Hepatology · doi:10.1002/hep.23441 · Cited by 222

Autophagic elimination of misfolded procollagen aggregates in the endoplasmic reticulum as a means of cell protection

Ishida, Y., Yamamoto, A., Kitamura, A., Lamandé, S. R., Yoshimori, T., Bateman, J. F., Kubota, H., & Nagata, K. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-11-1092 · Cited by 221

Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine

Keipert, S., Ost, M., Johann, K., Imber, F., Jastroch, M., van Schothorst, E. M., Keijer, J., & Klaus, S. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00330.2013 · Cited by 221

PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage

Vasheghani, F., Zhang, Y., Li, Y.-H., Blati, M., Fahmi, H., Lussier, B., Roughley, P., Lagares, D., Endisha, H., Saffar, B., et al. (2015) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2014-205743 · Cited by 221

Function and Mechanisms of Autophagy in Brain and Spinal Cord Trauma

Lipinski, M. M., Wu, J., Faden, A. I., & Sarkar, C. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6306 · Cited by 221

Autophagy as a modulator of cell death machinery

Noguchi, M., Hirata, N., Tanaka, T., Suizu, F., Nakajima, H., & Chiorini, J. A. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2724-5 · Cited by 223

p53/microRNA-214/ULK1 axis impairs renal tubular autophagy in diabetic kidney disease

Ma, Z., Lin, L., Livingston, M. J., Zhang, D., Mi, Q., Zhang, M., Ding, H., Huo, Y., Mei, C., & Dong, Z. (2020) · Journal of Clinical Investigation · doi:10.1172/jci135536 · Cited by 221

Extracellular Vesicles: New Classification and Tumor Immunosuppression

Sheta, M., Taha, E. A., Lu, Y., & Eguchi, T. (2023) · Biology · doi:10.3390/biology12010110 · Cited by 221

A Mammalian Autophagosome Maturation Mechanism Mediated by TECPR1 and the Atg12-Atg5 Conjugate

Chen, D., Fan, W., Lu, Y., Ding, X., Chen, S., & Zhong, Q. (2012) · Molecular Cell · doi:10.1016/j.molcel.2011.12.036 · Cited by 221

PRDX1 activates autophagy via the PTEN-AKT signaling pathway to protect against cisplatin-induced spiral ganglion neuron damage

Liu, W., Xu, L., Wang, X., Zhang, D., Sun, G., Wang, M., Wang, M., Han, Y., Chai, R., & Wang, H. (2021) · Autophagy · doi:10.1080/15548627.2021.1905466 · Cited by 221

AMPK and autophagy in glucose/glycogen metabolism

Ha, J., Guan, K., & Kim, J. (2015) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2015.08.002 · Cited by 219

Epithelial barrier: an interface for the cross‐communication between gut flora and immune system

Goto, Y., & Kiyono, H. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01078.x · Cited by 219

Curcumin Ameliorates the Neurodegenerative Pathology in A53T α-synuclein Cell Model of Parkinson’s Disease Through the Downregulation of mTOR/p70S6K Signaling and the Recovery of Macroautophagy

Jiang, T., Zhang, Y., Zhou, H., Wang, H., Tian, L., Liu, J., Ding, J., & Chen, S. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-012-9431-7 · Cited by 220

Chaperone-mediated autophagy at a glance

Kaushik, S., Bandyopadhyay, U., Sridhar, S., Kiffin, R., Martínez‐Vicente, M., Kon, M., Orenstein, S. J., Wong, E. S. P., & Cuervo, A. M. (2011) · Journal of Cell Science · doi:10.1242/jcs.073874 · Cited by 219

Macrophage autophagy in macrophage polarization, chronic inflammation and organ fibrosis

Wen, J.-H., Li, D.-Y., Liang, S., Yang, C., Tang, J., & Liu, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.946832 · Cited by 219

Differential Roles of GSK-3β During Myocardial Ischemia and Ischemia/Reperfusion

Zhai, P., Sciarretta, S., Galeotti, J., Volpe, M., & Sadoshima, J. (2011) · Circulation Research · doi:10.1161/circresaha.111.249532 · Cited by 218

ER stress and impaired autophagy flux in neuronal degeneration and brain injury

Yin, Y., Sun, G., Li, E., Kiselyov, K. I., & Sun, D. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.08.008 · Cited by 218

Autophagic protein LC3B confers resistance against hypoxia-induced pulmonary hypertension.

Lee, S.-J., Smith, A., Guo, L., Alastalo, T.-P., Li, M., Sawada, H., Liu, X., Chen, Z.-H., Ifedigbo, E., Jin, Y., et al. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201005-0746oc · Cited by 217

Two-Site Recognition of Phosphatidylinositol 3-Phosphate by PROPPINs in Autophagy

Baskaran, S., Ragusa, M. J., Bouřa, E., & Hurley, J. H. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.05.027 · Cited by 215

Mitophagy is primarily due to alternative autophagy and requires the MAPK1 and MAPK14 signaling pathways

Hirota, Y., Yamashita, S.-I., Kurihara, Y., Jin, X., Aihara, M., Saigusa, T., Kang, D., & Kanki, T. (2015) · Autophagy · doi:10.1080/15548627.2015.1023047 · Cited by 218

Roles of zinc and metallothionein-3 in oxidative stress-induced lysosomal dysfunction, cell death, and autophagy in neurons and astrocytes

Lee, S.-J., & Koh, J. (2010) · Molecular Brain · doi:10.1186/1756-6606-3-30 · Cited by 216

Chemical Inducers of Autophagy That Enhance the Clearance of Mutant Proteins in Neurodegenerative Diseases

Renna, M., Jiménez-Sánchez, M., Sarkar, S., & Rubinsztein, D. C. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.r109.072181 · Cited by 215

Autophagy: Regulation and role in disease

Meijer, A. J., & Codogno, P. (2009) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360903044068 · Cited by 215

Apoptosis and Autophagy: Decoding Calcium Signals that Mediate Life or DeathPreprint

Harr, M. W., & Distelhorst, C. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005579 · Cited by 217

Parkinson’s disease as a result of aging

Rodriguez, M., Rodriguez‐Sabate, C., Morales, I., Sanchez, A., & Sabate, M. (2015) · Aging Cell · doi:10.1111/acel.12312 · Cited by 214

mTORC1 phosphorylates the ULK1-mAtg13-FIP200 autophagy regulatory complex

Chan, E. Y. (2009) · Science Signaling · doi:10.1126/scisignal.284pe51 · Cited by 214

Autophagy mediates pharmacological lifespan extension by spermidineand resveratrol

Morselli, E., Galluzzi, L., Kepp, O., Criollo, A., Maiuri, M. C., Tavernarakis, N., Madeo, F., & Kroemer, G. (2009) · Aging · doi:10.18632/aging.100110 · Cited by 213

Dietary Restriction Ameliorates Diabetic Nephropathy through Anti-Inflammatory Effects and Regulation of the Autophagy via Restoration of Sirt1 in Diabetic Wistar Fatty (fa/fa) Rats: A Model of Type 2 Diabetes

Kitada, M., Takeda, A., Nagai, T., Ito, H., Kanasaki, K., & Koya, D. (2011) · Experimental Diabetes Research · doi:10.1155/2011/908185 · Cited by 213

New frontiers in promoting tumour cell death: targeting apoptosis, necroptosis and autophagy

Long, J. S., & Ryan, K. M. (2012) · Oncogene · doi:10.1038/onc.2012.7 · Cited by 213

The Ccz1-Mon1-Rab7 module and Rab5 control distinct steps of autophagy

Hegedűs, K., Takáts, S., Boda, A., Jipa, A., Nagy, P., Varga, K., Kovács, A. L., & Juhász, G. (2016) · Molecular Biology of the Cell · doi:10.1091/mbc.e16-03-0205 · Cited by 213

MAPT/Tau accumulation represses autophagy flux by disrupting IST1-regulated ESCRT-III complex formation: a vicious cycle in Alzheimer neurodegeneration

Feng, Q., Luo, Y., Zhang, X., Yang, X., Hong, X.-Y., Sun, D., Li, X., Hu, Y., Li, X., Zhang, J., et al. (2019) · Autophagy · doi:10.1080/15548627.2019.1633862 · Cited by 213

Sirtuins and renal diseases: relationship with aging and diabetic nephropathy

Kitada, M., Kume, S., Takeda‐Watanabe, A., Kanasaki, K., & Koya, D. (2012) · Clinical Science · doi:10.1042/cs20120190 · Cited by 212

Mammalian Target of Rapamycin: Discovery of Rapamycin Reveals a Signaling Pathway Important for Normal and Cancer Cell Growth

Gibbons, J. J., Abraham, R. T., & Yu, K. (2009) · Seminars in Oncology · doi:10.1053/j.seminoncol.2009.10.011 · Cited by 212

Phosphate-induced autophagy counteracts vascular calcification by reducing matrix vesicle release

Dai, X.-Y., Zhao, M.-M., Cai, Y., Guan, Q.-C., Zhao, Y., Guan, Y., Kong, W., Zhu, W., Xu, M., & Wang, X. (2013) · Kidney International · doi:10.1038/ki.2012.482 · Cited by 212

Autophagy in health and disease. 1. Regulation and significance of autophagy: an overview

Mehrpour, M., Esclatine, A., Beau, I., & Codogno, P. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00507.2009 · Cited by 211

TheArabidopsisMultistress Regulator TSPO Is a Heme Binding Membrane Protein and a Potential Scavenger of Porphyrins via an Autophagy-Dependent Degradation Mechanism

Vanhee, C., Zapotoczny, G., Masquelier, D., Ghislain, M., & Batoko, H. (2011) · The Plant Cell · doi:10.1105/tpc.110.081570 · Cited by 211

Cellular Proteostasis in Neurodegeneration

Kurtishi, A., Rosen, B., Patil, K. S., Alves, G. W., & Møller, S. G. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1334-z · Cited by 210

Mechanisms of Photoreceptor Death in Retinitis Pigmentosa

Newton, F. G., & Megaw, R. D. (2020) · Genes · doi:10.3390/genes11101120 · Cited by 210

Impaired autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in rodent models of acute pancreatitis

Mareninova, O. A., Hermann, K. J., French, S. W., OʼKonski, M. S., Pandol, S. J., Webster, P. C., Erickson, A. H., Katunuma, N., Gorelick, F. S., Gukovsky, I., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38674 · Cited by 210

Disrupted autophagy after spinal cord injury is associated with ER stress and neuronal cell death

Liu, S., Sarkar, C., Dinizo, M., Faden, A. I., Koh, E. Y., Lipinski, M. M., & Wu, J. (2015) · Cell Death & Disease · doi:10.1038/cddis.2014.527 · Cited by 209

Rapamycin attenuates mitochondrial dysfunction via activation of mitophagy in experimental ischemic stroke

Li, Q., Zhang, T., Wang, J., Zhang, Z., Zhai, Y., Yang, G.-Y., & Sun, X. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.01.032 · Cited by 209

Following autophagy step by step

Hansen, T. E., & Johansen, T. (2011) · BMC Biology · doi:10.1186/1741-7007-9-39 · Cited by 209

Ulk1-mediated Atg5-independent macroautophagy mediates elimination of mitochondria from embryonic reticulocytes

Honda, S., Arakawa, S., Nishida, Y., Yamaguchi, H., Ishii, E., & Shimizu, S. (2014) · Nature Communications · doi:10.1038/ncomms5004 · Cited by 210

Phosphatidylinositol 3-kinase and COPII generate LC3 lipidation vesicles from the ER-Golgi intermediate compartment

Ge, L., Zhang, M., & Schekman, R. W. (2014) · eLife · doi:10.7554/elife.04135 · Cited by 210

How do ESCRT proteins control autophagy?

Rusten, T. E., & Stenmark, H. (2009) · Journal of Cell Science · doi:10.1242/jcs.050021 · Cited by 209

Regulation of Amyloid Precursor Protein Processing by the Beclin 1 Complex

Jaeger, P. A., Pickford, F., Sun, C.-H. J., Lucin, K. M., Masliah, E., & Wyss‐Coray, T. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011102 · Cited by 208

Regulation of mATG9 trafficking by Src- and ULK1-mediated phosphorylation in basal and starvation-induced autophagy

Zhou, C., Ma, K., Gao, R., Mu, C., Chen, L., Liu, Q., Luo, Q., Feng, D., Zhu, Y., & Chen, Q. (2016) · Cell Research · doi:10.1038/cr.2016.146 · Cited by 208

Phosphorylation of ULK1 by AMPK regulates translocation of ULK1 to mitochondria and mitophagy

Tian, W., Li, W., Chen, Y., Yan, Z., Huang, X., Zhuang, H., Zhong, W., Chen, Y., Wu, W., Lin, C., et al. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.05.020 · Cited by 210

Proteostasis Failure in Neurodegenerative Diseases: Focus on Oxidative Stress

Höhn, A., Tramutola, A., & Cascella, R. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/5497046 · Cited by 208

Arctigenin Effectively Ameliorates Memory Impairment in Alzheimer's Disease Model Mice Targeting Both -Amyloid Production and Clearance

Zhu, Z., Yan, J., Jiang, W., Yao, X., Chen, J., Chen, L., Li, C., Hu, L., Jiang, H., & Shen, X. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4790-12.2013 · Cited by 207

Chromatin structure as a mediator of aging

Feser, J., & Tyler, J. K. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.11.016 · Cited by 206

Autophagy is a regulator of TGF-β1-induced fibrogenesis in primary human atrial myofibroblasts

Ghavami, S., Cunnington, R. H., Gupta, S., Yeganeh, B., Filomeno, K. L., Freed, D. H., Chen, S., Klonisch, T. C., Halayko, A. J., Ambrose, E., et al. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.36 · Cited by 206

Autophagy and doxorubicin resistance in cancer

Chen, C., Lu, L., Yan, S., Yi, H., Yao, H., Wu, D., He, G., Tao, X., & Deng, X. (2017) · Anti-Cancer Drugs · doi:10.1097/cad.0000000000000572 · Cited by 206

Betulinic acid inhibits pyroptosis in spinal cord injury by augmenting autophagy via the AMPK-mTOR-TFEB signaling pathway

Wu, C., Chen, H. A., Zhuang, R., Zhang, H., Wang, Y., Hu, X., Xu, Y. M., Li, J., Li, Y., Wang, X., et al. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.57825 · Cited by 206

Organelle-Specific Initiation of Autophagy

Sica, V., Galluzzi, L., Bravo-San Pedro, J. M., Izzo, V., Maiuri, M. C., & Kroemer, G. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.07.021 · Cited by 205

Oxidant stress in mitochondrial DNA damage, autophagy and inflammation in atherosclerosis

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Scoparone improves hepatic inflammation and autophagy in mice with nonalcoholic steatohepatitis by regulating the ROS/P38/Nrf2 axis and PI3K/AKT/mTOR pathway in macrophages

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