The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Autophagy fights disease through cellular self-digestion
Open accessAbstract
Autophagy, or cellular self-digestion, is a cellular pathway involved in protein and organelle degradation, with an astonishing number of connections to human disease and physiology. For example, autophagic dysfunction is associated with cancer, neurodegeneration, microbial infection and ageing. Paradoxically, although autophagy is primarily a protective process for the cell, it can also play a role in cell death. Understanding autophagy may ultimately allow scientists and clinicians to harness this process for the purpose of improving human health.
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“Proteostasis involves mechanisms for the stabilization of correctly folded proteins, most prominently the heat-shock family of proteins, and mechanisms for the degradation of proteins by the proteasome or the lysosome (Hartl et al., 2011; Koga et al., 2011; Mizushima et al., 2008).”
From The Hallmarks of Aging (2013) · cites this paper as Mizushima et al., 2008
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“The neuroprotective function of macroautophagy has become an interesting focus in neurodegenerative disease, exemplified in Huntington's disease (Menzies et al., 2006;Mizushima et al., 2008), as well as in animal models (Hara et al., 2006;Komatsu et al., 2006).”
From Depletion of 26S Proteasomes in Mouse Brain Neurons Causes Neurodegeneration and Lewy-Like Inclusions Resembling Human Pale Bodies (2008) · cites this paper as Mizushima et al., 2008
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“Three different forms of autophagy have been described in mammalian cells: macroautophagy, microautophagy and chaperone-mediated autophagy (Fig. 3) (Cuervo, 2009; He and Klionsky, 2009; Mizushima et al., 2008).”
From Protein Homeostasis and Aging: the importance of exquisite quality control (2011) · cites this paper as Mizushima et al., 2008
In the citing paper
“macro-autophagy (hereafter referred to as autophagy)—a tightly regulated major lysosomal degradation pathway (27–30)—has been implicated in establishing the SASP through the target of rapamycin (TOR) autophagy spatial coupling compartment (TASCC).”
From The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. (2015) · cites this paper as [27]
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Citations
Cites
1 retracted
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Metadata
- Authors
- Mizushima, N., Levine, B., Cuervo, A. M., & Klionsky, D. J.
- Affiliations
- Tokyo Medical and Dental University (JP)
- The University of Texas at Dallas (US)
- University of Michigan (US)
- Corresponding author
- Klionsky, Daniel J.
- Venue
- Nature
- Published
- 2008-02
- Volume
- 451
- Issue
- 7182
- Pages
- 1069-1075
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC2670399
- OpenAlex
- W1994823455
- Cited by
- 6,452
- References
- 60
- Citations by year
- 2026: 126 · 2025: 233 · 2024: 302 · 2023: 305 · 2022: 361 · 2021: 381 · 2020: 412 · 2019: 392 · 2018: 388 · 2017: 434 · 2016: 439 · 2015: 430 · 2014: 456 · 2013: 400 · 2012: 378
- FWCI
- 35.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Funders
- American Cancer Society
- Ellison Medical Foundation
- Ministry of Education, Culture, Sports, Science and Technology
- Toray Science Foundation
- National Institutes of Health
- National Institute on Aging (R03AG019834, R01AG021904, R21AG025355)
- National Cancer Institute
- National Institute of General Medical Sciences
- National Institute of Allergy and Infectious Diseases
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Keywords
- autophagy, protein degradation, organelle degradation, cytoprotection, cell death, cancer, neurodegeneration, microbial infection, aging
- MeSH terms
- Aging, Animals, Autophagy, Cell Survival, Humans, Immunity, Innate, Neoplasms, Cell Death, Neurodegenerative Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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