Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

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  1. WNT Signaling and Colorectal Cancer
    Emma M. Schatoff, Benjamin I. Leach, Lukas E. Dow · 2017 · Current Colorectal Cancer Reports
  2. Neuro-Immune Interactions at Barrier Surfaces
    Henrique Veiga‐Fernandes, Daniel Mucida · 2016 · Cell
  3. Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium
    Yu Matsuzawa, Yusuke Shono, Luis E. Gomez, Vanessa M. Hubbard-Lucey, Michael Cammer, Jessica Anne Neil, Md. Zahidunnabi Dewan, Sophia R. Lieberman, Amina Lazrak, Jill M. Marinis et al. · 2017 · The Journal of Experimental Medicine
  4. The Hippo signaling pathway and stem cell biology
    Azucena Ramos, Fernando D. Camargo · 2012 · Trends in Cell Biology
  5. Mature Chief Cells Are Cryptic Progenitors for Metaplasia in the Stomach
    Ki Taek Nam, Hyuk–Joon Lee, Josane F. Sousa, Victoria G. Weis, Ryan L. O'Neal, Paul E. Finke, Judith Romero–Gallo, Guanglu Shi, Jason C. Mills, Richard M. Peek et al. · 2010 · Gastroenterology
  6. Regulation and plasticity of intestinal stem cells during homeostasis and regeneration
    Joep Beumer, Hans C. Clevers · 2016 · Development
  7. CFTR modulator theratyping: Current status, gaps and future directions
    John Paul Clancy, Calvin U. Cotton, Scott H. Donaldson, George Marty Solomon, Donald R. VanDevanter, Michael Boyle, Martina Gentzsch, Jerry A. Nick, Beate Illek, J. Wallenburg et al. · 2018 · Journal of Cystic Fibrosis
  8. PDGFRα + pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo
    Greicius, Gediminas, Kabiri, Zahra, Sigmundsson, Kristmundur, Liang, Chao, Bunte, Ralph, Singh, Manvendra K., Virshup, David M. · 2018 · Proceedings of the National Academy of Sciences
  9. Artificial three-dimensional niches deconstruct pancreas development in vitro
    Chiara Greggio, Filippo De Franceschi, Manuel Figueiredo-Larsen, Samy Gobaa, Adrian Ranga, Henrik Semb, Matthias P. Lütolf, Anne Grapin‐Botton · 2013 · Development
  10. Stem cells living with a Notch
    Koch, Ute, Lehal, Rajwinder, Radtke, Freddy · 2013 · Development
  11. Phenotypic landscape of intestinal organoid regeneration
    Lukonin, Ilya, Serra, Denise, Challet Meylan, Ludivine, Volkmann, Katrin, Baaten, Janine, Zhao, Rui, Meeusen, Shelly, Colman, Karyn, Maurer, Francisca, Stadler, Michael B. et al. · 2020 · Nature
  12. Promotion of Intestinal Epithelial Cell Turnover by Commensal Bacteria: Role of Short-Chain Fatty Acids
    Jung-ha Park, Takenori Kotani, Tasuku Konno, Jajar Setiawan, Yasuaki Kitamura, Shinya Imada, Yutaro Usui, Naoya Hatano, Masakazu Shinohara, Yasuyuki Saito et al. · 2016 · PLoS ONE
  13. Growth of Epithelial Organoids in a Defined Hydrogel
    Broguiere, Nicolas, Isenmann, Luca, Hirt, Christian, Ringel, Till, Placzek, Silja, Cavalli, Emma, Ringnalda, Femke, Villiger, Lukas, Züllig, Richard, Lehmann, Roger et al. · 2018 · Advanced Materials
  14. Mutant p53 in colon cancer
    Mizuho Nakayama, Masanobu Oshima · 2018 · Journal of Molecular Cell Biology
  15. Organoids: The current status and biomedical applications
    Siqi Yang, Hai‐Jie Hu, Heng‐Chung Kung, Rui-Qi Zou, Yu-Shi Dai, Ya-Fei Hu, Tiantian Wang, Tian‐Run Lv, Jun Yu, Fu‐Yu Li · 2023 · MedComm
  16. Paneth Cell Multipotency Induced by Notch Activation following Injury
    Shiyan Yu, Kevin Tong, Yanlin Zhao, Iyshwarya Balasubramanian, George S. Yap, Ronaldo P. Ferraris, Edward M. Bonder, Michael Paul Verzi, Nan Gao · 2018 · Cell stem cell
  17. Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells
    Nalapareddy, Kodandaramireddy, Nattamai, Kalpana J., Kumar, Rupali S., Karns, Rebekah, Wikenheiser-Brokamp, Kathryn A., Sampson, Leesa L., Mahe, Maxime M., Sundaram, Nambirajan, Yacyshyn, Mary-Beth, Yacyshyn, Bruce et al. · 2017 · Cell Reports
  18. Frizzled proteins are colonic epithelial receptors for C. difficile toxin B
    Liang Tao, Jie Zhang, Paul Meraner, Alessio Tovaglieri, Xiaoqian Wu, Ralf Gerhard, Xinjun Zhang, William B. Stallcup, Ji Miao, Xi He et al. · 2016 · Nature
  19. Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient
    Joep Beumer, Benedetta Artegiani, Yorick Post, Frank M. Reimann, Fiona Mary Gribble, Thuc Nghi Nguyen, Hongkui Zeng, Maaike van den Born, Johan H. van Es, Hans C. Clevers · 2018 · Nature Cell Biology
  20. Three-dimensional in vitro culture models in oncology research
    Camille Jubelin, Javier Muñoz-García, Laurent Griscom, Denis Cochonneau, Emilie Ollivier, Marie‐Françoise Heymann, François M. Vallette, Lisa Oliver, Dominique Heymann · 2022 · Cell & Bioscience
  21. The Cytosolic Bacterial Peptidoglycan Sensor Nod2 Affords Stem Cell Protection and Links Microbes to Gut Epithelial Regeneration
    Nigro, Giulia, Rossi, Raffaella, Commere, Pierre-Henri, Jay, Philippe, Sansonetti, Philippe J. · 2014 · Cell Host & Microbe
  22. Personalized Cancer Medicine: An Organoid Approach
    Hamidreza Aboulkheyr Es, Leila Montazeri, Amir Reza Aref, Massoud Vosough, Hossein Baharvand · 2018 · Trends in biotechnology
  23. The Intestinal Stem Cell Niche: Homeostasis and Adaptations
    António J. M. Santos, Yuan‐Hung Lo, Amanda T. Mah, Calvin Jay Kuo · 2018 · Trends in Cell Biology
  24. Human gastrointestinal epithelia of the esophagus, stomach, and duodenum resolved at single-cell resolution
    Georg A. Busslinger, Bas L.A.M. Weusten, Auke Bogte, Harry Begthel, Lodewijk A.A. Brosens, Hans C. Clevers · 2021 · Cell Reports
  25. Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury
    Subhrajit Saha, Evelyn Aranda, Yoku Hayakawa, Payel Bhanja, Safinur Atay, Nils Patrik Brodin, Jiufeng Li, Samuel Asfaha, Laibin Liu, Yagnesh H. Tailor et al. · 2016 · Nature Communications
  26. Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts
    Schuijers, Jurian, Junker, Jan Philipp, Mokry, Michal, Hatzis, Pantelis, Koo, Bon-Kyoung, Sasselli, Valentina, van der Flier, Laurens G., Cuppen, Edwin, van Oudenaarden, Alexander, Clevers, Hans · 2015 · Cell Stem Cell
  27. Intestinal Epithelial and Intraepithelial T Cell Crosstalk Mediates a Dynamic Response to Infection
    David P. Hoytema van Konijnenburg, Bernardo Sgarbi Reis, Virginia Ahn Pedicord, Júlia Farache, Gabriel D. Victora, Daniel Mucida · 2017 · Cell
  28. Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium
    Pentinmikko, Nalle, Iqbal, Sharif, Mana, Miyeko, Andersson, Simon, Cognetta, Armand B., Suciu, Radu M., Roper, Jatin, Luopajärvi, Kalle, Markelin, Eino, Gopalakrishnan, Swetha et al. · 2019 · Nature
  29. A Critical Role for the Wnt Effector Tcf4 in Adult Intestinal Homeostatic Self-Renewal
    Johan H. van Es, Andrea Haegebarth, Pekka Kujala, Shalev Itzkovitz, Bon‐Kyoung Koo, Sylvia F. Boj, Jeroen Korving, Maaike van den Born, Alexander van Oudenaarden, Sylvie Robine et al. · 2012 · Molecular and Cellular Biology
  30. Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids
    Marko Nikolić, Oriol Caritg, Quitz Jeng, Jo-Anne Johnson, Dawei Sun, Kate J. Howell, Jane Brady, Usua Laresgoiti, George Edward Allen, Richard Butler et al. · 2017 · eLife
  31. Salmonella Manipulation of Host Signaling Pathways Provokes Cellular Transformation Associated with Gallbladder Carcinoma
    Tiziana Scanu, Robbert M. Spaapen, Jeroen M. Bakker, Chandra Bhan Pratap, Lin-en Wu, Ingrid Hofland, Annegien Broeks, Vijay Kumar Shukla, Mohan Kumar H, Hans Janssen et al. · 2015 · Cell Host & Microbe
  32. 3D neural tissue models: From spheroids to bioprinting
    Pei Zhuang, Alfred Xuyang Sun, Jia An, Chee Kai Chua, Sing Yian Chew · 2017 · Biomaterials
  33. Interaction of Salmonella enterica Serovar Typhimurium with Intestinal Organoids Derived from Human Induced Pluripotent Stem Cells
    Jessica L. Forbester, David Goulding, Ludovic Vallier, Nicholas R. F. Hannan, Christine Hale, Derek Pickard, Subhankar Mukhopadhyay, Gordon Dougan · 2015 · Infection and Immunity
  34. Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell–derived IFN-γ
    Henner F. Farin, Wouter R. Karthaus, Pekka Kujala, Maryam Rakhshandehroo, Gerald Schwank, Robert G.J. Vries, Eric Kalkhoven, Edward E. S. Nieuwenhuis, Hans C. Clevers · 2014 · The Journal of Experimental Medicine
  35. Long-term culture, genetic manipulation and xenotransplantation of human normal and breast cancer organoids
    Johanna F. Dekkers, Esmée J. van Vliet, Norman Sachs, Jennifer M. Rosenbluth, Oded Kopper, Heggert G Rebel, Ellen J. Wehrens, Carol Piani, Jane E. Visvader, Carla S. Veríssimo et al. · 2021 · Nature Protocols
  36. A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release
    Constanza Alcaino, Kaitlyn R. Knutson, Anthony J. Treichel, Gulcan Yildiz, Peter R. Strege, David Robert Linden, Joyce H. Li, Andrew B. Leiter, Joseph H. Szurszewski, Gianrico Farrugia et al. · 2018 · Proceedings of the National Academy of Sciences
  37. Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche
    Hayley L. Belnoue-Davis, Shazia Irshad, Mukesh Bansal, Hannah Rafferty, Tatjana Boitsova, Chiara Bardella, Emma Jaeger, Annabelle Lewis, Luke Freeman-Mills, Francesc Castro-Giner et al. · 2014 · Nature Medicine
  38. Mechanisms of metastatic colorectal cancer
    Adrià Cañellas-Socias, Elena Sancho, Eduard Batlle · 2024 · Nature Reviews Gastroenterology & Hepatology
  39. 3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade
    Aref, Amir R., Campisi, Marco, Ivanova, Elena, Portell, Andrew, Larios, Dalia, Piel, Brandon P., Mathur, Natasha, Zhou, Chensheng, Coakley, Raven Vlahos, Bartels, Alan et al. · 2018 · Lab on a Chip
  40. Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening
    Verissimo, Carla S, Overmeer, René M, Ponsioen, Bas, Drost, Jarno, Mertens, Sander, Verlaan-Klink, Ingrid, Gerwen, Bastiaan van, van der Ven, Marieke, Wetering, Marc van de, Egan, David A et al. · 2016 · eLife
  41. Identification of a cKit(+) colonic crypt base secretory cell that supports Lgr5(+) stem cells in mice
    Rothenberg, Michael E., Nusse, Ysbrand, Kalisky, Tomer, Lee, John J., Dalerba, Piero, Scheeren, Ferenc, Lobo, Neethan, Kulkarni, Subhash, Sim, Sopheak, Qian, Dalong et al. · 2012 · Gastroenterology
  42. Stem Cells and the Differentiation Hierarchy in Mammary Gland Development
    Nai Yang Fu, Emma Nolan, Geoffrey John Lindeman, Jane E. Visvader · 2019 · Physiological Reviews
  43. Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis
    Palikuqi, Brisa, Nguyen, Duc-Huy T., Li, Ge, Schreiner, Ryan, Pellegata, Alessandro F., Liu, Ying, Redmond, David, Geng, Fuqiang, Lin, Yang, Gómez-Salinero, Jesus M. et al. · 2020 · Nature
  44. Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids
    Arianna Fumagalli, Jarno Drost, Saskia J.E. Suijkerbuijk, Ruben van Boxtel, Joep de Ligt, G. Johan A. Offerhaus, Harry Begthel, Evelyne Beerling, Ee Hong Tan, Owen James Sansom et al. · 2017 · Proceedings of the National Academy of Sciences
  45. A novel human gastric primary cell culture system for modelling Helicobacter pylori infection in vitro
    Philipp Schlaermann, Benjamin Toelle, Hilmar Berger, Sven Christian Schmidt, Matthias Glanemann, Jürgen Ordemann, Sina Bartfeld, Hans‐Joachim Mollenkopf, Thomas F. Meyer · 2014 · Gut
  46. Establishment and Culture of Human Intestinal Organoids Derived from Adult Stem Cells
    Cayetano Pleguezuelos‐Manzano, Jens Puschhof, Stieneke van den Brink, Veerle Geurts, Joep Beumer, Hans C. Clevers · 2020 · Current Protocols in Immunology
  47. Intestinal organoid cocultures with microbes
    Jens Puschhof, Cayetano Pleguezuelos‐Manzano, Adriana Martínez-Silgado, Ninouk Akkerman, Aurelia Saftien, Charelle Boot, Amy de Waal, Joep Beumer, Devanjali Dutta, Inha Heo et al. · 2021 · Nature Protocols
  48. NOTUM from Apc-mutant cells biases clonal competition to initiate cancer
    Flanagan, Dustin J., Pentinmikko, Nalle, Luopajärvi, Kalle, Willis, Nicky J., Gilroy, Kathryn, Raven, Alexander P., Mcgarry, Lynn, Englund, Johanna I., Webb, Anna T., Scharaw, Sandra et al. · 2021 · Nature
  49. Induction of Expandable Tissue-Specific Stem/Progenitor Cells through Transient Expression of YAP/TAZ
    T. Panciera, L. Azzolin, Atsushi Fujimura, D. di Biagio, C. Frasson, S. Bresolin, Sandra M. Soligo, G. Basso, S. Bicciato, A. Rosato et al. · 2016 · Cell Stem Cell
  50. Monoclonal Antibodies Against Lgr5 Identify Human Colorectal Cancer Stem Cells
    Kristel Kemper, Pramudita R. Prasetyanti, Wim de Lau, Hans M. Rodermond, Hans C. Clevers, Jan Paul Medema · 2012 · Stem Cells
  51. Colon cancer stem cells
    Lucia Ricci‐Vitiani, Eros Fabrizi, Elisabetta Palio, Ruggero D. Maria · 2009 · Journal of Molecular Medicine
  52. Peyer's Patch M Cells Derived from Lgr5+ Stem Cells Require SpiB and Are Induced by RankL in Cultured “Miniguts”
    Wim de Lau, Pekka Kujala, Kerstin Schneeberger, Sabine Middendorp, Vivian Sze Wing Li, Nick Barker, Anton C. Martens, Frans M. Hofhuis, Rodney P. DeKoter, Peter J. Peters et al. · 2012 · Molecular and Cellular Biology
  53. Microtechnology-based methods for organoid models
    Vanessa Velasco, S. Ali Shariati, Rahim Esfandyarpour · 2020 · Microsystems & Nanoengineering
  54. An Enteroendocrine Cell – Enteric Glia Connection Revealed by 3D Electron Microscopy
    Bohórquez, Diego V., Samsa, Leigh A., Roholt, Andrew, Medicetty, Satish, Chandra, Rashmi, Liddle, Rodger A. · 2014 · PLoS ONE
  55. Wnt some lose some: transcriptional governance of stem cells by Wnt/β-catenin signaling
    Wen‐Hui Lien, Elaine V. Fuchs · 2014 · Genes & Development
  56. Primary Mouse Small Intestinal Epithelial Cell Cultures
    Toshiro Sato, Hans C. Clevers · 2012 · Methods in molecular biology
  57. Fermentable carbohydrate stimulates FFAR2-dependent colonic PYY cell expansion to increase satiety
    Lucy J. Brooks, Alexander Viardot, Anastasia Tsakmaki, Émilie Stolarczyk, Jane K. Howard, Patrice D. Cani, Amandine Everard, Michelle Sleeth, Arianna Psichas, Jelena Anastasovskaj et al. · 2016 · Molecular Metabolism
  58. Lactobacillus murinus alleviate intestinal ischemia/reperfusion injury through promoting the release of interleukin-10 from M2 macrophages via Toll-like receptor 2 signaling
    Jingjuan Hu, Fan Deng, Bing-Cheng Zhao, Zebin Lin, Qi‐Shun Sun, Xiao Yi Yang, Mei Wu, Shi-Da Qiu, Yu Chen, Zhengzheng Yan et al. · 2022 · Microbiome
  59. Experimental models of the gut microbiome
    Koen Venema, Pieter Van den Abbeele · 2013 · Best Practice & Research Clinical Gastroenterology
  60. A High-Throughput Organoid Microinjection Platform to Study Gastrointestinal Microbiota and Luminal Physiology
    Ian Williamson, Jason W. Arnold, Leigh Ann Samsa, Liam T. Gaynor, Matthew DiSalvo, Jordan L. Cocchiaro, Ian M. Carroll, M. Andrea Azcárate-Peril, John Franklin Rawls, Nancy L. Allbritton et al. · 2018 · Cellular and Molecular Gastroenterology and Hepatology
  61. Adult mammalian stem cells: the role of Wnt, Lgr5 and R‐spondins
    Jurian Schuijers, Hans C. Clevers · 2012 · The EMBO Journal
  62. Organoid Models of Human Gastrointestinal Development and Disease
    Priya H. Dedhia, Nina Bertaux‐Skeirik, Yana L. Zavros, Jason R. Spence · 2016 · Gastroenterology
  63. Stem Cell-Derived Human Intestinal Organoids as an Infection Model for Rotaviruses
    Stacy R. Finkbeiner, Xi‐Lei Zeng, Budi Utama, Robert L. Atmar, Noah F. Shroyer, Mary Kolb Estes · 2012 · mBio
  64. IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation
    Shengyi Sun, Guojun Shi, Haibo Sha, Yewei Ji, Xuemei Han, Xin Shu, Hongming Ma, Takamasa Inoue, Beixue Gao, Hana Kim et al. · 2015 · Nature Cell Biology
  65. Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium
    Hiroyuki Miyoshi, Kelli L. VanDussen, Nicole P. Malvin, Hyunji Ryu, Yi Wang, Naomi M. Sonnek, Chin‐Wen Lai, Thaddeus S. Stappenbeck · 2016 · The EMBO Journal
  66. Ascl2-dependent cell dedifferentiation drives regeneration of ablated intestinal stem cells
    Murata, Kazutaka, Jadhav, Unmesh, Madha, Shariq, van Es, Johan, Dean, Justin, Cavazza, Alessia, Wucherpfennig, Kai, Michor, Franziska, Clevers, Hans, Shivdasani, Ramesh A. · 2020 · Cell Stem Cell
  67. An intestinal organ culture system uncovers a role for the nervous system in microbe-immune crosstalk
    Yissachar, Nissan, Zhou, Yan, Ung, Lloyd, Lai, Nicole Y., Mohan, James F., Ehrlicher, Allen, Weitz, David A., Kasper, Dennis L., Chiu, Isaac M., Mathis, Diane et al. · 2017 · Cell
  68. Shaping the intestinal brush border
    Scott William Crawley, Mark S. Mooseker, Matthew J. Tyska · 2014 · The Journal of Cell Biology
  69. Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids
    Ana C.F. Bolhaqueiro, Bas Ponsioen, Björn Bakker, Sjoerd J. Klaasen, Emre Küçükköse, Richard H. van Jaarsveld, Judith Vivié, Ingrid Verlaan-Klink, Nizar Hami, Diana C.J. Spierings et al. · 2019 · Nature Genetics
  70. A Senescence-Inflammatory Switch from Cancer-Inhibitory to Cancer-Promoting Mechanism
    Pribluda, Ariel, Elyada, Ela, Wiener, Zoltan, Hamza, Haya, Goldstein, Robert E., Biton, Moshe, Burstain, Ido, Morgenstern, Yael, Brachya, Guy, Billauer, Hana et al. · 2013 · Cancer Cell
  71. Epithelial organization, cell polarity and tumorigenesis
    Luke Martin McCaffrey, Ian G. Macara · 2011 · Trends in Cell Biology
  72. Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function
    Elaine E. Storm, Steffen Durinck, Felipe de Sousa e Melo, Jarrod R. Tremayne, Noelyn M. Kljavin, Christine Tan, Xiaofen Ye, Cecilia Chiu, Thinh Pham, Jo-Anne Hongo et al. · 2015 · Nature
  73. Wnt Signaling and Injury Repair
    Jemima L. Whyte, A. A. Smith, Jill Ann Helms · 2012 · Cold Spring Harbor Perspectives in Biology
  74. Designing Regenerative Biomaterial Therapies for the Clinic
    E. Thomas Pashuck, Molly M. Stevens · 2012 · Science Translational Medicine
  75. Wnt signalling: conquering complexity
    Katrin E. Wiese, Roeland Nusse, Renée van Amerongen · 2018 · Development
  76. Synthetic dynamic hydrogels promote degradation-independent in vitro organogenesis
    Chrisnandy, Antonius, Blondel, Delphine, Rezakhani, Saba, Broguiere, Nicolas, Lutolf, Matthias P. · 2022 · Nature Materials
  77. Colorectal Cancer Stem Cells
    George Vaiopoulos, Ioannis D. Kostakis, Michael Koutsilieris, Athanasios G. Papavassiliou · 2012 · Stem Cells
  78. Long-Term In Vitro Expansion of Salivary Gland Stem Cells Driven by Wnt Signals
    Martti Maimets, Cecilia Rocchi, Reinier Bron, Sarah A. Pringle, Jeroen Kuipers, Ben N. G. Giepmans, Robert G.J. Vries, Hans C. Clevers, Gerald de Haan, Ronald P. van Os et al. · 2015 · Stem Cell Reports
  79. Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer
    Kevin P. O’Rourke, Evangelia Loizou, Geulah Livshits, Emma M. Schatoff, Timour Baslan, Eusebio Manchado, Janelle M. Simon, Paul Bernard Romesser, Benjamin I. Leach, Teng Han et al. · 2017 · Nature Biotechnology
  80. Paneth Cells Respond to Inflammation and Contribute to Tissue Regeneration by Acquiring Stem-like Features through SCF/c-Kit Signaling
    Mark Schmitt, Matthias Schewe, Andrea Sacchetti, Danny Feijtel, Wesley S. van de Geer, Miriam Teeuwssen, Hein F.B.M. Sleddens, Rosalie Joosten, Martin E. van Royen, Harmen J.G. van de Werken et al. · 2018 · Cell Reports
  81. In vitro models replicating the human intestinal epithelium for absorption and metabolism studies: A systematic review
    Arianna Fedi, Chiara Vitale, Giulia Ponschin, Seyoum Ayehunie, Marco Fato, Silvia Scaglione · 2021 · Journal of Controlled Release
  82. Wnt signaling in stem and cancer stem cells
    Peter Wend, Jane D. Holland, Ulrike Ziebold, Walter Birchmeier · 2010 · Seminars in Cell and Developmental Biology
  83. Prime editing for functional repair in patient-derived disease models
    Imre Firmin Schene, Indi P. Joore, Rurika Oka, Michal Mokrý, Anke H.M. van Vugt, Ruben van Boxtel, Hubert P. J. van der Doef, Luc J. W. van der Laan, Monique M. A. Verstegen, Peter M. van Hasselt et al. · 2020 · Nature Communications
  84. Challenges in long-term imaging and quantification of single-cell dynamics
    Stavroula Skylaki, Oliver Hilsenbeck, Timm Schroeder · 2016 · Nature Biotechnology
  85. Both fallopian tube and ovarian surface epithelium are cells-of-origin for high-grade serous ovarian carcinoma
    Shuang Zhang, Igor Dolgalev, Tao Zhang, Hao Ran, Douglas A. Levine, Benjamin G. Neel · 2019 · Nature Communications
  86. HNF4 Regulates Fatty Acid Oxidation and Is Required for Renewal of Intestinal Stem Cells in Mice
    Lei Chen, Roshan P. Vasoya, Natalie H. Toke, Aditya Parthasarathy, Shirley Luo, Eric N. Chiles, Juan Flores, Nan Gao, Edward M. Bonder, Xiaoyang Su et al. · 2019 · Gastroenterology
  87. Controlling the polarity of human gastrointestinal organoids to investigate epithelial biology and infectious diseases
    Julia Y. Co, Mar Margalef-Català, Denise M. Monack, Manuel Ricardo Amieva · 2021 · Nature Protocols
  88. The Spectrum of Achalasia: Lessons From Studies of Pathophysiology and High-Resolution Manometry
    Peter J. Kahrilas, Guy E. Boeckxstaens · 2013 · Gastroenterology
  89. Toll-like receptor 4–mediated lymphocyte influx induces neonatal necrotizing enterocolitis
    Charlotte E. Egan, Chhinder P. Sodhi, Misty L. Good, Joyce Lin, Hongpeng Jia, Yukihiro Yamaguchi, Peng Lu, Congrong Ma, Maria F. Branca, Samantha Weyandt et al. · 2015 · Journal of Clinical Investigation
  90. Development of a primary mouse intestinal epithelial cell monolayer culture system to evaluate factors that modulate IgA transcytosis
    Clara Moon, Kelli L. VanDussen, Hiroyuki Miyoshi, Thaddeus S. Stappenbeck · 2013 · Mucosal Immunology
  91. Acetate differentially regulates IgA reactivity to commensal bacteria
    Tadashi Takeuchi, Eiji Miyauchi, Takashi Kanaya, Tamotsu Kato, Yumiko Nakanishi, Takashi Watanabe, Toshimori Kitami, Takashi Taida, Takaharu Sasaki, Hiroki Negishi et al. · 2021 · Nature
  92. Multiplexed Epitope-Based Tissue Imaging for Discovery and Healthcare Applications
    Bernd Bodenmiller · 2016 · Cell Systems
  93. Progressive plasticity during colorectal cancer metastasis
    Moorman, Andrew, Benitez, Elizabeth K., Cambuli, Francesco, Jiang, Qingwen, Mahmoud, Ahmed, Lumish, Melissa, Hartner, Saskia, Balkaran, Sasha, Bermeo, Jonathan, Asawa, Simran et al. · 2025 · Nature
  94. A PDX/Organoid Biobank of Advanced Prostate Cancers Captures Genomic and Phenotypic Heterogeneity for Disease Modeling and Therapeutic Screening
    Michael L. Beshiri, Caitlin M. Tice, Crystal Tran, Holly M. Nguyen, Adam G. Sowalsky, Supreet Agarwal, Keith H. Jansson, Qi Yang, Kerry M. McGowen, JuanJuan Yin et al. · 2018 · Clinical Cancer Research
  95. Epithelial MHC Class II Expression and Its Role in Antigen Presentation in the Gastrointestinal and Respiratory Tracts
    Jonathan E. Wosen, Dhriti Mukhopadhyay, Claudia Macaubas, Elizabeth Mellins · 2018 · Frontiers in Immunology
  96. Patient-derived tumor organoids: a new avenue for preclinical research and precision medicine in oncology
    Lucie Thorel, Marion Perréard, Romane Florent, Jordane Divoux, Sophia Coffy, Audrey Vincent, Cédric Gaggioli, Géraldine Guasch, Xavier Gidrol, Louis‐Bastien Weiswald et al. · 2024 · Experimental & Molecular Medicine
  97. Innate immune signalling at the intestinal epithelium in homeostasis and disease
    Johanna Pott, Mathias Walter Hornef · 2012 · EMBO Reports
  98. Establishment of Patient-Derived Organoids and Drug Screening for Biliary Tract Carcinoma
    Yoshimasa Saito, Toshihide Muramatsu, Yae Kanai, Hidenori Ojima, Aoi Sukeda, Nobuyoshi Hiraoka, Eri Arai, Yuko Sugiyama, Juntaro Matsuzaki, Ryoei Uchida et al. · 2019 · Cell Reports
  99. Duodenum Intestine-Chip for preclinical drug assessment in a human relevant model
    Magdalena J. Kasendra, Raymond Luc, Jianyi Yin, Dimitris V. Manatakis, Gauri Kulkarni, Carolina Lucchesi, Josiah D. Sliz, Athanasia P. Apostolou, Laxmi Sunuwar, Jenifer Obrigewitch et al. · 2020 · eLife
  100. Clinical applications of human organoids
    Monique M. A. Verstegen, Robert Paul Coppes, Anne Béghin, Paolo De Coppi, M Gerli, Nienke de Graeff, Qiuwei Pan, Yoshimasa Saito, Shaojun Shi, AMIR ABBAS ZADPOOR et al. · 2025 · Nature Medicine